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1. 发明申请

US20100029507A1 THE BIOCHIP FOR THE DETECTION OF PHOSPHORYLATION AND THE DETECTION METHOD USING THE SAME 审中-公开
标题翻译：用于检测磷酸化的生物技术和使用其的检测方法
公开(公告)号：US20100029507A1
公开(公告)日：2010-02-04
申请号：US11776969
申请日：2007-07-12
申请人： Sang Hyun Park , Hui Jeong Gwon , Kyong Cheol Ko , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Kyong Cheol Ko , Myung Woo Byun
IPC分类号： C40B30/08 , C40B40/10
CPC分类号： C12Q1/485 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , G01N33/54353 , G01N2500/00
摘要： The present invention relates to a biochip for the detection of phosphorylation and a method for measuring phosphorylation using the same, more precisely a biochip integrated with the substrate of kinase and a kit for measuring phosphorylation comprising the biochip and a radio-labeled co-factor, and a method for measuring phosphorylation using the same. The kit for the detection of phosphorylation of the present invention facilitates simple and fast measurement of phosphorylation with a minimum amount of a sample, compared with the conventional method using an antibody, because it uses a radioisotope. This chip and kit can be effectively used for the analysis of kinase activity since this method favors fast mass analysis.
摘要翻译：本发明涉及用于检测磷酸化的生物芯片和使用其的磷酸化测定方法，更确切地说，与激酶底物整合的生物芯片和用于测量磷酸化的试剂盒包括生物芯片和放射性标记的辅因子，以及使用其测定磷酸化的方法。与使用抗体的常规方法相比，本发明的用于检测本发明的磷酸化的试剂盒由于使用放射性同位素，与使用抗体的常规方法相比，促进了用最少量的样品简单且快速地测量磷酸化。该芯片和试剂盒可以有效地用于激酶活性的分析，因为该方法有利于快速质量分析。

2. 发明授权

US08247538B2 Preparation method of radioisotope labeling compound using carbon nanotube 有权
标题翻译：使用碳纳米管的放射性同位素标记化合物的制备方法
公开(公告)号：US08247538B2
公开(公告)日：2012-08-21
申请号：US11788801
申请日：2007-04-20
申请人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： C07F13/00 , C07C279/02
CPC分类号： C07F13/005 , C07C277/00 , C07C279/06
摘要： Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.
摘要翻译：本文公开了使用CNT制备放射性同位素标记化合物的方法。它包括用放射性同位素填充碳纳米管; 并用放入碳纳米管的放射性同位素标记生理活性物质。利用CNT，该方法可以以高产率和简单的方式制备放射性同位素标记的化合物。此外，当保留未反应时，放射性同位素可以通过过滤CNT来回收，从而实现放射性污染的防止和放射性废物的减少。此外，放射性同位素标记的化合物可用作成像肝胆系统的造影剂。

3. 发明申请

US20080214797A1 Preparation method of radioisotope labeling compound using carbon nanotube 有权
标题翻译：使用碳纳米管的放射性同位素标记化合物的制备方法
公开(公告)号：US20080214797A1
公开(公告)日：2008-09-04
申请号：US11788801
申请日：2007-04-20
申请人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： C07F13/00 , C07C279/02
CPC分类号： C07F13/005 , C07C277/00 , C07C279/06
摘要： Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.
摘要翻译：本文公开了使用CNT制备放射性同位素标记化合物的方法。它包括用放射性同位素填充碳纳米管; 并用放入碳纳米管的放射性同位素标记生理活性物质。利用CNT，该方法可以以高产率和简单的方式制备放射性同位素标记的化合物。此外，当保留未反应时，放射性同位素可以通过过滤CNT来回收，从而实现放射性污染的防止和放射性废物的减少。此外，放射性同位素标记的化合物可用作成像肝胆系统的造影剂。

