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1. 发明申请

US20050112024A1 Sample collection cup with integrated activatable sample analysis system 有权
标题翻译：样品收集杯具有集成的可激活的样品分析系统
公开(公告)号：US20050112024A1
公开(公告)日：2005-05-26
申请号：US10990297
申请日：2004-11-15
申请人： Lijian Guo , Yuzhang Wu , Jielin Dai , Hsiaoho Tung
发明人： Lijian Guo , Yuzhang Wu , Jielin Dai , Hsiaoho Tung
IPC分类号： A61B10/00 , B01L3/00 , G01N20060101 , G01N31/22 , G01N33/49 , G01N33/493
CPC分类号： A61B10/0096 , A61B10/007 , B01L3/502 , B01L3/5023 , B01L2200/141 , B01L2300/042 , B01L2300/047 , B01L2300/048 , B01L2300/0663 , B01L2300/0832 , B01L2300/0864 , B01L2400/0644 , G01N33/49 , G01N33/493
摘要： Medical and environmental diagnostic devices are described and claimed. Preferred embodiments feature cup within cup configurations wherein one cup is dedicated, for the most part, to sample collection and another cup is dedicated, for the most part, to assay performance. Communication between the cups is afforded by what is believed to be a unique valve assembly and lid tandem.
摘要翻译：描述和要求保护医疗和环境诊断装置。优选的实施方案在杯配置中具有杯特征，其中一个杯专门用于大部分样品收集，另一杯专用于大部分分析性能。杯子之间的通信由被认为是独特的阀组件和盖子串联提供。

2. 发明申请

US20050119589A1 Rapid sample collection and analysis device and methods of use 审中-公开
标题翻译：样品收集和分析装置及其使用方法
公开(公告)号：US20050119589A1
公开(公告)日：2005-06-02
申请号：US10990295
申请日：2004-11-15
申请人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： A61B5/00 , A61B10/00 , A61M1/00 , B01L3/00 , B65D81/00 , G01N20060101 , G01N31/22 , G01N33/48 , G01N33/487
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/0074 , A61B2010/0077 , B01L3/5023 , B01L3/5027 , B01L3/5029 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , G01N33/48714
摘要： The present invention is directed to devices and methods for determining the presence of analyte in a fluid sample. The devices utilize a sample collection well, an expression plate for expressing sample into the sample collection well, a plunger that drives a lance, and a test compartment containing test elements. The devices also preserve an aliquot of fluid sample in a reservoir for later confirmation testing. When the plunger is lowered into the sample collection well, a lance on the device punctures a frangible material that covers a sample outlet. When the sample outlet is thus opened, fluid sample flows from the sample collection cup to the test compartment. In one embodiment the plunger is lowered as a cap is applied to the device. The devices are useful for detecting the presence of analyte in a wide variety of fluid samples, such as saliva, oral fluids, and more. The invention also provides methods of using the devices, and kits containing the devices.
摘要翻译：本发明涉及用于确定流体样品中分析物的存在的装置和方法。这些装置利用样品收集井，用于将样品表达到样品收集孔中的表达板，驱动喷枪的柱塞和包含测试元件的测试隔室。这些装置还在储存器中保留液体样品的等分试样用于稍后的确认测试。当柱塞下降到样品收集井中时，设备上的喷枪刺穿覆盖样品出口的易碎材料。当样品出口因此打开时，流体样品从样品收集杯流出到测试室。在一个实施例中，当帽被施加到装置时，柱塞下降。这些装置可用于检测各种流体样品（例如唾液，口服液体等）中分析物的存在。本发明还提供了使用这些装置的方法和包含装置的试剂盒。

