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1. 发明授权

US4855142A Pharmaceutical plaster 失效
标题翻译：制药膏药
公开(公告)号：US4855142A
公开(公告)日：1989-08-08
申请号：US156639
申请日：1988-02-17
申请人： Peter Fankhauser , Joel Sinnreich , Rolf Dobmeier
发明人： Peter Fankhauser , Joel Sinnreich , Rolf Dobmeier
IPC分类号： A61K9/00 , A61K9/70 , A61K47/00 , A61L15/24 , A61L15/58
CPC分类号： A61K9/7061 , A61K9/006 , A61K9/7084 , A61L15/24 , A61L15/58
摘要： The invention relates to a pharmaceutical plaster that adheres to the mucosa, consisting of two discrete layers that adhere well to one another, which may contain pharmaceutical active ingredients suitable for topical application or for systemic treatment. It is distinguished by outstanding long-lasting adhesion to the mucosa and is very pleasant in use, especially in the mouth as an oral plaster.
摘要翻译：本发明涉及一种粘附于粘膜的药用石膏，其由彼此粘附的两个不连续的层构成，其可以含有适于局部施用或全身治疗的药物活性成分。其特征在于对粘膜具有优异的持久粘附性，并且在使用中非常愉快，特别是在口腔中作为口服膏药。

2. 发明授权

US5079008A Transdermal monolith systems 失效
标题翻译：超导单相系统
公开(公告)号：US5079008A
公开(公告)日：1992-01-07
申请号：US547538
申请日：1990-06-29
申请人： Joel Sinnreich , Peter Fankhauser
发明人： Joel Sinnreich , Peter Fankhauser
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , Y10S514/946 , Y10S514/947
摘要： The invention relates to a monolith transdermal therapeutic system for the delivery of permeable drugs, especially formoterol, in the form of a matrix system comprising three layers: a) a backing layer which is impermeable to the components of the adhesive layer b),b) an adhesive layer capable of releasing the drug and consisting of a permeable polymeric material which is compatible with the skin and contains at least one drug which is capable of permeation across the skin, a combination of eucalyptol having a purity of at least 70% with an additional flux enhancer and further optional pharmaceutical excipients, andc) a protective release liner which can be peeled from the adhesive contact layer b).
摘要翻译：本发明涉及一种整体式透皮治疗系统，用于以包含三层的基质系统的形式递送可渗透药物，特别是福莫特罗：a）对粘合剂层b）的组分不可渗透的背衬层，b）能够释放药物并且由可渗透的聚合材料组成的粘合剂层，其与皮肤相容并且含有至少一种能够穿过皮肤渗透的药物，具有至少70％纯度的桉树脑和额外的通量增强剂和另外的任选的药物赋形剂，和c）可以从粘合剂接触层b）剥离的保护性剥离衬垫。

3. 发明授权

US4996058A Covered retard forms 失效
标题翻译：覆盖延迟形式
公开(公告)号：US4996058A
公开(公告)日：1991-02-26
申请号：US242833
申请日：1988-09-12
申请人： Joel Sinnreich
发明人： Joel Sinnreich
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61K9/58 , A61K31/195 , A61K47/32 , A61P21/02
CPC分类号： A61K9/009 , A61K9/0065
摘要： The invention relates to a covered, solid retard form which in the case of oral administration remains in the stomach during periodic emptying and ensures continuous release. This dosage form contains the following components:(a) at least one component that expands on contact with body fluid and that contains a physiologically active substance or a combination of such substances,(b) at least one permeable hydrophilic membrane which surrounds component (a) and which is expansible at the site of use, and optionally(c) a covering which surrounds components (a) and membrance (b) and which disintegrates without delay under the action of a body fluid at the site of use.
摘要翻译：本发明涉及覆盖的固体滞后形式，其在口服给药的情况下在定期排空期间保持在胃中并确保持续释放。该剂型包含以下组分：（a）至少一种在与体液接触时膨胀并且含有生理活性物质或这些物质的组合的组分，（b）至少一种可渗透亲水膜，其包围组分（a ），并且其在使用部位是可膨胀的，以及任选地（c）围绕组分（a）和膜（b）的覆盖物，并且其在使用地点的体液作用下不会延迟地分解。

