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1. 发明授权

US5468635A In vitro method for stimulating cell growth by culturing cells in a serum-free culture medium comprising human lysozyme 失效
标题翻译：通过在包含人溶菌酶的无血清培养基中培养细胞来刺激细胞生长的体外方法
公开(公告)号：US5468635A
公开(公告)日：1995-11-21
申请号：US243074
申请日：1994-05-16
申请人： Koji Komiya , Tetsuya Takezono , Noritsugu Yabe , Hisao Matsui
发明人： Koji Komiya , Tetsuya Takezono , Noritsugu Yabe , Hisao Matsui
IPC分类号： C12N5/10 , C12N5/07 , C12N5/078 , C12N5/0783 , C12N5/09 , C12N5/16 , C12P21/00 , C12P21/08 , C12R1/91 , C12N5/00
CPC分类号： C12N5/0636 , C12N2500/90 , C12N2501/23 , C12N2501/70
摘要： The invention relates to an agent for promoting growth in animal cells. The agent contains a serum-free medium and lysozyme. The agent can optionally contain cytokines. The invention further relates to an in vitro method of stimulating the growth of T lymphoblastoid cells and peripheral blood lymphocytes, which comprises the step of culturing the T lymphoblastoid cells or peripheral blood lymphocytes in a serum-free culture medium comprising human lysozyme, as a growth stimulating agent, at a concentration of about 4-100 mg/liter.
摘要翻译：本发明涉及促进动物细胞生长的药剂。该试剂含有无血清培养基和溶菌酶。该试剂可任选地含有细胞因子。本发明还涉及刺激T淋巴母细胞细胞和外周血淋巴细胞生长的体外方法，其包括在包含人溶菌酶的无血清培养基中培养T淋巴母细胞细胞或外周血淋巴细胞作为生长的步骤浓度为约4-100mg /升的刺激剂。

2. 发明授权

US5336605A Production of podophyllotoxins using podophyllum 失效
标题翻译：使用鬼臼鱼生产鬼臼毒素
公开(公告)号：US5336605A
公开(公告)日：1994-08-09
申请号：US11671
申请日：1993-02-01
申请人： Ko Sakata , Eitaroh Morita , Tetsuya Takezono
发明人： Ko Sakata , Eitaroh Morita , Tetsuya Takezono
IPC分类号： A01H4/00 , C12N5/00 , C12N5/04 , C12P17/18 , C12N5/02
CPC分类号： C12N5/04 , A01H4/00 , C12N5/0025 , C12P17/181
摘要： A process for the preparation of an adventive embryo of a plant belonging to the genus Podophyllum, comprising the steps of preparing cells of a plant belonging to the genus Podophyllum, incubating the cells in a sugar free medium or a medium containing up to 2% by weight sugar, and then incubating the cells in a medium containing more than 2% by weight of sugar to generate an adventive embryo; a process for the production of a podophyllotoxin compound comprising the steps of preparing an adventive embryo of a plant belonging to the genus Podophyllum, culturing the adventive embryo to generate an adventitious organ, culturing the adventitious organ to produce a podophyllotoxin compound, and recovering the podophyllotoxin compound; and a process for the production of a podophyllotoxin compound, comprising the steps of preparing de-differentiated cells or tissue of a plant belonging to the genus Podophyllum culturing the de-differentiated cells or tissue in a liquid medium to generate a differentiated organ, culturing the differentiated organ on a solid medium to produce a podophyllotoxin compound, and recovering the podophyllotoxin compound.
摘要翻译：一种制备属于Podophyllum属的植物的外来胚胎的方法，包括以下步骤：制备属于Podophyllum属植物的细胞，将无细胞培养基中的细胞或含有高达2％的培养基重量糖，然后将细胞在含有超过2重量％糖的培养基中培养以产生外来胚胎; 一种生产鬼臼毒素化合物的方法，包括以下步骤：制备属于Podophyllum属植物的外来胚胎，培养外来胚胎以产生外来器官，培养外来器官以产生鬼臼毒素化合物，并回收鬼臼毒素复合; 以及生产鬼臼毒素化合物的方法，包括以下步骤：在液体培养基中培养属于茯苓属的植物的去分化细胞或组织培养分化的细胞或组织以产生分化的器官，培养分离的器官在固体培养基上产生鬼臼毒素化合物，并回收鬼臼毒素化合物。

