专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09035088B2 Method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof by means of acrylnitriles and use thereof 有权
标题翻译：通过丙烯腈生产单氨基官能化二烷基次膦酸及其酯和盐的方法及其用途
公开(公告)号：US09035088B2
公开(公告)日：2015-05-19
申请号：US13127072
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C07F9/22 , C07F9/32 , C07F9/30 , C07F9/48 , C08K5/5313 , C09K21/12
CPC分类号： C07F9/3211 , C07F9/301 , C07F9/3264 , C07F9/4816 , C07F9/4866 , C08K5/5313 , C09K21/12
摘要： The invention relates to a method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof by means of acrylnitriles, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with an acrylnitrile of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted to yield a mono-aminofunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst C or a reduction agent, wherein R1, R2, R3, R4, R5, R6, R7 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl and X stands for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and Y stands for a mineral acid, a carboxylic acid, a Lewis acid or an organic acid, n=an integer or fractional number of 0 to 4 and the catalysts A and C are formed by transition metals, transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and catalyst B is formed by compounds forming peroxides, peroxo compounds, azo compounds, alkali metals, alkaline earth metals, alkali hydrides, alkaline earth hydrides and/or alkali alcoholates and alkaline earth alcoholates.
摘要翻译：本发明涉及一种通过丙烯腈生产单氨基官能化二烷基次膦酸及其酯及其盐的方法，其特征在于a）将次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基膦酸盐或盐酯（II），b）将由此得到的烷基膦酸，其盐或酯（II）与式（V）的丙烯腈反应，得到单官能化二烷基次膦酸衍生物（Ⅵ）在催化剂B存在下，和c）将由此得到的单官能化二烷基次膦酸衍生物（Ⅵ）反应，得到单氨基官能化二烷基次膦酸衍生物（Ⅲ），其中催化剂C或还原剂存在下，其中对于H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基，R 1，R 2，R 3，R 4，R 5，R 6，R 7相同或不同，彼此独立烷基芳基，X代表H，C1-C18烷基，C6-C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K 和/或质子化的氮碱，Y表示无机酸，羧酸，路易斯酸或有机酸，n = 0至4的整数或分数，催化剂A和C由过渡金属形成由过渡金属和/或过渡金属化合物和至少一种配体组成的过渡金属化合物和/或催化剂体系和催化剂B通过形成过氧化物，过氧化合物，偶氮化合物，碱金属，碱土金属，碱金属氢化物，碱土金属氢化物和/或碱金属醇盐和碱土金属盐。

2. 发明申请

US20110237720A1 Method for Producing Dialkylphosphinic Acids and Esters and Salts Thereof by Means of Vinyl Compounds and Use Thereof 审中-公开
标题翻译：通过乙烯基化合物生产二烷基次膦酸及其酯及其盐的方法及用途
公开(公告)号：US20110237720A1
公开(公告)日：2011-09-29
申请号：US13125361
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313 , C07F9/32 , C07F9/30 , C07F5/06 , C07F7/28
CPC分类号： C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3217 , C07F9/3241 , C07F9/3264 , C07F9/4816 , C07F9/4866 , C08K5/5313 , C08L21/00 , C09K21/12
摘要： The invention relates to a method for producing mono-carboxyfunctionalized dialkylphosphinic acids and esters and salts thereof by means of vinyl compounds, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with acetylenic compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted with carbon monoxide to yield a mono-carboxyfunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst C, wherein R1, R2, R3, R4, R5, R6 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, and X and Y are the same or different and stand independently of each other for H, C1-C18 alkyl, C6-C18 aryl, C8-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and the catalysts A, B, C and D are formed by transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand.
摘要翻译：本发明涉及通过乙烯基化合物制备单羧基官能化的二烷基次膦酸及其酯和盐的方法，其特征在于a）将次膦酸源（I）与烯烃（IV）反应，得到烷基膦酸盐或其酯（II），b）将如此得到的烷基膦酸，其盐或酯（II）与式（V）的炔属化合物反应，得到单官能化二烷基次膦酸衍生物（VI ），c）将如此得到的单官能化二烷基次膦酸衍生物（Ⅵ）与一氧化碳反应，得到单羧基官能化二烷基次膦酸衍生物（Ⅲ），其中催化剂C存在下，其中对于H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，C 6 -C 18烷基，C 6 -C 18芳基， X和Y相同或相同对于H，C 1 -C 18烷基，C 6 -C 18芳基，C 8 -C 18芳烷基，C 6 -C 18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn， Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K和/或质子化的氮碱，催化剂A，B，C和D由过渡金属和/或过渡金属化合物和/或催化剂由过渡金属和/或过渡金属化合物和至少一种配体组成的体系。

