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    • 1. 发明授权
    • Pyrimidine-2,4,6-triones
    • 嘧啶-2,4,6-三硝基吡啶
    • US06265578B1
    • 2001-07-24
    • US09483858
    • 2000-01-17
    • Louise Helen FoleyRobert Edward PalermoPing Wang
    • Louise Helen FoleyRobert Edward PalermoPing Wang
    • C07D23962
    • C07D239/62A61K31/513
    • A compound of formula I wherein R1 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryloxy or alkylalkoxy, and R2 is aryloxy, or a pharmaceutically acceptable salt of an acidic compound of formula I, or a prodrug thereof. The compounds of formula I and their aforementioned salts and prodrugs can be used in the treatment or control of cancer associated with overexpresison of gelatinase-A and/or gelatinase-B, particularly skin cancer, breast cancer, prostate cancer, colon cancer, lung cancer, and gastric cancer. The compounds of the invention are also useful for other diseases associated with unregulated degradation of extracellular matrix, including rheumatoid arthritis, osteoarthritis, multiple sclerosis, corneal ulceration, periodontal disease and the like.
    • 式I的化合物,其中R 1是氢,烷基,取代的烷基,烯基,取代的烯基,炔基,取代的炔基,烷氧基,取代的烷氧基,芳氧基或烷基烷氧基,R 2是芳氧基或式I的酸性化合物的药学上可接受的盐, 其前药。 式I化合物及其上述盐和前药可用于治疗或控制与明胶酶-A和/或明胶酶-B(特别是皮肤癌,乳腺癌,前列腺癌,结肠癌,肺癌)过度表达相关的癌症 和胃癌。 本发明的化合物还可用于与细胞外基质的不受限制降解有关的其它疾病,包括类风湿性关节炎,骨关节炎,多发性硬化,角膜溃疡,牙周病等。
    • 5. 发明授权
    • Trim assembly for covering airbag
    • 用于覆盖安全气囊的修整组件
    • US09221416B2
    • 2015-12-29
    • US14235983
    • 2011-08-30
    • Ping WangYohann BonifaceJérôme Mezière
    • Ping WangYohann BonifaceJérôme Mezière
    • B60R21/205B60R21/215
    • B60R21/215B60R2021/21506B60R2021/21537
    • A trim assembly for covering an airbag, comprising: a carrier provided with a through-opening for the airbag; a surface decor; an inlay applied between the carrier and the surface decor and covering the through-opening, the inlay extending, on one side, beyond an edge of the through-opening to overlap a region of the carrier to form an hinge for an airbag flap formed by the surface decor and the inlay; and a fastening strap for fastening the inlay to the carrier at the overlapping region, wherein it comprises at least one retaining element arranged at the overlapping region, the retaining element cooperating with the inlay for retaining the airbag flap on the carrier upon an opening of the airbag flap.
    • 一种用于覆盖气囊的装饰组件,包括:设置有用于所述气囊的通孔的载体; 表面装饰; 所述承载件与所述表面装饰之间施加并覆盖所述通孔的嵌体,所述嵌体在一侧延伸超过所述通孔的边缘以与所述载体的区域重叠以形成用于由 表面装饰和镶嵌; 以及紧固带,用于在所述重叠区域处将所述嵌入物紧固到所述载体,其中,所述紧固带包括布置在所述重叠区域处的至少一个保持元件,所述保持元件与所述嵌体配合,以将所述气囊瓣保持在所述载体上, 安全气囊。