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1. 发明申请

US20060243696A1 Tip design for reducing capillary leakage and water loss for plastic container closures 审中-公开
标题翻译：尖端设计，用于减少塑料容器封闭件的毛细管泄漏和水分流失
公开(公告)号：US20060243696A1
公开(公告)日：2006-11-02
申请号：US11115563
申请日：2005-04-27
申请人： Lon Spada , Scott Gerondale , John Dries
发明人： Lon Spada , Scott Gerondale , John Dries
IPC分类号： B65D45/00 , B65D39/08 , B65D45/32
CPC分类号： B65D47/122 , B65D53/02
摘要： A plastic container closure includes a bottle having an open end with a circumferential bottle shoulder and a tip insertable into the bottle opened end with a tip shoulder overlaying the bottle shoulder. The compressible seal ring is provided and disposed between the bottle shoulder and the tip shoulder and a tip-covering cap engagable with the bottle and the cap compressed to the seal.
摘要翻译：塑料容器封闭件包括具有开口端的瓶子，其具有圆周瓶肩部和可插入瓶子开口端的尖端，其顶端肩部覆盖在瓶肩上。可压缩的密封环设置并设置在瓶肩和尖端肩部之间，并且可与瓶子接合的顶盖盖被压缩到密封件上。

2. 发明申请

US20060111680A1 Autoclaveable small-volume dropper bottle 有权
标题翻译：高压灭菌小容量滴瓶
公开(公告)号：US20060111680A1
公开(公告)日：2006-05-25
申请号：US10997266
申请日：2004-11-23
申请人： Lon Spada , Paul Butorac , Scott Gerondale
发明人： Lon Spada , Paul Butorac , Scott Gerondale
IPC分类号： A61M35/00 , B65D47/18
CPC分类号： A61F9/0008 , B65D1/32 , B65D47/18
摘要： A terminally sterilizable container includes a polypropylene bottle having a body with a manually squeezable sidewall and a thickness preventing water loss. The bottle body includes shoulders for providing autoclave produced pressure distribution and deformation resistance along with an elongated tips outfitted to a neck of the body and having a lumen therethrough with a drop dispensing orifice. A cap enclosed the elongated tip and includes enclosed with a nub for sealing the orifice to prevent autoclave produced pressure leaks.
摘要翻译：末端可灭菌的容器包括具有手动可挤压侧壁的主体和防止水分损失的厚度的聚丙烯瓶。瓶体包括用于提供高压釜产生的压力分布和变形阻力的肩部以及装配到主体的颈部并且具有通过其的腔的液滴分配孔的细长尖端。盖子包住细长的尖端，并且包括用小孔封闭以密封孔口，以防止高压釜产生的压力泄漏。

3. 发明申请

US20060032873A1 Container system 审中-公开
标题翻译：集装箱系统
公开(公告)号：US20060032873A1
公开(公告)日：2006-02-16
申请号：US10916067
申请日：2004-08-11
申请人： Scott Gerondale , Lon Spada , Paul Butorac
发明人： Scott Gerondale , Lon Spada , Paul Butorac
IPC分类号： B65D25/40
CPC分类号： B65D1/0246 , B65D47/18
摘要： A container system includes a squeeze bottle of a specific volume having a neck with an open end and a medicament disposed within the bottle. A tip is provided which is insertable into the open end of the squeezable bottle and includes an internal tapered nozzle with the nozzle having increased diameter toward a tip opening. A cap is provided for removable attachment to the bottleneck for sealing the tip opening and a shoulder formed in the bottle proximate the neck and disposed at an angle is provided in order to enhance bubbless flow of the medicament to the nozzle and facilitate tamper proof sealing of the cap.
摘要翻译：容器系统包括具有开口端的颈部的特定容积的挤压瓶和设置在瓶内的药物。提供了可插入可压缩瓶的开口端的尖端，并且包括内部锥形喷嘴，其中喷嘴具有朝向尖端开口的直径增加的直径。提供了用于可拆卸地连接到瓶颈以用于密封尖端开口的盖，并且提供形成在瓶中靠近颈部并以一定角度设置的肩部，以便增强药剂到喷嘴的无气泡流动，并且便于防止这顶帽子。

