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1. 发明授权

US07550112B2 Sample collection cup with integrated activatable sample analysis system 有权
标题翻译：样品收集杯具有集成的可激活的样品分析系统
公开(公告)号：US07550112B2
公开(公告)日：2009-06-23
申请号：US10990297
申请日：2004-11-15
申请人： Lijian Gou , Yuzhang Wu , Jielin Dai , Hsiaoho Edward Tung
发明人： Lijian Gou , Yuzhang Wu , Jielin Dai , Hsiaoho Edward Tung
IPC分类号： G01N21/00 , B01L3/00 , G01N21/77 , G01N21/03
CPC分类号： A61B10/0096 , A61B10/007 , B01L3/502 , B01L3/5023 , B01L2200/141 , B01L2300/042 , B01L2300/047 , B01L2300/048 , B01L2300/0663 , B01L2300/0832 , B01L2300/0864 , B01L2400/0644 , G01N33/49 , G01N33/493
摘要： Medical and environmental diagnostic devices are described and claimed. Preferred embodiments feature cup within cup configurations wherein one cup is dedicated, for the most part, to sample collection and another cup is dedicated, for the most part, to assay performance. Communication between the cups is afforded by what is believed to be a unique valve assembly and lid tandem.
摘要翻译：描述和要求保护医疗和环境诊断装置。优选的实施方案在杯配置中具有杯特征，其中一个杯专门用于大部分样品收集，另一杯专用于大部分分析性能。杯子之间的通信由被认为是独特的阀组件和盖子串联提供。

2. 发明授权

US07544324B2 Rapid sample analysis storage devices and methods of use 有权
标题翻译：快速样品分析储存装置及使用方法
公开(公告)号：US07544324B2
公开(公告)日：2009-06-09
申请号：US10990324
申请日：2004-11-15
申请人： Hsiaoho Edward Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Edward Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： G01N21/00 , G01N9/30 , G01N31/22 , G01N33/48
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/0074 , A61B2010/0077 , B01L3/5023 , B01L3/5027 , B01L3/5029 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , G01N33/48714
摘要： The present invention provides test devices for detecting an analyte suspected of being present in a liquid sample. The devices contain a reservoir compartment, a test compartment, and a port for a sample collection well. The devices also have a rotatable sample collection well located in the port. The device has an upper chamber for insertion of a sample applicator, an expression plate for wringing out the sample applicator and applying sample to the device, a lower chamber, and an aliquot outlet and a reservoir outlet for the movement of sample through the device. The device also contains test elements for detecting the analyte of interest. By rotating the sample collection well, the operator is able to direct distribution of collected sample in the device. Methods of using the devices and kits containing the devices are also provided.
摘要翻译：本发明提供了用于检测疑似存在于液体样品中的分析物的测试装置。设备包含储存室，测试隔间和样品收集井的端口。这些设备还具有位于端口中的可旋转样品收集。该装置具有用于插入样品施加器的上室，用于拧紧样品施加器并将样品施加到装置的下表面板，下室和用于样品运动通过装置的等分出口和储存器出口。该装置还包含用于检测感兴趣的分析物的测试元件。通过旋转样品收集井，操作者能够将收集的样品直接分布在装置中。还提供了使用包含装置的装置和试剂盒的方法。

3. 发明申请

US20090308185A1 DEVICE FOR DETECTING ANALYTES IN FLUID SAMPLES 审中-公开
标题翻译：用于检测流体样品中分析物的装置
公开(公告)号：US20090308185A1
公开(公告)日：2009-12-17
申请号：US12091368
申请日：2006-10-20
申请人： Yuzhang Wu , Haipeng Hu , Jielin Dai , Lijian Gou
发明人： Yuzhang Wu , Haipeng Hu , Jielin Dai , Lijian Gou
IPC分类号： G01N33/00
CPC分类号： G01N33/54366 , A61B10/007 , B01L3/502 , B01L2300/0663 , B01L2300/087 , B01L2400/0478 , Y10T436/2575
摘要： The present invention provides a device (100) for detecting the presence of an analyte in a liquid sample. The device (100) has an opening (115) for introducing the liquid sample into a first chamber (301) for collecting the liquid sample, and a second chamber (601) connected to the first chamber (301) by a passageway (205) and containing a test element. The device also has a third chamber (701) connected to the second chamber (601) by a channel and containing a movable member (311) having first and second positions. The third chamber (701) is divided by the movable member (311) into first (901) and second (902) zones, and the first zone (901) has a vent hole (165). The movable member (311) is in contact with at least one wall of the third chamber (701) to prevent gas communication between the first and second zones (901, 902).
摘要翻译：本发明提供一种用于检测液体样品中分析物的存在的装置（100）。装置（100）具有用于将液体样品引入用于收集液体样品的第一室（301）的开口（115）和通过通道（205）连接到第一室（301）的第二室（601）并包含测试元素。该装置还具有通过通道连接到第二室（601）的第三室（701）并且容纳具有第一和第二位置的可动构件（311）。第三室（701）由可移动部件（311）分成第一（901）和第二（902）区域，第一区域（901）具有通气孔（165）。可移动构件（311）与第三腔室（701）的至少一个壁接触，以防止第一和第二区域（901,902）之间的气体连通。

