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1. 发明授权

US07293175B2 Automatic information sanitizer 有权
标题翻译：自动信息消毒剂
公开(公告)号：US07293175B2
公开(公告)日：2007-11-06
申请号：US09895801
申请日：2001-06-29
申请人： Larry Brown , Thomas Marso , Russell Savage
发明人： Larry Brown , Thomas Marso , Russell Savage
IPC分类号： H04L9/00
CPC分类号： H04L63/105 , G06F21/62 , G06F2221/2113
摘要： An automatic data sanitizer module sanitizes formatted data from an external source system according to stored sanitization rules for release to an external destination system so that the destination system receives only that data for which it is authorized. The module generally includes an Input Comms module, a Message Processor, an Output Guard a Downgrader and an Output Comms module. The Input Comms module supports the communications protocol dictated by the external source system. The Processor sanitizes the message according to the rules written for the specific external system under consideration. The Guard verifies the modifications performed by the Processor. The Downgrader moves the resulting file to the Output Comms working directory and the Output Comms makes the resulting message available to the destination system. The system supports a variety of different formats and greatly facilitates the timely dissemination of information within a multi-level secure environment while protecting security interests.
摘要翻译：自动数据消毒器模块根据存储的消毒规则对来自外部源系统的格式化数据进行消毒，以释放到外部目的地系统，使得目的地系统仅接收其授权的数据。该模块通常包括输入通信模块，消息处理器，输出保护降级器和输出通信模块。 Input Comms模块支持由外部源系统指定的通信协议。处理器根据为考虑的特定外部系统编写的规则对消息进行消毒。 Guard将验证处理器执行的修改。降级程序将生成的文件移动到Output Comms工作目录，并且Output Comms将生成的消息用于目标系统。该系统支持多种不同格式，极大地方便了多层次安全环境中及时传播信息，同时保护安全利益。

2. 发明申请

US20060024379A1 Protein microspheres having injectable properties at high concentrations 失效
标题翻译：具有高浓度注射性能的蛋白微球
公开(公告)号：US20060024379A1
公开(公告)日：2006-02-02
申请号：US11127704
申请日：2005-05-12
申请人： Larry Brown , Vered Bisker-Leib , Debra LaFreniere , John McGeehan , Julia Rashba-Step , Terrence Scott
发明人： Larry Brown , Vered Bisker-Leib , Debra LaFreniere , John McGeehan , Julia Rashba-Step , Terrence Scott
IPC分类号： A61K39/395 , A61K9/50 , A61K9/16
CPC分类号： C07K16/2896 , A61K9/0019 , A61K9/10 , A61K9/1688 , C07K16/2866 , C07K16/36 , C07K2317/24
摘要： The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.
摘要翻译：本发明涉及制备方法的组合物和组合物活性剂颗粒的小组合物。根据生产方法，将活性剂溶解在含有溶解的相分离增强剂（PSEA）的水溶性或水溶性溶剂中以形成单一液相中的溶液。使溶液进行液固相分离，使活性剂形成基本上无定形或非结晶的小球形，并且可以通过高浓度的细针针进行注射。本发明对高分子量蛋白质具有特殊应用。

3. 发明申请

US20050184042A1 Method and apparatus for cover assembly for thermal cycling of samples 有权
标题翻译：用于样品热循环的盖组件的方法和装置
公开(公告)号：US20050184042A1
公开(公告)日：2005-08-25
申请号：US11103059
申请日：2005-04-11
申请人： Larry Brown , William Brumley , Kenneth Zajac
发明人： Larry Brown , William Brumley , Kenneth Zajac
IPC分类号： B01L3/00 , B01L7/00 , C12M1/00 , C12M1/38 , F27D11/00 , G05D23/20 , H02H3/05 , H05B3/06 , H05B3/20 , H05B3/34
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844
摘要： A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element areas; a heater backing plate providing stability to the resistive heater; a force distribution system that distributes a force over the heater backing plate; and a support plate providing stiffness for the force distribution system, wherein the arrangement of the resistive heater, the heater backing plate, the force distribution system and the support plate provide substantial temperature uniformity among a plurality of sample tubes for receiving samples of biological material. The flexible heating cover assembly improves the uniformity, efficiency, quality, reliability and controllability of the thermal response during thermal cycling of the biological material.
摘要翻译：一种用于加热具有显着温度均匀性的生物材料样品的装置的柔性加热盖组件包括具有多个可接合外壳部件的壳体; 电阻加热器，具有多个加热元件区域; 加热器背板，为电阻加热器提供稳定性; 力分配系统，其在加热器背板上分布力; 以及为力分配系统提供刚度的支撑板，其中电阻加热器，加热器背板，力分配系统和支撑板的布置在用于接收生物材料样品的多个样品管之间提供显着的温度均匀性。柔性加热盖组件改善了生物材料热循环期间的热响应的均匀性，效率，质量，可靠性和可控性。

