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    • 7. 发明授权
    • Cyclic diesters and their use as perfuming ingredients
    • 环状二酯及其作为加香成分的用途
    • US5614486A
    • 1997-03-25
    • US448285
    • 1995-05-23
    • Wolfgang K. GierschPeter Fankhauser
    • Wolfgang K. GierschPeter Fankhauser
    • A61K8/37A61K8/00A61Q13/00C11B9/00A61K7/46
    • C11B9/0061C11B9/0034
    • The compounds of formula ##STR1## wherein the Z group can be located in positions ortho-, meta- or para-relative to the carboxylic group, symbol R.sup.1 stands for a saturated or unsaturated, linear or branched C.sub.1 to C.sub.4 alkyl radical anda. the dotted lines represent a cyclohexanic moiety and Z represents a ##STR2## group, R.sup.2 being a saturated or unsaturated, linear or branched C.sub.1 to C.sub.4 alkyl radical; orb. the dotted lines represent a cyclohexanic or benzenic moiety and Z represents a group of formula ##STR3## in which R.sup.2 is a saturated or unsaturated, linear or branched C.sub.1 to C.sub.4 alkyl radical, are useful as perfuming ingredients for the preparation of perfuming compositions and a variety of perfumed consumer articles. They impart to the latter odor notes of the fruity and floral type.
    • 式(I)的化合物,其中Z基团可以位于相对于羧基的邻位,间位或对位的位置,符号R1表示饱和或不饱和的直链或支链C1至C4烷基 和a。 虚线代表环己烷基,Z代表一个基团,R2是饱和或不饱和的直链或支链C 1 -C 4烷基; 或b。 虚线表示环己酮或苯部分,Z表示式为“IMAGE”的基团,其中R2为饱和或不饱和的直链或支链C1至C4烷基,可用作加香组分用于制备加香组合物和 各种香水消费品。 它们赋予水果和花卉类型的后一种气味。
    • 9. 发明授权
    • Transdermal monolith systems
    • 超导单相系统
    • US5079008A
    • 1992-01-07
    • US547538
    • 1990-06-29
    • Joel SinnreichPeter Fankhauser
    • Joel SinnreichPeter Fankhauser
    • A61K9/70
    • A61K9/7053Y10S514/946Y10S514/947
    • The invention relates to a monolith transdermal therapeutic system for the delivery of permeable drugs, especially formoterol, in the form of a matrix system comprising three layers: a) a backing layer which is impermeable to the components of the adhesive layer b),b) an adhesive layer capable of releasing the drug and consisting of a permeable polymeric material which is compatible with the skin and contains at least one drug which is capable of permeation across the skin, a combination of eucalyptol having a purity of at least 70% with an additional flux enhancer and further optional pharmaceutical excipients, andc) a protective release liner which can be peeled from the adhesive contact layer b).
    • 本发明涉及一种整体式透皮治疗系统,用于以包含三层的基质系统的形式递送可渗透药物,特别是福莫特罗:a)对粘合剂层b)的组分不可渗透的背衬层,b) 能够释放药物并且由可渗透的聚合材料组成的粘合剂层,其与皮肤相容并且含有至少一种能够穿过皮肤渗透的药物,具有至少70%纯度的桉树脑和 额外的通量增强剂和另外的任选的药物赋形剂,和c)可以从粘合剂接触层b)剥离的保护性剥离衬垫。