4. 发明授权

US07851496B2 Ionic liquid type crown ether derivatives, method for preparing the same and method for isolating metal ions using the same 有权
标题翻译：离子液体型冠醚衍生物，其制备方法以及使用该衍生物分离金属离子的方法
公开(公告)号：US07851496B2
公开(公告)日：2010-12-14
申请号：US11473751
申请日：2006-06-23
申请人： Sang Hyun Park , Seung Ho Jang , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Seung Ho Jang , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： A61K31/4188 , A61K51/04 , C07D273/00
CPC分类号： C07D491/14 , Y02P20/582
摘要： Disclosed relates to an ionic liquid type crown ether derivative, expressed by Chemical Formula 1 below, for isolating metal ions, a method for preparing the same and a method for isolating selectively the metal ions using the cycle size of the same. The present invention can provide the ionic liquid type crown ether and isolate metal ions including radioactive isotopes efficiently using the same. Furthermore, the prevent invention provides crown ether valuably used as a recyclable and environment-friendly isolating medium by preparing crown ether of ionic liquid type. wherein m, n, X− and R are identical with those in the description.
摘要翻译：本发明涉及离子液体型冠醚衍生物，由下述化学式1表示，用于分离金属离子，其制备方法以及使用其周期尺寸选择性地分离金属离子的方法。本发明可以提供离子液体型冠醚，并且使用它们有效地分离包括放射性同位素的金属离子。此外，本发明提供了通过制备离子液体型冠醚可贵地用作可回收和环境友好的隔离介质的冠醚。其中m，n，X和R与说明书中的相同。

5. 发明授权

US07459141B2 Technetium-99m-labeled organic germanium nanocolloids, method of preparing the same and use thereof 有权
标题翻译：锝-99m标记的有机锗纳米胶体及其制备方法及其应用
公开(公告)号：US07459141B2
公开(公告)日：2008-12-02
申请号：US11474717
申请日：2006-06-26
申请人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： A61K51/00 , C07J13/00
CPC分类号： C07F13/005 , A61K51/0478 , A61K51/1217
摘要： Disclosed relates to organic germanium nanocolloids, to which technetium-99m (99mTc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention, 99mTc-labeled organic germanium nanocolloids having high labeling efficiency and stability can be provided. Moreover, since the 99mTc-labeled organic germanium nanocolloids of the invention are accumulated in the spleen considerably higher than the conventional spleen-imaging agent, it is possible to use the 99mTc-labeled organic germanium nanocolloids of the present invention as a therapeutic radiopharmaceutical for the spleen imaging.
摘要翻译：涉及有机锗纳米胶体，锝-99m（99mTc），放射性核素被标记，其方法和包括其的脾显像剂。根据本发明，可以提供具有高标记效率和稳定性的99mTc标记的有机锗纳米胶体。此外，由于本发明的99mTc标记的有机锗纳米胶体在脾脏中积累显着高于常规脾显像剂，因此可以使用本发明的99mTc标记的有机锗纳米胶体作为治疗性放射性药物脾脏成像。

6. 发明授权

US08518898B2 Cytoprotective composition comprising hesperidin or pharmaceutically acceptable salt thereof as an active ingredient 有权
标题翻译：包含橙皮苷或其药学上可接受的盐作为活性成分的细胞保护组合物
公开(公告)号：US08518898B2
公开(公告)日：2013-08-27
申请号：US12208643
申请日：2008-09-11
申请人： Sang Hyun Park , Kannampalli Pradeep , Kyong Cheol Ko
发明人： Sang Hyun Park , Kannampalli Pradeep , Kyong Cheol Ko
IPC分类号： A61K31/70
CPC分类号： A61K31/7048
摘要： Disclosed is a cytoprotective composition comprising hesperidin or a pharmaceutically acceptable salt thereof as an active ingredient. Having the ability to protect cells from radiation-induced injuries in addition to being non-toxic to cells, hesperidin in accordance with the present invention can be used as an active cytoprotective agent.
摘要翻译：公开了包含橙皮苷或其药学上可接受的盐作为活性成分的细胞保护组合物。除了对细胞无毒以外，具有保护细胞免受辐射诱发的损伤的能力，根据本发明的橙皮苷可用作活性细胞保护剂。

7. 发明申请

US20090227526A1 CYTOPROTECTIVE COMPOSITION COMPRISING HESPERIDIN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT 有权
标题翻译：作为活性成分包含苯哌草啶或其药学上可接受的盐的CYPOPROTECTIVE COMPORITION
公开(公告)号：US20090227526A1
公开(公告)日：2009-09-10
申请号：US12208643
申请日：2008-09-11
申请人： Sang Hyun Park , Kannampalli Pradeep , Kyong Cheol Ko
发明人： Sang Hyun Park , Kannampalli Pradeep , Kyong Cheol Ko
IPC分类号： A61K31/7048 , A61P43/00
CPC分类号： A61K31/7048
摘要： Disclosed is a cytoprotective composition comprising hesperidin or a pharmaceutically acceptable salt thereof as an active ingredient. Having the ability to protect cells from radiation-induced injuries in addition to being non-toxic to cells, hesperidin in accordance with the present invention can be used as an active cytoprotective agent.
摘要翻译：公开了包含橙皮苷或其药学上可接受的盐作为活性成分的细胞保护组合物。除了对细胞无毒以外，具有保护细胞免受辐射诱发的损伤的能力，根据本发明的橙皮苷可用作活性细胞保护剂。