4. 发明申请

US20070031472A1 Steroid-containing sustained release intraocular implants and related methods 有权
标题翻译：类固醇持续释放眼内植入物及相关方法
公开(公告)号：US20070031472A1
公开(公告)日：2007-02-08
申请号：US11474149
申请日：2006-06-23
申请人： Glenn Huang , Thierry Nivaggioli , Lon Spada , Hiroshi Sugimoto , Wendy Blanda , James Chang , Orest Olejnik
发明人： Glenn Huang , Thierry Nivaggioli , Lon Spada , Hiroshi Sugimoto , Wendy Blanda , James Chang , Orest Olejnik
IPC分类号： A61K31/573 , A61F2/02
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

5. 发明申请

US20050274744A1 Dispensing tip 有权
标题翻译：点胶尖
公开(公告)号：US20050274744A1
公开(公告)日：2005-12-15
申请号：US10865055
申请日：2004-06-10
申请人： Lon Spada , Paul Butorac
发明人： Lon Spada , Paul Butorac
IPC分类号： A61F9/00 , B05C5/02 , B65D47/18 , A61M29/00
CPC分类号： A61F9/0026 , B65D47/18
摘要： A dispensing tip includes a body suitable for attachment to a dispensing bottle along with a nozzle having a lumen therethrough for flow of liquid formulation and an egress orifice which is in fluid communication with the lumen for the formation of droplets. A concave arcuate surface of revolution about the egress orifice is provided and depending therefrom for enhancing droplet separation from the egress orifice which in turn insures uniform droplet formation and dispensement.
摘要翻译：分配尖端包括适于附接到分配瓶的主体以及具有用于液体制剂流动的通孔的喷嘴以及与内腔流体连通以形成液滴的出口孔。提供了围绕出口孔的凹曲面的旋转表面，并且由此排出用于增强与出口孔的液滴分离，从而确保均匀的液滴形成和分配。

6. 发明申请

US20050244475A1 Biodegradable intravitreal tyrosine kinase implants 有权
标题翻译：可生物降解的玻璃体内酪氨酸激酶植入物
公开(公告)号：US20050244475A1
公开(公告)日：2005-11-03
申请号：US11119001
申请日：2005-04-29
申请人： Jeffrey Edelman , Patrick Hughes , Thomas Malone , Gerald DeVries , Joan-En Chang-Lin , Jane Shiah , Thierry Nivaggioli , Lon Spada , Wendy Blanda
发明人： Jeffrey Edelman , Patrick Hughes , Thomas Malone , Gerald DeVries , Joan-En Chang-Lin , Jane Shiah , Thierry Nivaggioli , Lon Spada , Wendy Blanda
IPC分类号： A61F2/00 , A61K9/00 , A61K9/20 , A61K31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/204 , A61K31/404 , A61K31/454 , A61K31/5377 , A61K47/34
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
摘要翻译：生物相容性眼内植入物包括酪氨酸激酶抑制剂和可生物降解的聚合物，其有效促进酪氨酸激酶抑制剂延长一段时间的眼睛玻璃体。植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症如眼后病症的发生。

7. 发明申请

US20050244473A1 Memantine intravitreal implants 审中-公开
标题翻译：美金刚玻璃体内植入物
公开(公告)号：US20050244473A1
公开(公告)日：2005-11-03
申请号：US11117879
申请日：2005-04-29
申请人： Patrick Hughes , Lon Spada , Hiroshi Sugimoto , Wendy Blanda , James Chang
发明人： Patrick Hughes , Lon Spada , Hiroshi Sugimoto , Wendy Blanda , James Chang
IPC分类号： A61K9/00 , A61K31/13 , A61F2/00
CPC分类号： A61K9/0051
摘要： Biocompatible intraocular implants include an anti-excitotoxic agent and a biodegradable polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.
摘要翻译：生物相容性眼内植入物包括抗兴奋性毒性剂和可生物降解的聚合物，其有效促进抗兴奋性毒性剂长时间释放到眼睛中。植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