4. 发明授权

US4461709A Separation of polyvalent cations by transport through liquid membrane 失效
标题翻译：通过液膜转运分离多价阳离子
公开(公告)号：US4461709A
公开(公告)日：1984-07-24
申请号：US421210
申请日：1982-09-22
申请人： Hans Batzer , Joel Sinnreich
发明人： Hans Batzer , Joel Sinnreich
IPC分类号： B01D11/04 , B01D61/38 , C07C69/757 , C02F1/26
CPC分类号： B01D61/38 , Y10S204/13 , Y10S423/07 , Y10S423/14
摘要： Use of succinosuccinic acid diesters of the formula ##STR1## in which R is an alkyl, alkenyl or cycloalkyl having 4 to 24 C atoms, either dissolved in a water-immiscible organic solvent, or at elevated temperature in the form of their melts, as cation-selective liquid membranes.
摘要翻译：使用式“IMAGE”的琥珀二琥珀酸二酯，其中R是具有4至24个C原子的烷基，链烯基或环烷基，或者溶解在与水不混溶的有机溶剂中，或以其熔体形式在升高的温度下，作为阳离子选择性液膜。

5. 发明授权

US4357453A Photocurable polymers obtained from succinylosuccinic acid and maleic acid derivatives, processes for the preparation of the polymers, and use of the polymers 失效
标题翻译：由琥珀酸琥珀酸和马来酸衍生物获得的光固化聚合物，聚合物的制备方法和聚合物的用途
公开(公告)号：US4357453A
公开(公告)日：1982-11-02
申请号：US259324
申请日：1981-04-30
申请人： Hans Batzer , Joel Sinnreich
发明人： Hans Batzer , Joel Sinnreich
IPC分类号： C08F2/00 , B01D71/48 , B01D71/58 , C08F2/48 , C08F290/00 , C08F299/00 , C08G63/00 , C08G63/52 , C08G63/54 , C08G63/685 , G03F7/038 , C08G63/02 , C08G63/12
CPC分类号： B01D71/58 , B01D71/48 , C08G63/54 , G03F7/0384
摘要： Novel photo-crosslinkable polymers are obtained by reacting, and polycondensing, bis-(hydroxyalkyl) succinylosuccinates or bis-(hydroxycycloalkyl) succinylosuccinates with maleic anhydride, maleinimid or N-methylmaleinimid in a molar ratio of 1:1 to 1:2. The novel polymers are useful as photoresists, and the films consisting of the crosslinked polymers are useful as solvent-resistant membranes for reverse osmosis.
摘要翻译：通过使双（（羟基烷基）琥珀酸二琥珀酸酯或二 - （羟基环烷基）琥珀酸琥珀酸盐与摩尔比为1:1至1:2的马来酸酐，马来酰亚胺或N-甲基马来酰亚胺反应并缩聚得到新的光交联聚合物。新型聚合物可用作光致抗蚀剂，并且由交联聚合物组成的膜可用作用于反渗透的耐溶剂膜。

6. 发明授权

US3994952A Anti-tricyclo[6.4.0.0..sup.2,7 ]1,4,7,10-tetracarboxy-2,5,8,11-tetrahydroxy-dodeca-4,10-diene and esters thereof, a process for their preparation, and their use in preparing linear polyesters 失效
标题翻译：反三环{8 6.4.0.0。{hu 2,7 {b {9,1,4,7,10-四羧基-2,5,8,11-四羟基 - 十二碳-4,10-二烯及其酯，一制备方法及其在制备线性聚酯中的应用
公开(公告)号：US3994952A
公开(公告)日：1976-11-30
申请号：US492088
申请日：1974-07-26
申请人： Joel Sinnreich , Hans Batzer
发明人： Joel Sinnreich , Hans Batzer
IPC分类号： C07C69/95 , C07C51/00 , C07C62/32 , C07C67/00 , C08G63/00 , C08G63/06 , C08G63/52 , C08G63/60 , D01F6/62 , C07C61/32 , C07C69/74
CPC分类号： C08G63/06
摘要： Compounds of formula I ##SPC1##wherein R denotes hydrogen or an aliphatic or aromatic radical. These compounds are prepared by irradiation of succinylsuccinic acid or diesters thereof, in the crystalline state, with UV light rays or with .gamma.-radiation.
摘要翻译：式I + Q 10的化合物，其中R表示氢或脂族或芳族基团。这些化合物通过用紫外光或γ辐射以结晶状态照射琥珀酰基琥珀酸或其二酯制备。