4. 发明申请

US20050006535A1 Pipe and cable holder 有权
标题翻译：管道和电缆架
公开(公告)号：US20050006535A1
公开(公告)日：2005-01-13
申请号：US10734953
申请日：2003-12-12
申请人： Larry Brown , Dennis Hart
发明人： Larry Brown , Dennis Hart
IPC分类号： F16L3/10 , F16L3/08
CPC分类号： F16L3/10 , Y10T24/14 , Y10T24/142
摘要： A clamp assembly releasably secures a plumbing pipe to a support. The assembly has a clamp base releasably connected to a clamping block by pawls that releasably engage a pair of ratchet arms extending from the base. Each of the base and clamping block has two inclined surfaces forming a generally V-shaped notch that opens toward the pipe. A cap is optionally placed over one or both of the V-shaped notches and is interposed between the notch and the pipe. At least one resilient leg or a flange may extend from the base opposite the ratchet arms, with the flange and/or the arms resiliently engaging opposite sides of the support to hold the clamp assembly in position.
摘要翻译：夹具组件将管道管可释放地固定到支撑件上。组件具有通过可释放地接合从基部延伸的一对棘轮臂的可释放地连接到夹持块的夹具基座。基座和夹紧块中的每一个具有形成朝向管道开口的大致V形凹口的两个倾斜表面。盖可选地放置在V形凹口中的一个或两个上，并且插入在凹口和管之间。至少一个弹性腿或凸缘可以从与棘轮臂相对的基部延伸，其中凸缘和/或臂弹性地接合支撑件的相对侧，以将夹具组件保持在适当位置。

5. 发明申请

US20050005105A1 Remote access control feature for limiting access to configuration file components 审中-公开
标题翻译：远程访问控制功能用于限制对配置文件组件的访问
公开(公告)号：US20050005105A1
公开(公告)日：2005-01-06
申请号：US10602754
申请日：2003-06-24
申请人： Larry Brown , Mark Mayernick , Simon Lavaud , David Ryan
发明人： Larry Brown , Mark Mayernick , Simon Lavaud , David Ryan
IPC分类号： G06F9/00 , G06F11/30 , G06F12/14 , H04L9/00 , H04L12/24
CPC分类号： G06F21/305 , G06F21/6218 , G06F2221/2141 , H04L41/0816 , H04L41/28 , H04L41/5067 , H04L63/105
摘要： A security system for use in a distributed network includes a service provider selectively accessible via a network by a plurality of end users each having an access device for accessing the network. A control mechanism is included which is disposed at a location of the service provider and accesses and modifies stored information on each access device of the end users to designate portions of the information to prevent access thereof by the end users.
摘要翻译：用于分布式网络的安全系统包括可由多个终端用户通过网络选择性地访问的服务提供商，每个最终用户具有用于访问网络的接入设备。包括一个控制机制，其设置在服务提供商的一个位置处，并访问和修改最终用户的每个访问设备上的存储信息，以指定信息的部分，以防止最终用户访问它们。

