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    • 1. 发明授权
    • Process for preparing liposome composition
    • 制备脂质体组合物的方法
    • US5662931A
    • 1997-09-02
    • US505180
    • 1995-08-11
    • Koji MunechikaTomoyo SekiNorihide KishiHiroshi MatsudaYasuo Ueda
    • Koji MunechikaTomoyo SekiNorihide KishiHiroshi MatsudaYasuo Ueda
    • A61K9/127
    • A61K9/1277
    • The object of the present invention is to provide a process for preparing a drug-containing liposome composition in which (1) a drug to be included into liposomes, particularly a physiologically active protein having a molecular weight of from 500 to 100,000, can be prevented from decomposition and (2) a high rate of drug inclusion can be attained; (3) the resulting liposome composition can be subcutaneously or intramuscularly administered and (4) makes contribution to sustained release of the drug. The process comprises (1) dissolving a lipid in a first organic solvent, (2) adding a drug-containing aqueous solution to the lipid solution, followed by emulsifying to obtain an emulsion, (3) mixing the emulsion at a low temperature with a second organic solvent in which the lipid is sparingly soluble, (4) collecting the precipitated fraction, and (5) suspending the precipitated fraction in an aqueous solvent.
    • PCT No.PCT / JP94 / 00075 Sec。 371日期:1995年8月11日 102(e)日期1995年8月11日PCT 1994年1月20日PCT PCT。 WO94 / 18948 PCT公开 日本1994年9月1日本发明的目的是提供一种制备含药物的脂质体组合物的方法,其中(1)包含在脂质体中的药物,特别是分子量为500〜 100,000,可以防止分解,(2)可以获得高速率的药物包合; (3)所得的脂质体组合物可以皮下或肌肉内施用,(4)有助于药物的持续释放。 该方法包括(1)将脂质溶解在第一有机溶剂中,(2)向脂质溶液中加入含药水溶液,然后乳化以获得乳液,(3)将低温下的乳液与 第二有机溶剂,其中脂质微溶,(4)收集沉淀的级分,和(5)将沉淀的级分悬浮在水性溶剂中。
    • 6. 发明申请
    • Strain Measuring Method, Strain Measuring Device and Program
    • 应变测量方法,应变测量装置和程序
    • US20130013224A1
    • 2013-01-10
    • US13394116
    • 2010-09-02
    • Yukihiro ItoKenyu InoueHiroshi MatsudaMasakazu Uchino
    • Yukihiro ItoKenyu InoueHiroshi MatsudaMasakazu Uchino
    • G06F19/00G01L1/24
    • G01B11/16G01B11/0608G01B11/24
    • A strain measuring device is provided which is not affected by a change in the intensity and irradiation direction of light received by a measurement target and which enables stable measurement. A computer functions as minute region extracting device for extracting respective surface height distributions of minute regions a and b containing points A and B in a predetermined region from an initial surface height distribution obtained by measuring the predetermined region (6) of the measurement target by a surface height measuring device, coordinate calculating device for calculating coordinates of points A′ and B′ in minute regions a′ and b′ most similar to the minute regions a and b over a time-advanced surface height distribution of the predetermined region 6 and corresponding to the points A and B in the minute regions a and b, respectively, and strain calculating device for calculating a strain in a direction of a line AB of the measurement target.
    • 提供一种应变测量装置,其不受测量对象所接收的光的强度和照射方向的变化的影响,能够进行稳定的测量。 计算机用作微区域提取装置,用于从通过测量目标的预定区域(6)获得的初始表面高度分布提取预定区域中包含点A和B的微小区域a和b的各个表面高度分布, 表面高度测量装置,用于计算与预定区域6的时间提前表面高度分布最相似的微小区域a'和b'的微小区域a'和b'中的点A'和B'的坐标的坐标计算装置 分别与微小区域a和b中的点A和点B相对应,以及应变计算装置,用于计算测量对象的线AB的方向上的应变。
    • 7. 发明申请
    • IMAGE FORMING APPARATUS, CONTROL METHOD THEREOF, AND STORAGE MEDIUM
    • 图像形成装置,其控制方法和存储介质
    • US20120250094A1
    • 2012-10-04
    • US13434469
    • 2012-03-29
    • Hiroshi Matsuda
    • Hiroshi Matsuda
    • G06K15/02
    • G06K15/12G06K15/129G06K15/1857
    • An image forming apparatus includes a renderer configured to render a one page amount of image data based on intermediate data generated by either a first execution unit or a second execution unit, a printer engine configured to form image data of a page rendered by the renderer on a recording medium, and after forming the image data, stop each unit in the engine when there is no image data formation instruction corresponding to a next page of the page even after a cycle down time limit has elapsed, and a request unit configured to, during generation of intermediate data of a predetermined page by the first execution unit, request an extension of the cycle down time limit set in the printer engine based on a number of pages of rendered image data corresponding to intermediate data of pages following the predetermined page.
    • 一种图像形成装置,包括:渲染器,被配置为基于由第一执行单元或第二执行单元生成的中间数据来呈现一页数量的图像数据,打印机引擎被配置为形成由渲染器呈现的页面的图像数据 记录介质,并且在形成图像数据之后,即使在经过了循环停止时间限制之后,当也没有与页面的下一页对应的图像数据形成指令时,停止发动机中的每个单元,以及请求单元, 在由第一执行单元生成预定页面的中间数据期间,基于与预定页面之后的页面的中间数据对应的渲染图像数据的页数,请求在打印机引擎中设置的循环下降时间的扩展。