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1. 发明申请

US20110024353A1 BLOOD TREATMENT APPARATUS 有权
标题翻译：血液治疗装置
公开(公告)号：US20110024353A1
公开(公告)日：2011-02-03
申请号：US12937786
申请日：2009-04-14
申请人： Lennart Jönsson , Olof Jansson , Mattias Holmer , Jan Sternby , Anders Nilsson , Per Hansson
发明人： Lennart Jönsson , Olof Jansson , Mattias Holmer , Jan Sternby , Anders Nilsson , Per Hansson
IPC分类号： B01D61/32
CPC分类号： A61M1/16 , A61M1/1006 , A61M1/1037 , A61M1/1039 , A61M1/106 , A61M1/1065 , A61M1/1086 , A61M1/1601 , A61M1/34 , A61M1/3403 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： A proposed blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Additionally, the fluid pumps are configured to control the operation of the blood pumps via the blood treatment fluid. Moreover, a flow control device is configured to control a trans-membrane flow between the blood side and the a fluid side of the blood treatment unit. Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.
摘要翻译：所提出的血液处理装置包括：血液处理单元，一对流体泵和一对血液泵。血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。流体泵配置成使血液处理液通过血液处理单元。血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。另外，流体泵配置成通过血液处理流体来控制血液泵的操作。此外，流量控制装置被配置为控制血液侧和血液处理单元的流体侧之间的跨膜流动。因此，例如超滤可以以非常直接的方式调整到期望的水平。

2. 发明授权

US08580110B2 Blood treatment apparatus 有权
标题翻译：血液处理仪
公开(公告)号：US08580110B2
公开(公告)日：2013-11-12
申请号：US12937786
申请日：2009-04-14
申请人： Lennart Jönsson , Olof Jansson , Mattias Holmer , Jan Sternby , Anders Nilsson , Per Hansson
发明人： Lennart Jönsson , Olof Jansson , Mattias Holmer , Jan Sternby , Anders Nilsson , Per Hansson
IPC分类号： B01D61/32 , B01D61/34 , B01D61/28
CPC分类号： A61M1/16 , A61M1/1006 , A61M1/1037 , A61M1/1039 , A61M1/106 , A61M1/1065 , A61M1/1086 , A61M1/1601 , A61M1/34 , A61M1/3403 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： A proposed blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Additionally, the fluid pumps are configured to control the operation of the blood pumps via the blood treatment fluid. Moreover, a flow control device is configured to control a trans-membrane flow between the blood side and the a fluid side of the blood treatment unit. Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.
摘要翻译：所提出的血液处理装置包括：血液处理单元，一对流体泵和一对血液泵。血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。流体泵配置成使血液处理液通过血液处理单元。血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。另外，流体泵配置成通过血液处理流体来控制血液泵的操作。此外，流量控制装置被配置为控制血液侧和血液处理单元的流体侧之间的跨膜流动。因此，例如超滤可以以非常直接的方式调整到期望的水平。

3. 发明授权

US08545427B2 Blood treatment apparatus and method 有权
标题翻译：血液处理装置及方法
公开(公告)号：US08545427B2
公开(公告)日：2013-10-01
申请号：US13124316
申请日：2009-10-12
申请人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
发明人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
IPC分类号： A61M37/00 , C02F1/44 , F04B43/08
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus, including a blood treatment unit configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps configured to pass blood treatment fluid through the blood treatment unit, a pair of blood pumps configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel, each blood pump including a pump chamber and a flexible member separating the pumping chamber into a first blood accumulating container and a second working fluid accumulating container where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. A control unit and a measuring device are configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers whereby the pumped mass or volume of working fluid is determined by the control unit at an arbitrary position of the flexible member.
摘要翻译：一种血液处理装置，包括：血液处理单元，其构造为接收未经处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理流体;一对流体泵，被配置为使血液处理液通过所述血液处理单元，被配置为从血液源提取未处理的血液的血液泵，将提取的血液通过血液处理单元并将处理的血液输送到目标血管，每个血液泵包括泵室和将泵送室分离成第一血液积聚的柔性构件容器和第二工作流体积聚容器，其中柔性构件构造成改变第一和第二积聚容器之间的体积关系。控制单元和测量装置被配置为发出指示接收到或从第二积聚容器中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或体积的工作流体由控制单元确定在柔性构件的任意位置。

