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1. 发明授权

US06379325B1 Opto-acoustic transducer for medical applications 失效
标题翻译：用于医疗应用的光学传感器
公开(公告)号：US06379325B1
公开(公告)日：2002-04-30
申请号：US09350494
申请日：1999-07-09
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B1720
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.
摘要翻译：本发明是用于在生物介质中产生声振动的光学激活换能器。传感器位于可以位于导管内的光纤的端部。用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。传感器通过热冷却过程返回到其原始状态。传感器在环境介质中的运动将声能耦合到介质中。通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。

2. 发明授权

US5944687A Opto-acoustic transducer for medical applications 失效
公开(公告)号：US5944687A
公开(公告)日：1999-08-31
申请号：US639018
申请日：1996-04-24
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/20
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

3. 发明授权

US06022309A Opto-acoustic thrombolysis 失效
公开(公告)号：US06022309A
公开(公告)日：2000-02-08
申请号：US639017
申请日：1996-04-24
申请人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
发明人： Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Pat Fitch
IPC分类号： A61B17/22 , A61B17/00 , A61B18/00 , A61B18/26 , A61B19/00 , A61B17/36
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00022 , A61B2017/22084 , A61B2090/378
摘要： This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, thrombolytic agent, blood or thrombus, and generates an acoustic impulse in the fluid through thermoelastic and/or thermodynamic mechanisms. By pulsing the laser at a repetition rate (which may vary from 10 Hz to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus or treating vasospasm. The catheter can also incorporate thrombolytic drug treatments as an adjunct therapy and it can be operated in conjunction with ultrasonic detection equipment for imaging and feedback control and with optical sensors for characterization of thrombus type and consistency.

4. 发明申请

US20060146988A1 Early Answer 审中-公开
标题翻译：早期答案
公开(公告)号：US20060146988A1
公开(公告)日：2006-07-06
申请号：US10905202
申请日：2004-12-21
申请人： Dennis Matthews
发明人： Dennis Matthews
IPC分类号： H04M1/64
CPC分类号： H04M19/04 , H04M1/64
摘要： An answering machine for preventing the ring of phones in the same location, by answering the phone before the other phones on the same line has a chance to answer. This has many uses two examples but not limited to these examples are Sleeping Baby or Third Shift workers trying to sleep during the day or night. The machine looks for the wave form of the ring on the line and answers at a fast rate, Plays a prerecorded message to the user instructing them to call back later, message recording system can take a message, or allow them to press a key on there phone and ring a ringer on the box if it is an emergency. Unit can also have the option of using a remote ringer triggered by RF signal, or by connecting to the line in another room or area that has access to the same phone line. A telephone ring is an AC signal between 15-68 HZ. We can watch the line for an AC signal when the phone is on the hook and wait for this signal by watching for a pulse (Fig A) or wave (Fig B) within this frequency range. Most of the time this signal is a square wave (Pulse), but some older phone companies still exist that use a wave form.
摘要翻译：一种用于在相同位置防止电话环的应答机，通过在同一线路上的其他电话之前接听电话机会有机会回答。这有许多用途两个例子，但不限于，这些例子是睡觉宝宝或三班班工作者白天或晚上睡觉。机器会在线上查找戒指的波形并以较快的速度进行应答，播放预先记录的消息给用户，指示他们稍后回来，消息录制系统可以收到消息，或者允许他们按下如果是紧急情况，那里有电话和响铃的方框。单元还可以选择使用由RF信号触发的远程振铃器，或者连接到可以访问同一电话线路的另一个房间或区域中的线路。电话铃是15-68HZ之间的交流信号。当手机挂机时，我们可以观看交流信号线路，并在该频率范围内观看脉冲（图A）或波形（图B）等待该信号。大部分时间这个信号是一个方波（Pulse），但是一些较旧的电话公司仍然存在使用波形。

5. 发明授权

US06607487B2 Ultrasound image guided acetabular implant orientation during total hip replacement 失效
公开(公告)号：US06607487B2
公开(公告)日：2003-08-19
申请号：US09767454
申请日：2001-01-23
申请人： John Chang , Waleed Haddad , Jan-Ulco Kluiwstra , Dennis Matthews , Kenneth Trauner
发明人： John Chang , Waleed Haddad , Jan-Ulco Kluiwstra , Dennis Matthews , Kenneth Trauner
IPC分类号： A61B800
CPC分类号： A61B8/4281 , A61B17/1746 , A61B90/36 , A61B2017/00296 , A61B2017/3413 , A61B2090/067 , A61B2090/378 , A61B2090/3916 , A61F2/32 , A61F2/34 , A61F2/4609 , A61F2/4657 , A61F2/4684 , A61F2002/30606 , A61F2002/3611 , A61F2002/4668
摘要： A system for assisting in precise location of the acetabular implant during total hip replacement. The system uses ultrasound imaging for guiding the placement and orientation of the implant.