7. 发明授权

US5827984A Apparatus for simulating the effect of the living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form 失效
标题翻译：用于模拟生物体对形状变化，药物剂型的分解和溶解行为和活性成分释放的影响的装置
公开(公告)号：US5827984A
公开(公告)日：1998-10-27
申请号：US592419
申请日：1996-02-06
申请人： Joel Sinnreich , Christian Bosshard
发明人： Joel Sinnreich , Christian Bosshard
IPC分类号： A61K9/00 , G01N13/00 , G01N33/15
CPC分类号： B01F1/0011 , B01F11/0082 , B01F11/0088 , G01N13/00 , G01N33/15 , G01N2013/006
摘要： An apparatus for simulating the effect of a living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form, including a beaker-shaped container for accommodating a test medium and the pharmaceutical dosage form and an agitating device for agitating the test medium, which agitating device can be moved periodically in a reciprocating movement into and back out of the container, wherein the agitating device includes a piston-shaped head portion arranged on a piston rod, which head portion is provided with through-openings for the test medium and the distance of the piston-shaped head portion from the container floor can be altered periodically in accordance with the periodic reciprocating movement of the agitating device, wherein, the piston rod is suspended from a gallows-shaped boom or the piston rod passes through a bore in the gallows-shaped boom in such a manner that downward movement of the piston-shaped head portion arranged on the piston rod is caused by gravity alone and wherein there is arranged in the container an intermediate base supported on the container floor, the base being provided with through-openings for the test medium and serving as a support for the dosage form, wherein the distance between the intermediate base and the container floor is adjustable by a device for adjusting the distance between the base and the floor.
摘要翻译： PCT No.PCT / EP94 / 02485第 371日期1996年2月6日 102（e）日期1996年2月6日PCT提交1994年7月28日PCT公布。公开号WO95 / 15329 日期1995年6月8日一种用于模拟生物体对形状变化，药物剂型的崩解和溶解行为和活性成分释放的影响的装置，包括用于容纳测试介质的烧杯状容器和所述药剂剂型和用于搅拌所述测试介质的搅拌装置，所述搅拌装置可以以往复运动方式周期性地移动进入和离开所述容器，其中所述搅拌装置包括布置在活塞杆上的活塞形头部，该头部设置有用于测试介质的通孔，并且可以根据搅拌装置的周期性往复运动周期性地改变活塞头部与容器底板的距离，其中，活塞杆悬挂从绞架形吊杆或活塞杆以向下移动的方式穿过绞架形吊杆中的孔布置在活塞杆上的活塞头部的引导由重力单独引起，并且其中在容器中布置有支撑在容器底板上的中间基座，底座设置有用于测试介质的通孔，并用作用于剂型的支撑件，其中中间基座和容器地板之间的距离可通过用于调节基座和地板之间的距离的装置来调节。

