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1. 发明申请

US20150086103A1 MEDICAL IMAGE PROCESSOR AND STORAGE MEDIUM 有权
标题翻译：医学图像处理器和存储介质
公开(公告)号：US20150086103A1
公开(公告)日：2015-03-26
申请号：US14387415
申请日：2013-03-27
申请人： Konica Minolta, Inc. , Tohoku University
发明人： Akinori Tsunomori , Hisatake Okada , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06K9/0014 , G01N21/6458 , G06K9/00147 , G06T7/0012 , G06T2207/10061 , G06T2207/10064 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096
摘要： A medical image processor and a storage medium are shown. According to one implementation, the medical image processor includes the following. An input unit is used to input a cell shape image and a fluorescent image showing expression of a specific protein. A cell nucleus extracting unit extracts a cell nucleus. A fluorescent bright point extracting unit extracts a fluorescent bright point. A region estimating unit sets a predetermined region. When the set region does not overlap with another, it is estimated to include one cell. When a plurality of the set regions overlap, it is estimated to include a plurality of cells. A feature amount calculating unit calculates a feature amount. A determining unit determines whether each estimated cell region is cancer and determines an expression status in the region based on the calculated feature amount. An output unit outputs a determination result.
摘要翻译：显示医用图像处理器和存储介质。根据一个实施方案，医学图像处理器包括以下。输入单元用于输入细胞形状图像和显示特定蛋白质表达的荧光图像。细胞核提取单元提取细胞核。荧光亮点提取单元提取荧光亮点。区域估计单元设定预定区域。当设定区域与另一区域不重叠时，估计包含一个单元。当多个集合区域重叠时，估计包括多个单元。特征量计算单元计算特征量。确定单元确定每个估计的细胞区域是否是癌症，并且基于所计算的特征量确定该区域中的表达状态。输出单元输出确定结果。

2. 发明申请

US20150049936A1 MEDICAL IMAGE PROCESSOR AND STORAGE MEDIUM 有权
标题翻译：医学图像处理器和存储介质
公开(公告)号：US20150049936A1
公开(公告)日：2015-02-19
申请号：US14387405
申请日：2013-03-27
申请人： Konica Minolta, Inc. , Tohoku University
发明人： Akinori Tsunomori , Hisatake Okada , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe
IPC分类号： G06K9/00 , G06T7/00 , G06K9/46
CPC分类号： G06K9/0014 , G01N21/6456 , G01N21/6458 , G06K9/4661 , G06T7/0012 , G06T2207/10064 , G06T2207/20021 , G06T2207/20104 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096
摘要： A medical image processor and storage medium are shown. According to one implementation, a medical image processor includes an input unit, an operation unit, a cell nucleus extracting unit, a fluorescent bright point extracting unit, a feature amount calculating unit, and an output unit. The input unit is used to input a cell shape image showing a shape of a cell and a fluorescent image showing expression of a specific protein as a fluorescent bright point. The operation unit is used to specify an analysis target region. The cell nucleus extracting unit extracts a region of a cell nucleus. The fluorescent bright point extracting unit extracts a fluorescent bright point. The feature amount calculating unit calculates a feature amount showing an expression amount of the specific protein. The output unit outputs the calculated feature amount.
摘要翻译：显示医疗图像处理器和存储介质。根据一个实施方式，医用图像处理器包括输入单元，操作单元，单元核提取单元，荧光亮点提取单元，特征量计算单元和输出单元。输入单元用于输入显示细胞形状的细胞形状图像和显示特定蛋白质的表达的荧光图像作为荧光亮点。操作单元用于指定分析目标区域。细胞核提取单元提取细胞核的区域。荧光亮点提取单元提取荧光亮点。特征量计算单元计算显示特定蛋白质的表达量的特征量。输出单元输出计算出的特征量。