4. 发明授权

US09011770B2 Device for detecting analytes in fluid samples 有权
标题翻译：用于检测流体样品中分析物的装置
公开(公告)号：US09011770B2
公开(公告)日：2015-04-21
申请号：US11260496
申请日：2005-10-26
申请人： Yuzhang Wu , Haipeng Hu , Jielin Dai , Lijian Gou
发明人： Yuzhang Wu , Haipeng Hu , Jielin Dai , Lijian Gou
IPC分类号： G01N21/00 , G01N33/543 , B01L3/00 , A61B10/00
CPC分类号： G01N33/54366 , A61B10/007 , B01L3/502 , B01L2300/0663 , B01L2300/087 , B01L2400/0478 , Y10T436/2575
摘要： The present invention provides a device for detecting the presence of an analyte in a liquid sample. The device has an opening for introducing the liquid sample into a first chamber for collecting the liquid sample, and a second chamber connected to the first chamber by a passageway and containing a test element. The device also has a third chamber connected to the second chamber by a channel and containing a movable member having first and second positions. The third chamber is divided by the movable member into first and second zones, and the first zone has a vent hole. The movable member is in contact with at least one wall of the third chamber to prevent gas communication between the first and second zones.
摘要翻译：本发明提供一种用于检测液体样品中分析物的存在的装置。该装置具有用于将液体样品引入到用于收集液体样品的第一室中的开口，以及通过通道连接到第一室并且容纳测试元件的第二室。该装置还具有通过通道连接到第二室的第三室，并且容纳具有第一和第二位置的可动构件。第三室由可移动部件分成第一和第二区域，第一区域具有通气孔。可移动构件与第三室的至少一个壁接触以防止第一和第二区之间的气体连通。

5. 发明申请

US20070092402A1 Device for detecting analytes in fluid samples 有权
标题翻译：用于检测流体样品中分析物的装置
公开(公告)号：US20070092402A1
公开(公告)日：2007-04-26
申请号：US11260496
申请日：2005-10-26
申请人： Yuzhang Wu , Haipeng Hu , Jielin Dai , Lijian Gou
发明人： Yuzhang Wu , Haipeng Hu , Jielin Dai , Lijian Gou
IPC分类号： G01N31/22
CPC分类号： G01N33/54366 , A61B10/007 , B01L3/502 , B01L2300/0663 , B01L2300/087 , B01L2400/0478 , Y10T436/2575
摘要： The present invention provides a device for detecting the presence of an analyte in a liquid sample. The device has an opening for introducing the liquid sample into a first chamber for collecting the liquid sample, and a second chamber connected to the first chamber by a passageway and containing a test element. The device also has a third chamber connected to the second chamber by a channel and containing a movable member having first and second positions. The third chamber is divided by the movable member into first and second zones, and the first zone has a vent hole. The movable member is in contact with at least one wall of the third chamber to prevent gas communication between the first and second zones.
摘要翻译：本发明提供一种用于检测液体样品中分析物的存在的装置。该装置具有用于将液体样品引入到用于收集液体样品的第一室中的开口，以及通过通道连接到第一室并且容纳测试元件的第二室。该装置还具有通过通道连接到第二室的第三室，并且容纳具有第一和第二位置的可动构件。第三室由可移动部件分成第一和第二区域，第一区域具有通气孔。可移动构件与第三室的至少一个壁接触以防止第一和第二区之间的气体连通。