6. 发明授权

US4952406A Feedback controlled release 失效
标题翻译：反馈控制释放
公开(公告)号：US4952406A
公开(公告)日：1990-08-28
申请号：US36158
申请日：1987-04-03
申请人： Larry Brown , Fariba Fischel-Ghodsian , Robert S. Langer
发明人： Larry Brown , Fariba Fischel-Ghodsian , Robert S. Langer
IPC分类号： A61K9/00 , A61K38/28 , C12N11/10
CPC分类号： A61K9/0024 , A61K38/28 , C12N11/10
摘要： A controlled release system using a feedback-responsive controller reversibly changes the pH of the aqueous microenvironment of a biologically active compound sequestered in an aqueous-fluid-penetrable, aqueous-insoluble biocompatible material; the pH change is effected in response to a change in the concentration of the target compound in the aqueous medium surrounding the insoluble material; as a result of the pH change, the aqueous solubility and therefore the release rate of the active compound is reversibly changed.
摘要翻译：使用反馈响应控制器的控制释放系统可逆地改变在水溶液渗透的水不溶性生物相容性材料中螯合的生物活性化合物的水性微环境的pH; 响应于围绕不溶性材料的水性介质中的目标化合物的浓度变化而进行pH变化; 作为pH变化的结果，活性化合物的水溶性和因此的释放速率是可逆地改变的。

7. 发明授权

US10232913B1 Pontoon boat driven by PWC 有权
公开(公告)号：US10232913B1
公开(公告)日：2019-03-19
申请号：US15883954
申请日：2018-01-30
申请人： Larry Brown , Danielle Brown
发明人： Larry Brown , Danielle Brown
IPC分类号： B63B35/70 , B63B21/62 , B63B35/66 , B63B21/56 , B63B1/12 , B63B59/02
摘要： The present invention relates to a pontoon boats that may couple and be driven by a PWC. The invention further relates to pontoon boats having a portion that moves into an open water recess at the rear of the pontoon boat. The invention further relates to an engagement assembly for securing a PWC to such a pontoon boat.

8. 发明授权

US10099597B2 Portable hoist assembly 有权
公开(公告)号：US10099597B2
公开(公告)日：2018-10-16
申请号：US15240452
申请日：2016-08-18
申请人： Tommy Roberts , Larry Brown
发明人： Tommy Roberts , Larry Brown
IPC分类号： B60P1/04 , B60P1/54 , B62D63/06
摘要： A portable hoist assembly for lifting, relocating and lowering loads includes a trailer that is both wheeled and configured to couple to a vehicle. A power module, a lift arm and an actuator are coupled to the trailer. The actuator is operationally coupled to the power module and the lift arm. A fastener is operationally coupled proximate to a second end of the lift arm. The fastener is configured to couple the lift arm to a load. The actuator is positioned to motivate the lift arm and the fastener upwardly and downwardly. The load that is coupled to the lift arm is elevated from a first resting position to a raised position, repositioned by movement of the trailer, and lowered from the raised position to a second resting position.

9. 发明申请

US20180050622A1 Portable Hoist Assembly 审中-公开
公开(公告)号：US20180050622A1
公开(公告)日：2018-02-22
申请号：US15240452
申请日：2016-08-18
申请人： Tommy Roberts , Larry Brown
发明人： Tommy Roberts , Larry Brown
IPC分类号： B60P1/54 , B62D63/06
CPC分类号： B60P1/5423 , B62D61/065 , B62D61/12 , B62D63/064 , B66C23/06 , B66C23/44
摘要： A portable hoist assembly for lifting, relocating and lowering loads includes a trailer that is both wheeled and configured to couple to a vehicle. A power module, a lift arm and an actuator are coupled to the trailer. The actuator is operationally coupled to the power module and the lift arm. A fastener is operationally coupled proximate to a second end of the lift arm. The fastener is configured to couple the lift arm to a load. The actuator is positioned to motivate the lift arm and the fastener upwardly and downwardly. The load that is coupled to the lift arm is elevated from a first resting position to a raised position, repositioned by movement of the trailer, and lowered from the raised position to a second resting position.

10. 发明申请

US20060024240A1 Delivery of as-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 有权
标题翻译：递送寡核苷酸微球以诱导树突状细胞耐受治疗自身免疫性1型糖尿病
公开(公告)号：US20060024240A1
公开(公告)日：2006-02-02
申请号：US11127360
申请日：2005-05-12
申请人： Larry Brown , Vered Bisker-Leib , Terrence Scott , Debra Lafreniere , Jennifer Mochen , Nick Giannoukakls
发明人： Larry Brown , Vered Bisker-Leib , Terrence Scott , Debra Lafreniere , Jennifer Mochen , Nick Giannoukakls
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。微球合并反义（AS）寡核苷酸。一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。

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