3. 发明授权

US09189678B2 Medical image processor and storage medium 有权
标题翻译：医用图像处理器和存储介质
公开(公告)号：US09189678B2
公开(公告)日：2015-11-17
申请号：US14387415
申请日：2013-03-27
申请人： Konica Minolta, Inc. , Tohoku University
发明人： Akinori Tsunomori , Hisatake Okada , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe
IPC分类号： G06K9/00 , G06T7/00 , G01N21/64
CPC分类号： G06K9/0014 , G01N21/6458 , G06K9/00147 , G06T7/0012 , G06T2207/10061 , G06T2207/10064 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096
摘要： A medical image processor and a storage medium are shown. According to one implementation, the medical image processor includes the following. An input unit is used to input a cell shape image and a fluorescent image showing expression of a specific protein. A cell nucleus extracting unit extracts a cell nucleus. A fluorescent bright point extracting unit extracts a fluorescent bright point. A region estimating unit sets a predetermined region. When the set region does not overlap with another, it is estimated to include one cell. When a plurality of the set regions overlap, it is estimated to include a plurality of cells. A feature amount calculating unit calculates a feature amount. A determining unit determines whether each estimated cell region is cancer and determines an expression status in the region based on the calculated feature amount. An output unit outputs a determination result.
摘要翻译：显示医用图像处理器和存储介质。根据一个实施方案，医学图像处理器包括以下。输入单元用于输入细胞形状图像和显示特定蛋白质表达的荧光图像。细胞核提取单元提取细胞核。荧光亮点提取单元提取荧光亮点。区域估计单元设定预定区域。当设定区域与另一区域不重叠时，估计包含一个单元。当多个集合区域重叠时，估计包括多个单元。特征量计算单元计算特征量。确定单元确定每个估计的细胞区域是否是癌症，并且基于所计算的特征量确定该区域中的表达状态。输出单元输出确定结果。

4. 发明授权

US09483684B2 Medical image processor and storage medium 有权
标题翻译：医用图像处理器和存储介质
公开(公告)号：US09483684B2
公开(公告)日：2016-11-01
申请号：US14387405
申请日：2013-03-27
申请人： Konica Minolta, Inc. , Tohoku University
发明人： Akinori Tsunomori , Hisatake Okada , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe
IPC分类号： G06K9/00 , G01N21/64 , G06K9/46 , G06T7/00
CPC分类号： G06K9/0014 , G01N21/6456 , G01N21/6458 , G06K9/4661 , G06T7/0012 , G06T2207/10064 , G06T2207/20021 , G06T2207/20104 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096
摘要： A medical image processor and storage medium are shown. According to one implementation, a medical image processor includes an input unit, an operation unit, a cell nucleus extracting unit, a fluorescent bright point extracting unit, a feature amount calculating unit, and an output unit. The input unit is used to input a cell shape image showing a shape of a cell and a fluorescent image showing expression of a specific protein as a fluorescent bright point. The operation unit is used to specify an analysis target region. The cell nucleus extracting unit extracts a region of a cell nucleus. The fluorescent bright point extracting unit extracts a fluorescent bright point. The feature amount calculating unit calculates a feature amount showing an expression amount of the specific protein. The output unit outputs the calculated feature amount.
摘要翻译：显示医疗图像处理器和存储介质。根据一个实施方式，医用图像处理器包括输入单元，操作单元，单元核提取单元，荧光亮点提取单元，特征量计算单元和输出单元。输入单元用于输入显示细胞形状的细胞形状图像和显示特定蛋白质的表达的荧光图像作为荧光亮点。操作单元用于指定分析目标区域。细胞核提取单元提取细胞核的区域。荧光亮点提取单元提取荧光亮点。特征量计算单元计算显示特定蛋白质的表达量的特征量。输出单元输出计算出的特征量。

5. 发明授权

US10551386B2 Biological substance detection method 有权
公开(公告)号：US10551386B2
公开(公告)日：2020-02-04
申请号：US15399489
申请日：2017-01-05
申请人： Konica Minolta, Inc.
发明人： Kensaku Takanashi , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe
IPC分类号： G01N33/58 , G01N21/64 , G01N33/569 , G01N33/574
摘要： The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of a part stained for morphological observation when the fluorescent label used for the immunostaining is observed.

6. 发明授权

US09244076B2 Fluorescent label for biological substance detection method 有权
标题翻译：生物物质检测方法荧光标签
公开(公告)号：US09244076B2
公开(公告)日：2016-01-26
申请号：US14200139
申请日：2014-03-07
申请人： Konica Minolta, Inc.
发明人： Kensaku Takanashi , Hisatake Okada , Yasushi Nakano
IPC分类号： A61K9/14 , G01N33/58 , G01N21/64 , G01N33/569 , G01N33/574
CPC分类号： G01N33/582 , G01N21/6428 , G01N33/56966 , G01N33/57492 , G01N2021/6439 , G01N2333/70596
摘要： The present invention provides a fluorescent label that can be used for carrying out a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The fluorescent label is a fluorescent dye-containing nanoparticle in which the parent material is a cross-linked polymer and the fluorescent dye is an aromatic ring-based dye molecule. The cross-linked polymer is suitably a melamine resin or a styrene resin. The aromatic ring-based dye molecule is suitably a perylene and more suitably a perylene diimide. The dye molecule can have a polar group such as sulfonic acid group or its acid halide.
摘要翻译：本发明提供一种荧光标记，其可用于进行用于特异性检测病理标本中的生物物质的生物物质检测方法，通过该方法，使用荧光标记进行免疫染色并使用染色剂进行形态观察染色同时进行形态学观察，即使通过用激发光照射使荧光标记和/或染色剂劣化，也可以适当地评价荧光观察和免疫染色的结果。荧光标记是含荧光染料的纳米颗粒，其中母体是交联聚合物，荧光染料是芳族环基染料分子。交联聚合物适当地是三聚氰胺树脂或苯乙烯树脂。芳族环染料分子合适地是苝，更合适地是苝二酰亚胺。染料分子可以具有极性基团，例如磺酸基或其酰卤。

