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1. 发明授权

US09339465B2 Nucleic acid microspheres, production and delivery thereof 有权
标题翻译：核酸微球，其生产和递送
公开(公告)号：US09339465B2
公开(公告)日：2016-05-17
申请号：US12878783
申请日：2010-09-09
申请人： Terrence Scott , Debra Lafreniere , Vered Bisker-Leib , Larry Brown
发明人： Terrence Scott , Debra Lafreniere , Vered Bisker-Leib , Larry Brown
IPC分类号： A61K9/14 , A61K31/7088 , A61P37/00 , B32B5/16 , A61K9/16 , C12N15/11 , C12N15/113
CPC分类号： A61K9/1629 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2320/32 , Y10T428/2982
摘要： Nucleic acids are prepared by dissolving compounds containing them in a suitable solvent or solvent system and forming microspheres from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nucleic acids is useful, such as in treatment of autoimmune disease.
摘要翻译：通过将含有它们的化合物溶解在合适的溶剂或溶剂体系中并从所得溶液中形成微球体来制备核酸。将微球施用于个体，作为防止核酸递送有用的条件的保护，例如治疗自身免疫性疾病。

2. 发明授权

US08075919B2 Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation 有权
标题翻译：通过控制相分离制备的小球形颗粒的制备方法，用途和组成
公开(公告)号：US08075919B2
公开(公告)日：2011-12-13
申请号：US10894430
申请日：2004-07-19
申请人： Larry Brown , John K. McGeehan , Julia Rashba-Step , Terrence L. Scott
发明人： Larry Brown , John K. McGeehan , Julia Rashba-Step , Terrence L. Scott
IPC分类号： A61K9/16
CPC分类号： B01J13/06 , A61K9/5026 , A61K9/5031 , A61K38/28
摘要： The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 μm to about 200 μm.
摘要翻译：本发明涉及通过在单一液相中提供溶液来制备活性剂的小球形颗粒的方法。单液相包含活性剂，相分离增强剂和第一溶剂。在溶液中以受控的速率诱导相变，引起活性剂的液固相分离并形成固相和液相。固相包含活性剂的固体小球形颗粒。液相包含相分离增效剂和溶剂。小球形颗粒基本上是球形的并且具有约0.01μm至约200μm的尺寸。

3. 发明申请

US20110192940A1 PIPE LOCATOR AND SUPPORT 有权
标题翻译：管道定位器和支撑
公开(公告)号：US20110192940A1
公开(公告)日：2011-08-11
申请号：US13087772
申请日：2011-04-15
申请人： Larry Brown , Virgil E. O'Neil , John R. Thomas , Jeffery A. Jaramillo
发明人： Larry Brown , Virgil E. O'Neil , John R. Thomas , Jeffery A. Jaramillo
IPC分类号： F16L3/22
CPC分类号： F16L3/223 , E03C1/021 , E03C2001/028 , F16L5/00
摘要： An plumbing pipe locator and support is provided for fixing plumbing pipes in position relative to studs in a building. The pipe locator and support comprises an elongated supporting strap having upper and lower sides extending along opposing sides of a longitudinal axis. A first plurality of longitudinally aligned, larger pipe openings are interspersed with a second plurality of smaller, aligned fastener openings that extend into ends of the strap. The upper and lower sides undulate to provide a substantially uniform width between first holes and the adjacent sides and the second holes and the adjacent sides. This undulating surface can provide a strap using less material, with reduced manufacturing time, and a strap that can bend without forming creases or stress fractures.
摘要翻译：提供了一种管道定位器和支撑件，用于将管道管道相对于建筑物中的螺柱固定在适当位置。管定位器和支撑件包括细长的支撑带，其具有沿着纵向轴线的相对侧延伸的上侧和下侧。第一组多个纵向排列较大的管道开口与第二多个较小的对准的紧固件开口相交，该紧固件开口延伸到带的端部。上侧和下侧波动以在第一孔和相邻侧面以及第二孔和相邻侧面之间提供基本均匀的宽度。这种起伏的表面可以使用较少的材料提供带，减少制造时间，以及可以弯曲而不形成折痕或应力断裂的带。

