专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050285082A1 Cross-linked encapsulated phosphorescent molecules 有权
标题翻译：交联包封的磷光分子
公开(公告)号：US20050285082A1
公开(公告)日：2005-12-29
申请号：US10879933
申请日：2004-06-29
申请人： Lei Huang , Xuedong Song , Bin Wu , Rosann Kaylor
发明人： Lei Huang , Xuedong Song , Bin Wu , Rosann Kaylor
IPC分类号： C08F214/06 , C08K5/00 , C08K9/08 , C08L53/00 , C09K11/02 , C09K11/06 , C09K11/08
CPC分类号： C08K5/0041 , C08F214/06 , C08K9/08 , C08L53/00 , C09K11/02 , C09K11/06 , C09K2211/185 , Y10T428/2998 , C08L2666/02
摘要： There is provided herein cross-linked, phosphorescent micro- and nano-particles and applications of those particles. The invention uses halogen-containing polymers and co-polymers (HCPs) as an encapsulation matrix for organic and organometallic phosphorescent compounds to form micro- or nano-particles. The phosphorescence of these encapsulated phosphorescent particles is substantially unaffected by phosphorescence quenchers such as oxygen and water molecules at ambient conditions. The invention provides methods of making cross-linked phosphorescent particles. HCPs may be directly cross-linked through linking moieties that are a part of the polymer, or cross-linked through other separate bridging or cross-linking materials Cross-linked particles are more stable than the non-cross-linked counterparts and more resistant to temperature, surfactants, and organic solvents.
摘要翻译：本文提供了交联的磷光微粒和纳米颗粒以及这些颗粒的应用。本发明使用含卤聚合物和共聚物（HCP）作为有机和有机金属磷光化合物的包封基质以形成微米或纳米颗粒。这些包封的磷光颗粒的磷光在环境条件下基本上不受磷光猝灭剂如氧和水分子的影响。本发明提供制备交联磷光颗粒的方法。 HCP可以通过作为聚合物的一部分的连接部分直接交联，或者通过其它单独的桥连或交联材料交联。交联颗粒比非交联对应物更稳定，并且更耐抗温度，表面活性剂和有机溶剂。

2. 发明申请

US20060223193A1 Diagnostic test kits employing an internal calibration system 有权
公开(公告)号：US20060223193A1
公开(公告)日：2006-10-05
申请号：US11094498
申请日：2005-03-30
申请人： Xuedong Song , Chibueze Chidebelu-Eze , Rosann Kaylor
发明人： Xuedong Song , Chibueze Chidebelu-Eze , Rosann Kaylor
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , Y10T436/10 , Y10T436/105831
摘要： A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy, calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal.

3. 发明授权

US07943089B2 Laminated assay devices 有权
标题翻译：层压测定装置
公开(公告)号：US07943089B2
公开(公告)日：2011-05-17
申请号：US10741434
申请日：2003-12-19
申请人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
发明人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
IPC分类号： G01N27/00
CPC分类号： G01N33/5438
摘要： An electrochemical-based assay device capable of detecting the presence or quantity of an analyte of interest that is provided. The device contains two or more substrates, one containing a detection working electrode and another containing an auxiliary electrode, such as a counter/reference electrode(s). The substrates are positioned in a face-to-face relationship so that the electrodes are adjacent to each other during performance of the assay. Besides the electrodes, any of a variety of other components may also be employed in the assay device.
摘要翻译：能够检测所提供的感兴趣分析物的存在或数量的基于电化学的测定装置。该装置包含两个或更多个基板，一个包含检测工作电极，另一个基板包含辅助电极，例如计数器/参考电极。基板以面对面的关系定位，使得在测定过程中电极彼此相邻。除了电极之外，还可以在测定装置中使用各种其它组分中的任何一种。

4. 发明申请

US20070048182A1 Nitrite detection technique 有权
标题翻译：亚硝酸盐检测技术
公开(公告)号：US20070048182A1
公开(公告)日：2007-03-01
申请号：US11217099
申请日：2005-08-31
申请人： Xuedong Song , Rosann Kaylor
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： B01L3/00
CPC分类号： G01N33/526 , G01N2800/348 , Y10T436/173076
摘要： A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.
摘要翻译：提供了用于检测测试样品中亚硝酸盐存在或不存在的诊断测试试剂盒。测试试剂盒包括能够与亚硝酸盐反应形成重氮离子的芳族伯胺。测试试剂盒还包括侧流装置，其包括色谱介质和在流过色谱介质之后接收测试样品的吸收材料。色谱介质限定了检测区，其中含有能够与重氮离子反应形成指示剂（例如偶氮化合物）的检测试剂（例如亲核芳族胺）。指示剂显示与检测试剂的颜色不同的颜色。

5. 发明授权

US07285424B2 Membrane-based assay devices 有权
标题翻译：基于膜的测定装置
公开(公告)号：US07285424B2
公开(公告)日：2007-10-23
申请号：US10228836
申请日：2002-08-27
申请人： Xuedong Song , Rosann Kaylor
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： G01N33/53
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

