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1. 发明授权

US09345764B2 Moesin modulators and uses thereof 有权
标题翻译：莫辛调节剂及其用途
公开(公告)号：US09345764B2
公开(公告)日：2016-05-24
申请号：US13878232
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
IPC分类号： C07K7/08 , A61K38/08 , A61K38/20 , A61K45/06 , A61K38/19 , A61K38/10 , C07K7/06 , A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/2086 , A61K45/06 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/28 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.
摘要翻译：本申请提供了用于治疗和诊断与moesin活化相关的疾病和病症的组合物和方法。

2. 发明申请

US20130210678A1 MOESIN FRAGMENTS AND USES THEREOF 有权
标题翻译： MOESIN片段及其用途
公开(公告)号：US20130210678A1
公开(公告)日：2013-08-15
申请号：US13878230
申请日：2011-10-08
申请人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , C07K14/705
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present invention provides compositions and methods useful for detecting and monitoring autoimmune diseases.
摘要翻译：本发明提供了用于检测和监测自身免疫疾病的组合物和方法。

3. 发明授权

US08415347B2 Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives 失效
标题翻译：取代四环四氢呋喃，吡咯烷和四氢噻吩衍生物
公开(公告)号：US08415347B2
公开(公告)日：2013-04-09
申请号：US12850958
申请日：2010-08-05
申请人： José Maria Cid-Núñez , Antonius Adrianus Hendrikus Petrus Megens , Andrés Avelino Trabanco-Suárez , Mohamed Koukni , Georges Joseph Cornelius Hoornaert , Frans Josef Cornelius Compernolle , Tomasz Kozlecki , Hua Mao , Sushil Chandra Jha , Francisco Javier Fernández-Gadea
发明人： José Maria Cid-Núñez , Antonius Adrianus Hendrikus Petrus Megens , Andrés Avelino Trabanco-Suárez , Mohamed Koukni , Georges Joseph Cornelius Hoornaert , Frans Josef Cornelius Compernolle , Tomasz Kozlecki , Hua Mao , Sushil Chandra Jha , Francisco Javier Fernández-Gadea
IPC分类号： A61K31/5377 , A61K31/403 , A61K31/496 , A61K31/381 , A61K31/4985 , A61K31/352 , A61K31/435 , C07D491/044 , C07D209/58 , C07D413/04 , C07D333/80 , C07D487/04
CPC分类号： C07D333/80 , C07D209/70 , C07D221/18 , C07D307/93 , C07D311/94 , C07D487/04 , C07D491/04
摘要： This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production.The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
摘要翻译：本发明涉及对5-羟色胺受体，特别是5-HT2A和5-HT2C受体以及对多巴胺受体，特别是多巴胺D2受体和去甲肾上腺素再摄取抑制性质具有结合亲和力的新型取代四环四氢呋喃，吡咯烷和四氢噻吩衍生物，包含根据本发明的化合物，其用作药物，特别是用于预防和/或治疗一系列精神和神经障碍，特别是某些精神病性，心血管和胃肠功能障碍及其生产方法。根据本发明的化合物可以由通式（I）表示，并且还包括其药学上可接受的酸或碱加成盐，其立体化学异构形式，其N-氧化物形式及其前药，其中所有取代基定义为在权利要求1中。

4. 发明申请

US20110086546A1 LOW PROFILE CONNECTOR WITH COMBO SOLDER TAILS 有权
标题翻译：低配置连接器与组合焊尾
公开(公告)号：US20110086546A1
公开(公告)日：2011-04-14
申请号：US12755383
申请日：2010-04-06
申请人： Yu-Hua Mao , Zhi-Hong Fang
发明人： Yu-Hua Mao , Zhi-Hong Fang
IPC分类号： H01R13/648
CPC分类号： H01R12/7052 , H01R12/716 , H01R13/6594
摘要： A low profile connector for mounting on a PCB comprising: an insulative housing, a plurality of terminals, a shielding shell and an auxiliary member. Each terminal is provided with a contacting section and a solder portion extending beyond insulative housing for connecting with the PCB. The shielding shell defines a mating opening surrounding the contact portion, and the auxiliary member defines a main portion attached to a bottom surface of the shielding shell and at least one horizontal portion located at one end thereof for mounting on an upper surface of the PCB. The shielding shell further includes a vertical portion perpendicular to the horizontal portion for inserting a hole of the PCB, and the horizontal portion of the auxiliary member has a concavity for receiving the vertical portion which decreasing space that the connector located on the PCB.
摘要翻译：一种用于安装在PCB上的小型连接器，包括：绝缘壳体，多个端子，屏蔽壳体和辅助构件。每个端子设置有接触部分和延伸超过绝缘壳体的焊接部分，用于与PCB连接。屏蔽壳限定了围绕接触部分的配合开口，并且辅助构件限定附接到屏蔽壳的底表面的主要部分和位于其一端的至少一个水平部分，用于安装在PCB的上表面上。屏蔽壳还包括垂直于水平部分的垂直部分，用于插入PCB的孔，并且辅助部件的水平部分具有用于接收垂直部分的凹部，该凹部减小了位于PCB上的连接器的空间。