4. 发明授权

US08485999B2 Blood treatment apparatus and method 有权
标题翻译：血液处理装置及方法
公开(公告)号：US08485999B2
公开(公告)日：2013-07-16
申请号：US13124258
申请日：2009-10-12
申请人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
发明人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter is determined based on a difference between (i) a first amount of fresh blood treatment fluid received into the blood treatment unit, and (ii) a second amount of used blood treatment fluid emitted from the blood treatment unit during another well-defined period.
摘要翻译：血液处理装置包括：血液处理单元，一对流体泵和一对血液泵。血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。流体泵配置成使血液处理液通过血液处理单元。血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。流量测量装置，例如在完成一个操作周期期间，确定在装置的操作的良好定义的周期期间反映相对于血液处理单元的平均流量的至少一个血流参数。基于（i）接收到血液处理单元中的第一量的新鲜血液处理液和（ii）从血液处理单元发出的第二量的使用的血液处理液的差异来确定至少一个血流参数在另一个明确的时期。

5. 发明申请

US20110201989A1 BLOOD TREATMENT APPARATUS AND METHOD 有权
标题翻译：血液处理装置和方法
公开(公告)号：US20110201989A1
公开(公告)日：2011-08-18
申请号：US13124316
申请日：2009-10-12
申请人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
发明人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
IPC分类号： A61M1/16 , B01D33/70
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus, including a blood treatment unit configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps configured to pass blood treatment fluid through the blood treatment unit, a pair of blood pumps configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel, each blood pump including a pump chamber and a flexible member separating the pumping chamber into a first blood accumulating container and a second working fluid accumulating container where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. A control unit and a measuring device are configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers whereby the pumped mass or volume of working fluid is determined by the control unit at an arbitrary position of the flexible member.
摘要翻译：一种血液处理装置，包括：血液处理单元，其构造为接收未经处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理流体;一对流体泵，被配置为使血液处理液通过所述血液处理单元，被配置为从血液源提取未处理的血液的血液泵，将提取的血液通过血液处理单元并将处理的血液输送到目标血管，每个血液泵包括泵室和将泵送室分离成第一血液积聚的柔性构件容器和第二工作流体积聚容器，其中柔性构件构造成改变第一和第二积聚容器之间的体积关系。控制单元和测量装置被配置为发出指示接收到或从第二积聚容器中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或体积的工作流体由控制单元确定在柔性构件的任意位置。

6. 发明申请

US20110201988A1 BLOOD TREATMENT APPARATUS AND METHOD 有权
标题翻译：血液处理装置和方法
公开(公告)号：US20110201988A1
公开(公告)日：2011-08-18
申请号：US13124258
申请日：2009-10-12
申请人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
发明人： Mattias Holmer , Lennart Jönsson , Anders Wallenborg , Per Hansson
IPC分类号： A61M1/34 , A61M1/36
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter is determined based on a difference between (i) a first amount of fresh blood treatment fluid received into the blood treatment unit, and (ii) a second amount of used blood treatment fluid emitted from the blood treatment unit during another well-defined period.
摘要翻译：血液处理装置包括：血液处理单元，一对流体泵和一对血液泵。血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。流体泵配置成使血液处理液通过血液处理单元。血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。流量测量装置，例如在完成一个操作周期期间，确定在装置的操作的良好定义的周期期间反映相对于血液处理单元的平均流量的至少一个血流参数。基于（i）接收到血液处理单元中的第一量的新鲜血液处理液和（ii）从血液处理单元发出的第二量的使用的血液处理液的差异来确定至少一个血流参数在另一个明确的时期。

