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1. 发明授权

US07918350B2 Separation apparatus and method 有权
标题翻译：分离装置及方法
公开(公告)号：US07918350B2
公开(公告)日：2011-04-05
申请号：US12399545
申请日：2009-03-06
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
IPC分类号： B04B3/00 , B04B1/06 , B04B1/12 , B04B7/10 , B01D21/26 , B01D45/12
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

2. 发明申请

US20090218277A1 SEPARATION APPARATUS AND METHOD 有权
标题翻译：分离装置和方法
公开(公告)号：US20090218277A1
公开(公告)日：2009-09-03
申请号：US12399545
申请日：2009-03-06
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
IPC分类号： B01D17/038
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

3. 发明授权

US07297272B2 Separation apparatus and method 有权
标题翻译：分离装置及方法
公开(公告)号：US07297272B2
公开(公告)日：2007-11-20
申请号：US10827603
申请日：2004-04-19
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur
IPC分类号： B04B3/00 , B04B1/06 , B04B1/12 , B04B7/10 , B01D21/26 , B01D45/12
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

4. 发明申请

US20080087601A1 Separation Apparatus and Method 审中-公开
标题翻译：分离装置及方法
公开(公告)号：US20080087601A1
公开(公告)日：2008-04-17
申请号：US11927033
申请日：2007-10-29
申请人： Kyungyoon Min , Richard Brown , Alp Akonur
发明人： Kyungyoon Min , Richard Brown , Alp Akonur
IPC分类号： B01D21/26
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

5. 发明申请

US20080087614A1 Separation Apparatus and Method 审中-公开
公开(公告)号：US20080087614A1
公开(公告)日：2008-04-17
申请号：US11927126
申请日：2007-10-29
申请人： Kyungyoon Min , Richard Brown , Alp Akonur
发明人： Kyungyoon Min , Richard Brown , Alp Akonur
IPC分类号： B01D21/26
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

6. 发明申请

US20100217178A1 PREDICTION OF PERITONEAL DIALYSIS THERAPY OUTCOMES USING DIALYSATES MIXED AT DIFFERENT GLUCOSE CONCENTRATIONS 审中-公开
标题翻译：使用在不同葡萄糖浓度下混合的透析液来预测眼底透析治疗的成果
公开(公告)号：US20100217178A1
公开(公告)日：2010-08-26
申请号：US12389751
申请日：2009-02-20
申请人： Ying-Cheng Lo , Alp Akonur , Isaac Martis , Andrew C. Hayes
发明人： Ying-Cheng Lo , Alp Akonur , Isaac Martis , Andrew C. Hayes
IPC分类号： A61M1/28 , G06N5/02 , G06F17/10 , G06G7/60
CPC分类号： A61M1/28 , A61M1/1613 , A61M1/287 , G06F19/3481 , G16H50/50
摘要： A method for peritoneal dialysis treatment includes (i) predicting results of a plurality of patient therapy outcomes for a plurality of different mixed dextrose level dialysis solutions; (ii) selecting one of the mixed dextrose level solutions for a patient based on the results; and (iii) performing at least one therapy using different unmixed dextrose level solutions that combine to simulate a like cumulative concentration that would be achieved using the selected mixed dextrose level solution.
摘要翻译：腹膜透析治疗的方法包括（i）预测多种不同混合葡萄糖水平透析溶液的多种患者治疗结果的结果; （ii）基于结果选择患者的混合葡萄糖水平溶液之一; 和（iii）使用不同混合葡萄糖水平溶液进行至少一种治疗，其组合以模拟使用所选择的混合葡萄糖水平溶液将达到的类似累积浓度。

7. 发明授权

US08926551B2 Peritoneal dialysis therapy with large dialysis solution volumes 有权
标题翻译：腹膜透析治疗大量透析液量
公开(公告)号：US08926551B2
公开(公告)日：2015-01-06
申请号：US12498853
申请日：2009-07-07
申请人： Ying-Cheng Lo , Alp Akonur , Yuanpang S. Ding
发明人： Ying-Cheng Lo , Alp Akonur , Yuanpang S. Ding
IPC分类号： A61M1/00 , A61M1/28
CPC分类号： A61M1/28 , A61M1/282
摘要： Patients suffering from acute renal failure must be diagnosed and treated quickly so that a physician can confidently prescribe either peritoneal dialysis or hemodialysis. In one way of quickly treating the patients, software is used to calculate a suitable peritoneal dialysis prescription without regard to how short or how long a dialysis cycle is used, and without regard to a total dialysate fluid volume for a therapy. For patients with suitable peritoneal membrane transport properties, the software program suggests that, at least over a short period of time, unexpectedly high ultrafiltrate volumes and high clearances may be achieved.
摘要翻译：患急性肾衰竭的患者必须迅速诊断和治疗，以便医生可以自信地开出腹膜透析或血液透析。以快速治疗患者的一种方式，使用软件来计算合适的腹膜透析处方，而不考虑使用透析循环的短暂或多长时间，并且不考虑用于治疗的总透析液体积。对于具有适当腹膜转运性质的患者，软件程序表明，至少在短时间内，可能会实现出乎意料的高超滤液体积和高清除率。