6. 发明授权

US07114403B2 Fluid collection and application device and methods of use of same 有权
标题翻译：流体收集和应用装置及其使用方法
公开(公告)号：US07114403B2
公开(公告)日：2006-10-03
申请号：US10855155
申请日：2004-05-27
申请人： Yuchang Wu , Hsiaoho Edward Tung , Huiyan Guo , Fei Gao , Jielin Dai , Haipeng Hu
发明人： Yuchang Wu , Hsiaoho Edward Tung , Huiyan Guo , Fei Gao , Jielin Dai , Haipeng Hu
IPC分类号： G01N1/00
CPC分类号： A61B10/0051 , B01L3/0272 , B01L3/5029
摘要： The present invention is a device for conveniently collecting and storing liquid samples, as well as applying an aliquot of the sample to a test device, such as a lateral flow immunoassay. The present invention comprises an absorbent swab and a dropper container containing an expression means for expressing the collected sample from the swab. After the collected sample has been expressed into the reservoir of the device, the device is capped. The device can be inverted over a test device, the sides of the reservoir squeezed and an aliquot of the sample applied, in a drop-wise manner, to the sample application well of the test device. The present invention is particularly useful for collecting viscous samples, such as saliva or oral fluid, in a drug of abuse testing setting.
摘要翻译：本发明是用于方便地收集和储存液体样品的装置，以及将样品的等分试样施加到测试装置，例如横向流动免疫测定。本发明包括吸收棉签和滴管容器，该容器包含用于从拭子表达所收集的样品的表达装置。收集的样品已经被表达到设备的储存器中之后，装置被盖上。该装置可以在测试装置上倒置，储存器的侧面被挤压，并且样品的等分试样以滴下方式施加到测试装置的样品应用井。本发明特别可用于在滥用试验设备的药物中收集粘性样品，例如唾液或口腔液。

7. 发明授权

US08871155B2 Devices for detecting analytes in fluid sample 有权
标题翻译：用于检测流体样品中分析物的装置
公开(公告)号：US08871155B2
公开(公告)日：2014-10-28
申请号：US12095325
申请日：2006-11-13
申请人： Yuzhang Wu , Yun Ling , Jielin Dai
发明人： Yuzhang Wu , Yun Ling , Jielin Dai
IPC分类号： G01N35/00 , B01L3/00
CPC分类号： B01L3/5023 , B01L3/5029 , B01L2200/027 , B01L2300/0663 , G01N2035/00108
摘要： A device for detecting the presence or amount of an analyte in a fluid sample and method thereof, comprises a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample, and has a first position and a second, locked position within the receiving cup. The absorbent member is uncompressed in the first position and is compressed in the second, locked position. The sample collector or the receiving cup has at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample.
摘要翻译：用于检测流体样品中分析物的存在或量的装置及其方法包括样品收集器和接收杯，用于将样品收集器接收并保持在接收杯内。样品收集器包含用于收集流体样品的可压缩吸收件，并且在接收杯内具有第一位置和第二锁定位置。吸收体在第一位置未被压缩并在第二锁定位置被压缩。样品收集器或接收杯具有至少一个具有用于检测流体样品中分析物的存在或量的试剂的测试元件。

8. 发明申请

US20050112024A1 Sample collection cup with integrated activatable sample analysis system 有权
标题翻译：样品收集杯具有集成的可激活的样品分析系统
公开(公告)号：US20050112024A1
公开(公告)日：2005-05-26
申请号：US10990297
申请日：2004-11-15
申请人： Lijian Guo , Yuzhang Wu , Jielin Dai , Hsiaoho Tung
发明人： Lijian Guo , Yuzhang Wu , Jielin Dai , Hsiaoho Tung
IPC分类号： A61B10/00 , B01L3/00 , G01N20060101 , G01N31/22 , G01N33/49 , G01N33/493
CPC分类号： A61B10/0096 , A61B10/007 , B01L3/502 , B01L3/5023 , B01L2200/141 , B01L2300/042 , B01L2300/047 , B01L2300/048 , B01L2300/0663 , B01L2300/0832 , B01L2300/0864 , B01L2400/0644 , G01N33/49 , G01N33/493
摘要： Medical and environmental diagnostic devices are described and claimed. Preferred embodiments feature cup within cup configurations wherein one cup is dedicated, for the most part, to sample collection and another cup is dedicated, for the most part, to assay performance. Communication between the cups is afforded by what is believed to be a unique valve assembly and lid tandem.
摘要翻译：描述和要求保护医疗和环境诊断装置。优选的实施方案在杯配置中具有杯特征，其中一个杯专门用于大部分样品收集，另一杯专用于大部分分析性能。杯子之间的通信由被认为是独特的阀组件和盖子串联提供。

