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1. 发明申请

US20080063602A1 Magnetic Resonance Imaging Contrast Agents Synthesized Using Ring-Opening Metathesis Polymerization 有权
标题翻译：使用开环复分解聚合合成的磁共振成像对比剂
公开(公告)号：US20080063602A1
公开(公告)日：2008-03-13
申请号：US11743740
申请日：2007-05-03
申请人： Laura Kiessling , Ronald Raines , Matthew Allen
发明人： Laura Kiessling , Ronald Raines , Matthew Allen
IPC分类号： A61K49/06 , A61B5/055 , C08G73/00
CPC分类号： A61K49/128
摘要： Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedical research applications. The polymeric chelates are generated using ring-opening metathesis polymerization (ROMP). Polymers can have multiple sites for functionalization allowing for the synthesis of multimodal and targeted contrast agents. Hydroxypyridonate (HOPO)-based chelating moieties are integrated into a ROMP-derived polymer. More specifically, the HOPO-based chelating moiety is integrated into a benzonorbornadiene unit that constitutes the backbone of the polymer. The ROMP-derived polymer chelators can comprise multiple metal ions, particularly Gd(III) ions, in polymers of varying lengths to provide a series of agents with controlled relaxivites. Polymer chelates include those that are water-soluble.
摘要翻译：聚合螯合剂和金属螯合物，特别是镧系元素金属螯合剂，更具体地，可用作Gd（III）的螯合剂，用作治疗和诊断应用以及临床和生物医学研究应用的磁共振成像（MRI）中的造影剂。使用开环易位聚合（ROMP）产生聚合物螯合物。聚合物可以具有多个用于官能化的位点，允许合成多峰和靶向造影剂。将羟基吡啶酮（HOPO）基螯合部分整合到ROMP衍生的聚合物中。更具体地，基于HOPO的螯合部分整合成构成聚合物主链的苯并降二烯单元。 ROMP衍生的聚合物螯合剂可以在不同长度的聚合物中包含多种金属离子，特别是Gd（III）离子，以提供具有受控弛豫物质的一系列试剂。聚合物螯合物包括那些水溶性螯合物。

2. 发明申请

US20060025578A1 Chemical synthesis of reagents for peptide coupling 有权
标题翻译：肽偶联试剂的化学合成
公开(公告)号：US20060025578A1
公开(公告)日：2006-02-02
申请号：US11229926
申请日：2005-09-19
申请人： Ronald Raines , Laura Kiessling , Bradley Nilsson , Yi He , Matthew Soellner , Ronald Hinklin
发明人： Ronald Raines , Laura Kiessling , Bradley Nilsson , Yi He , Matthew Soellner , Ronald Hinklin
IPC分类号： C07F9/02 , C07K14/00
CPC分类号： C07F9/5004 , C07F9/5045 , C07K1/006 , C07K5/06026
摘要： The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
摘要翻译：本发明提供了用于合成膦硫醇试剂以及用于形成酰胺键的新型受保护试剂的改进方法，特别是用于肽连接。本发明提供了可用作形成酰胺键的试剂的膦 - 硼烷络合物，特别是用于在任何两个氨基酸，肽或蛋白质之间形成酰胺键。

3. 发明申请

US20130178617A1 CATALYTIC CONVERSION OF CELLULOSE TO FUELS AND CHEMICALS USING BORONIC ACIDS 有权
标题翻译：使用硼酸的纤维素催化转化为燃料和化学品
公开(公告)号：US20130178617A1
公开(公告)日：2013-07-11
申请号：US13629588
申请日：2012-09-27
申请人： Ronald Raines , Benjamin Caes , Michael Palte
发明人： Ronald Raines , Benjamin Caes , Michael Palte
IPC分类号： C07D307/50 , B01J27/20
CPC分类号： C07D307/50 , B01J21/02 , B01J23/92 , B01J27/08 , B01J27/20 , B01J27/32 , B01J31/146 , B01J37/0209 , B01J2231/641 , C07D307/48 , Y02P20/584
摘要： Methods and catalyst compositions for formation of furans from carbohydrates. A carbohydrate substrate is heating in the presence of a 2-substituted phenylboronic acid (or salt or hydrate thereof) and optionally a magnesium or calcium halide salt. The reaction is carried out in a polar aprotic solvent other than an ionic liquid, an ionic liquid or a mixture thereof. Additional of a selected amount of water to the reaction can enhance the yield of furans.
摘要翻译：用于从碳水化合物形成呋喃的方法和催化剂组合物。在2-取代的苯基硼酸（或其盐或水合物）和任选的卤化镁或卤化钙盐的存在下加热碳水化合物底物。该反应在除离子液体，离子液体或其混合物之外的极性非质子溶剂中进行。反应中额外的选择量的水可以提高呋喃的产率。