6. 发明授权

US06384915B1 Catheter guided by optical coherence domain reflectometry 失效
标题翻译：导管由光学相干畴反射法引导
公开(公告)号：US06384915B1
公开(公告)日：2002-05-07
申请号：US09050570
申请日：1998-03-30
申请人： Matthew Everett , Billy W. Colston , Luiz B. Da Silva , Dennis Matthews
发明人： Matthew Everett , Billy W. Colston , Luiz B. Da Silva , Dennis Matthews
IPC分类号： G01N1502
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0084
摘要： A guidance and viewing system based on multiplexed optical coherence domain reflectometry is incorporated into a catheter, endoscope, or other medical device to measure the location, thickness, and structure of the arterial walls or other intra-cavity regions at discrete points on the medical device during minimally invasive medical procedures. The information will be used both to guide the device through the body and to evaluate the tissue through which the device is being passed. Multiple optical fibers are situated along the circumference of the device. Light from the distal end of each fiber is directed onto the interior cavity walls via small diameter optics (such as gradient index lenses and mirrored corner cubes). Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers and multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The system may also be implemented in a nonmedical inspection device.
摘要翻译：基于复合光学相干畴反射测量的引导和观察系统被并入到导管，内窥镜或其他医疗装置中，以测量医疗装置上的离散点处的动脉壁或其它腔内区域的位置，厚度和结构在微创医疗程序中。该信息将用于引导装置穿过身体并评估装置通过的组织。多个光纤沿着设备的圆周设置。来自每根纤维的远端的光通过小直径光学器件（例如梯度折射率透镜和镜像角立方体）被引导到内腔壁上。可以包括前视和侧视纤维。然后从空腔壁反射或散射的光被纤维收集，并在近端多路复用到光学低相干反射计的样品臂。该系统还可以在非医疗检查装置中实现。

7. 发明授权

US06175669B1 Optical coherence domain reflectometry guidewire 失效
标题翻译：光学相干畴反射导丝
公开(公告)号：US06175669B1
公开(公告)日：2001-01-16
申请号：US09050571
申请日：1998-03-30
申请人： Billy W. Colston , Matthew Everett , Luiz B. Da Silva , Dennis Matthews
发明人： Billy W. Colston , Matthew Everett , Luiz B. Da Silva , Dennis Matthews
IPC分类号： G02B600
CPC分类号： A61B5/6852 , A61B1/00177 , A61B1/00181 , A61B5/0066 , A61B5/0084
摘要： A guidewire with optical sensing capabilities is based on a multiplexed optical coherence domain reflectometer (OCDR), which allows it to sense location, thickness, and structure of the arterial walls or other intra-cavity regions as it travels through the body during minimally invasive medical procedures. This information will be used both to direct the guidewire through the body by detecting vascular junctions and to evaluate the nearby tissue. The guidewire contains multiple optical fibers which couple light from the proximal to distal end. Light from the fibers at the distal end of the guidewire is directed onto interior cavity walls via small diameter optics such as gradient index lenses and mirrored corner cubes. Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers, which are multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The guidewire can also be used in nonmedical applications.
摘要翻译：具有光学感测能力的导丝基于多路复用光学相干域反射计（OCDR），其允许其在微创医疗中穿过身体时感测动脉壁或其他腔内区域的位置，厚度和结构程序。该信息将用于通过检测血管结点引导导线穿过身体并评估附近的组织。导丝包含多个光纤，其将光从近端耦合到远端。来自导线远端的纤维的光通过诸如梯度折射率透镜和镜像角立方体的小直径光学器件引导到内腔壁上。可以包括前视和侧视纤维。然后从空腔壁反射或散射的光被纤维收集，纤维在近端被多路复用到光学低相干反射计的样品臂。导丝也可用于非医疗应用。

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