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    • 3. 发明授权
    • Piperidine derivative
    • 哌啶衍生物
    • US08377967B2
    • 2013-02-19
    • US12864878
    • 2008-11-20
    • Kunihiko HigashiuraTakashi OginoTaizo ItoHiroyuki Iwatsuki
    • Kunihiko HigashiuraTakashi OginoTaizo ItoHiroyuki Iwatsuki
    • A61K31/4535C07D409/02A61P37/08
    • C07D495/04C07D409/04C07D497/04
    • The present invention provides a compound a piperidine derivative having excellent histamine receptor antagonistic action, which is useful as active ingredients of a pharmaceutical composition, especially an antihistamine. The piperidine derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low brain transfer even in a cerebral receptor binding test where a mouse is orally administered with the compound, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The piperidine derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
    • 本发明提供了具有优异的组胺受体拮抗作用的化合物哌啶衍生物,其可用作药物组合物,特别是抗组胺药的活性成分。 本发明的哌啶衍生物具有有效的组胺受体拮抗作用。 此外,本发明的化合物即使在小鼠口服给药化合物的脑受体结合试验中也显示低脑转移,因此该化合物具有减轻中枢神经系统中的副作用的优选性质,例如嗜睡。 本发明的哌啶衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药例如嗜睡是非常有用的。
    • 5. 发明授权
    • Boot band
    • 启动乐队
    • US07743472B2
    • 2010-06-29
    • US10513917
    • 2003-06-05
    • Takashi Ogino
    • Takashi Ogino
    • F16L33/02
    • F16L33/035F16L33/025Y10T24/1457Y10T24/1478Y10T24/1482
    • A boot-band that (a) does not excessively clamp a boot, (b) can prevent leakage of grease from the boot and the boot-band, and (c) uniformly produces a tight contact force on the boot without deteriorating the contact force on the boot. This boot-band includes a metallic belt-shaped member (2), and its clamping force, which is generated in the direction that shortens the circumference of the metallic belt-shaped member (2), is exercised under a ring-shaped condition in such a way that one end of the metallic belt-shaped member overlaps the other end thereof, and in such a way that both ends are wound around the outer periphery of the boot. A smaller-cross-sectional area (5a) is formed in a part of the belt-shaped member (2); the smaller-cross-sectional area (5a) and the general part (8), whose cross-sectional area is not reduced, are elongated due to plastic deformation caused by the clamping force.
    • (a)不过分夹紧靴子的靴带,(b)可以防止靴子和靴带的润滑脂泄漏,​​(c)在靴子上均匀地产生紧密的接触力而不会使接触力恶化 在开机 这种靴带包括金属带状构件(2),并且其在缩短金属带状构件(2)的圆周的方向上产生的夹紧力在环形状态下被执行 使得金属带状构件的一端与其另一端重叠的方式,并且以这样的方式将两端缠绕在护罩的外周。 在带状构件(2)的一部分中形成有较小的横截面积(5a); 截面积不减小的较小横截面积(5a)和一般部分(8)由于夹紧力引起的塑性变形而伸长。
    • 6. 发明申请
    • Oxepin derivative
    • 奥克辛衍生物
    • US20100004456A1
    • 2010-01-07
    • US12311215
    • 2007-09-27
    • Kunihiko HigashiuraTakashi OginoKazuhito FurukawaYuriko Yamazaki
    • Kunihiko HigashiuraTakashi OginoKazuhito FurukawaYuriko Yamazaki
    • C07D405/04
    • C07D405/04
    • The present invention provides a compound, an oxepin derivative having excellent histamine receptor antagonistic action, which is useful as an antihistamine. The oxepin derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low intracerebral migration even when a mouse that is orally administered with the compound is subjected to an intracerebral receptor binding test, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The oxepin derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