8. 发明申请

US20050211734A1 Skirted closure for small dropper bottles 审中-公开
标题翻译：小滴瓶的裙边
公开(公告)号：US20050211734A1
公开(公告)日：2005-09-29
申请号：US10808652
申请日：2004-03-24
申请人： Lon Spada , Paul Butorac
发明人： Lon Spada , Paul Butorac
IPC分类号： B65D41/04 , B65D47/18
CPC分类号： B65D41/0428
摘要： A closure for a dropper bottle includes a nozzle having a neck and a shoulder. The neck includes an aperture at an end thereof for dropwise dispensing of a liquid, and the shoulder includes an outstanding circumferential ring and threads disposed between the ring and the neck. A cap is provided with a top and an axially downwardly extending skirt. The top has a seat for sealably engaging the aperture, and the skirt has internal grooves for engaging the nozzle threads and an internal circumferential lip for sealably engaging the ring. The lip is spaced apart from the aperture for enabling simultaneous sealing of the aperture and the ring upon rotation of said cap onto said nozzle.
摘要翻译：用于滴管瓶的封闭件包括具有颈部和肩部的喷嘴。颈部在其一端包括用于液体滴落的孔，肩部包括突出的周向环和设置在环与颈部之间的螺纹。帽设置有顶部和轴向向下延伸的裙部。顶部具有用于密封地接合孔的座，裙部具有用于接合喷嘴螺纹的内部凹槽和用于密封地接合环的内周唇缘。所述唇缘与所述孔间隔开，以便在将所述帽旋转到所述喷嘴上时能够同时密封所述孔和所述环。

9. 发明申请

US20070059336A1 Anti-angiogenic sustained release intraocular implants and related methods 审中-公开
标题翻译：抗血管生成持续释放眼内植入物及相关方法
公开(公告)号：US20070059336A1
公开(公告)日：2007-03-15
申请号：US11364687
申请日：2006-02-27
申请人： Patrick Hughes , Thomas Malone , Gerald De Vries , Jeffrey Edelman , Wendy Blanda , Lon Spada , Peter Baciu , Scott Whitcup
发明人： Patrick Hughes , Thomas Malone , Gerald De Vries , Jeffrey Edelman , Wendy Blanda , Lon Spada , Peter Baciu , Scott Whitcup
IPC分类号： A61K38/18 , A61K39/395
CPC分类号： A61K48/0041 , A61K9/0051
摘要： Biocompatible intraocular drug delivery systems include a anti-angiogenic therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of implants or microparticles, and combinations thereof. The therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three dimensional structure when released into an eye of a patient, or the therapeutic agent may have an altered three dimensional structure but retain its therapeutic activity. The therapeutic agent may be selected from the group consisting of anti-angiogenesis peptides, hormones and nucleic acid agents. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy among others.
摘要翻译：生物相容性眼内药物递送系统包括抗血管生成治疗剂和植入物，微粒，多种植入物或微粒形式的聚合物组分及其组合。治疗剂以生物活性形式释放，例如，当释放到患者的眼睛中时，治疗剂可以保持其三维结构，或者治疗剂可以具有改变的三维结构，但保持其治疗活性。治疗剂可以选自抗血管生成肽，激素和核酸试剂。植入物可以置于眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变等。

10. 发明申请

US20050244474A1 Steroid-containing sustained release intraocular implants and related methods 有权
标题翻译：类固醇持续释放眼内植入物及相关方法
公开(公告)号：US20050244474A1
公开(公告)日：2005-11-03
申请号：US11118288
申请日：2005-04-29
申请人： Glenn Huang , Thierry Nivaggioli , Lon Spada , Hiroshi Sugimoto , Wendy Blanda , James Chang , Orest Olejnik
发明人： Glenn Huang , Thierry Nivaggioli , Lon Spada , Hiroshi Sugimoto , Wendy Blanda , James Chang , Orest Olejnik
IPC分类号： A61K9/00 , A61K31/00 , A61K31/573 , A61K45/06 , A61F2/00
CPC分类号： A61K9/0051 , A61K9/0092 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.
摘要翻译：生物相容性眼内植入物包括彼此相关的类固醇和聚合物，以促进类固醇进入眼睛大于约两个月的时间。类固醇可以与可生物降解的聚合物基质相关联，例如两种可生物降解聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。植入物可以放置在眼睛中以治疗一种或多种眼睛状况。类固醇从植入物中释放超过约两个月，可能会释放超过几年。

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