8. 发明授权

US08180574B2 Simplified peritoneal equilibration test for peritoneal dialysis 有权
标题翻译：腹膜透析简化腹膜平衡试验
公开(公告)号：US08180574B2
公开(公告)日：2012-05-15
申请号：US12498847
申请日：2009-07-07
申请人： Ying-Cheng Lo , Alp Akonur , Sarah Stobo Prichard
发明人： Ying-Cheng Lo , Alp Akonur , Sarah Stobo Prichard
IPC分类号： G01N33/48 , G06F19/00
CPC分类号： A61M1/28 , A61M1/1619
摘要： A simplified peritoneal equilibration test (S-PET) is disclosed. Instead of a lengthy peritoneal equilibration test (PET), the simplified procedure requires no blood sample and may use data from as few as two or three samples to classify a peritoneal membrane of a user. Typically, a peritoneal membrane or peritoneum of a dialysis patient, or other person, is classed as a high transport membrane, high-average transport membrane, a low-average transport membrane or a low transporter membrane. The S-PET may be performed at home by a user without the need to submit a blood sample. Kits for analyzing the samples may be furnished for home use. The kits may use disposable strips, microfluidic analyzers or chemical reagents, or may alternatively include reusable analysis equipment, such as optical or conductivity analysis equipment.
摘要翻译：公开了一种简化的腹膜平衡试验（S-PET）。代替长时间的腹膜平衡试验（PET），简化的程序不需要血液样品，并且可以使用少至两个或三个样品的数据来分类用户的腹膜。通常，透析患者或其他人的腹膜或腹膜被分类为高运输膜，高平均运输膜，低平均运输膜或低转运膜。 S-PET可以由用户在家进行，而不需要提交血样。用于分析样品的试剂盒可供家庭使用。试剂盒可以使用一次性条，微流控分析仪或化学试剂，或者可以替代地包括可重复使用的分析设备，例如光学或电导率分析设备。

9. 发明申请

US20090131859A1 FLOW PULSATILITY DAMPENING DEVICES FOR CLOSED-LOOP CONTROLLED INFUSION SYSTEMS 有权
标题翻译：用于闭环控制输注系统的流动脉冲阻尼装置
公开(公告)号：US20090131859A1
公开(公告)日：2009-05-21
申请号：US11941840
申请日：2007-11-16
申请人： Jorge DelCastillo , Alp Akonur
发明人： Jorge DelCastillo , Alp Akonur
IPC分类号： A61M31/00
CPC分类号： A61M5/14212 , A61M5/14216 , A61M5/14224 , A61M5/14228 , A61M5/14232 , A61M5/16831 , A61M5/172 , A61M2206/10 , A61M2206/22 , F04B39/005
摘要： A flow monitoring infusion system that includes an infusion circuit having a fluid with a pulsatile fluid flow flowing therethrough. The infusion circuit includes a dampening element having a dampening chamber that absorbs the pressure fluctuations of the pulsatile fluid flow to transform the pulsatile fluid flow to a more smooth fluid flow. A fluid flow sensor that measures the flowrate of the more smooth fluid flow is disposed along the infusion circuit downstream of the dampening element.
摘要翻译：一种流量监测输注系统，其包括具有流过其中的脉动流体流体的流体的输注电路。输注电路包括具有阻尼室的阻尼元件，该阻尼室吸收脉动流体流的压力波动，以将脉动流体流转换成更平滑的流体流。测量更平滑流体流动的流量的流体流量传感器沿着润湿元件下游的输注回路设置。

10. 发明授权

US08868350B2 Therapy prediction and optimization for renal failure blood therapy, especially home hemodialysis 有权
公开(公告)号：US08868350B2
公开(公告)日：2014-10-21
申请号：US13088044
申请日：2011-04-15
申请人： Alp Akonur , John Kenneth Leypoldt , Ying-Cheng Lo , Baris Ugur Agar
发明人： Alp Akonur , John Kenneth Leypoldt , Ying-Cheng Lo , Baris Ugur Agar
IPC分类号： G01N33/48 , A61M1/16 , A61M1/36 , G06F19/00
CPC分类号： A61M1/1603 , A61M1/16 , A61M1/1611 , A61M1/1613 , A61M1/1619 , A61M1/3609 , A61M2202/0498 , A61M2205/15 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/20 , G06F19/3481
摘要： A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.

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