7. 发明授权

US11378517B2 Biological substance detection method 有权
公开(公告)号：US11378517B2
公开(公告)日：2022-07-05
申请号：US15950648
申请日：2018-04-11
申请人： Konica Minolta, Inc.
发明人： Kensaku Takanashi , Hideki Goda , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Motohiro Takeda , Noriaki Ohuchi
IPC分类号： G01N21/64 , G01N33/58 , G01N33/483
摘要： A biological substance detection method for detecting a biological substance specifically in a pathological specimen, includes a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label.

8. 发明申请

US20150160103A1 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD 审中-公开
标题翻译：组织染色方法，组织评价方法和生物传感器检测方法
公开(公告)号：US20150160103A1
公开(公告)日：2015-06-11
申请号：US14626329
申请日：2015-02-19
申请人： Konica Minolta, Inc.
发明人： Takuji AIMIYA , Hideki Gouda , Hisatake Okada , Yasushi Nakano
IPC分类号： G01N1/30 , G01N33/74 , G01N33/58
CPC分类号： G01N1/30 , B82Y15/00 , B82Y30/00 , G01N21/6428 , G01N33/582 , G01N33/588 , G01N33/74 , G01N33/743 , G01N2001/302 , G01N2021/6441 , G01N2333/71 , G01N2333/723 , G01N2333/91205
摘要： A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances accumulated therein; in the stained tissue, counting fluorescent points or measuring fluorescent brightness; and evaluating the expression level of a biosubstance, which matches the biosubstance recognition site, in the aforesaid tissue on the basis of the number of the fluorescent points or fluorescent brightness that was measured.
摘要翻译：一种组织染色方法，包括：用染色试剂染色组织，其中生物素识别位点与携带其中积聚的多种荧光物质的颗粒结合; 在染色的组织中，计数荧光点或测量荧光亮度; 并根据测定的荧光点数或荧光亮度，评价与上述组织中生物素识别位点相符合的生物体的表达水平。

9. 发明授权

US11435348B2 Tissue staining method 有权
公开(公告)号：US11435348B2
公开(公告)日：2022-09-06
申请号：US16715180
申请日：2019-12-16
申请人： Konica Minolta, Inc.
发明人： Hideki Gouda , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe
IPC分类号： G01N33/569 , G01N1/30
摘要： It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.

10. 发明授权

US11275087B2 Test support method for supporting prediction of pathological complete response (pCR) using fluorescent nanoparticles 有权
公开(公告)号：US11275087B2
公开(公告)日：2022-03-15
申请号：US15806970
申请日：2017-11-08
申请人： Konica Minolta, Inc.
发明人： Hideki Gouda , Masaru Takahashi , Kensaku Takanashi , Hisatake Okada , Yuichi Ozaki , Yuka Yoshihara , Yasushi Nakano , Kohsuke Gonda , Noriaki Ohuchi , Mika Watanabe , Norikazu Masuda , Masakazu Toi , Hiroshi Tada , Minoru Miyashita
IPC分类号： G01N33/574 , G01N33/52 , G01N33/53 , G06K9/00 , G01N33/58 , G01N1/30 , G01N33/50
摘要： The present invention relates to a test support method which is a means for predicting whether or not pathological complete response (pCR) will be attained when a preoperative chemotherapy with an anticancer drug is performed, the method using a sample (breast cancer tissue section) collected from a breast cancer patient to be subjected to the preoperative chemotherapy. The test support method includes: [1] the step of acquiring a fluorescence image of a breast cancer tissue section, which fluorescence image shows bright spots of fluorescent nanoparticles labeling one or more kinds of breast cancer-related proteins; [2] the step of acquiring at least one index relating to the expression level(s) of the breast cancer-related protein(s) on the basis of the bright spots of the fluorescence image; and [3] the step of acquiring information for predicting pCR by performing an analysis using the above-described at least one index.

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