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1. 发明授权

US07795355B2 Preparation of functional polymers 有权
标题翻译：官能聚合物的制备
公开(公告)号：US07795355B2
公开(公告)日：2010-09-14
申请号：US10591425
申请日：2005-03-07
申请人： Krzyszlof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
发明人： Krzyszlof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
IPC分类号： C08F8/30
CPC分类号： C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
摘要： The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
摘要翻译：本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。本发明的一个实施方案包括对聚合物进行点击化学反应。优选地，通过受控聚合方法制备聚合物。因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。

2. 发明申请

US20110060107A1 PREPARATION OF FUNCTIONAL POLYMERS 审中-公开
标题翻译：功能聚合物的制备
公开(公告)号：US20110060107A1
公开(公告)日：2011-03-10
申请号：US12877589
申请日：2010-09-08
申请人： Krzysztof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
发明人： Krzysztof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
IPC分类号： C08F8/30
CPC分类号： C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
摘要： The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials.Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form block copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
摘要翻译：本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。本发明的一个实施方案包括对聚合物进行点击化学反应。优选地，通过控制聚合方法制备聚合物。因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。

3. 发明授权

US07417096B2 Preparation of transition metal nanoparticles and surfaces modified with (CO) polymers synthesized by RAFT 失效
标题翻译：制备用RAFT合成的（CO）聚合物改性的过渡金属纳米粒子和表面
公开(公告)号：US07417096B2
公开(公告)日：2008-08-26
申请号：US11586126
申请日：2006-10-25
申请人： Charles L. McCormick, III , Andrew B. Lowe , Brent S. Sumerlin
发明人： Charles L. McCormick, III , Andrew B. Lowe , Brent S. Sumerlin
IPC分类号： C08F214/06
CPC分类号： B82Y30/00 , C01G5/00 , C01G7/00 , C01G55/00 , C01P2004/64 , C08F2/38 , C08F2/44 , C08F4/00 , C09C3/10 , Y10T428/31
摘要： A new, facile, general one-phase method of generating thiol-functionalized transition metal nanoparticles and surface modified by (co)polymers synthesized by the RAFT method is described. The method includes the steps of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a collidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as fuctionalization with a variety of different chemical groups, expanding their utility and application.
摘要翻译：描述了通过RAFT方法合成的由（共）聚合物生成巯基官能化的过渡金属纳米颗粒和表面改性的新的，简单的通用单相方法。该方法包括使用RAFT方法在水溶液中形成（共）聚合物的步骤，从合适的过渡金属形成碰撞过渡金属前体溶液; 将金属前体溶液或表面添加到（共）聚合物溶液中，向溶液中加入还原剂以原位还原金属胶体以产生稳定的纳米颗粒或表面，并以这样的方式分离稳定的纳米颗粒或表面，使得聚集被最小化。使用这些方法产生的官能化表面可以进一步进行平面表面修饰，例如用各种不同化学基团进行功能化，扩展其实用性和应用。

4. 发明授权

US07138468B2 Preparation of transition metal nanoparticles and surfaces modified with (CO)polymers synthesized by RAFT 有权
标题翻译：制备用RAFT合成的（CO）聚合物改性的过渡金属纳米粒子和表面
公开(公告)号：US07138468B2
公开(公告)日：2006-11-21
申请号：US10400346
申请日：2003-03-27
申请人： Charles L. McCormick, III , Andrew B. Lowe , Brent S. Sumerlin
发明人： Charles L. McCormick, III , Andrew B. Lowe , Brent S. Sumerlin
IPC分类号： C08F214/26
CPC分类号： B82Y30/00 , C01G5/00 , C01G7/00 , C01G55/00 , C01P2004/64 , C08F2/38 , C08F2/44 , C08F4/00 , C09C3/10 , Y10T428/31
摘要： A new, facile, general one-phase method of generating thio-functionalized transition metal nanoparticles and surfaces modified by (co)polymers synthesized by the RAFT method is described. The method includes the stops of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a colloidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as functionalization with a variety of different chemical groups, expanding their utility and application.
摘要翻译：描述了产生硫官能化过渡金属纳米颗粒和通过RAFT方法合成的（共）聚合物改性的表面的新的，简单的通用单相方法。该方法包括使用RAFT方法在水溶液中形成（共）聚合物的步骤，从合适的过渡金属形成胶态过渡金属前体溶液; 将金属前体溶液或表面添加到（共）聚合物溶液中，向溶液中加入还原剂以原位还原金属胶体以产生稳定的纳米颗粒或表面，并以这样的方式分离稳定的纳米颗粒或表面，使得聚集被最小化。使用这些方法产生的功能化表面可以进一步进行平面表面改性，例如用各种不同化学基团进行功能化，扩展它们的用途和应用。