3. 发明申请

US20050048192A1 Methods for ligation of molecules to surfaces 有权
标题翻译：将分子连接到表面的方法
公开(公告)号：US20050048192A1
公开(公告)日：2005-03-03
申请号：US10930702
申请日：2004-08-30
申请人： Ronald Raines , Matthew Soellner
发明人： Ronald Raines , Matthew Soellner
IPC分类号： C07F9/48 , C07F9/50 , C07K1/08 , C07K1/107 , A61L2/00
CPC分类号： C07K1/1077 , C07F9/4866 , C07F9/5004 , C07F9/5022 , C07F9/5054 , C07K1/082 , C07K1/1072 , Y10S530/81
摘要： The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to form an amide bond. The method of the invention is particularly well-suited to the immobilization of peptides, proteins or protein fragments to surfaces.
摘要翻译：本发明是一种或多种分子与一个或多个表面共价连接的方法，其是位点特异性的并且快速和高产率。与表面的共价连接基于叠氮化物和膦硫代酯的反应以形成酰胺键。本发明的方法特别适用于将肽，蛋白质或蛋白质片段固定在表面上。

4. 发明授权

US2864845A Carbon functional organo-silicon phosphonates 失效
标题翻译：碳功能有机硅膦酸盐
公开(公告)号：US2864845A
公开(公告)日：1958-12-16
申请号：US67430657
申请日：1957-07-26
申请人： CITIES SERVICE RES & DEV CO
发明人： KERSCHNER PAUL M , GREENWALD BERTRAND W
IPC分类号： C07F9/48
CPC分类号： C07F9/4866

5. 发明授权

US08877957B2 Sythesis of P-chiral compounds 有权
标题翻译： P手性化合物的合成
公开(公告)号：US08877957B2
公开(公告)日：2014-11-04
申请号：US13912393
申请日：2013-06-07
申请人： Jean-Luc Montchamp , Olivier Berger
发明人： Jean-Luc Montchamp , Olivier Berger
IPC分类号： C07F9/48 , C07F9/572 , C07F9/32
CPC分类号： C07F9/4875 , C07F9/3276 , C07F9/4866 , C07F9/5728
摘要： Shown is the preparation and subsequent elaboration of P-chiral compounds that can be used as a building block for many P-chiral ligands used, for example, in asymmetric catalytic reactions. Specifically, a synthesis is shown for RP(O)(OR*)CH2OH, with R=H, Ph, aryl, alkyl, and R*=menthol (and other chiral alcohol-derived moieties), especially HP(O)(OMen)CH2OH (Men=L-menthol). This versatile building block is easily synthesized via reaction of inexpensive starting materials, H3PO2, menthol as the chiral auxiliary, and paraformaldehyde.
摘要翻译：显示了可用作许多P型手性配体的结构单元，例如在不对称催化反应中使用的P-手性化合物的制备和随后的制备。具体地说，对于RP（O）（OR *）CH 2 OH，其中R = H，Ph，芳基，烷基和R * =薄荷醇（和其它手性醇衍生部分），特别是HP（O）（OMen ）CH2OH（Men = L-薄荷醇）。这种多功能的结构单元通过廉价起始材料H3PO2，作为手性助剂的薄荷醇和多聚甲醛的反应容易地合成。

6. 发明申请

US20130331594A1 Sythesis of P-Chiral Compounds 有权
标题翻译： P手性化合物的合成
公开(公告)号：US20130331594A1
公开(公告)日：2013-12-12
申请号：US13912393
申请日：2013-06-07
申请人： Jean-Luc Montchamp , Olivier Berger
发明人： Jean-Luc Montchamp , Olivier Berger
IPC分类号： C07F9/48
CPC分类号： C07F9/4875 , C07F9/3276 , C07F9/4866 , C07F9/5728
摘要： Shown is the preparation and subsequent elaboration of P-chiral compounds that can be used as a building block for many P-chiral ligands used, for example, in asymmetric catalytic reactions. Specifically, a synthesis is shown for RP(O)(OR*)CH2OH, with R=H, Ph, aryl, alkyl, and R*=menthol (and other chiral alcohol-derived moieties), especially HP(O)(OMen)CH2OH (Men=L-menthol). This versatile building block is easily synthesized via reaction of inexpensive starting materials, H3PO2, menthol as the chiral auxiliary, and paraformaldehyde.
摘要翻译：显示了可用作许多P型手性配体的结构单元，例如在不对称催化反应中使用的P-手性化合物的制备和随后的制备。具体地说，对于RP（O）（OR *）CH 2 OH，其中R = H，Ph，芳基，烷基和R * =薄荷醇（和其它手性醇衍生部分），特别是HP（O）（OMen ）CH2OH（Men = L-薄荷醇）。这种多功能的结构单元通过廉价起始材料H3PO2，作为手性助剂的薄荷醇和多聚甲醛的反应容易地合成。