3. 发明申请

US20050106750A1 Sample collection cup with integrated sample analysis system 有权
标题翻译：带集成样品分析系统的样品收集杯
公开(公告)号：US20050106750A1
公开(公告)日：2005-05-19
申请号：US10989935
申请日：2004-11-15
申请人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： A61B10/00 , B01L3/00 , G01N1/00 , G01N21/03 , G01N21/86 , G01N21/00
CPC分类号： A61B10/007 , B01L3/502 , B01L3/5023 , B01L2200/025 , B01L2300/042 , B01L2300/045 , B01L2300/047 , B01L2300/0663 , B01L2300/0825 , B01L2300/0832 , B01L2300/0864 , B01L2400/0481 , B01L2400/0487 , G01N1/14 , G01N21/03 , G01N21/8483 , G01N2021/0325
摘要： The present invention is directed to devices and methods for collecting liquid samples and of testing the sample for the presence of an analyte of interest and/or a physical property. In one embodiment the device is a urine cup having an interior for containing a liquid sample, a lid, and a chamber for holding liquid. The device contains a test component for determining the presence of an analyte in the liquid sample and/or a physical property. A tube is immersed in liquid sample when the device is filled with liquid sample to be tested. When the lid is applied to the device (e.g., by screwing or snapping on), liquid sample is forced through the tube and into the chamber holding the test component.
摘要翻译：本发明涉及用于收集液体样品和测试样品以存在感兴趣的分析物和/或物理性质的装置和方法。在一个实施例中，该装置是具有用于容纳液体样品，盖子和用于保持液体的室的内部的尿杯。该装置含有用于确定液体样品中分析物的存在和/或物理性质的测试组分。当装置充满待测试的液体样品时，将管浸入液体样品中。当将盖子施加到装置上（例如通过拧紧或扣合）时，液体样品被迫通过管并进入保持测试部件的室中。

4. 发明申请

US20050202568A1 Fluid sample analysis device with sealable sample storage reservoir 审中-公开
标题翻译：具有密封样品储存库的流体样品分析装置
公开(公告)号：US20050202568A1
公开(公告)日：2005-09-15
申请号：US10989624
申请日：2004-11-15
申请人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： A61B5/00 , A61B10/00 , A61M1/00 , B01L3/00 , B65D81/00 , G01N20060101 , G01N31/22 , G01N33/48 , G01N33/487
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/0074 , A61B2010/0077 , B01L3/5023 , B01L3/5027 , B01L3/5029 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , G01N33/48714
摘要： The present invention is directed to devices and methods for determining the presence of analyte in a fluid sample. The devices utilize a sample collection well, an expression plate for expressing sample into the sample collection well, a plunger that drives a seal, and a test compartment containing test elements. The devices also contain a reservoir for preserving an aliquot of sample for later confirmation testing. When the plunger is lowered into the sample collection well, an aliquot of sample is sealed in the reservoir. In one embodiment the plunger is lowered as a cap is applied to the device. The devices are useful for detecting the presence of analyte in a wide variety of fluid samples, such as saliva. The invention also provides methods of using the devices, and kits containing the devices.
摘要翻译：本发明涉及用于确定流体样品中分析物的存在的装置和方法。这些装置利用样品收集井，用于将样品表达到样品收集井中的表达板，驱动密封的柱塞和包含测试元件的测试隔室。这些装置还包含用于保存样品等分试样用于稍后确认测试的储存器。当柱塞下降到样品收集井中时，样品的等分试样被密封在储存器中。在一个实施例中，当帽被施加到装置时，柱塞下降。该装置可用于检测多种流体样品（例如唾液）中分析物的存在。本发明还提供了使用这些装置的方法和包含装置的试剂盒。