3. 发明授权

US4656307A Derivative of brendane and process for preparing the same 失效
标题翻译：布伦烷的衍生物及其制备方法
公开(公告)号：US4656307A
公开(公告)日：1987-04-07
申请号：US755241
申请日：1985-07-15
申请人： Yoshihiro Kobori , Tetsuya Takezono
发明人： Yoshihiro Kobori , Tetsuya Takezono
IPC分类号： B01J31/12 , C07B61/00 , C07C51/00 , C07C51/14 , C07C62/24 , C07C67/00 , C07C67/38 , C07C69/757 , C07C61/12
CPC分类号： C07C62/24
摘要： According to the invention a derivative of brendane is provided. The derivative of brendane is represented by the general formula of: ##STR1## wherein R is a hydrogen atom or a hydrocarbon group having 1 to 6 carbon atoms, and R.sup.1 to R.sup.3 each represent a hydrogen atom or a methyl group. The brendane derivative is prepared by reacting an alkenylnorbornene of the general formula of: ##STR2## wherein R.sup.1 to R.sup.3 each represent a hydrogen atom or a methyl group, with carbon monoxide and an alcohol or water in the presence of a catalyst of Group VIII metal compound of the periodic table.
摘要翻译：根据本发明，提供了布伦烷衍生物。布伦烷的衍生物由以下通式表示：其中R是氢原子或具有1至6个碳原子的烃基，R1至R3各自表示氢原子或甲基。布伦烷衍生物通过在VIII族金属的催化剂存在下使通式为：其中R 1至R 3各自表示氢原子或甲基的烯基降冰片烯与一氧化碳和醇或水反应制备周期表的化合物。

4. 发明授权

US4645576A Process for isolating and recovering butene-1 of high purity 失效
标题翻译：用于分离和回收高纯度丁烯-1的方法
公开(公告)号：US4645576A
公开(公告)日：1987-02-24
申请号：US608746
申请日：1984-05-10
申请人： Tetsuya Takezono , Takaaki Amari , Hirosuke Imai
发明人： Tetsuya Takezono , Takaaki Amari , Hirosuke Imai
IPC分类号： B01J21/12 , C07B61/00 , C07C1/00 , C07C7/00 , C07C7/177 , C07C11/08 , C07C67/00 , B01D3/34
CPC分类号： C07C7/005 , C07C7/177 , Y10S203/06
摘要： This invention provides a process for isolating and recovering butene-1 of high purity at high yield. Firstly, a butane-butene fraction containing 0.1 to 7 wt % of isobutylene, 10 to 50 wt % of butene-1 and 5 to 20 wt % of isobutane is rectified to reduce the content of isobutane to not more than 0.1 wt %. Then, the rectified butane-butene fraction is passed through a reactor packed with an extrusion molded silica-alumina catalyst to polymerize isobutylene at a reaction velocity as high as 50 times or more of that of butene-1, thus forming oligomers of isobutylene. Finally, the hydrocarbon mixture from the reactor is rectified to remove the oligomers of isobutylene and the other C.sub.4 -hydrocarbons.
摘要翻译：本发明提供以高产率分离和回收高纯度的丁烯-1的方法。首先，将含有0.1〜7重量％的异丁烯，10〜50重量％的丁烯-1和5〜20重量％的异丁烷的丁烷 - 丁烯馏分进行精馏，将异丁烷的含量降低至0.1重量％以下。然后，将精馏的丁烷 - 丁烯馏分通过填充有挤出成型二氧化硅 - 氧化铝催化剂的反应器，以高达丁烯-1的50倍以上的反应速度聚合异丁烯，从而形成异丁烯的低聚物。最后，将来自反应器的烃混合物进行精馏以除去异丁烯和其它C 4烃的低聚物。