5. 发明授权

US07186786B2 Chain transfer agents for RAFT polymerization in aqueous media 有权
公开(公告)号：US07186786B2
公开(公告)日：2007-03-06
申请号：US11057762
申请日：2005-02-14
申请人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
发明人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
IPC分类号： C08L33/26
CPC分类号： C07D213/30 , C07C327/36 , C08F2/38 , C08F4/00 , C08F220/56
摘要： Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.

6. 发明授权

US07179872B2 Chain transfer agents for RAFT polymerization in aqueous media 有权
标题翻译：用于水性介质中RAFT聚合的链转移剂
公开(公告)号：US07179872B2
公开(公告)日：2007-02-20
申请号：US11057760
申请日：2005-02-14
申请人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
发明人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
IPC分类号： C08F2/38
CPC分类号： C07D213/30 , C07C327/36 , C08F2/38 , C08F4/00 , C08F220/56
摘要： Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.
摘要翻译：通过产生窄范围分子量合成的聚合物和共聚物可以具有与通过常规方法合成的聚合物不同的性质。然而，为了获得这样的聚合物，必须控制聚合。一种受控聚合是可逆的加成 - 断裂链转移（RAFT）方法，其具有活性聚合的特征。本发明公开了一组适用于RAFT聚合的链转移剂的二硫代酯和三硫代酯。本发明还公开了在水介质中进行的RAFT聚合。

7. 发明授权

US06855840B2 Chain transfer agents for raft polymerization in aqueous media 有权
标题翻译：用于水性介质中筏聚合的链转移剂
公开(公告)号：US06855840B2
公开(公告)日：2005-02-15
申请号：US10337225
申请日：2003-01-06
申请人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
发明人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
IPC分类号： C07C327/36 , C07D213/30 , C08F2/00 , C08F2/38 , C08F4/00 , C07C327/00
CPC分类号： C07D213/30 , C07C327/36 , C08F2/38 , C08F4/00 , C08F220/56
摘要： Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.
摘要翻译：通过产生窄范围分子量合成的聚合物和共聚物可以具有与通过常规方法合成的聚合物不同的性质。然而，为了获得这样的聚合物，必须控制聚合。一种受控聚合是可逆的加成 - 断裂链转移（RAFT）方法，其具有活性聚合的特征。本发明公开了一组适用于RAFT聚合的链转移剂的二硫代酯和三硫代酯。本发明还公开了在水介质中进行的RAFT聚合。

8. 发明授权

US08084558B2 Preparation of transition metal nanoparticles and surfaces modified with (co)polymers synthesized by RAFT 有权
标题翻译：制备用RAFT合成的（共）聚合物改性的过渡金属纳米粒子和表面
公开(公告)号：US08084558B2
公开(公告)日：2011-12-27
申请号：US12176670
申请日：2008-07-21
申请人： Charles L. McCormick, III , Andrew B. Lowe , Brent S. Sumerlin
发明人： Charles L. McCormick, III , Andrew B. Lowe , Brent S. Sumerlin
IPC分类号： C08F214/06
CPC分类号： B82Y30/00 , C01G5/00 , C01G7/00 , C01G55/00 , C01P2004/64 , C08F2/38 , C08F2/44 , C08F4/00 , C09C3/10 , Y10T428/31
摘要： A new, facile, general one-phase method of generating thiol-functionalized transition metal nanoparticles and surfaces modified by (co)polymers synthesized by the RAFT method is described. The method includes the steps of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a colloidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as functionalization with a variety of different chemical groups, expanding their utility and application.
摘要翻译：描述了通过RAFT方法合成的由（共）聚合物修饰的产生巯基官能化的过渡金属纳米颗粒和表面改性的新的，简单的通用单相方法。该方法包括使用RAFT方法在水溶液中形成（共）聚合物的步骤，从合适的过渡金属形成胶态过渡金属前体溶液; 将金属前体溶液或表面添加到（共）聚合物溶液中，向溶液中加入还原剂以原位还原金属胶体以产生稳定的纳米颗粒或表面，并以这样的方式分离稳定的纳米颗粒或表面，使得聚集被最小化。使用这些方法产生的功能化表面可以进一步进行平面表面改性，例如用各种不同化学基团进行功能化，扩展它们的用途和应用。

