专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120041498A1 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 有权
标题翻译：用于增强或影响神经刺激效能和/或效率的系统和方法
公开(公告)号：US20120041498A1
公开(公告)日：2012-02-16
申请号：US13179133
申请日：2011-07-08
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

2. 发明授权

US08606361B2 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
公开(公告)号：US08606361B2
公开(公告)日：2013-12-10
申请号：US13179133
申请日：2011-07-08
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

3. 发明申请

US20100004500A1 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：US20100004500A1
公开(公告)日：2010-01-07
申请号：US12561950
申请日：2009-09-17
申请人： Bradford Evan Gliner , Jeffrey Balzer , Brad Fowler , Leif R. Sloan
发明人： Bradford Evan Gliner , Jeffrey Balzer , Brad Fowler , Leif R. Sloan
IPC分类号： A61N2/04
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

4. 发明授权

US07483747B2 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：US07483747B2
公开(公告)日：2009-01-27
申请号：US11182713
申请日：2005-07-15
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/00
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

5. 发明授权

US08538537B2 Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders 有权
标题翻译：用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神障碍和神经病理障碍）的系统和方法
公开(公告)号：US08538537B2
公开(公告)日：2013-09-17
申请号：US12330437
申请日：2008-12-08
申请人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
发明人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

6. 发明授权

US08090446B2 Methods and systems for establishing neural stimulation parameters and providing neural stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法和系统
公开(公告)号：US08090446B2
公开(公告)日：2012-01-03
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

7. 发明授权

US07983762B2 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：US07983762B2
公开(公告)日：2011-07-19
申请号：US12327711
申请日：2008-12-03
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

8. 发明申请

US20090299435A1 Systems and Methods for Enhancing or Affecting Neural Stimulation Efficiency and/or Efficacy 有权
标题翻译：增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：US20090299435A1
公开(公告)日：2009-12-03
申请号：US12327711
申请日：2008-12-03
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

9. 发明申请

US20090149898A1 Systems and Methods for Providing Targeted Neural Stimulation Therapy to Address Neurological Disorders, Including Neuropyschiatric and Neuropyschological Disorders 有权
标题翻译：提供靶向神经刺激治疗解决神经障碍，包括神经精神和神经病理障碍的系统和方法
公开(公告)号：US20090149898A1
公开(公告)日：2009-06-11
申请号：US12330437
申请日：2008-12-08
申请人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
发明人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

10. 发明申请

US20090099622A1 Methods and Systems for Establishing Neural Stimulation Parameters and Providing Neural Stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法与系统
公开(公告)号：US20090099622A1
公开(公告)日：2009-04-16
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式