4. 发明申请

US20060292137A1 Cytotoxic ribonuclease variants 有权
标题翻译：细胞毒性核糖核酸酶变体
公开(公告)号：US20060292137A1
公开(公告)日：2006-12-28
申请号：US11454418
申请日：2006-06-16
申请人： Ronald Raines , George Phillips , R. Johnson , Jason McCoy
发明人： Ronald Raines , George Phillips , R. Johnson , Jason McCoy
IPC分类号： A61K38/46 , C12N9/22
CPC分类号： C12N9/22 , A61K38/00
摘要： This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase 1 hRI complex. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译：本发明涉及通过分析核糖核酸酶1和核糖核酸酶抑制剂（hRI）之间的相互作用鉴定的人核糖核酸酶1（RNase 1）的细胞毒性变体，如RNase 1 hRI复合物的三维（3-D）原子结构所定义。还公开了hRI.RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。

5. 发明申请

US20050214839A1 Nuclease inhibitors and methods for their use 有权
标题翻译：核酸酶抑制剂及其使用方法
公开(公告)号：US20050214839A1
公开(公告)日：2005-09-29
申请号：US11084068
申请日：2005-03-18
申请人： Ronald Raines , Bryan Smith , Matthew Soellner , David Lynn
发明人： Ronald Raines , Bryan Smith , Matthew Soellner , David Lynn
IPC分类号： C12N9/22 , C12N9/99 , C12Q1/68
CPC分类号： G01N1/34 , C12N9/22 , C12N9/99
摘要： A class of anionic oligomers and polymers that function for inhibition of nucleases, particularly RNase. Specific inhibitors include mixtures of oligomers of vinyl sulfate. Methods for inhibition or inactivation of one or more nucleases in vitro which comprises the step of contacting the one or more nucleases in a biological medium with one or more of the anionic oligomeric or polymeric inhibitors of this invention. Kits for carrying out a biological procedure, biological reaction and/or a biological assay containing one or more inhibitors of this invention. The use of oligomers and/or polymers of this invention as additives in buffers or reagents. The inhibitors of the invention can also be attached to surfaces to provide for removal of nucleases from media, solutions or other liquids in contact with the solid.
摘要翻译：一类用于抑制核酸酶，特别是核糖核酸酶的阴离子低聚物和聚合物。特异性抑制剂包括乙烯基硫酸酯的低聚物的混合物。用于在体外抑制或失活一种或多种核酸酶的方法，其包括使生物培养基中的一种或多种核酸酶与本发明的一种或多种阴离子低聚物或聚合物抑制剂接触的步骤。用于进行生物学过程，生物反应和/或含有本发明的一种或多种抑制剂的生物测定的试剂盒。使用本发明的低聚物和/或聚合物作为缓冲液或试剂中的添加剂。本发明的抑制剂也可附着于表面以提供从与固体接触的介质，溶液或其它液体中除去核酸酶。

6. 发明申请

US20070275897A1 Collagen mimics 有权
标题翻译：胶原蛋白模拟物
公开(公告)号：US20070275897A1
公开(公告)日：2007-11-29
申请号：US11807270
申请日：2007-05-25
申请人： Ronald Raines , Matthew Shoulders , Jonathan Hodges
发明人： Ronald Raines , Matthew Shoulders , Jonathan Hodges
IPC分类号： A61K38/39 , C07K7/06 , C07K7/08
CPC分类号： C07K14/78 , C07K5/0821 , C07K14/001
摘要： Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly)n, where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.
摘要翻译：公开了具有式（Xaa-Yaa-Gly）N 3的三肽单元的新型胶原模拟物，其中位置Xaa或Yaa之一是体积大的非吸电子脯氨酸衍生物。通过在天然胶原螺旋中的Xaa或Yaa位置取代脯氨酸衍生物，螺旋的稳定性仅由于相对于现有已知的胶原相关三螺旋的空间效应而增加。还公开了制备新型胶原模拟物的方法。