7. 发明授权

US10493197B2 Blood treatment apparatus with flow divider for limiting an electrical current 有权
公开(公告)号：US10493197B2
公开(公告)日：2019-12-03
申请号：US13824892
申请日：2011-09-14
申请人： Per Hansson , Thomas Hertz , Mattias Holmer , Lennart Jonsson , Anders Nilsson , Anders Wallenborg , Johan Andersson
发明人： Per Hansson , Thomas Hertz , Mattias Holmer , Lennart Jonsson , Anders Nilsson , Anders Wallenborg , Johan Andersson
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , Y10T29/49002
摘要： A blood treatment apparatus comprising: a blood treatment unit; a blood line configured to extract blood from a blood source, pass the blood through the blood treatment unit and deliver treated blood to a target vessel; and a fluid line configured to pass treatment fluid through the blood treatment unit and deliver used treatment fluid to a fluid sink. A flow divider is arranged in the fluid line that separates treatment fluid into a first fluid section and a second fluid section, thereby electrically isolating the fluid sections such that electrical current flowing in the fluid line between the fluid sections is limited. Related manufacturing and verification methods are also described.

8. 发明申请

US20130319920A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：US20130319920A1
公开(公告)日：2013-12-05
申请号：US13824892
申请日：2011-09-14
申请人： Per Hansson , Thomas Hertz , Mattias Holmer , Lennart Jonsson , Anders Nilsson , Anders Wallenborg , Johan Andersson
发明人： Per Hansson , Thomas Hertz , Mattias Holmer , Lennart Jonsson , Anders Nilsson , Anders Wallenborg , Johan Andersson
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus comprising: a blood treatment unit; a blood line configured to extract blood from a blood source, pass the blood through the blood treatment unit and deliver treated blood to a target vessel; and a fluid line configured pass treatment fluid through the blood treatment unit and deliver used treatment fluid to a fluid sink. A flow divider is arranged in the fluid line separates treatment fluid into to a first fluid section and a second fluid section, thereby electrically isolating the fluid sections such that electrical current flowing in the fluid line between the fluid sections is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置，包括：血液处理单元; 构成为从血液源提取血液的血液线，使血液通过血液处理单元，将处理后的血液输送到目标血管; 并且流体管线配置使处理流体通过血液处理单元并将使用的处理流体输送到流体槽。流体分配器设置在流体管线中，将处理流体分离成第一流体部分和第二流体部分，由此电流隔离流体部分，使得在流体部分之间的流体管线中流动的电流受到限制。还描述了相关的制造和验证方法。

9. 发明申请

US20050145549A1 Circuit for extracorporeal blood treatment and flow-inverting device utilized therein 有权
标题翻译：其中使用体外血液处理和流量反转装置的电路
公开(公告)号：US20050145549A1
公开(公告)日：2005-07-07
申请号：US10976416
申请日：2004-10-29
申请人： Lennart Jonsson , Mattias Holmer , Per Hansson
发明人： Lennart Jonsson , Mattias Holmer , Per Hansson
IPC分类号： A61M1/36 , A61M39/22 , B01D35/02 , A61M1/34
CPC分类号： A61M1/367 , A61M1/3658 , A61M39/223 , Y10T137/87249
摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.
摘要翻译：公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血液泵之间。即使在由血泵控制的患者侧动脉和静脉分支中的倒置循环之后，流动反转装置也能够使过滤单元内的血液流量保持不变。

10. 发明申请

US20080208102A1 CIRCUIT FOR EXTRACORPOREAL BLOOD TREATMENT AND FLOW-INVERTING DEVICE THEREIN 有权
标题翻译：超声波血液治疗电路及其逆流装置
公开(公告)号：US20080208102A1
公开(公告)日：2008-08-28
申请号：US12115160
申请日：2008-05-05
申请人： Lennart Jonsson , Mattias Holmer , Per Hansson
发明人： Lennart Jonsson , Mattias Holmer , Per Hansson
IPC分类号： A61M1/14
CPC分类号： A61M1/367 , A61M1/3658 , A61M39/223 , Y10T137/87249
摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.
摘要翻译：公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血液泵之间。即使在由血泵控制的患者侧动脉和静脉分支中的倒置循环之后，流动反转装置也能够使过滤单元内的血液流量保持不变。

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