8. 发明授权

US5032403A Multilayer plaster 失效
标题翻译：多层石膏
公开(公告)号：US5032403A
公开(公告)日：1991-07-16
申请号：US387322
申请日：1989-07-28
申请人： Joel Sinnreich
发明人： Joel Sinnreich
IPC分类号： A61K9/70 , A61K47/22
CPC分类号： A61K9/7053 , A61K47/22 , Y10S514/946 , Y10S514/947
摘要： The invention relates to a transdermal therapeutic system in the form of a multilayer plaster for the administration of active substances which are able to permeate, in the form of a matrix system containing at least three layers:(a) a covering layer which is impermeable for the constituents of the reservoir b);(b) a reservoir layer which is able to deliver active substance and which consists of optionally crosslinked block copolymer based on styrene, alkadienes and optionally alkenes mixed with adhesive polymers and is optionally provided with an additional adhesive membrane layer and contains at least one active substance capable of skin permeation, at least one agent promoting the skin permeability of active substances and optionally further pharmaceutical auxiliaries, and(c) a protective film which can be pulled off the reservoir layer.
摘要翻译：本发明涉及一种多层石膏形式的透皮治疗系统，用于施用活性物质，活性物质能够以包含至少三层的基质体系的形式渗透：（a）不渗透的覆盖层，水库的组成部分b）; （b）储存层，其能够递送活性物质，并且由任选交联的基于苯乙烯，链烯二烯和任选的烯烃与粘合剂聚合物混合的嵌段共聚物组成，并且任选地具有另外的粘合膜层并且含有至少一种活性物质能够皮肤渗透，促进活性物质的皮肤渗透性和任选的其它药物助剂的至少一种试剂，和（c）可以从储存层中拉出的保护膜。

9. 发明授权

US4400296A Cation-selective liquid membranes and their use 失效
标题翻译：阳离子选择性液膜及其用途
公开(公告)号：US4400296A
公开(公告)日：1983-08-23
申请号：US274962
申请日：1981-06-18
申请人： Hans Batzer , Joel Sinnreich
发明人： Hans Batzer , Joel Sinnreich
IPC分类号： B01D11/04 , B01D61/38 , C07C69/757 , B01F1/00
CPC分类号： B01D61/38 , Y10S204/13 , Y10S423/07 , Y10S423/14
摘要： Use of succinosuccinic acid diesters of the formula ##STR1## in which R is an alkyl, alkenyl or cycloalkyl having 4 to 24 C atoms, either dissolved in a water-immiscible organic solvent, or at elevated temperature in the form of their melts, as cation-selective liquid membranes.
摘要翻译：使用式“IMAGE”的琥珀二琥珀酸二酯，其中R是具有4至24个C原子的烷基，链烯基或环烷基，或者溶解在与水不混溶的有机溶剂中，或以其熔体形式在升高的温度下，作为阳离子选择性液膜。

10. 发明授权

US4305823A Semipermeable membranes from modified polymers 失效
标题翻译：来自改性聚合物的半透膜
公开(公告)号：US4305823A
公开(公告)日：1981-12-15
申请号：US172313
申请日：1980-07-25
申请人： Hans Batzer , Joel Sinnreich
发明人： Hans Batzer , Joel Sinnreich
IPC分类号： C08F8/00 , B01D71/18 , B01D71/82 , C08B3/06 , C08B3/16 , C08B13/00 , C08F8/14 , B01D31/00
CPC分类号： B01D71/18 , B01D71/82 , C08B13/00 , C08B3/16 , C08F8/14
摘要： Polymers from the group consisting of cellulose and its ester and ether derivatives, of polyvinyl alcohol and its ester derivatives, copolymers with vinyl esters and homopolymers and copolymers of acrylates and methacrylates are modified with monofunctional or difunctional cyclic .beta.-ketonic acids or their esters, in particular with succinylsuccinic acid or its ester derivatives. The modified polymers are particularly suitable for obtaining semi-permeable membranes for osmotic separation methods.
摘要翻译：来自由纤维素及其酯和醚衍生物组成的组的聚乙烯醇及其酯衍生物，与乙烯基酯的共聚物和丙烯酸酯和甲基丙烯酸酯的均聚物和共聚物的聚合物用单官能或双官能的环状β-酮酸或其酯改性，特别是与琥珀酰基琥珀酸或其酯衍生物。改性聚合物特别适用于获得用于渗透分离方法的半透膜。

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