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    • 6. 发明授权
    • Method of making antiperspirant active compositions having SEC chromatogram exhibiting high SEC peak 4 intensity
    • 具有SEC色谱图显示高SEC峰值4强度的止汗活性组合物的方法
    • US08562956B2
    • 2013-10-22
    • US13565370
    • 2012-08-02
    • Long Pan
    • Long Pan
    • A61K8/28A61K8/26
    • A61K8/416A61K8/26A61K8/28A61K8/44A61Q15/00
    • A method of making an antiperspirant active composition comprising: heating an aqueous solution containing an aluminum salt having an aluminum to chloride molar ratio of about 0.3:1 to about 3:1, optionally with a buffer agent, at a temperature of about 50° C. to about 95° C. to reflux for a period of time of about 1 hour to about 5 hours to obtain an aluminum salt solution; adding an aqueous solution of an inorganic base to obtain an aluminum salt solution having an OH:Al molar ratio of about 2:1 to about 2.6:1 to obtain a pH adjusted aluminum salt solution having a pH of about 2 to about 5; and optionally adding an aqueous solution containing a zirconium compound to the pH adjusted aluminum salt solution to thereby obtain an aluminum-zirconium salt solution having a molar ratio of aluminum to zirconium of about 5:1 to about 10:1.
    • 一种制备止汗活性组合物的方法,其包括:在约50℃的温度下,将包含铝至氯化物摩尔比为约0.3:1至约3:1的铝盐水溶液任选加入缓冲剂中 至约95℃,回流约1小时至约5小时,得到铝盐溶液; 加入无机碱的水溶液,得到OH:Al摩尔比为约2:1至约2.6:1的铝盐溶液,得到pH为约2至约5的pH调节的铝盐溶液; 并且任选地将含锆化合物的水溶液加入到pH调节的铝盐溶液中,从而获得铝与锆的摩尔比为约5:1至约10:1的铝 - 锆盐溶液。
    • 7. 发明申请
    • COMPOSITIONS AND METHOD OF DELIVERY
    • 组合物和交付方法
    • US20120225806A1
    • 2012-09-06
    • US13505859
    • 2010-11-05
    • Long PanClaudio OrtizAllen Puchalski
    • Long PanClaudio OrtizAllen Puchalski
    • A61K8/58A61Q13/00
    • A61K8/58A61K8/19A61K8/4926A61K2800/31A61K2800/58A61Q15/00
    • A method of delivering a material to a person comprising applying an anhydrous composition to a person, wherein the anhydrous composition comprises a base and metal organic framework formed from a recyclable porous material with the material adsorbed into the metal organic framework, and the recyclable porous material has a structure that breaks down when contacted with water to release the material. An anhydrous composition comprising a base and a metal organic framework formed from a recyclable porous material with the material adsorbed into the metal organic framework, wherein the recyclable porous material has a structure that breaks down when contacted with water to release the material.
    • 一种将材料递送给人的方法,包括向人施用无水组合物,其中所述无水组合物包含由可回收的多孔材料形成的基材和金属有机骨架,其中所述材料被吸附到所述金属有机骨架中,并且所述可再循环多孔材料 具有当与水接触以释放材料时分解的结构。 一种无水组合物,其包含基底和由可回收的多孔材料形成的金属有机骨架,其中所述材料吸附到所述金属有机骨架中,其中所述可再循环多孔材料具有当与水接触以分解材料时分解的结构。
    • 8. 发明授权
    • Oxo-hexameric zirconium-octaamino acid antiperspirant salts
    • 氧六氟锆 - 八氨基酸止汗盐
    • US07897799B2
    • 2011-03-01
    • US12293463
    • 2008-09-12
    • Long PanLaTonya KilpatrickXiaozhong Tang
    • Long PanLaTonya KilpatrickXiaozhong Tang
    • C07F7/00A61Q15/00
    • A61Q15/00A61K8/28A61K8/44A61K2800/58C07F7/003
    • A process for preparing oxo-hexameric zirconium-octaamino acid, such as glycine, salt comprising: mixing zirconium (Zr):amino acid:and mineral acid, in a molar ratio of 1:about 1 to about 15:about 1.5 to about 3 to form a mixture; optionally, filtering the mixture; and optionally, drying the mixture. An oxo-hexameric zirconium-octaamino acid salt of the molecular formula: oxo-[Zr6AminoAcid8].Xy.nH2O, wherein Zr is zirconium, X is an anion of a mineral acid, and n and y are numerical values from 0 to 20. A method of making an antiperspirant active zirconium-aluminum-amino acid compound comprising mixing an oxo-hexameric zirconium-octaamino acid salt with aluminum chlorohydrex and/or aluminum chloride, and drying the mixture. The smallest oxo-hexameric zirconium-octaamino acid salt of this invention provides stability, efficacy, and shelf life of zirconium-amino acid species for formulations in antiperspirant and/or deodorant compositions.
    • 一种制备氧代 - 六聚锆 - 八氨基酸如甘氨酸盐的方法,包括:将锆(Zr):氨基酸和无机酸以摩尔比1:约1:约15:约1.5至3 形成混合物 任选地,过滤混合物; 并任选地干燥混合物。 分子式为氧代 - [Zr6AminoAcid8] Xy.nH2O的氧代六聚体锆 - 八氨基酸盐,其中Zr是锆,X是无机酸的阴离子,n和y是0至20的数值。 一种制备止汗活性锆 - 铝 - 氨基酸化合物的方法,包括将氧代六聚体锆 - 八氨基酸盐与氯化铝和/或氯化铝混合并干燥该混合物。 本发明的最小的氧代 - 六聚体锆 - 八氨基酸盐为止汗剂和/或除臭剂组合物中的制剂提供了锆 - 氨基酸种类的稳定性,有效性和保质期。