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1. 发明授权

US08113209B2 Sub-dermal laser skin treatment 有权
标题翻译：皮下激光皮肤治疗
公开(公告)号：US08113209B2
公开(公告)日：2012-02-14
申请号：US11704710
申请日：2007-02-09
申请人： Leonardo Masotti , George E. S. Cho
发明人： Leonardo Masotti , George E. S. Cho
IPC分类号： A61B19/00
CPC分类号： A61B18/22 , A61B2017/00057 , A61B2017/00084 , A61B2018/00005 , A61B2018/2288 , A61B2090/3937 , A61B2562/0276
摘要： A method and system for skin tightening comprises a hollow cannula that contains an optical fiber connected to a laser source. The cannula is inserted subcutaneously into a patient so that the end of the fiber is located within the tissue underlying the dermis. The source emits an output pulse that is conveyed by the fiber to the dermis, where the pulse causes collagen destruction and shrinkage within the treatment area. Radiation from the skin surface is detected to prevent non-reversible damage to the dermis, such as skin necrosis and excessive collagen melting. This method of sub-cutaneous laser treatment can also be used to treat striae, or stretch marks.
摘要翻译：用于皮肤紧固的方法和系统包括中空插管，其包含连接到激光源的光纤。将套管皮下插入患者体内，使得纤维的末端位于真皮下面的组织内。源发射由纤维传送到真皮的输出脉冲，其中脉冲导致治疗区域内的胶原蛋白破坏和收缩。检测皮肤表面的辐射以防止对真皮的不可逆损伤，例如皮肤坏死和过度的胶原蛋白熔化。这种亚皮肤激光治疗方法也可用于治疗条纹或妊娠纹。

2. 发明授权

US07975702B2 System and method for laser lipolysis 有权
标题翻译：激光脂解的系统和方法
公开(公告)号：US07975702B2
公开(公告)日：2011-07-12
申请号：US11099216
申请日：2005-04-05
申请人： George E. S. Cho , Leonardo Masotti
发明人： George E. S. Cho , Leonardo Masotti
IPC分类号： A61B19/00
CPC分类号： A61B18/22 , A61B2017/00057 , A61B2017/00084 , A61B2018/00005 , A61B2018/2288 , A61B2090/3937 , A61B2562/0276
摘要： A device and related method for the removal of subcutaneous adipose layers comprises a laser source; an optical fiber for conveying a laser beam emitted by the laser source; and a hollow cannula for guiding the fiber to the subcutaneous treatment area. The cannula has a curved portion at its distal end, where the curved portion can be shaped to roughly conform to the contour of the patient's body structure. In this way, laser energy from the fiber, applied to the adipose layers, is generally directed away from the lower dermis of the patient, minimizing the risk of non-reversible damage to the dermis, including skin necrosis. In another embodiment, the optical fiber is a side-firing fiber that directs the laser energy away from the dermis. In other embodiments, a radiation detector, such as a thermal or optical sensor, monitors the temperature at the surface of the skin above the treatment area to warn the operator of harmful temperatures in the lower dermis. In another embodiment, a temperature sensitive material is applied to the surface of the skin above the treatment area to warn of harmful dermal temperatures. In another embodiment, a cooling mechanism cools the surface of the skin above the treatment area to prevent damage to the dermis.
摘要翻译：用于去除皮下脂肪层的装置和相关方法包括激光源; 用于传送由激光源发射的激光束的光纤; 以及用于将纤维引导到皮下治疗区域的中空套管。套管在其远端处具有弯曲部分，其中弯曲部分可以被成形为大致符合患者身体结构的轮廓。以这种方式，施加到脂肪层的来自纤维的激光能量通常远离患者的下部真皮，从而最小化对真皮的不可逆损伤的风险，包括皮肤坏死。在另一个实施例中，光纤是将激光能量远离真皮的侧发光纤。在其他实施例中，放射线检测器（例如热或光学传感器）监测治疗区域上方皮肤表面的温度，以向操作者警告下层真皮中的有害温度。在另一个实施方案中，将感温材料施加到处理区域上方的皮肤表面以警告有害的皮肤温度。在另一个实施例中，冷却机构将治疗区域上方的皮肤表面冷却以防止对真皮的损伤。

3. 发明授权

US06570900B2 Method and apparatus for replenishing dye solution in a dye laser 失效
标题翻译：用于在染料激光器中补充染料溶液的方法和装置
公开(公告)号：US06570900B2
公开(公告)日：2003-05-27
申请号：US09877500
申请日：2001-06-08
申请人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
发明人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
IPC分类号： H01S320
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter to remove by-products of the laser process. Solute concentration is monitored and dye and additives removed by the filter are replenished by a metering pump. Precise temperature control assures consistent filtering of dye by the filter for more consistent color and energy output. To control the metering pump, the differential output of a two-channel absorption detector is digitized. The digitized signal is loaded into a counter which drives the metering pump. The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.
摘要翻译：在染料激光系统中，在系统操作之前，多孔床式过滤器装载有染料。随着反复点燃，染料溶液被多孔床过滤器过滤，以除去激光过程的副产物。监测溶质浓度，并通过计量泵补充由过滤器除去的染料和添加剂。精确的温度控制确保了滤色片对染料的一致过滤，从而获得更一致的色彩和能量输出。为了控制计量泵，双通道吸收检测器的差分输出被数字化。数字化信号被装载到驱动计量泵的计数器中。通过在溶液中加入pH缓冲液来增强染料溶液的有效寿命。