5. 发明申请

US20050180882A1 Rapid sample analysis and storage devices and methods of use 有权
标题翻译：快速样品分析和储存装置及使用方法
公开(公告)号：US20050180882A1
公开(公告)日：2005-08-18
申请号：US10990324
申请日：2004-11-15
申请人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： A61B5/00 , A61B10/00 , A61M1/00 , B01L3/00 , B65D81/00 , G01N20060101 , G01N31/22 , G01N33/48 , G01N33/487
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/0074 , A61B2010/0077 , B01L3/5023 , B01L3/5027 , B01L3/5029 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , G01N33/48714
摘要： The present invention provides test devices for detecting an analyte suspected of being present in a liquid sample. The devices contain a reservoir compartment, a test compartment, and a port for a sample collection well. The devices also have a rotatable sample collection well located in the port. The device has an upper chamber for insertion of a sample applicator, an expression plate for wringing out the sample applicator and applying sample to the device, a lower chamber, and an aliquot outlet and a reservoir outlet for the movement of sample through the device. The device also contains test elements for detecting the analyte of interest. By rotating the sample collection well, the operator is able to direct distribution of collected sample in the device. Methods of using the devices and kits containing the devices are also provided.
摘要翻译：本发明提供了用于检测疑似存在于液体样品中的分析物的测试装置。设备包含储存室，测试隔间和样品收集井的端口。这些设备还具有位于端口中的可旋转样品收集。该装置具有用于插入样品施加器的上室，用于拧紧样品施加器并将样品施加到装置的下表面板，下室和用于样品运动通过装置的等分出口和储存器出口。该装置还包含用于检测感兴趣的分析物的测试元件。通过旋转样品收集井，操作者能够将收集的样品直接分布在装置中。还提供了使用包含装置的装置和试剂盒的方法。

6. 发明申请

US20050048670A1 Biological specimen collection and analysis system 有权
标题翻译：生物样本收集和分析系统
公开(公告)号：US20050048670A1
公开(公告)日：2005-03-03
申请号：US10766204
申请日：2004-01-27
申请人： Yuzhang Wu , Ying Yang , Jieling Dai , Hsiaoho Tung
发明人： Yuzhang Wu , Ying Yang , Jieling Dai , Hsiaoho Tung
IPC分类号： A61B10/00 , B01L3/00
CPC分类号： B01L3/502 , A61B10/0045 , A61B10/007 , B01L2200/0605 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0663 , B01L2400/0478 , Y10T436/2575
摘要： Disclosed is a device for collecting a fluid specimen. The device comprises a container that can receive a fluid specimen; a plunger movably positioned within the container, wherein the plunger can move from an initial position at an upper region of the container to a secondary position below the first position; a fluid segregation chamber that can receive a portion of the fluid specimen from the container, wherein any fluid in the segregation chamber is segregated from the fluid specimen in the container; a fluid flow lumen that provides a passageway for at least a portion of the fluid specimen to flow into the fluid segregation chamber, wherein a first end of the passageway has a first opening that opens into the fluid segregation chamber and a second end of the passageway has a second opening that can receive at least a portion of the fluid specimen; and a seal member that covers the first opening or the second opening to prevent fluid from flowing therethrough. A test element can be used to push the plunger from the initial position toward the secondary position to break the seal member and cause at least a portion of the fluid specimen to flow through the second opening into the fluid flow lumen and into the fluid segregation chamber through the first opening.
摘要翻译：公开了一种用于收集流体样本的装置。该装置包括容纳流体样本的容器; 活塞可移动地定位在所述容器内，其中所述柱塞可以从所述容器的上部区域的初始位置移动到所述第一位置下方的次要位置; 流体分离室，其可以从容器接收流体样本的一部分，其中分离室中的任何流体与容器中的流体样本分离; 流体流动腔，其为所述流体样本的至少一部分提供通道以流入所述流体分离室，其中所述通道的第一端具有通向所述流体分离室的第一开口和所述通道的第二端具有可接收至少一部分流体试样的第二开口; 以及密封构件，其覆盖所述第一开口或所述第二开口以防止流体流过。可以使用测试元件将柱塞从初始位置推向次要位置以破坏密封构件，并使至少一部分流体样品流过第二开口进入流体流动腔并进入流体分离室通过第一个开口。