9. 发明申请

US20090226883A1 DEVICES AND METHODS FOR DETECTING ANALYTES IN FLUID SAMPLES 有权
标题翻译：用于检测流体样品中分析物的装置和方法
公开(公告)号：US20090226883A1
公开(公告)日：2009-09-10
申请号：US12095325
申请日：2006-11-13
申请人： Yuzhang Wu , Yun Ling , Jielin Dai
发明人： Yuzhang Wu , Yun Ling , Jielin Dai
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： B01L3/5023 , B01L3/5029 , B01L2200/027 , B01L2300/0663 , G01N2035/00108
摘要： A device for detecting the presence or amount of an analyte in a fluid sample and method thereof, comprises a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample, and has a first position and a second, locked position within the receiving cup. The absorbent member is uncompressed in the first position and is compressed in the second, locked position. The sample collector or the receiving cup has at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample.
摘要翻译：用于检测流体样品中分析物的存在或量的装置及其方法包括样品收集器和接收杯，用于将样品收集器接收并保持在接收杯内。样品收集器包含用于收集流体样品的可压缩吸收件，并且在接收杯内具有第一位置和第二锁定位置。吸收体在第一位置未被压缩并在第二锁定位置被压缩。样品收集器或接收杯具有至少一个具有用于检测流体样品中分析物的存在或量的试剂的测试元件。

10. 发明申请

US20050119589A1 Rapid sample collection and analysis device and methods of use 审中-公开
标题翻译：样品收集和分析装置及其使用方法
公开(公告)号：US20050119589A1
公开(公告)日：2005-06-02
申请号：US10990295
申请日：2004-11-15
申请人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
发明人： Hsiaoho Tung , Yuzhang Wu , Jielin Dai , Ying Yang
IPC分类号： A61B5/00 , A61B10/00 , A61M1/00 , B01L3/00 , B65D81/00 , G01N20060101 , G01N31/22 , G01N33/48 , G01N33/487
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/0074 , A61B2010/0077 , B01L3/5023 , B01L3/5027 , B01L3/5029 , B01L2200/027 , B01L2200/0605 , B01L2300/0825 , B01L2400/0406 , B01L2400/0644 , G01N33/48714
摘要： The present invention is directed to devices and methods for determining the presence of analyte in a fluid sample. The devices utilize a sample collection well, an expression plate for expressing sample into the sample collection well, a plunger that drives a lance, and a test compartment containing test elements. The devices also preserve an aliquot of fluid sample in a reservoir for later confirmation testing. When the plunger is lowered into the sample collection well, a lance on the device punctures a frangible material that covers a sample outlet. When the sample outlet is thus opened, fluid sample flows from the sample collection cup to the test compartment. In one embodiment the plunger is lowered as a cap is applied to the device. The devices are useful for detecting the presence of analyte in a wide variety of fluid samples, such as saliva, oral fluids, and more. The invention also provides methods of using the devices, and kits containing the devices.
摘要翻译：本发明涉及用于确定流体样品中分析物的存在的装置和方法。这些装置利用样品收集井，用于将样品表达到样品收集孔中的表达板，驱动喷枪的柱塞和包含测试元件的测试隔室。这些装置还在储存器中保留液体样品的等分试样用于稍后的确认测试。当柱塞下降到样品收集井中时，设备上的喷枪刺穿覆盖样品出口的易碎材料。当样品出口因此打开时，流体样品从样品收集杯流出到测试室。在一个实施例中，当帽被施加到装置时，柱塞下降。这些装置可用于检测各种流体样品（例如唾液，口服液体等）中分析物的存在。本发明还提供了使用这些装置的方法和包含装置的试剂盒。

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