4. 发明授权

US5672170A Laser transmyocardial revascularization arrangement 失效
标题翻译：激光经心肌血运重建安排
公开(公告)号：US5672170A
公开(公告)日：1997-09-30
申请号：US666251
申请日：1996-06-20
申请人： George E. S. Cho , Horace W. Furumoto
发明人： George E. S. Cho , Horace W. Furumoto
IPC分类号： A61B17/00 , A61B18/24 , A61B5/06 , A61B5/00 , A61N1/362
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2017/00703 , A61B2018/00392
摘要： The present invention involves a system for transmyocardial revascularization of a beating heart, including a laser device for ablating wall tissue of the heart being treated, with a pacemaker connected to the heart being treated, to provide electrical signals to control the cardiac cycle of that heart, and a conditioning circuit connected to both the pacemaker and to the laser, to permit the controlled "safe period" firing of the laser. The laser includes an optic waveguide articulably arranged to irradiate the wall of the heart. The conditioning circuit is programmed to permit the firing of the laser upon the time of the cardiac cycle of the heart during a non-ventricular repolarization time period.
摘要翻译：本发明涉及一种用于搏动心脏的心肌心肌血运重建的系统，包括用于消除正在治疗的心脏的壁组织的激光装置，其中起搏器连接到被治疗的心脏，以提供电信号以控制该心脏的心动周期以及连接起搏器和激光两者的调节电路，以允许激光的受控的“安全期”的烧制。该激光器包括可枢转地布置成照射心脏壁的光波导。调理电路被编程为允许在非心室复极化时间段期间在心脏心脏周期时激光的激发。

5. 发明授权

US08322348B2 Methods and systems for laser treatment using non-uniform output beam 有权
标题翻译：使用不均匀输出光束进行激光治疗的方法和系统
公开(公告)号：US08322348B2
公开(公告)日：2012-12-04
申请号：US12947310
申请日：2010-11-16
申请人： Mirko Georgiev Mirkov , Rafael Armando Sierra , George E. S. Cho
发明人： Mirko Georgiev Mirkov , Rafael Armando Sierra , George E. S. Cho
IPC分类号： A61B19/00
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Methods and apparatus for treatment, such as skin rejuvenation treatment, using non-uniform laser radiation. An output beam from a laser source is coupled into an optical system that modifies the beam to provide a large-diameter beam having a non-uniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin.
摘要翻译：治疗方法和设备，如皮肤嫩肤治疗，使用不均匀的激光辐射。来自激光源的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，所述大直径光束由处理中的较低强度区域包围的多个高强度区域组成光束。可以同时治疗大面积的组织，优选直径为7-10mm，同时最小化对皮肤的燃烧或其它损伤的风险。

6. 发明授权

US07856985B2 Method of treatment body tissue using a non-uniform laser beam 有权
标题翻译：使用不均匀输出光束进行激光治疗的方法和系统
公开(公告)号：US07856985B2
公开(公告)日：2010-12-28
申请号：US11347672
申请日：2006-02-03
申请人： Mirko Georgiev Mirkov , Rafael Armando Sierra , George E. S. Cho
发明人： Mirko Georgiev Mirkov , Rafael Armando Sierra , George E. S. Cho
IPC分类号： A61B19/00
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Methods and apparatus for treatment, such as skin rejuvenation treatment, using non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a non-uniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production). A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin.In one embodiment, the invention uses a fiber bundle to provide a non-uniform energy output beam. In another embodiment, the invention uses a diffractive lens array to produce the non-uniform output beam. A cooling system can also be integrated with the laser treatment system.
摘要翻译：治疗方法和设备，如皮肤嫩肤治疗，使用不均匀的激光辐射。激光辐射的高强度部分导致处理区域的选定部分内的胶原蛋白破坏和收缩，而辐射的较低强度部分引起成纤维细胞刺激，导致治疗区域的其它部分的胶原产生。来自激光源（例如Nd：YAG激光器）的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，该光束由多个高强度区域被处理梁内的低强度区域包围。较高强度区域将目标组织的部分热量选择为足以进行第一次处理（例如胶原收缩）的温度，而较低强度区域为第二次处理提供足够的能量（例如刺激的胶原产生）。可以同时治疗大面积的组织，优选直径为7-10mm，同时最小化对皮肤的燃烧或其它损伤的风险。在一个实施例中，本发明使用纤维束来提供不均匀的能量输出束。在另一个实施例中，本发明使用衍射透镜阵列来产生不均匀的输出光束。冷却系统也可以与激光治疗系统集成。