8. 发明授权

US06979431B2 Method for labelling technetium or rhenium using borohydride exchange resin 失效
标题翻译：使用硼氢化物交换树脂标记锝或铼的方法
公开(公告)号：US06979431B2
公开(公告)日：2005-12-27
申请号：US10253515
申请日：2002-09-24
申请人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
发明人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
IPC分类号： C01B17/20 , C07F13/00 , A61K51/00 , C01G47/00 , C01G57/00
CPC分类号： C07F13/005
摘要： A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.
摘要翻译：一种用锝或铼标记硫化物的方法，包括在硼氢化物交换树脂存在下二硫化物与高铁酸盐或高铼酸盐的反应，以获得锝或铼与硫化物的络合物。该方法可以用锝或铼直接标记二硫化物，可以跳过硫醇保护的S-前体的合成步骤，可用于高附加值放射性药物。

9. 发明授权

US06936240B2 Method for the preparation of technetium or rhenium complex for radiopharmaceuticals 失效
标题翻译：用于制备放射性药物的锝或铼络合物的方法
公开(公告)号：US06936240B2
公开(公告)日：2005-08-30
申请号：US10287133
申请日：2002-10-31
申请人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
发明人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
IPC分类号： A61K51/00 , A61K51/04 , C07F13/00 , A61M36/14
CPC分类号： C07F13/005 , A61K51/0402 , A61K51/0476 , A61K51/0489
摘要： The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2˜14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.
摘要翻译：本发明涉及在还原剂存在下，通过高锝酸盐或高铼酸盐与配体的反应制备放射性药物的锝或铼络合物的方法，其中还原剂是硼氢化物交换树脂（BER）。本发明的硼氢化物交换树脂具有在广泛的Ph范围内稳定的优点，包括酸性或碱性条件（Ph 2〜14），因此适用于生物材料，并且在施用时易于通过过滤除去。此外，由于放射性标记的复合物在比常规还原剂所需的条件更温和的条件下生产，并且具有高放射化学纯度和高标记效率，所以常规的还原剂可以被本发明的BER代替。

10. 发明申请

US20070140959A1 Method of preparing rhenium-tricarbonyl complex and its precursor 审中-公开
标题翻译：制备铼三羰基络合物及其前体的方法
公开(公告)号：US20070140959A1
公开(公告)日：2007-06-21
申请号：US11471910
申请日：2006-06-20
申请人： Sang Hyun Park , Seung Ho Jang , Myung Woo Byun
发明人： Sang Hyun Park , Seung Ho Jang , Myung Woo Byun
IPC分类号： A61K51/00 , C07F13/00
CPC分类号： C01G47/00 , A61K51/0402 , A61K51/0474 , A61K51/0476 , A61K51/1282 , C01G47/003 , C01P2002/87
摘要： Disclosed herein is a method of preparing a 188Re-tricarbonyl complex for radiopharmaceutical use and of preparing a precursor thereof, and a contrast agent using the same. Particularly, this invention provides a method of preparing a 188Re-tricarbonyl precursor by reacting perrhenate with borane-ammonia (BH3.NH3), potassium boranocarbonate (K2[H3BCO2]) and phosphate in the presence of borohydride exchange resin as a reducing agent, and a method of preparing a 188Re-tricarbonyl complex by reacting the 188Re-tricarbonyl precursor with a ligand. According to the method of this invention, the borohydride exchange resin is used as a reducing agent and as an anion scavenger, thereby obtaining the 188Re-tricarbonyl precursor and complex having high radiolabeling yield and high purity. In addition, the 188Re-tricarbonyl complex can be used as a contrast agent having excellent plasma stability.
摘要翻译：本发明公开了一种制备用于放射性药物使用的188重复三羰基络合物和制备其前体的方法，以及使用其的造影剂。特别地，本发明提供了一种通过使高铼酸盐与硼烷 - 氨（BH 3 N，NH 3）反应制备188重复三羰基前体的方法，硼酸氢钾（K 2 H 3 BCO 2））和磷酸盐在硼氢化物交换树脂作为还原剂存在下反应，和通过使188重复三羰基前体与配体反应制备188重复三羰基络合物的方法。根据本发明的方法，使用硼氢化物交换树脂作为还原剂和阴离子清除剂，从而获得具有高放射性标记产率和高纯度的重氮三羰基前体和复合物。另外，重复三羰基复合物可用作具有优异的等离子体稳定性的造影剂。

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