5. 发明授权

US5225343A Process for preparation of an adventive embryo of podophyllum 失效
标题翻译：制备PODOPHYLLUM的先进的EMBRYO的方法
公开(公告)号：US5225343A
公开(公告)日：1993-07-06
申请号：US603361
申请日：1990-10-26
申请人： Ko Sakata , Eitaroh Morita , Tetsuya Takezono
发明人： Ko Sakata , Eitaroh Morita , Tetsuya Takezono
IPC分类号： A01H4/00 , C12N5/00 , C12N5/04 , C12P17/18
CPC分类号： C12N5/04 , A01H4/00 , C12N5/0025 , C12P17/181
摘要： A process for the preparation of an adventive embryo of a plant belonging to the genus Podophyllum, comprising the steps of preparing cells of a plant belonging to the genus Podophyllum, incubating the cells in a sugar free medium or a medium containing up to 2% by weight sugar, and then incubating the cells in a medium containing more than 2% by weight of sugar to generate an adventive embryo; a process for the production of a podophyllotoxin compound comprising the steps of preparing an adventive embryo of a plant belonging to the genus Podophyllum, culturing the adventive embryo to generate an adventitious organ, culturing the adventitious organ to produce a podophyllotoxin compound, and recovering the podophyllotoxin compound; and a process for the production of a podophyllotoxin compound, comprising the steps of preparing de-differentiated cells or tissue of a plant belonging to the genus Podophyllum culturing the de-differentiated cells or tissue in a liquid medium to generate a differentiated organ, culturing the differentiated organ on a solid medium to produce a podophyllotoxin compound, and recovering the podophyllotoxin compound.

6. 发明授权

US4650885A Process for preparing derivatives of naphthazarin 失效
标题翻译：制备萘氮芥衍生物的方法
公开(公告)号：US4650885A
公开(公告)日：1987-03-17
申请号：US857357
申请日：1986-04-30
申请人： Yoshihiro Kobori , Tetsuya Takezono
发明人： Yoshihiro Kobori , Tetsuya Takezono
IPC分类号： C07D307/12
CPC分类号： C07D307/12
摘要： A process is provided for preparing a derivative of naphthazarin represented by the general formula (I) of: ##STR1## wherein X.sub.1, X.sub.2 and X.sub.3 each stands for an atom or a group consisting of hydrogen, a hydroxyl group, organic residues and halogens; and R.sub.1 to R.sub.6 each stands for an atom or a group selected from the group consisting of hydrogen and hydrocarbon groups. The derivative of naphthazarin is prepared by the step of reacting, in the presence of an acid catalyst, the following compounds represented by the general formulae (II) and (III): ##STR2## wherein R is an atom or a group selected from the group consisting of hydroxyl, oxyhydrocarbon, siloxy and acyloxy groups and halogen atoms.
摘要翻译：提供了制备由以下通式（I）表示的萘甲素衍生物的方法：其中X1，X2和X3各自表示原子或由氢，羟基，有机残基组成的组和卤素; R1〜R6各自表示选自氢和烃基的原子或基团。通过在酸催化剂存在下使通式（II）和（III）表示的下列化合物反应的方法制备萘氮杂衍生物：其中R 是选自羟基，羟基烃，甲硅烷氧基和酰氧基和卤素原子的原子或基团。