7. 发明授权

US06246710B1 Method and apparatus for replenishing dye solution in a dye laser 失效
标题翻译：用于在染料激光器中补充染料溶液的方法和装置
公开(公告)号：US06246710B1
公开(公告)日：2001-06-12
申请号：US08929883
申请日：1997-09-15
申请人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
发明人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
IPC分类号： H01S322
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter to remove by-products of the laser process. Solute concentration is monitored and dye and additives removed by the filter are replenished by a metering pump. Precise temperature control assures consistent filtering of dye by the filter for more consistent color and energy output. To control the metering pump, the differential output of a two-channel absorption detector is digitized. The digitized signal is loaded into a counter which drives the metering pump. The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.
摘要翻译：在染料激光系统中，在系统操作之前，多孔床式过滤器装载有染料。随着反复点燃，染料溶液被多孔床过滤器过滤，以除去激光过程的副产物。监测溶质浓度，并通过计量泵补充由过滤器除去的染料和添加剂。精确的温度控制确保了滤色片对染料的一致过滤，从而获得更一致的色彩和能量输出。为了控制计量泵，双通道吸收检测器的差分输出被数字化。数字化信号被装载到驱动计量泵的计数器中。通过在溶液中加入pH缓冲液可以增强染料溶液的使用寿命。

8. 发明授权

US5668824A Method and apparatus for replenishing dye solution in a dye laser 失效
标题翻译：用于在染料激光器中补充染料溶液的方法和装置
公开(公告)号：US5668824A
公开(公告)日：1997-09-16
申请号：US165331
申请日：1993-12-10
申请人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
发明人： Horace W. Furumoto , Harry L. Ceccon , George E. S. Cho , Mark P. Hacker
IPC分类号： H01S3/131 , H01S3/02 , H01S3/213 , H01S3/20
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter to remove by-products of the laser process. Solute concentration is monitored and dye and additives removed by the filter are replenished by a metering pump. Precise temperature control assures consistent filtering of dye by the filter for more consistent color and energy output. To control the metering pump, the differential output of a two-channel absorption detector is digitized. The digitized signal is loaded into a counter which drives the metering pump. The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.
摘要翻译：在染料激光系统中，在系统操作之前，多孔床式过滤器装载有染料。随着反复点燃，染料溶液被多孔床过滤器过滤，以除去激光过程的副产物。监测溶质浓度，并通过计量泵补充由过滤器除去的染料和添加剂。精确的温度控制确保了滤色片对染料的一致过滤，从而获得更一致的色彩和能量输出。为了控制计量泵，双通道吸收检测器的差分输出被数字化。数字化信号被装载到驱动计量泵的计数器中。通过在溶液中加入pH缓冲液可以增强染料溶液的使用寿命。

9. 发明授权

US4681092A Balloon catheter wrapping apparatus 失效
标题翻译：气球导管包装机
公开(公告)号：US4681092A
公开(公告)日：1987-07-21
申请号：US736598
申请日：1985-05-21
申请人： George E. S. Cho , Stephen B. Kessler
发明人： George E. S. Cho , Stephen B. Kessler
IPC分类号： A61M25/00 , A61B17/03 , A61F2/958 , A61M1/10 , A61M25/01 , A61M25/02 , A61B19/00
CPC分类号： A61M25/10 , A61M1/1072 , A61M25/1038
摘要： An apparatus for wrapping a balloon catheter such as an intra-aortic balloon catheter is disclosed. The wrapping apparatus comprises a housing having a channel which receives the balloon membrane of the intra-aortic balloon. The wrapping apparatus also includes a clutching means located in the channel for exerting a predetermined pressure on the balloon membrane to enable the balloon membrane to be wrapped as the wrapping apparatus is rotated relative to the balloon catheter. The clutching means also permits relatively free rotation of the balloon membrane within the wrapping apparatus after the balloon membrane has been wrapped.The clutching means can include a shoe and a biasing means for biasing the shoe towards the balloon membrane with a predetermined pressure while the balloon membrane is being wrapped, yet enable the balloon membrane to rotate relatively freely within the wrapping apparatus after the balloon membrane has been wrapped to a predetermined degree.The clutching means, alternatively, can include flexible vanes projecting inwardly within the channel such that the vanes contact the balloon membrane during wrapping and provide a predetermined pressure onto the balloon membrane which aids in wrapping yet permits the wrapped balloon membrane to rotate relatively freely within the wrapping apparatus.
摘要翻译：公开了一种用于包裹气球导管的装置，例如主动脉内气囊导管。包装装置包括具有容纳主动脉内气囊的球囊膜的通道的壳体。包装设备还包括位于通道中的离合装置，用于在球囊膜上施加预定压力，以使包囊装置相对于球囊导管旋转时能够包裹球囊膜。在气囊膜被包裹之后，离合装置还允许气囊膜在包裹装置内相对自由旋转。离合装置可以包括鞋和偏置装置，用于在球囊膜被包裹的同时以预定的压力将靴子朝向球囊膜偏置，但是在球囊膜已经被覆盖之后，使球囊膜能够在包裹装置内相对自由地旋转包装预定的程度。或者，离合装置可以包括在通道内向内突出的柔性叶片，使得叶片在包裹期间接触球囊膜，并且在球囊膜上提供预定的压力，这有助于包裹，但允许包裹的球囊膜在内包装机

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