7. 发明授权

US08486353B2 Sample collection cup with integrated activatable sample analysis system 有权
标题翻译：样品收集杯具有集成的可激活的样品分析系统
公开(公告)号：US08486353B2
公开(公告)日：2013-07-16
申请号：US11845346
申请日：2007-08-27
申请人： Yuzhang Wu , Lijiang Guo , Jeilin Dai , Hsiaoho Tung
发明人： Yuzhang Wu , Lijiang Guo , Jeilin Dai , Hsiaoho Tung
IPC分类号： B01L3/00
CPC分类号： A61B10/0096 , A61B10/007 , B01L3/502 , B01L3/5023 , B01L2200/141 , B01L2300/042 , B01L2300/047 , B01L2300/048 , B01L2300/0663 , B01L2300/0832 , B01L2300/0864 , B01L2400/0644 , G01N33/49 , G01N33/493
摘要： Medical and environmental diagnostic devices are described and claimed. Preferred embodiments feature cup (1) within cup configurations wherein one cup is dedicated, for the most part, to sample collection and another cup (2) is dedicated, for the most part, to assay performance. Communication between the cups is afforded by what is believed to be a unique valve assembly (3) and lid (7) tandem.
摘要翻译：描述和要求保护医疗和环境诊断装置。优选的实施方案在杯配置中具有杯（1），其中一个杯专用于大部分样品收集，另一个杯（2）主要用于测定性能。杯子之间的通信由被认为是独特的阀组件（3）和盖（7）串联提供。

8. 发明申请

US20050008538A1 Compact analyte testing cassette with true positive and negative analyte controls 有权
标题翻译：紧凑的分析物检测盒带有真正的正和负分析物对照
公开(公告)号：US20050008538A1
公开(公告)日：2005-01-13
申请号：US10890544
申请日：2004-07-12
申请人： David Anderson , Hsiaoho Tung , Haipeng Hu , Yuchang Wu
发明人： David Anderson , Hsiaoho Tung , Haipeng Hu , Yuchang Wu
IPC分类号： A61B20060101 , G01N21/86 , G01N31/22 , G01N33/14 , G01N33/558 , G01N33/94
CPC分类号： G01N33/94 , G01N31/22 , G01N33/14 , G01N33/558 , Y10T436/13
摘要： The present disclosure includes but is not limited to an assay or test device, such as an immunological assay device, with positive and negative controls for each analyte of interest. In general, the device has a bi-fold, tri-fold or quarter-fold cassette, each folded side having one or more test strips contained therein. The device is compact and easily used by the worker. The present device is particularly useful in a clinical drug of abuse testing setting, in which the use of internal quality controls is regulated by the USCMS and the College of American Pathologists. In addition, the present device provides the advantages of ease of use, small size and reduced cost compared to other devices currently available on the market.
摘要翻译：本公开包括但不限于对于感兴趣的每种分析物的阳性和阴性对照的测定或测试装置，例如免疫测定装置。通常，该装置具有双折，三折或四分之一折盒，每个折叠侧具有容纳在其中的一个或多个测试条。该设备紧凑，工作人员很容易使用。本设备在滥用测试设置的临床药物中特别有用，其中使用内部质量控制由USCMS和美国病理学家学院进行调节。此外，与目前市场上可获得的其它装置相比，本装置提供了易于使用，小尺寸和降低成本的优点。

9. 发明申请

US20050009200A1 Sanitary and compact fecal occult blood collector 有权
标题翻译：卫生和紧凑型粪便潜血收集器
公开(公告)号：US20050009200A1
公开(公告)日：2005-01-13
申请号：US10890541
申请日：2004-07-12
申请人： Huiyan Guo , Hsiaoho Tung , Shaomin Sun , Yuchang Wu , Rong Yang , Yun Ling
发明人： Huiyan Guo , Hsiaoho Tung , Shaomin Sun , Yuchang Wu , Rong Yang , Yun Ling
IPC分类号： A61B10/00 , B01L3/00 , G01N1/00
CPC分类号： B01L3/5029 , A61B10/0038 , A61B10/0096 , B01L2200/185 , B01L2300/024 , B01L2300/025 , B01L2300/0825 , B01L2300/105 , Y10T436/25 , Y10T436/2525
摘要： A biological sample collection and test kit and a method of using the kit are disclosed in the application. The kit includes a swab, having a sample collection portion, a cover for covering the sample collection portion of the swab for hygienic purpose. Also disclosed is a package for the swab and the cover.
摘要翻译：应用中公开了生物样品收集和测试试剂盒以及使用该试剂盒的方法。试剂盒包括具有样品收集部分的拭子，用于覆盖棉签的样品收集部分以用于卫生目的的盖子。还公开了用于拭子和盖子的包装。

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