7. 发明授权

US4404409A Process for preparing methyl tertiary-butyl ether 失效
标题翻译：制备甲基叔丁基醚的方法
公开(公告)号：US4404409A
公开(公告)日：1983-09-13
申请号：US125655
申请日：1980-02-28
申请人： Yasuo Fujiwara , Tetsuya Takezono
发明人： Yasuo Fujiwara , Tetsuya Takezono
IPC分类号： C07C43/04 , B01J31/00 , C07B61/00 , C07C41/06 , C07C41/00
CPC分类号： C07C41/06
摘要： A process for continuously preparing methyl tertiary-butyl ether with high yield involves reacting an isobutylene-containing/hydrocarbon and methanol by continuously passing the isobutylene and methanol, in a molar ratio of isobutylene to methanol of 1 to 0.6-1.4 at a temperature of 60.degree.-100.degree. C. at a liquid space velocity of 0.1-50 l/hour and at a pressure of 1-50 atmospheres, through a first reactor filled with strong acid type cation exchange resin particles having an average particle diameter of 0.2-10 mm; dividing the mixture of the reaction products in two streams, the flow rate of the first stream being 3-15 times the flow rate of the second stream; recycling the first stream to the first reactor; passing the second stream, at a temperature of 20.degree.-55.degree. C. at a liquid space velocity of 0.1-50 l/hour and at a pressure of 1-50 atmospheres, through a second reactor filled with strong acid type cation exchange resin particles having an average particle diameter of 0.2-10 mm; passing the stream from the second reactor through a fixed bed filled with a water-insoluble solid particulate acid neutralizing agent having an average particle diameter of 0.1-10 mm at a temperature of about 0.degree.-55.degree. C.; passing the resulting reaction mixture into a flashing tower whereby the unreacted hydrocarbon is removed; and recovering a mixture containing MTBE from the bottom of the flashing tower.
摘要翻译：以高产率连续制备甲基叔丁基醚的方法包括使异丁烯/烃和甲醇通过连续使异丁烯和甲醇以异丁烯与甲醇的摩尔比在1至0.6-1.4的温度下反应，温度为60℃ 以0.1-50升/小时的液体空间速度和1-50大气压的压力，通过填充有强酸型阳离子交换树脂颗粒的平均粒径为0.2-10的第一反应器毫米将反应产物的混合物分成两股，第一流的流量为第二料流的流量的3-15倍; 将第一流回收到第一反应器; 在20〜-5℃的温度下以0.1-50升/小时的液体空间速度和1-50大气压的压力，通过填充有强酸型阳离子交换树脂的第二反应器平均粒径为0.2-10mm的颗粒; 使来自第二反应器的物流在约0-55℃的温度下通过填充有平均粒径为0.1-10mm的水不溶性固体颗粒酸中和剂的固定床; 将所得反应混合物通入闪蒸塔，除去未反应的烃; 并从闪光塔的底部回收含有MTBE的混合物。

8. 发明授权

US4356339A Process for isolating and recovering butene-1 of high purity 失效
标题翻译：用于分离和回收高纯度丁烯-1的方法
公开(公告)号：US4356339A
公开(公告)日：1982-10-26
申请号：US328317
申请日：1981-12-07
申请人： Masao Imaizumi , Tetsuya Takezono , Takaaki Amari , Yutaka Oguchi
发明人： Masao Imaizumi , Tetsuya Takezono , Takaaki Amari , Yutaka Oguchi
IPC分类号： C07C7/177 , C07C11/08 , C07C7/12
CPC分类号： C07C11/08 , C07C7/177 , Y02P20/582
摘要： A process for isolating and recovering butene-1 of high purity at a high yield is provided. The process comprises the steps of continuously passing a butane-butene fraction containing 0.1 to 15 wt % of isobutylene and 10 to 50 wt % of butene-1 through a first reactor packed with a strongly acidic cation exchange resin having an average particle size of from 0.2 to 10 mm at a temperature of from 30.degree. to 100.degree. C. and at a space velocity of liquid of from 0.1 to 50 hr.sup.-1 under a pressure of from 1 to 50 atm., dividing the output mixture flowing out of said first reactor into two flows at a division ratio in flow rate of 1.about.15:1, recirculating the first flow having the flow rate of 1.about.15 into said first reactor packed with said cation exchange resin, passing the second flow having the flow rate of 1 through a second reactor packed with a strongly acidic cation exchange resin under the conditions similar to those of the first reactor, distilling the output flow from said second reactor to separate the same into a heavy hydrocarbon fraction containing oligomers of isobutylene and a light hydrocarbon fraction containing butane and butene, and rectifying said light hydrocarbon fraction to isolate butene-1 from other C.sub.4 -hydrocarbons.
摘要翻译：提供了以高产率分离和回收高纯度的丁烯-1的方法。该方法包括以下步骤：将含有0.1至15重量％的异丁烯和10至50重量％的丁烯-1的丁烷 - 丁烯馏分连续通过填充有平均粒度为在30〜100℃的温度下，在1〜50个大气压的压力为0.1〜50小时-1的液体空间速度下0.2〜10mm，将输出混合物从所述将第一反应器分成两个流量，流速为1分钟的分流比为15:1，将具有1分歧15的流速的第一流再循环到装有阳离子交换树脂的第一反应器中，使具有流速的第二流在与第一反应器类似的条件下通过填充有强酸性阳离子交换树脂的第二反应器蒸馏来自第二反应器的输出流，将其分离成含有低聚物的重质烃馏分 rs的异丁烯和含有丁烷和丁烯的轻烃馏分，并精馏所述轻烃馏分以将丁烯-1与其它C 4烃分离。