9. 发明申请

US20100029545A1 BORONIC ACID-CONTAINING BLOCK COPOLYMERS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物递送的含硼酸的嵌段共聚物
公开(公告)号：US20100029545A1
公开(公告)日：2010-02-04
申请号：US12534916
申请日：2009-08-04
申请人： Brent S. Sumerlin , Jennifer N. Cambre , Debashish Roy
发明人： Brent S. Sumerlin , Jennifer N. Cambre , Debashish Roy
IPC分类号： A61K38/28 , A61K47/30 , A61K9/14
CPC分类号： A61K9/1273 , A61K9/1075 , A61K38/28 , C08F2/38
摘要： Polymeric nanoaggregate drug-delivery compositions including boron-containing copolymers are described. The drug-delivery compositions may further include a therapeutic agent comprising a nucleic acid, a polynucletide, a peptide, a polypeptide, a protein, a pharmaceutical or any combinations thereof. Methods for making the polymeric nanoaggregate compositions including at least one therapeutic agent (for example, insulin) as well as methods for administration of these compositions to mammals are also set forth. The disclosure also describes compositions and methods for controlled drug delivery. Further, polymeric nanoaggregate boron-containing compositions including insulin and methods for monitoring and regulating blood glucose levels of a mammal are also described. The disclosure also describes methods for treatment and/or control of diabetes mellitus by administering polymeric nanoaggregate boron-containing compositions including insulin to a mammal in need.
摘要翻译：描述了包含含硼共聚物的聚合物纳米颗粒药物递送组合物。药物递送组合物可以进一步包括包含核酸，多核苷酸，肽，多肽，蛋白质，药物或其任何组合的治疗剂。还提出了制备包含至少一种治疗剂（例如胰岛素）的聚合物纳米颗粒组合物的方法以及将这些组合物施用于哺乳动物的方法。本公开还描述了用于受控药物递送的组合物和方法。此外，还描述了包含胰岛素的聚合纳米颗粒含硼组合物以及用于监测和调节哺乳动物血糖水平的方法。本公开还描述了通过向需要的哺乳动物施用包含胰岛素的聚合纳米颗粒含硼组合物来治疗和/或控制糖尿病的方法。

10. 发明授权

US07402690B2 Chain transfer agents for raft polymerization in aqueous media 失效
标题翻译：用于水性介质中筏聚合的链转移剂
公开(公告)号：US07402690B2
公开(公告)日：2008-07-22
申请号：US11699266
申请日：2007-01-29
申请人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
发明人： Charles L. McCormick , Michael S. Donovan , Andrew B. Lowe , Brent S. Sumerlin , David B. Thomas
IPC分类号： C07C329/14
CPC分类号： C07D213/30 , C07C327/36 , C08F2/38 , C08F4/00 , C08F220/56
摘要： Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.
摘要翻译：通过产生窄范围分子量合成的聚合物和共聚物可以具有与通过常规方法合成的聚合物不同的性质。然而，为了获得这样的聚合物，必须控制聚合。一种受控聚合是可逆的加成 - 断裂链转移（RAFT）方法，其具有活性聚合的特征。本发明公开了一组适用于RAFT聚合的链转移剂的二硫代酯和三硫代酯。本发明还公开了在水介质中进行的RAFT聚合。

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