4. 发明授权

US07621487B2 Twist-lock base for pipe holders 有权
标题翻译：管夹的扭锁底座
公开(公告)号：US07621487B2
公开(公告)日：2009-11-24
申请号：US11313566
申请日：2005-12-21
申请人： Larry Brown , Dennis Hart
发明人： Larry Brown , Dennis Hart
IPC分类号： F16L3/08
CPC分类号： F16L3/1025 , F16L3/24
摘要： A support is provided for conduit held on a channel member having a C-shaped cross section with lips extending toward the back wall of the channel. The support has a base with one surface adapted to fasten to the conduit. The second surface has a twist-lock fastener that includes a first and second plate, each having a width sized to fit through the space between the lips and having a length about the same as the distance between the sides of the channel. Two V-shaped deformable members join these plates adjacent the ends on the longest side of the plates. Each V-shaped member is joined to a different plate and the bends at the juncture of the two legs of the V-shaped member abut the side walls of the channel. The bends are adjacent the ends and extend beyond the plates to wedge against the channel sides as a screw draws the plates together and moves the legs of the V shaped member toward each other.
摘要翻译：提供了一种用于保持在具有C形横截面的通道构件上的管道的支撑，其中嘴唇朝向通道的后壁延伸。支撑件具有一个底部，一个表面适于紧固到导管。第二表面具有扭锁紧固件，其包括第一板和第二板，每个板具有尺寸适合穿过唇缘之间的空间的宽度，并且具有与通道侧面之间的距离大致相同的长度。两个V形可变形构件将这些板连接在板的最长侧的端部附近。每个V形构件连接到不同的板，并且在V形构件的两个腿的接合处的弯曲部邻接通道的侧壁。当螺钉将板拉在一起并使V形构件的腿朝向彼此移动时，弯曲部相邻于端部并延伸超过板，以抵靠通道侧。

5. 发明申请

US20080039369A1 MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES 有权
标题翻译：用于预防和/或逆转新型自动免疫糖尿病的基于微阵列的组合物
公开(公告)号：US20080039369A1
公开(公告)日：2008-02-14
申请号：US11834550
申请日：2007-08-06
申请人： Larry Brown , Nick Giannoukakis , Kimberly Gillis
发明人： Larry Brown , Nick Giannoukakis , Kimberly Gillis
IPC分类号： A61K31/7088 , A61K38/28 , A61P3/10 , A61P37/00
CPC分类号： A61K31/7088 , A61K9/0024 , A61K9/1641 , A61K9/19 , A61K38/28 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2320/32 , A61K2300/00
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。微球合并反义（AS）寡核苷酸。一种方法包括使用反义方法在体内逆转NOD小鼠中的自身免疫性糖尿病状态。靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。

6. 发明申请

US20070138350A1 Twist-lock base for pipe holders 有权
标题翻译：管夹的扭锁底座
公开(公告)号：US20070138350A1
公开(公告)日：2007-06-21
申请号：US11313566
申请日：2005-12-21
申请人： Larry Brown , Dennis Hart
发明人： Larry Brown , Dennis Hart
IPC分类号： F16L3/08
CPC分类号： F16L3/1025 , F16L3/24
摘要： A support is provided for conduit held on a channel member having a C-shaped cross section with lips extending toward the back wall of the channel. The support has a base with one surface adapted to fasten to the conduit. The second surface has a twist-lock fastener that includes a first and second plate, each having a width sized to fit through the space between the lips and having a length about the same as the distance between the sides of the channel. Two V-shaped deformable members join these plates adjacent the ends on the longest side of the plates. Each V-shaped member is joined to a different plate and the bends at the juncture of the two legs of the V-shaped member abut the side walls of the channel. The bends are adjacent the ends and extend beyond the plates to wedge against the channel sides as a screw draws the plates together and moves the legs of the V shaped member toward each other.
摘要翻译：提供了一种用于保持在具有C形横截面的通道构件上的管道的支撑，其中嘴唇朝向通道的后壁延伸。支撑件具有一个底部，一个表面适于紧固到导管。第二表面具有扭锁紧固件，其包括第一板和第二板，每个板具有尺寸适合穿过唇缘之间的空间的宽度，并且具有与通道侧面之间的距离大致相同的长度。两个V形可变形构件将这些板连接在板的最长侧的端部附近。每个V形构件连接到不同的板，并且在V形构件的两个腿的接合处的弯曲部邻接通道的侧壁。当螺钉将板拉在一起并使V形构件的腿朝向彼此移动时，弯曲部相邻于端部并延伸超过板，以抵靠通道侧。

7. 发明申请

US20060018971A1 Nucleic acid microspheres, production and delivery thereof 有权
标题翻译：核酸微球，其生产和递送
公开(公告)号：US20060018971A1
公开(公告)日：2006-01-26
申请号：US11127362
申请日：2005-05-12
申请人： Terrence Scott , Debra Lafreniere , Vered Bisker-Leib , Larry Brown
发明人： Terrence Scott , Debra Lafreniere , Vered Bisker-Leib , Larry Brown
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： A61K9/1629 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2320/32 , Y10T428/2982
摘要： Nucleic acids are prepared by dissolving compounds containg them in a suitable solvent or solvent system and forming microshperes from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nuceic acids is useful, such as in treatment of autoimmune disease.
摘要翻译：通过将含有它们的化合物溶解在合适的溶剂或溶剂体系中并从所得溶液中形成微胶粒来制备核酸。将微球体施用于个体，作为防止尿酸递送有用的条件，例如治疗自身免疫性疾病。