7. 发明申请

US20050059711A1 Potentiators of insulin secretion 有权
标题翻译：胰岛素分泌增强剂
公开(公告)号：US20050059711A1
公开(公告)日：2005-03-17
申请号：US10922442
申请日：2004-08-20
申请人： Alan Attie , Mary Rabaglia , Ronald Raines , Mark Gray-Keller
发明人： Alan Attie , Mary Rabaglia , Ronald Raines , Mark Gray-Keller
IPC分类号： A61K31/00 , A61K31/194 , A61K31/225 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/415 , A61K31/44 , A61K31/4422 , A61K31/455 , A61P3/10 , G01N33/50
CPC分类号： G01N33/507 , A61K31/00 , A61K31/194 , A61K31/225 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/415 , A61K31/44 , A61K31/4422 , A61K31/455 , G01N33/5008 , G01N33/5038 , G01N2333/62 , Y10S514/866
摘要： The present invention relates to a recognition that an analog of αKG can increase glucose-induced insulin secretion in vitro and in vivo in animals, particularly in mammals, and more particularly in humans and in rodents. By employing the methods of the invention, insulin secretion can be increased.
摘要翻译：本发明涉及αKG类似物可以在动物，特别是哺乳动物，特别是人和啮齿动物体内和体内增加葡萄糖诱导的胰岛素分泌的认识。通过采用本发明的方法，可以增加胰岛素分泌。

8. 发明申请

US20050048192A1 Methods for ligation of molecules to surfaces 有权
标题翻译：将分子连接到表面的方法
公开(公告)号：US20050048192A1
公开(公告)日：2005-03-03
申请号：US10930702
申请日：2004-08-30
申请人： Ronald Raines , Matthew Soellner
发明人： Ronald Raines , Matthew Soellner
IPC分类号： C07F9/48 , C07F9/50 , C07K1/08 , C07K1/107 , A61L2/00
CPC分类号： C07K1/1077 , C07F9/4866 , C07F9/5004 , C07F9/5022 , C07F9/5054 , C07K1/082 , C07K1/1072 , Y10S530/81
摘要： The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to form an amide bond. The method of the invention is particularly well-suited to the immobilization of peptides, proteins or protein fragments to surfaces.
摘要翻译：本发明是一种或多种分子与一个或多个表面共价连接的方法，其是位点特异性的并且快速和高产率。与表面的共价连接基于叠氮化物和膦硫代酯的反应以形成酰胺键。本发明的方法特别适用于将肽，蛋白质或蛋白质片段固定在表面上。

9. 发明授权

US09162999B2 Catalytic conversion of cellulose to fuels and chemicals using boronic acids 有权
标题翻译：使用硼酸将纤维素催化转化为燃料和化学品
公开(公告)号：US09162999B2
公开(公告)日：2015-10-20
申请号：US13629588
申请日：2012-09-27
申请人： Ronald Raines , Benjamin Caes , Michael Palte
发明人： Ronald Raines , Benjamin Caes , Michael Palte
IPC分类号： C07D307/50 , B01J27/20 , B01J21/02 , B01J23/92 , B01J27/32 , C07D307/48 , B01J31/14 , B01J27/08 , B01J37/02
CPC分类号： C07D307/50 , B01J21/02 , B01J23/92 , B01J27/08 , B01J27/20 , B01J27/32 , B01J31/146 , B01J37/0209 , B01J2231/641 , C07D307/48 , Y02P20/584
摘要： Methods and catalyst compositions for formation of furans from carbohydrates. A carbohydrate substrate is heating in the presence of a 2-substituted phenylboronic acid (or salt or hydrate thereof) and optionally a magnesium or calcium halide salt. The reaction is carried out in a polar aprotic solvent other than an ionic liquid, an ionic liquid or a mixture thereof. Additional of a selected amount of water to the reaction can enhance the yield of furans.
摘要翻译：用于从碳水化合物形成呋喃的方法和催化剂组合物。在2-取代的苯基硼酸（或其盐或水合物）和任选的卤化镁或卤化钙盐的存在下加热碳水化合物底物。该反应在除离子液体，离子液体或其混合物之外的极性非质子溶剂中进行。反应中额外的选择量的水可以提高呋喃的产率。

10. 发明申请

US20050004032A1 Collagen mimics 有权
标题翻译：胶原蛋白模拟物
公开(公告)号：US20050004032A1
公开(公告)日：2005-01-06
申请号：US10874725
申请日：2004-06-23
申请人： Ronald Raines , Jonathan Hodges
发明人： Ronald Raines , Jonathan Hodges
IPC分类号： A61K38/00 , C07K20060101 , C07K5/08 , C07K14/00 , C07K14/78 , A61K38/39
CPC分类号： C07K5/0827 , A61K38/00 , C07K14/001 , C07K14/78
摘要： A novel collagen mimic comprising a tripeptide unit having the formula (flpYaaGly)n, where flp is 4(S)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the collagen-related triple helices (ProYaaGly)n, (hypYaaGly)n, and (HypYaaGly)n.
摘要翻译：公开了包含具有式（flpYaaGly）n的三肽单元的新型胶原模拟物，其中flp是4（S） - 氟-L-脯氨酸。胶原蛋白模拟物相对于胶原相关的三重螺旋（ProYaaGly）n，（hypYaaGly）n和（HypYaaGly）n具有增加的稳定性。

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