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    • 5. 发明授权
    • Reactive dyes, processes for their preparation and their use
    • 活性染料,其制备方法及其用途
    • US06592634B1
    • 2003-07-15
    • US09521711
    • 2000-03-09
    • Hans ReichertThomas Verdugo
    • Hans ReichertThomas Verdugo
    • D06P1382
    • C09B62/4403C09B62/021C09B62/043C09B62/205Y10S8/918
    • Reactive dyes of the formula (1) in which R1, R2, R3 and R4 independently of one another are hydrogen or substituted or unsubstituted C1-C4alkyl, (R5)0-2 and (R6)0-2 independently of one another are 0 to 2 identical or different substituents from the group consisting of C1-C4alkyl, C1-C4alkoxy, C2-C4alkanoylamino, halogen, carboxyl, sulfo, carbamoyl, N-C1-C4alkylcarbamoyl, N,N-di-C1-C4alkylcarbamoyl, C1-C4alkylsulfonyl, sulfamoyl, N-C1-C4alkylsulfamoyl and N,N-di-C1-C4alkylsulfamoyl, A is hydrogen or C1-C4alkyl which is unsubstituted or substituted by hydroxyl, sulfo, carboxyl or sulfato, phenyl or naphthyl which are unsubstituted or substituted by C1-C4alkyl, C1-C4alkoxy, C2-C4alkanoylamino, hydroxyl, carboxyl, carbamoyl, sulfo or halogen, phenyl-C1-C4alkylene which is unsubstituted or substituted in the phenyl ring by C1-C4alkyl, C1-C4alkoxy, C2-C4alkanoylamino, hydroxyl, carboxyl, sulfo, carbamoyl, ureido or halogen, or C5-C7cycloalkyl which is unsubstituted or substituted by C1-C4alkyl, B1 is an aliphatic or aromatic bridge member, and the remaining substituents are described in the specification.
    • 其中R 1,R 2,R 3和R 4彼此独立地是式(1)的反应性染料是氢或取代或未取代的C 1 -C 4烷基,(R 5)0-2和(R 6) 2个与C1-C4烷基,C1-C4烷氧基,C2-C4烷酰基氨基,卤素,羧基,磺基,氨基甲酰基,N-C1-C4烷基氨基甲酰基,N,N-二C1-C4烷基氨基甲酰基,C1-C4烷基磺酰基, 氨磺酰基,N-C 1 -C 4烷基氨磺酰基和N,N-二-C 1 -C 4烷基氨磺酰基,A是未取代或被羟基,磺基,羧基或硫酸酯取代的C 1 -C 4烷基,未被取代或被C1- C 1 -C 4烷基,C 1 -C 4烷氧基,C 2 -C 4烷酰基氨基,羟基,羧基,氨基甲酰基,磺基或卤素,苯基-C 1 -C 4亚烷基,其未被取代或在苯环中被C1-C4烷基,C1-C4烷氧基,C2-C4烷酰基氨基,羟基, ,磺基,氨基甲酰基,脲基或卤素,或未被取代或被C 1 -C 4烷基取代的C 5 -C 7环烷基 ,B1是脂族或芳族桥连构件,其余的取代基在说明书中描述。
    • 7. 发明授权
    • Enzyme-based time temperature indicator
    • 基于酶的时间温度指标
    • US07736866B2
    • 2010-06-15
    • US11659645
    • 2005-08-03
    • Hans ReichertPeter SimmendingerThomas Bolle
    • Hans ReichertPeter SimmendingerThomas Bolle
    • C12Q1/34
    • C12Q1/25G01K3/04G01N31/229
    • A time temperature indicator for indicating temperature change over time is provided, comprising an immobilized enzyme and a substrate of the enzyme, wherein the reaction of the substrate catalyzed by the enzyme produces a reaction product in a time and temperature dependent manner and wherein the formation of the reaction product can be detected by monitoring a physical characteristic of the substrate and/or the product which is linked to its concentration. Also provided is a method of time temperature indication comprising the step of an enzyme-catalyzed reaction, a method of printing the enzyme-based time temperature indicator on a packaging material or a label, a printing ink or printing ink concentrate comprising components of the enzyme-based time temperature indicator and a packaging material or a label comprising the enzyme-based time temperature indicator.
    • 提供了用于指示随时间的温度变化的时间温度指示器,其包括固定化酶和酶的底物,其中由酶催化的底物的反应以时间和温度依赖的方式产生反应产物,并且其中形成 可以通过监测与其浓度相关的底物和/或产物的物理特性来检测反应产物。 还提供了一种时间温度指示的方法,其包括酶催化反应的步骤,在包装材料或标签上印刷基于酶的时间温度指示剂的方法,包含酶的组分的印刷油墨或印刷油墨浓缩物 的时间温度指示剂和包含材料或包含基于酶的时间温度指示剂的标签。
    • 8. 发明申请
    • Enzyme-based time temperature indicator
    • 基于酶的时间温度指标
    • US20090226948A1
    • 2009-09-10
    • US11659645
    • 2005-08-03
    • Hans ReichertPeter SimmendingerThomas Bolle
    • Hans ReichertPeter SimmendingerThomas Bolle
    • C12Q1/44C12Q1/00C12Q1/34C09D11/02C07D487/04C07D498/04C07H17/02C07D403/04
    • C12Q1/25G01K3/04G01N31/229
    • The present invention relates to a time temperature indicator for indicating temperature change over time, comprising an immobilized enzyme and a substrate of the enzyme, wherein the reaction of the substrate catalyzed by the enzyme produces a reaction product in a time and temperature dependent manner and wherein the formation of the reaction product can be detected by monitoring a physical characteristic of the substrate and/or the product which is linked to its concentration. The invention further relates to a method of time temperature indication comprising the step of an enzyme-catalyzed reaction, a method of printing the enzyme-based time temperature indicator on a packaging material or a label, a printing ink or printing ink concentrate comprising components of the enzyme-based time temperature indicator and a packaging material or a label comprising the enzyme-based time temperature indicator.
    • 本发明涉及用于指示随着时间的温度变化的时间温度指示器,其包括固定化酶和酶底物,其中由酶催化的底物的反应以时间和温度依赖的方式产生反应产物,其中 通过监测与其浓度相关的底物和/或产物的物理特性,可以检测反应产物的形成。 本发明还涉及一种时间温度指示方法,其包括酶催化反应步骤,在包装材料或标签上印刷基于酶的时间温度指示剂的方法,印刷油墨或印刷油墨浓缩物,其包含 基于酶的时间温度指示剂和包含基于酶的时间温度指示剂的包装材料或标签。