9. 发明授权

US4256465A Method for producing methyl tert-butyl ether and fuel composition containing the same 失效
标题翻译：制备甲基叔丁基醚的方法和含有该叔丁基醚的燃料组合物
公开(公告)号：US4256465A
公开(公告)日：1981-03-17
申请号：US059377
申请日：1979-07-20
申请人： Tetsuya Takezono , Yasuo Fujiwara
发明人： Tetsuya Takezono , Yasuo Fujiwara
IPC分类号： C07C41/00 , C07C41/06 , C07C41/36 , C07C41/42 , C07C43/04 , C10L1/02 , C10L1/18
CPC分类号： C10L10/10 , C07C41/06 , C10L1/02 , C10L1/1852 , C10L10/02
摘要： A method for producing methyl tert-butyl ether which comprises the steps of: allowing isobutylene-containing hydrocarbon and methyl alcohol in a given molar ratio to react at a given temperature, pressure and liquid space velocity in the presence of strongly acidic cation-exchange resin catalyst; then passing the reaction product through a fixed bed filled with a water-insoluble, solid particulate acid-neutralizing agent; and subjecting the effluent to flashing operation, preferably also to rectification, to obtain methyl tert-butyl ether. Further included in the invention is the preparation of a fuel composition by mixing the thus obtained methyl tert-butyl ether into an internal combustion fuel.
摘要翻译：一种生产甲基叔丁基醚的方法，包括以下步骤：使含异丁烯的烃和甲醇以给定的摩尔比在给定的温度，压力和液体空间速度下在强酸性阳离子交换树脂催化剂; 然后使反应产物通过填充有不溶于水的固体颗粒酸中和剂的固定床; 并对流出物进行闪蒸操作，优选进行精馏，得到甲基叔丁基醚。本发明还包括通过将由此获得的甲基叔丁基醚混合到内燃燃料中制备燃料组合物。

10. 发明授权

US4182913A Method for producing methyl tert-butyl ether and fuel composition containing the same 失效
标题翻译：制备甲基叔丁基醚的方法和含有该叔丁基醚的燃料组合物
公开(公告)号：US4182913A
公开(公告)日：1980-01-08
申请号：US853192
申请日：1977-11-21
申请人： Tetsuya Takezono , Yasuo Fujiwara
发明人： Tetsuya Takezono , Yasuo Fujiwara
IPC分类号： C07C41/00 , C07C41/06 , C07C41/36 , C07C41/42 , C07C43/04 , C10L1/02 , C10L1/18
CPC分类号： C10L10/10 , C07C41/06 , C10L1/02 , C10L1/1852 , C10L10/02
摘要： A method for producing methyl tert-butyl ether which comprises the steps of: allowing isobutylene-containing hydrocarbon and methyl alcohol in a given molar ratio to react at a given temperature, pressure and liquid space velocity in the presence of strongly acidic cation-exchange resin catalyst; then passing the reaction product through a fixed bed filled with a water-insoluble, solid particulate acid-neutralizing agent; and subjecting the effluent to flashing operation, preferably also to rectification, to obtain methyl tert-butyl ether. Further included in the invention is the preparation of a fuel composition by mixing the thus obtained methyl tert-butyl ether into an internal combustion fuel.
摘要翻译：一种生产甲基叔丁基醚的方法，包括以下步骤：使含异丁烯的烃和甲醇以给定的摩尔比在给定的温度，压力和液体空间速度下在强酸性阳离子交换树脂催化剂; 然后使反应产物通过填充有不溶于水的固体颗粒酸中和剂的固定床; 并对流出物进行闪蒸操作，优选进行精馏，得到甲基叔丁基醚。本发明还包括通过将由此获得的甲基叔丁基醚混合到内燃燃料中制备燃料组合物。

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