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1. 发明申请

US20110208263A1 SYSTEM AND METHOD FOR TREATING PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS 审中-公开
标题翻译：用于治疗帕金森病和其他运动障碍的系统和方法
公开(公告)号：US20110208263A1
公开(公告)日：2011-08-25
申请号：US13100646
申请日：2011-05-04
申请人： Jeffrey Balzer , Allen Wyler
发明人： Jeffrey Balzer , Allen Wyler
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/32 , A61N1/36025 , A61N1/36067 , A61N1/375 , A61N1/3756
摘要： Systems and methods for treating movement disorders using cortical stimulation. In one embodiment, a method for treating movement disorders comprises determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part. The site can be determined by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part. The method can also include applying neural stimulation, such as electrical or magnetic waveforms, directly to the site.
摘要翻译：用皮质刺激治疗运动障碍的系统和方法。在一个实施方案中，用于治疗运动障碍的方法包括确定与受影响的身体部位的运动障碍有关的患者的脑的皮质部位。可以通过获得在患者皮层中发生的神经活动的表示并将神经活动的区域与受影响的身体部分相关联来确定该位点。该方法还可以包括将神经刺激（例如电或波形波形）直接应用于部位。

2. 发明授权

US07962218B2 System and method for treating Parkinson's Disease and other movement disorders 有权
标题翻译：治疗帕金森病和其他运动障碍的系统和方法
公开(公告)号：US07962218B2
公开(公告)日：2011-06-14
申请号：US11867654
申请日：2007-10-04
申请人： Jeffrey Balzer , Allen Wyler
发明人： Jeffrey Balzer , Allen Wyler
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/32 , A61N1/36025 , A61N1/36067 , A61N1/375 , A61N1/3756
摘要： Systems and methods for treating movement disorders using cortical stimulation. In one embodiment, a method for treating movement disorders comprises determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part. The site can be determined by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part. The method can also include applying neural stimulation, such as electrical or magnetic waveforms, directly to the site.
摘要翻译：用皮质刺激治疗运动障碍的系统和方法。在一个实施方案中，用于治疗运动障碍的方法包括确定与受影响的身体部位的运动障碍有关的患者的脑的皮质部位。可以通过获得在患者皮层中发生的神经活动的表示并将神经活动的区域与受影响的身体部分相关联来确定该位点。该方法还可以包括将神经刺激（例如电或波形波形）直接应用于部位。

3. 发明授权

US07945330B2 Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 有权
标题翻译：用于自动优化神经刺激器的刺激参数和电极配置的系统和方法
公开(公告)号：US07945330B2
公开(公告)日：2011-05-17
申请号：US12244610
申请日：2008-10-02
申请人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
发明人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译：用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。感测装置响应于刺激产生响应信号。该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到治疗电极。

4. 发明申请

US20080195175A1 SYSTEM AND METHOD FOR TREATING PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS 有权
标题翻译：用于治疗帕金森病和其他运动障碍的系统和方法
公开(公告)号：US20080195175A1
公开(公告)日：2008-08-14
申请号：US11867654
申请日：2007-10-04
申请人： Jeffrey Balzer , Allen Wyler
发明人： Jeffrey Balzer , Allen Wyler
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/32 , A61N1/36025 , A61N1/36067 , A61N1/375 , A61N1/3756
摘要： Systems and methods for treating movement disorders using cortical stimulation. In one embodiment, a method for treating movement disorders comprises determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part. The site can be determined by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part. The method can also include applying neural stimulation, such as electrical or magnetic waveforms, directly to the site.
摘要翻译：用皮质刺激治疗运动障碍的系统和方法。在一个实施方案中，用于治疗运动障碍的方法包括确定与受影响的身体部位的运动障碍有关的患者的脑的皮质部位。可以通过获得在患者皮层中发生的神经活动的表示并将神经活动的区域与受影响的身体部分相关联来确定该位点。该方法还可以包括将神经刺激（例如电或波形波形）直接应用于部位。

5. 发明申请

US20060195155A1 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 审中-公开
公开(公告)号：US20060195155A1
公开(公告)日：2006-08-31
申请号：US11389770
申请日：2006-03-27
申请人： Andrew Firlik , Jeffrey Balzer , Bradford Gliner , Alan Levy , Carlton Morgan
发明人： Andrew Firlik , Jeffrey Balzer , Bradford Gliner , Alan Levy , Carlton Morgan
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

6. 发明授权

US08121695B2 Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures 有权
标题翻译：用于减少在神经刺激阈值测试程序期间引起侧支神经活动的可能性的系统和方法
公开(公告)号：US08121695B2
公开(公告)日：2012-02-21
申请号：US12619188
申请日：2009-11-16
申请人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D Firlik
发明人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D Firlik
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/0531 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
摘要翻译：用于确定患者的神经刺激阈值的测试程序。在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。

7. 发明授权

US08019425B2 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
标题翻译：用于实现患者神经功能持续变化的方法和装置
公开(公告)号：US08019425B2
公开(公告)日：2011-09-13
申请号：US12343454
申请日：2008-12-23
申请人： Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Bradford Evan Gliner , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Bradford Evan Gliner , Katrina S. Firlik
IPC分类号： A61N1/00
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑部受损的神经功能的方法和装置。在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间向电极传送电刺激信号。在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。

8. 发明申请

US20110208264A1 SYSTEMS AND METHODS FOR AUTOMATICALLY OPTIMIZING STIMULUS PARAMETERS AND ELECTRODE CONFIGURATIONS FOR NEURO-STIMULATORS 有权
标题翻译：神经刺激仪自动优化刺激参数和电极配置的系统和方法
公开(公告)号：US20110208264A1
公开(公告)日：2011-08-25
申请号：US13101306
申请日：2011-05-05
申请人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
发明人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译：用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。在一个实施例中，系统包括电极阵列，其具有被配置为植入患者体内的可植入支撑构件和由支撑构件承载的多个治疗电极。系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。感测装置响应于刺激产生响应信号。该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或要传送到治疗电极。

9. 发明申请

US20100131034A1 SYSTEMS AND METHODS FOR AUTOMATICALLY OPTIMIZING STIMULUS PARAMETERS AND ELECTRODE CONFIGURATIONS FOR NEUROSTIMULATORS 有权
标题翻译：自动优化神经元参数和神经元电极配置的系统和方法
公开(公告)号：US20100131034A1
公开(公告)日：2010-05-27
申请号：US12619188
申请日：2009-11-16
申请人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
发明人： Bradford Evan Gliner , Jeffrey Balzer , Andrew D. Firlik
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61N1/0531 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
摘要翻译：用于确定患者的神经刺激阈值的测试程序。在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。

10. 发明申请

US20100004500A1 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：US20100004500A1
公开(公告)日：2010-01-07
申请号：US12561950
申请日：2009-09-17
申请人： Bradford Evan Gliner , Jeffrey Balzer , Brad Fowler , Leif R. Sloan
发明人： Bradford Evan Gliner , Jeffrey Balzer , Brad Fowler , Leif R. Sloan
IPC分类号： A61N2/04
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

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