5. 发明申请

US20110034088A1 ELECTRICAL CONNECTOR HAING HIGH DENSITY CONTACTS FOR MINIATURIZATION 有权
标题翻译：具有高密度接触件的电气连接器用于微型化
公开(公告)号：US20110034088A1
公开(公告)日：2011-02-10
申请号：US12758716
申请日：2010-04-12
申请人： YU-HUA MAO , ZHI-HONG FANG
发明人： YU-HUA MAO , ZHI-HONG FANG
IPC分类号： H01R13/502
CPC分类号： H01R12/724
摘要： An electrical connector includes an insulative housing (1) with a rear portion (11) and a front portion (12) along a first direction (A), a spacer (4) assembled on the rear portion (11) which has a plurality of first wedged positioning sections (42, 43) in an inner side thereof and arranged along a second direction (B) and a plurality of contacts (2) received in the insulative housing and comprising a soldering portion (203) extending out of the insulative housing. The spacer (4) includes a plurality of positioning grooves (45) in an external side thereof for receiving and positioning the soldering portions (203c) of one part contacts (23) located at an upper side of the front portion (12). The soldering portions (203a, 203b) of the other contacts (21a, 21b) are sandwiched between the spacer (4) and the rear portion (11) thereby forms a waved configuration.
摘要翻译：电连接器包括具有后部（11）和沿着第一方向（A）的前部（12）的绝缘壳体（1），组装在后部（11）上的间隔件（4）第一楔形定位部分（42,43）在其内侧并沿着第二方向（B）和多个接触件（2）布置并容纳在绝缘壳体中，并且包括从绝缘壳体延伸出的焊接部分（203）。间隔件（4）在其外侧包括多个定位槽（45），用于接收和定位位于前部（12）的上侧的一部分接触件（23）的焊接部分（203c）。另一个触点（21a，21b）的焊接部分（203a，203b）被夹在间隔件（4）和后部（11）之间，从而形成波形。

6. 外观设计

USD616828S1 Electrical connector 有权
公开(公告)号：USD616828S1
公开(公告)日：2010-06-01
申请号：US29345608
申请日：2009-10-20
申请人： Chang-Hsien Tung , Kuo-Chun Hsu , Yu-Hua Mao
设计人： Chang-Hsien Tung , Kuo-Chun Hsu , Yu-Hua Mao

7. 外观设计

USD607840S1 Electrical connector 有权
公开(公告)号：USD607840S1
公开(公告)日：2010-01-12
申请号：US29336471
申请日：2009-05-05
申请人： Yu-Hua Mao , Zhi-Hong Fang , Fa-Chun Wang
设计人： Yu-Hua Mao , Zhi-Hong Fang , Fa-Chun Wang

