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1. 发明授权

US07933644B2 Instantaneous autonomic nervous function and cardiac predictability based on heart and pulse rate variability analysis 失效
标题翻译：基于心脏和脉搏变异性分析的瞬时自主神经功能和心脏可预测性
公开(公告)号：US07933644B2
公开(公告)日：2011-04-26
申请号：US10552009
申请日：2004-03-26
申请人： Lid B. Wong , Donovan B. Yeates , Guanglin Li , Tarun Chandra , Mahandas A. Kizhakayil
发明人： Lid B. Wong , Donovan B. Yeates , Guanglin Li , Tarun Chandra , Mahandas A. Kizhakayil
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/04014 , A61B5/0472 , A61B5/4035 , A61B5/7257
摘要： A system and method that can simultaneously acquire electrocardiogram or pulse rate data (42, 44, 46), dynamically perform time-frequency (70) and chaotic analysis (60) in real-time, visually display the results in a convenient graphical format (50) and store the results in a computer file format (50).
摘要翻译：可以同时获取心电图或脉搏数据（42,44,46），实时动态执行时间频率（70）和混沌分析（60）的系统和方法，以方便的图形格式可视化显示结果（ 50）并将结果存储为计算机文件格式（50）。

2. 发明申请

US20070219455A1 Instantaneous Autonomic Nervous Function and Cardiac Predictability Based on Heart and Pulse Rate Variability Analysis 失效
标题翻译：基于心脏和心率变异性分析的瞬时自主神经功能和心脏可预测性
公开(公告)号：US20070219455A1
公开(公告)日：2007-09-20
申请号：US10552009
申请日：2004-03-26
申请人： Lid Wong , Donovan Yeates , Guanglin Li , Tarun Chandra , Mahandas Kizhakayil
发明人： Lid Wong , Donovan Yeates , Guanglin Li , Tarun Chandra , Mahandas Kizhakayil
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/04014 , A61B5/0472 , A61B5/4035 , A61B5/7257
摘要： A system and method that can simultaneously acquire electrocardiogram or pulse rate data (42, 44, 46), dynamically perform time-frequency (70) and chaotic analysis (60) in real-time, visually display the results in a convenient graphical format (50) and store the results in a computer file format (50).
摘要翻译：可以同时获取心电图或脉搏数据（42,44,46），实时动态执行时间频率（70）和混沌分析（60）的系统和方法，以方便的图形格式可视化显示结果（ 50）并将结果存储为计算机文件格式（50）。

3. 发明申请

US20060256342A1 Confocal microscope system for real-time simultaneous temporal measurements of metachronal wave period and ciliary beat frequency 审中-公开
标题翻译：共焦显微镜系统用于实时同步时间测量异时波周期和睫状脉搏频率
公开(公告)号：US20060256342A1
公开(公告)日：2006-11-16
申请号：US10550124
申请日：2004-03-26
申请人： Lid Wong , Donovan Yeates , Hua Mao , Tarun Chandra
发明人： Lid Wong , Donovan Yeates , Hua Mao , Tarun Chandra
IPC分类号： G01B9/02
CPC分类号： G02B21/0084 , G01N21/49
摘要： The present invention relates to a method and system that enables continuous real-time analysis of both ciliary beat frequency and metachronal wave frequency from a single spot in excised native ciliated epithelial tissues as well as in primary and subsequent epithelial cultures. Such method and system utilizes the concept of time-scale wavelet analysis and Hilbert Transformation for backscattered light derived from a confocal (conjugate) spot on the moving cilia. This light contains inherent high and low frequency components corresponding to CBF and MWF.
摘要翻译：本发明涉及一种方法和系统，其能够在切除的天然纤毛上皮组织以及初级和随后的上皮培养物中从单个斑点连续实时分析睫状节拍频率和异时波频率。这种方法和系统利用时间尺度小波分析和希尔伯特变换的概念，用于来自移动纤毛上的共焦点（共轭）斑点的背散射光。该灯含有对应于CBF和MWF的固有高频和低频分量。

4. 发明授权

US5468649A Process for labeling acridinium to microparticles and application in an instrument 失效
标题翻译：将吖啶标记为微粒并用于仪器中的方法
公开(公告)号：US5468649A
公开(公告)日：1995-11-21
申请号：US196536
申请日：1994-02-15
申请人： Dinesh O. Shah , Tarun Chandra , Kurt Klosterman
发明人： Dinesh O. Shah , Tarun Chandra , Kurt Klosterman
IPC分类号： G01N21/75 , G01N33/58 , G01N33/543 , G01N33/546
CPC分类号： G01N33/585
摘要： Embodiments of the invention provide methods of preparing an activated acridinium microparticle. Generally, the methods involve direct covalent coupling or an affinity format. The direct covalent coupling method involves coating a microparticle with a proteinaceous compound. Then, a 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate is coupled to the proteinaceous compound. In the affinity format, a microparticle is coated with a biotinylated proteinaceous compound. The microparticle is reacted with an anti-biotin labelled 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate. Methods are also provided for using such a microparticle. Those methods of use can estimate transfer efficiency, calibrate optics, and measure membrane pore size of a chemiluminescence based instrument. Test elements for analytical instruments are also provided.
摘要翻译：本发明的实施方案提供了制备活化的吖啶微粒的方法。通常，该方法涉及直接共价偶联或亲和格式。直接共价偶联法包括用蛋白质化合物包被微粒。然后，将10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸酯与蛋白质化合物偶联。在亲和性形式中，微粒被生物素化的蛋白质化合物包被。将微粒与抗生物素标记的10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸盐反应。还提供了使用这种微粒的方法。这些使用方法可以估计传递效率，校准光学和测量基于化学发光的仪器的膜孔径。还提供了分析仪器的测试元件。

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