6. 发明申请

US20050136529A1 Laminated assay devices 有权
标题翻译：层压测定装置
公开(公告)号：US20050136529A1
公开(公告)日：2005-06-23
申请号：US10741434
申请日：2003-12-19
申请人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
发明人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
IPC分类号： C12M1/34 , C12Q1/54 , G01N33/543 , G01N33/551
CPC分类号： G01N33/5438
摘要： An electrochemical-based assay device capable of detecting the presence or quantity of an analyte of interest that is provided. The device contains two or more substrates, one containing a detection working electrode and another containing an auxiliary electrode, such as a counter/reference electrode(s). The substrates are positioned in a face-to-face relationship so that the electrodes are adjacent to each other during performance of the assay. Besides the electrodes, any of a variety of other components may also be employed in the assay device.
摘要翻译：能够检测所提供的感兴趣分析物的存在或数量的基于电化学的测定装置。该装置包含两个或更多个基板，一个包含检测工作电极，另一个基板包含辅助电极，例如计数器/参考电极。基板以面对面的关系定位，使得在测定过程中电极彼此相邻。除了电极之外，还可以在测定装置中使用各种其它组分中的任何一种。

7. 发明申请

US20090314946A1 Membrane-Based Assay Devices that Utilize Time-Resolved Fluorescence 审中-公开
标题翻译：使用时间分辨荧光的基于膜的测定装置
公开(公告)号：US20090314946A1
公开(公告)日：2009-12-24
申请号：US12551048
申请日：2009-08-31
申请人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
发明人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
IPC分类号： G01N21/64 , G01T1/20
CPC分类号： G01N21/274 , G01N21/6408 , G01N21/6428 , G01N33/525 , G01N33/533 , G01N33/542 , G01N33/558 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2201/0696
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals generated by excited fluorescent labels. Because the labels can have relatively long emission lifetime, short-lived background interference can be practically eliminated through delayed fluorescence detection. In addition, the resulting fluorescent reader can have a simple and inexpensive design. For instance, in one embodiment, the reader can utilize a silicon photodiode and a pulsed light-emitting diode (LED) to accurately excite labels and detect fluorescence on a membrane-based assay device without requiring the use of expensive components, such as monochromators or narrow emission band width optical filters.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置利用时间分辨荧光检测激发的荧光标记产生的信号。因为标签的发光寿命可以较长，所以通过延迟荧光检测实际上可以消除短暂的背景干扰。此外，所得到的荧光读取器可以具有简单且便宜的设计。例如，在一个实施例中，读取器可以利用硅光电二极管和脉冲发光二极管（LED）来精确地激发标签并在基于膜的测定装置上检测荧光，而不需要使用昂贵的组件，例如单色仪或窄发射带宽滤光片。

8. 发明授权

US07632653B2 Membrane-based assay devices that utilize time-resolved fluorescence 有权
标题翻译：利用时间分辨荧光的基于膜的测定装置
公开(公告)号：US07632653B2
公开(公告)日：2009-12-15
申请号：US10286342
申请日：2002-11-01
申请人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
发明人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
IPC分类号： G01N33/533
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals generated by excited fluorescent labels. Because the labels can have relatively long emission lifetime, short-lived background interference can be practically eliminated through delayed fluorescence detection. In addition, the resulting fluorescent reader can have a simple and inexpensive design. For instance, in one embodiment, the reader can utilize a silicon photodiode and a pulsed light-emitting diode (LED) to accurately excite labels and detect fluorescence on a membrane-based assay device without requiring the use of expensive components, such as monochromators or narrow emission band width optical filters.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置利用时间分辨荧光检测激发的荧光标记产生的信号。因为标签的发光寿命可以较长，所以通过延迟荧光检测实际上可以消除短暂的背景干扰。此外，所得到的荧光读取器可以具有简单且便宜的设计。例如，在一个实施例中，读取器可以利用硅光电二极管和脉冲发光二极管（LED）来精确地激发标签并在基于膜的测定装置上检测荧光，而不需要使用昂贵的组件，例如单色仪或窄发射带宽滤光片。

9. 发明申请

US20080096288A1 MEMBRANE-BASED ASSAY DEVICES 有权
标题翻译：基于膜的测试装置
公开(公告)号：US20080096288A1
公开(公告)日：2008-04-24
申请号：US11876018
申请日：2007-10-22
申请人： Xuedong Song , Rosann Kaylor
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： G01N33/553
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

10. 发明授权

US07432105B2 Self-calibration system for a magnetic binding assay 有权
标题翻译：用于磁性结合测定的自校准系统
公开(公告)号：US07432105B2
公开(公告)日：2008-10-07
申请号：US10228837
申请日：2002-08-27
申请人： Xuedong Song , Rosann Kaylor
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： G01N31/00 , G01N33/553 , G01N33/53
CPC分类号： G01N33/582 , G01N33/54326 , Y10S435/967 , Y10S436/80 , Y10S436/905 , Y10T436/10 , Y10T436/101666 , Y10T436/105831
摘要： A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional to the intensity of the detection signal calibrated by the intensity of the calibration signal.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的存在或数量的自校准的磁性结合测定（例如，夹心，竞争性等）。磁结合测定法包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能产生校准信号的校准探针（例如，荧光磁性颗粒）。测试样品中分析物的量与由校准信号的强度校准的检测信号的强度成比例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式