8. 发明申请

US20090227129A1 Electrical connector having grounding bridge 有权
标题翻译：具有接地桥的电连接器
公开(公告)号：US20090227129A1
公开(公告)日：2009-09-10
申请号：US12381053
申请日：2009-03-05
申请人： Yu-Hua Mao , Zhi-Hong Fang , Xue-Qing Zhang
发明人： Yu-Hua Mao , Zhi-Hong Fang , Xue-Qing Zhang
IPC分类号： H01R13/648 , H01R24/00
CPC分类号： H01R13/648
摘要： An electrical connector includes an insulative housing (1) which comprise a pair of side walls (121) and a pair of end walls (122) linking with two ends of the side wall, a plurality of terminals (2) retained in the side wall and a pair of grounding bridges (3) received in the end wall. Each of the grounding bridge comprise a contacting part (31) engaging with a mating connector, a grounding part (32) and a conducting part (33) mechanically connecting with the contacting part and grounding part. And the conductive part (33) has a larger resistance compared with the contacting part and the grounding part. Therefore, the power current transmitting through the guiding bridge (3) can be lower.
摘要翻译：电连接器包括绝缘壳体（1），其包括一对侧壁（121）和与侧壁两端连接的一对端壁（122），多个端子（2）保持在侧壁和一对接纳在端壁上的接地桥（3）。每个接地桥包括与配合连接器接合的接触部分（31），与接触部分和接地部分机械连接的接地部分（32）和导电部分（33）。并且与接触部分和接地部分相比，导电部分（33）具有更大的电阻。因此，通过引导桥（3）传输的动力电流可以较低。

9. 发明申请

US20090163050A1 Electrical connector assembly having contacts without soldering legs 失效
标题翻译：电连接器组件具有没有焊接脚的触点
公开(公告)号：US20090163050A1
公开(公告)日：2009-06-25
申请号：US12317417
申请日：2008-12-22
申请人： Zhi-Hong Fang , Yu-Hua Mao
发明人： Zhi-Hong Fang , Yu-Hua Mao
IPC分类号： H01R12/14
CPC分类号： H01R12/7047 , H01R12/714
摘要： An electrical connector (100) assembled to a printed circuit board (5) for connecting with a mating connector, includes a longitudinal insulative housing (1) and a plurality of contacts (2, 3) received in the housing. Each of the contacts (2, 3) defines a retaining section (20, 30), a contacting portion (21) extending forwards from the retaining section for contacting with the mating connector and a compressing portion (220, 320) extending rearwards from the retaining section for connecting to the printed circuit board. The compressing portions are arranged in two rows, and the compressing portions nip and elastic compress against the printed circuit board instead of being soldered thereto to connect the electrical connector to the printed circuit board steadily.
摘要翻译：组装到用于与配合连接器连接的印刷电路板（5）的电连接器（100）包括纵向绝缘壳体（1）和容纳在壳体中的多个触点（2,3）。每个触头（2,3）限定保持部分（20,30），从保持部分向前延伸以与配合连接器接触的接触部分（21）和从该接合部分向后延伸的压缩部分（220,320）用于连接到印刷电路板的保持部分。压缩部分布置成两排，并且压缩部分夹持和弹性压靠印刷电路板，而不是被焊接到其上，以将电连接器稳定地连接到印刷电路板。

10. 发明授权

US07377821B2 Electrical connector 失效
标题翻译：电连接器
公开(公告)号：US07377821B2
公开(公告)日：2008-05-27
申请号：US11714496
申请日：2007-03-06
申请人： Ran Chen , Yu-Hua Mao , Wei Li
发明人： Ran Chen , Yu-Hua Mao , Wei Li
IPC分类号： H01R13/64
CPC分类号： H01R12/727 , H01R12/7005 , H01R12/7029 , H01R13/658
摘要： An electrical connector comprises an insulating housing defining a receiving space with an inserting port, a pair of guiding slot on two lateral sides of the receiving space and a plurality of first and second contact receiving channels, and a plurality of signal and power contacts respectively received in the first and the second contact receiving channels. The insulating housing has at least one protruding portion in front of the second contact receiving channel, a distance between the protruding portion and an opposed face of the insulating housing is narrow than a dimension of the guiding slot in a vertical direction to prevent a guiding post of a complementary connector from inserting into the second channel by mistake.
摘要翻译：电连接器包括绝缘壳体，其限定具有插入口的接收空间，在接收空间的两个横向侧上的一对引导槽和多个第一和第二接触接收通道，以及分别接收的多个信号和电源触点在第一和第二接触接收通道中。绝缘壳体在第二接触接收通道的前面具有至少一个突出部分，突出部分和绝缘壳体的相对面之间的距离比导向槽在垂直方向上的尺寸窄，以防止引导柱的互补连接器错误地插入第二通道。

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