8. 发明授权

US06986368B2 Hydraulic control system for tree cutting saw 失效
标题翻译：树锯锯液压控制系统
公开(公告)号：US06986368B2
公开(公告)日：2006-01-17
申请号：US10208806
申请日：2002-08-01
申请人： Larry Brown
发明人： Larry Brown
IPC分类号： A01G23/091
CPC分类号： F15B11/20 , A01G23/091
摘要： A hydraulic circuit for a tree-cutting machine having a feed mechanism powered by hydraulic fluid at the output of a hydraulic motor. The hydraulic motor may comprise a variable-displacement motor. The hydraulic circuit may comprise elements which provide an anti-stall mode, wherein the feed mechanism is operated to withdraw the cutting element upon pressure at an input port of the hydraulic motor exceeding a threshold.
摘要翻译：一种用于树切割机的液压回路，具有由液压马达的输出端上的液压流体驱动的进给机构。液压马达可以包括可变排量马达。液压回路可以包括提供防失速模式的元件，其中进给机构被操作以在液压马达的输入端口处的压力超过阈值时将切割元件撤回。

9. 发明申请

US20050136778A1 Ultrasonically laminated multi-ply fabrics 有权
标题翻译：超薄层压多层织物
公开(公告)号：US20050136778A1
公开(公告)日：2005-06-23
申请号：US10745339
申请日：2003-12-23
申请人： Craig Thomaschefsky , Larry Brown
发明人： Craig Thomaschefsky , Larry Brown
IPC分类号： B32B5/26 , B32B7/04 , B32B37/20 , B32B38/06 , D04H11/08 , D04H13/00 , B32B27/14
CPC分类号： B32B5/26 , B32B7/04 , B32B37/00 , B32B37/206 , B32B38/06 , B32B2307/728 , B32B2310/028 , B32B2432/00 , B32B2459/00 , D04H1/555 , D04H1/559 , Y10T428/24826 , Y10T442/659 , Y10T442/689
摘要： A multi-ply fabric is provided that includes an inner ply positioned between two outer plies that contain both thermoplastic fibers and absorbent staple fibers. The plies are ultrasonically bonded together. The material used to form the inner ply may be selectively controlled to optimize certain properties of the fabric for a particular application, such as strength, bulk, absorption capacity, absorption rate, handfeel, etc.
摘要翻译：提供了一种多层织物，其包括位于两个外层之间的内层，其中包含热塑性纤维和吸收性短纤维。层叠超声波粘合在一起。可以选择性地控制用于形成内层的材料，以针对特定应用（例如强度，体积，吸收能力，吸收率，手感等）优化织物的某些性能。

10. 发明申请

US20050097194A1 Downloadable code in a distributed process control system 有权
标题翻译：分布式过程控制系统中可下载的代码
公开(公告)号：US20050097194A1
公开(公告)日：2005-05-05
申请号：US10886272
申请日：2004-07-06
申请人： Clyde Eisenbeis , Brent Larson , Steve Packwood , Larry Brown
发明人： Clyde Eisenbeis , Brent Larson , Steve Packwood , Larry Brown
IPC分类号： G06F11/00 , G05B15/02 , G05B19/042 , G05B19/418 , G06F9/445 , G06F15/177 , G11C11/34
CPC分类号： G05B19/4185 , G05B19/0426 , G05B2219/23298 , G05B2219/25014 , G05B2219/25428 , G05B2219/31121 , G05B2219/31135 , G05B2219/31138 , Y02P90/18
摘要： The present invention is directed to a method of reprogramming a field device in a process control network using the standard communications protocol for the network, and a reprogrammable field device in the process control network adapted for being reprogrammed using the standard communications protocol for the network. The method and device of the present invention use the standard communications protocol to transmit the downloaded code to the field device and store the downloaded code in the field device while the device is enabled to perform process control. Once the new code is downloaded and stored in the field device, the field device is set to a steady state condition and/or disabled from performing process control, reprogrammed to execute the downloaded code, and reenabled to perform process control.
摘要翻译：本发明涉及一种使用网络的标准通信协议对过程控制网络中的现场设备进行重新编程的方法，以及适于使用网络的标准通信协议重新编程的过程控制网络中的可重新编程的现场设备。本发明的方法和装置使用标准通信协议将下载的代码发送到现场设备，并且在设备能够执行过程控制的同时将下载的代码存储在现场设备中。一旦将新代码下载并存储在现场设备中，现场设备被设置为稳定状态条件和/或禁止执行过程控制，重新编程以执行下载的代码，并重新启用以执行过程控制。

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