7. 发明申请

US20110245386A1 Method for the Production of Mixed-Substituted Dialkylphosphinic Acids, Esters, and Salts, and Use Thereof 审中-公开
标题翻译：混合取代的二烷基次膦酸，酯和盐的制备方法及其用途
公开(公告)号：US20110245386A1
公开(公告)日：2011-10-06
申请号：US13140236
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313 , C07F9/30 , C07F9/32 , C08L67/02 , C08L77/06
CPC分类号： C09K21/12 , C07F9/301 , C07F9/306 , C07F9/3211 , C07F9/4816 , C07F9/4866 , C08K5/5313
摘要： The invention relates to a method for producing mixed-substituted dialkyiphosphinic acids, esters, and salts, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to obtain an alkylphosphonous acid, the salt or ester (II) thereof, b) the obtained alkylphosphonous acid, the salt or ester (II) thereof is reacted with an olefin (IV) in the presence of a catalyst B to obtain the mixed-substituted dialkylphosphinic acid derivative (III), wherein R1, R2, R3, R4, R11, R12, R13, R14 are identical or different from each other and independently represent, inter alia, H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, X represents H, C1-C18-alkyl, C8-C18-aryl, C6-C18-aralkyl, C8-C18-alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogenous base, catalyst A represents transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and catalyst B represents compounds forming peroxides, and/or peroxo compounds, and/or azo compounds.
摘要翻译：本发明涉及一种制备混合取代二亚磷酸，酯和盐的方法，其特征在于a）在催化剂A存在下，使次膦酸源（I）与烯烃（Ⅳ）反应得到烷基亚磷酸，其盐或酯（II），b）在催化剂B存在下，将得到的烷基亚膦酸，其盐或酯（II）与烯烃（IV）反应，得到混合取代的二烷基次膦酸衍生物 III），其中R 1，R 2，R 3，R 4，R 11，R 12，R 13，R 14彼此相同或不同，并且独立地表示H，C 1 -C 18烷基，C 6 -C 18 - 芳基，C 6 -C 18 - 烷基，C 6 -C 18烷基芳基，X代表H，C 1 -C 18烷基，C 8 -C 18 - 芳基，C 6 -C 18 - 芳烷基，C 8 -C 18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti ，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K和/或质子化的含氮碱，催化剂A表示过渡金属和/或过渡金属化合物和/ 一个过境 n金属和/或过渡金属化合物和至少一种配体，催化剂B表示形成过氧化物的化合物，和/或过氧化合物和/或偶氮化合物。

8. 发明申请

US20110237721A1 Method for Producing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ester of a Carboxylic Acid and the Use Thereof 有权
公开(公告)号：US20110237721A1
公开(公告)日：2011-09-29
申请号：US13132153
申请日：2009-10-06
申请人： Michael Hill , Mathias Dietz , Werner Krause , Martin Sicken
发明人： Michael Hill , Mathias Dietz , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313 , C07F9/30 , C07F9/32
CPC分类号： C09K21/12 , C07F9/301 , C07F9/4816 , C07F9/4866 , C08K5/5313
摘要： The invention relates to a method for producing mono-carboxy-functionalized dialkyiphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphinic acid, the salt or the ester (II) thereof, b) reacting the alkylphosphinic acid so obtained, the salt or the ester (II) thereof with a vinyl ester of a carboxylic acid of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting the mono-functionalized dialkyiphosphinic acid derivative (VI) so obtained in the presence of a catalyst C to give a mono-functionalized dialkylphosphinic acid derivative (VII) and d) reacting the mono-functionalized dialkyiphosphinic acid derivative (VII); with an oxidant or in the presence of a catalyst D to give a mono-carboxy-functionalized dialkylphosphinic acid derivative (III), wherein R1, R2, R3, R4, R5, R6 are the same or different and independently of each other inter alia represent H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl and X and Y are the same or different and independently of each other represent H, C1-C18 alkyl, C8-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and the catalysts A and D are transition metals and/or transition metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand, and the catalyst B is a peroxide-forming compound and/or a peroxo compound and/or an azo compound, and the catalyst C is an acid or a base.

