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    • 3. 发明授权
    • Methods and compositions of matter concerning APRIL/G70, BCMA, BLYS/AGP-3 and TACI
    • 关于APRIL / G70,BCMA,BLYS / AGP-3和TACI的物质的方法和组成
    • US06774106B2
    • 2004-08-10
    • US09854864
    • 2001-05-14
    • Lars Eyde TheillGang Yu
    • Lars Eyde TheillGang Yu
    • A61K3816
    • C07K14/70575A61K38/00C07K2319/00
    • This invention concerns interactions among APRIL/G70, AGP-3/BLYS, BCMA, and TACI and related methods of use and compositions of matter. It has been found that (1) sAPRIL/G70 binds to the cell-surface receptors BCMA and TACI on T and B lymphoma cells, resulting in stimulation of proliferation of primary human and mouse B and T cells both in vitro and in vivo; (2) APRIL competes with AGP3's binding to TACI and BCMA; (3) sBCMA inhibits APRIL and AGP3 binding to its receptors; (4) sBCMA ameliorates T cell dependent and T cell independent humoral immune responses in vivo; (5) sTACI inhibits APRIL and AGP3 binding to its receptors and ameliorates T cell dependent and T cell independent humoral immune responses in vivo; and (6) BCMA exhibits similarity with TACI within a single cysteine rich domain located N-terminal to a potential transmembrane domain. These discoveries provides a strategy for development of therapeutics for treatment of autoimmune diseases, and cancer, for prevention of transplant rejection. Disease states and disease parameters associated with APRIL and AGP-3 may be affected by modulation of BCMA or TACI; disease states and parameters associated with TACI can be affected by modulation of APRIL; disease states and parameters can be affected by modulation of any of TACI, BCMA, APRIL and AGP-3 by a single therapeutic agent or two or more therapeutic agents together.
    • 本发明涉及APRIL / G70,AGP-3 / BLYS,BCMA和TACI之间的相互作用以及相关使用方法和物质组成。 已经发现(1)sAPRIL / G70结合T细胞和B淋巴瘤细胞上的细胞表面受体BCMA和TACI,导致在体外和体内刺激原代人和小鼠B和T细胞的增殖; (2)APRIL与AGP3与TACI和BCMA的绑定相竞争; (3)sBCMA抑制APRIL和AGP3与其受体的结合; (4)sBCMA体内改善T细胞依赖性和T细胞独立体液免疫应答; (5)sTACI抑制APRIL和AGP3与其受体的结合,并改善体内T细胞依赖性和T细胞独立的体液免疫应答; 和(6)BCMA在位于潜在跨膜结构域N末端的单个富含半胱氨酸的结构域中显示与TACI的相似性。 这些发现提供了治疗自身免疫性疾病和癌症治疗用于预防移植排斥反应的策略。 与APRIL和AGP-3相关的疾病状态和疾病参数可能受到BCMA或TACI调节的影响; 与TACI相关的疾病状态和参数可能受APRIL调节的影响; 疾病状态和参数可以通过单个治疗剂或两种或更多种治疗剂一起调节TACI,BCMA,APRIL和AGP-3中的任何一种来影响。
    • 9. 发明授权
    • Packing device of backlight module
    • 背光模组包装装置
    • US09102458B2
    • 2015-08-11
    • US13578108
    • 2012-07-09
    • Yicheng KuoShihhsiang ChenGang YuGege ZhouJiaqiang Wang
    • Yicheng KuoShihhsiang ChenGang YuGege ZhouJiaqiang Wang
    • B65D81/02B65D85/30B65D81/05B65D85/48
    • B65D81/05B65D85/48
    • The present disclosure belongs to the field of liquid crystal displays (LCDs), and more particularly relates to a packing device of a backlight module including a fixing frame, a rotating shaft, and a clamping piece which can rotate around the rotating shaft. The rotating shaft is fixed to the fixing frame. The clamping piece includes an upper arm and a lower arm, and the upper arm and the lower arm are respectively used for clamping upper and lower surfaces of the backlight module. When an opening formed by surrounding the upper arm and the lower arm is upward, one edge of the backlight module can be put above the lower arm. Then, the backlight module is slowly put down, and the lower arm of the clamping piece rotates around the fixing shaft under stress. When the opening formed by surrounding the upper arm and the lower arm of the clamping piece is in a horizontal direction, the lower arm comes into contact with the lower surface of the backlight module to form a supporting state, and the upper arm of the clamping piece is pressed against the upper surface of the backlight module. Thus, the backlight module is completely fixed. The packing device of the backlight module of the present disclosure can be up and down stacked, and the stress of each layer of backlight module is uniform. Thus, a problem of affecting optical quality of the backlight module due to gravity accumulation is solved.
    • 本公开属于液晶显示器(LCD)领域,更具体地说,涉及一种背光模块的包装装置,该背光模块包括可围绕旋转轴旋转的固定框架,旋转轴和夹紧件。 旋转轴固定在固定架上。 夹持件包括上臂和下臂,并且上臂和下臂分别用于夹紧背光模块的上表面和下表面。 当通过围绕上臂和下臂形成的开口向上时,背光模块的一个边缘可以放置在下臂上方。 然后,将背光模块慢慢放下,夹紧片的下臂在紧固下围绕固定轴旋转。 当通过围绕夹持件的上臂和下臂形成的开口处于水平方向时,下臂与背光模块的下表面接触以形成支撑状态,并且夹紧的上臂 片被压在背光模块的上表面上。 因此,背光模块完全固定。 本公开的背光模块的包装装置可以上下堆叠,并且每层背光模块的应力是均匀的。 因此,解决了由于重力累积而影响背光模块的光学质量的问题。
    • 10. 发明授权
    • LCD module and LCD device
    • LCD模块和LCD设备
    • US08926144B2
    • 2015-01-06
    • US13578212
    • 2012-07-09
    • Gang Yu
    • Gang Yu
    • F21V7/00G02F1/1335
    • F21V7/00G02F1/133605
    • The present disclosure provides a liquid crystal display (LCD) module and an LCD device. The LCD module includes a backplane, and a reflector sheet arranged on the backplane. The backplane is configured with a plurality of reinforced structures, a plurality of concave parts are formed between the reinforced structures, and the reflector sheet is arranged over the reinforced structures. The concave part(s) is configured with a support member used for supporting the reflector sheet. In the present disclosure, because the concave part of the backplane is configured with a support member used for supporting the reflector sheet, the reflector sheet is prevented from deforming and being depressed on the concave part of the backplane because of no support, and the reflector sheet is prevented from abnormally reflecting light because of deformation, thereby increasing the display effect of the LCD device.
    • 本公开提供了一种液晶显示器(LCD)模块和LCD装置。 LCD模块包括背板和布置在背板上的反射板。 背板配置有多个增强结构,在加强结构之间形成多个凹部,反射片设置在加强结构上。 凹部被构造有用于支撑反射片的支撑构件。 在本公开中,由于背板的凹部由支撑反射板的支撑构件构成,所以不会由于不支撑而防止反射板变形并且在背板的凹部凹陷,反射板 由于变形,防止片材异常反射光,从而增加LCD装置的显示效果。