    • 本发明提供一种化合物,具有优异的组胺受体拮抗作用的氧杂环丁衍生物,其可用作抗组胺药。 本发明的oxepin衍生物具有有效的组胺受体拮抗作用。 此外,本发明的化合物即使经口给予该化合物的小鼠进行脑内受体结合试验,也显示低脑内迁移,使得该化合物具有优选的减轻中枢神经系统副作用的性质,例如 作为嗜睡 本发明的oxepin衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药如睡意觉是非常有用的。
    • 7. 发明授权
    • Rider restraining device for two wheel vehicle
    • 车轮限制装置
    • US07434830B2
    • 2008-10-14
    • US11221783
    • 2005-09-09
    • Kazuhiko TsunodaNorihiro KurataYutaka MurataTakashi Ogino
    • Kazuhiko TsunodaNorihiro KurataYutaka MurataTakashi Ogino
    • B60R21/20B60R21/16
    • B62J27/00
    • An air-bag type rider restraining device for a two wheel vehicle having a scooter structure. A stay is firmly fixed by welding to a front portion of a head pipe. A connection member is fastened with two nuts onto the stay. An air bag supporting frame is connected and fixed to the connection member at its lower end so as to be directed rearwardly and obliquely upwardly along a handle pipe. The air bag supporting frame positions and fixes an air bag unit so as to be directed to a chest position of a rider above a center portion of a steering handle. A ring-like frame structure as an air bag holding member is disposed round a surface of the air bag unit facing the rider wherein a forward load applied to the air bag by holding the inflated air bag from behind is received by the ring-like frame structure.
    • 一种用于具有踏板车结构的双轮车辆的气囊式骑车人约束装置。 通过焊接牢固地固定住头管的前部。 连接构件用两个螺母固定在支架上。 安全气囊支撑框架在其下端连接并固定到连接构件,以便沿着把手管向后指向并向上倾斜。 气囊支撑框架将气囊单元定位并固定,以便指向驾驶员在转向手柄的中心部分上方的胸部位置。 作为气囊保持构件的环状框架结构设置在面向乘员的安全气囊单元的表面周围,其中通过从后面保持充气的气囊来施加到气囊的前向载荷被环形框架 结构体。
    • 8. 发明授权
    • Facilitated tightening device
    • 便于紧固装置
    • US07422404B2
    • 2008-09-09
    • US11124403
    • 2005-05-09
    • Yoshiharu KitamuraTakashi OginoYoshihiro Hemmi
    • Yoshiharu KitamuraTakashi OginoYoshihiro Hemmi
    • F16B39/00
    • F16B37/0857Y10S411/935
    • A facilitated tightening device allowing a bolt to be inserted smoothly by preventing a screw block engaged with the bolt from being inclined or falling down, comprising a base (2) having a bolt-insertion hole (7) partly forming a bolt-receiving face (9) and a slope portion (8) gradually decreasing in radius toward the insertion side of the bolt (6) in a manner so as to match the bolt-insertion hole (7) formed therein, a running screw (3) slid along the slope portion (8) as a result of the axial movement of the inserted bolt (6) to be engaged with the bolt (6), a spring piece (5) that presses the running screw (3) in the downward, in the diameter-reducing direction of the running screw (3), and guide projections (10, 11) that engage with the running screw (3) so as to prevent the screw block (3) from falling down into the base (2). Also, a groove for the running screw 2b is formed in the base 2 so as to prevent said running screw 3 from wobbling in the circumferential direction.
    • 一种容易的紧固装置,其允许螺栓通过防止与螺栓接合的螺钉块倾斜或坠落而平滑地插入,包括具有部分地形成螺栓接收面的螺栓插入孔(7)的基部(2) 9)和与螺栓(6)的插入侧朝向螺栓插入孔(7)的径向逐渐减小的倾斜部(8),沿着螺栓插入孔(7)滑动的行进螺钉(3) 由于所插入的螺栓(6)与螺栓(6)的轴向运动而导致的倾斜部分(8),弹簧片(5)以直径的方式向下挤压行进螺钉(3) 以及与行进螺钉(3)接合的导向突起(10,11),以防止螺栓(3)落入基座(2)中。 此外,在基座2上形成有用于行进螺钉2b的槽,以防止所述行进螺钉3沿圆周方向摆动。