9. 发明申请

US20110213060A1 Method for Producing Dialkylphosphinic Acids and Esters and Salts Thereof by Means of Acrylnitriles and Use Thereof 有权
标题翻译：通过丙烯腈生产二烷基次膦酸及其酯及其盐的方法及用途
公开(公告)号：US20110213060A1
公开(公告)日：2011-09-01
申请号：US13127069
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313 , C07F9/32 , C07F9/30
CPC分类号： C08K5/5313 , C07F9/301 , C07F9/3211 , C07F9/4816 , C07F9/4866 , C09K21/12
摘要： The invention relates to a method for producing mono-carboxyfunctionalized dialkylphosphinic acids and esters and salts thereof, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (H) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with compounds of formula (V) to yield mono-functionalized dialkylphosphinic acid derivatives (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivatives (VI) are reacted to yield a mono-carboxyfunctionalized diakylphosphinic acid derivative (III) in the presence of a catalyst C, wherein R1, R2, R3, R4, R5, R6, R7 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl and X and Y are the same or different and stand independently of each for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and the catalyst A is formed by transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and catalyst B is formed by compounds forming peroxides and/or peroxo compounds and/or azo compounds and/or alkali metals and/or alkaline earth metals, alkali hydrides, alkaline earth hydrides and/or alkali alcoholates and alkaline earth alcoholates, and catalyst C is an acid or a base.
摘要翻译：本发明涉及一种用于制备单羧基官能化二烷基次膦酸及其酯和盐的方法，其特征在于：a）将次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基膦酸，盐或酯（H）在催化剂A存在下，将由此得到的烷基膦酸，其盐或酯（II）与式（Ⅴ）化合物反应得到单官能化二烷基次膦酸衍生物（Ⅵ），在催化剂存在下 B和c）由此得到的单官能化二烷基次膦酸衍生物（Ⅵ）在催化剂C存在下反应得到单羧基官能化二烷基次膦酸衍生物（Ⅲ），其中R1，R2，R3，R4，R5，对于H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，X和Y相同或不同，R 6，R 7相同或不同，彼此独立地相互独立地表示并独立于H，C1-C18烷基 1，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li ，Na，K和/或质子化的氮碱，并且催化剂A由过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系形成，催化剂B由形成过氧化物和/或过氧化合物和/或偶氮化合物和/或碱金属和/或碱土金属，碱金属氢化物，碱土金属氢化物和/或碱金属醇盐和碱土金属醇盐的化合物和催化剂C形成是酸或碱。

10. 发明申请

US20110213059A1 Method for Producing Mono-Carboxyfunctionalized Dialkylphosphinic Acids and Esters and Salts Thereof by means of Vinylenes-Nitriles and Use Thereof 审中-公开
标题翻译：通过乙烯基腈制备单羧基官能化二烷基次膦酸及其酯及其盐的方法及用途
公开(公告)号：US20110213059A1
公开(公告)日：2011-09-01
申请号：US13125363
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313 , C07F9/30 , C07F9/32
CPC分类号： C07F9/3217 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3264 , C07F9/4816 , C07F9/4866 , C08K5/5313 , C09K21/12
摘要： The invention relates to a method for producing mono-carboxyfunctional zed dialkylphosphinic acids and esters and salts thereof by means of vinylenes/nitriles, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with acetylenic compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted with a hydrogen cyanide source to yield a mono-functionalized dialkylphosphinic acid derivative (VII) in the presence of a catalyst C, and d) the thus obtained monofunctionalized dialkylphosphinic acid derivative (VII); is reacted to yield a monocarboxyfunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst D, wherein R1, R2, R3, R4, R5, R6 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, and X and Y are the same or different and stand independently of each other for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and the catalysts A, B and C are formed by transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and the catalyst D is an acid or a base.
摘要翻译：本发明涉及通过乙烯/腈制备单羧基官能化的二烷基次膦酸及其酯和盐的方法，其特征在于a）将次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基膦酸，其盐或酯（II），b）将如此得到的烷基膦酸，其盐或酯（II）与式（V）的炔属化合物反应，得到单官能化二烷基次膦酸衍生物（Ⅵ）在催化剂B存在下反应，和c）将由此得到的单官能化二烷基次膦酸衍生物（Ⅵ）与氰化氢源反应，得到单官能化二烷基次膦酸衍生物（Ⅶ）催化剂C，和d）由此获得的单官能二烷基次膦酸衍生物（VII）; 在催化剂D的存在下反应得到单羧基官能化的二烷基次膦酸衍生物（III），其中R1，R2，R3，R4，R5，R6相同或不同，彼此独立地表示H ，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，X和Y相同或不同，H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K和/ 质子化的氮碱，并且催化剂A，B和C由过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系形成，催化剂D 是酸或碱。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式