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1. 发明申请

US20080139870A1 Systems and methods for treating patient hypertonicity 审中-公开
标题翻译：用于治疗患者高渗性的系统和方法
公开(公告)号：US20080139870A1
公开(公告)日：2008-06-12
申请号：US11638326
申请日：2006-12-12
申请人： Bradford E. Gliner , Brad Fowler , Justin Hulvershorn , Leif R. Sloan
发明人： Bradford E. Gliner , Brad Fowler , Justin Hulvershorn , Leif R. Sloan
IPC分类号： A61N2/02
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括识别与患者中的高渗性相关的皮质靶神经群体，以及通过向目标神经群体施加电磁信号来减少或消除患者的高渗性。在另外的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除另外的患者功能障碍。

2. 发明授权

US08090446B2 Methods and systems for establishing neural stimulation parameters and providing neural stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法和系统
公开(公告)号：US08090446B2
公开(公告)日：2012-01-03
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

3. 发明申请

US20090099622A1 Methods and Systems for Establishing Neural Stimulation Parameters and Providing Neural Stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法与系统
公开(公告)号：US20090099622A1
公开(公告)日：2009-04-16
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

4. 发明申请

US20080208285A1 Methods for Treating Neurological Disorders, Including Neuropsychiatric and Neuropsychological, Disorders, and Associated Systems 审中-公开
标题翻译：治疗神经系统疾病，包括神经精神和神经心理学，疾病和相关系统的方法
公开(公告)号：US20080208285A1
公开(公告)日：2008-08-28
申请号：US11961023
申请日：2007-12-20
申请人： Brad Fowler , Bradford E. Gliner , W. Douglas Sheffield , Leif R. Sloan
发明人： Brad Fowler , Bradford E. Gliner , W. Douglas Sheffield , Leif R. Sloan
IPC分类号： A61N1/02
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.
摘要翻译：公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法可以进一步包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

5. 发明授权

US08926676B2 Systems and methods for applying signals, including contralesional signals, to neural populations 有权
标题翻译：将信号（包括对数信号）应用于神经群体的系统和方法
公开(公告)号：US08926676B2
公开(公告)日：2015-01-06
申请号：US11697696
申请日：2007-04-06
申请人： Alvaro Pascual-Leone , Bradford E. Gliner , David Himes , Leif R. Sloan
发明人： Alvaro Pascual-Leone , Bradford E. Gliner , David Himes , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译：公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯。

6. 发明授权

US08262714B2 Techniques for selecting signal delivery sites and other parameters for treating depression and other neurological disorders, and associated systems and methods 有权
标题翻译：用于选择信号传递部位的技术和用于治疗抑郁症和其他神经障碍的其它参数，以及相关的系统和方法
公开(公告)号：US08262714B2
公开(公告)日：2012-09-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N5/055 , A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

7. 发明申请

US20130066391A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于选择信号传递站点和其他参数用于治疗衰竭和其他神经疾病的技术及相关系统和方法
公开(公告)号：US20130066391A1
公开(公告)日：2013-03-14
申请号：US13606906
申请日：2012-09-07
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is selected based in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍的信号递送部位和其它信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。部分基于第二成像信息选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

8. 发明申请

US20100036453A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：用于选择信号传递站点的技术和用于治疗衰竭和其他神经疾病的其他参数以及相关系统和方法
公开(公告)号：US20100036453A1
公开(公告)日：2010-02-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36 , A61B5/055
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑的第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

9. 发明授权

US07949401B2 Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods 有权
标题翻译：由神经元功能障碍，降解，损伤和/或坏死影响的组织的电磁信号传递，以及相关的系统和方法
公开(公告)号：US07949401B2
公开(公告)日：2011-05-24
申请号：US11697694
申请日：2007-04-06
申请人： Brad Fowler , Bradford E. Gliner , David Himes
发明人： Brad Fowler , Bradford E. Gliner , David Himes
IPC分类号： A61N1/36
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

10. 发明申请

US20110213440A1 ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：由神经元功能丧失，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递
公开(公告)号：US20110213440A1
公开(公告)日：2011-09-01
申请号：US13104802
申请日：2011-05-10
申请人： Brad Fowler , Bradford E. Gliner , David Himes
发明人： Brad Fowler , Bradford E. Gliner , David Himes
IPC分类号： A61N1/36
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

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