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    • 1. 发明授权
    • Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens and method of inhibiting terpenoid adsorption
    • 用于软性隐形眼镜的眼用组合物,增强软性隐形眼镜的润湿性的方法和抑制萜类吸附的方法
    • US06479556B2
    • 2002-11-12
    • US09931764
    • 2001-08-20
    • Koji DoiHisayuki NakayamaTakuya NakajimaNoriko Sakai
    • Koji DoiHisayuki NakayamaTakuya NakajimaNoriko Sakai
    • A01N3100
    • A61K31/125A61K9/0048A61K31/045Y10S514/912
    • The present invention provides an ophthalmic composition for soft contact lenses (SCL), which contains a terpenoid as an active ingredient, an ophthalmic composition for SCL, which contains polyoxyethylene sorbitan ester, a method of enhancing the wettability of soft contact lenses, which comprises bringing terpenoid into contact with SCL and a method of inhibiting adsorption of terpenoid onto SCL, which comprises adding polyoxyethylene sorbitan ester to an ophthalmic composition containing a terpenoid. The ophthalmic composition containing a terpenoid improves, for example, the wettability of SCL, thereby to inhibit decrease in the water content of SCL. As a result, it can inhibit a dry feeling and an uncomfortable feeling during wearing SCL and is useful for enhancing the wettability of SCL. Further, addition of polyoxyethylene sorbitan ester leads to the inhibition of adsorption of terpenoid onto SCL.
    • 本发明提供一种含有萜类化合物作为活性成分的软性隐形眼镜(SCL)用眼用组合物,含有聚氧乙烯山梨聚糖酯的SCL用眼用组合物,增强软性隐形眼镜的润湿性的方法, 萜类化合物与SCL接触以及抑制萜类化合物在SCL上吸附的方法,其包括将聚氧乙烯失水山梨醇酯加入到含有萜类化合物的眼用组合物中。 包含萜类化合物的眼用组合物改善了例如SCL的润湿性,从而抑制了SCL的水分含量的降低。 结果,可以抑制穿着SCL时的干燥感和不适感,并且对于提高SCL的润湿性是有用的。 此外,加入聚氧乙烯脱水山梨糖醇酯导致抑制萜类化合物在SCL上的吸附。
    • 2. 发明授权
    • Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens, and method of inhibiting terpenoid adsorption
    • 用于软性隐形眼镜的眼用组合物,增强软性隐形眼镜的润湿性的方法以及抑制萜类吸附的方法
    • US06545058B2
    • 2003-04-08
    • US09486212
    • 2000-02-24
    • Koji DoiHisayuki NakayamaTakuya NakajimaNoriko Sakai
    • Koji DoiHisayuki NakayamaTakuya NakajimaNoriko Sakai
    • A61K31045
    • A61K31/125A61K9/0048A61K31/045Y10S514/912
    • The present invention provides an ophthalmic composition for soft contact lenses (SCL), which contains a terpenoid as an active ingredient, an ophthalmic composition for SCL, which contains polyoxyethylene sorbitan ester, a method of enhancing the wettability of soft contact lenses, which comprises bringing terpenoid into contact with SCL and a method of inhibiting adsorption of terpenoid onto SCL, which comprises adding polyoxyethylene sorbitan ester to an ophthalmic composition containing a terpenoid. The ophthalmic composition containing a terpenoid improves, for example, the wettability of SCL, thereby to inhibit decrease in the water content of SCL. As a result, it can inhibit a dry feeling and an uncomfortable feeling during wearing SCL and is useful for enhancing the wettability of SCL. Further, addition of polyoxyethylene sorbitan ester leads to the inhibition of adsorption of terpenoid onto SCL.
    • 本发明提供一种含有萜类化合物作为活性成分的软性隐形眼镜(SCL)用眼用组合物,含有聚氧乙烯山梨聚糖酯的SCL用眼用组合物,增强软性隐形眼镜的润湿性的方法, 萜类化合物与SCL接触以及抑制萜类化合物在SCL上吸附的方法,其包括将聚氧乙烯失水山梨醇酯加入到含有萜类化合物的眼用组合物中。 包含萜类化合物的眼用组合物可改善例如SCL的润湿性,从而抑制SCL的水分含量降低。 结果,可以抑制穿着SCL时的干燥感和不适感,并且对于提高SCL的润湿性是有用的。 此外,加入聚氧乙烯脱水山梨糖醇酯导致抑制萜类化合物在SCL上的吸附。
    • 4. 发明授权
    • Agent for contact lenses
    • 隐形眼镜代理
    • US5994405A
    • 1999-11-30
    • US10798
    • 1998-01-22
    • Koji DoiShuuichi NishihataTakuya Nakajima
    • Koji DoiShuuichi NishihataTakuya Nakajima
    • A01N37/18A61L12/14A61K31/16
    • A61L12/14A01N37/18Y10S514/912
    • An agent for contact lenses, comprising chloroacetamide. According to the present invention, chloroacetamide, which is the bacteriocidal component to be contained, is scarcely adsorbed not only to hard contact lenses and gas-permeable hard contact lenses, but also to soft contact lenses, and even if adsorbed, moreover, chloroacetamide is quickly released and is not accumulated on the contact lens to a greater extent. The inventive agent containing, in addition to chloroacetamide, sodium lauryl sulfate shows more superior bacteriocidal effect and cleaning effect. Therefore, the present invention provides an agent for contact lenses having superior bacteriocidal effect and cleaning effect, which can be used safely and with ease for various contact lenses inclusive of soft contact lenses.
    • 隐形眼镜剂,包含氯乙酰胺。 根据本发明,作为所含有的杀菌成分的氯乙酰胺不仅难以吸附在硬性隐形眼镜和透气性硬隐形眼镜上,而且也被吸附在软性隐形眼镜上,而且氯乙酰胺是 迅速释放并且不会在隐形眼镜上积累更多的程度。 含有氯乙酰胺十二烷基硫酸钠的本发明剂具有更优异的杀菌效果和清洁效果。 因此,本发明提供了具有优良杀菌效果和清洁效果的隐形眼镜剂,其可以安全地并且容易地用于包括软性隐形眼镜的各种隐形眼镜。
    • 9. 发明授权
    • Photochromic compound and optical functional material
    • 光致变色化合物和光学功能材料
    • US07628938B2
    • 2009-12-08
    • US11723668
    • 2007-03-21
    • Tsuyoshi KawaiTakuya NakajimaShigekazu Kawai
    • Tsuyoshi KawaiTakuya NakajimaShigekazu Kawai
    • G02B5/23
    • G02B5/23C07D417/14
    • The present invention provides a photochromic compound that is colored when irradiated with visible light and quickly faded when set in a dark place. The photochromic compound according to the present invention is expressed by the following general formula (I): where each of A1, A2 and A3 is a five-member rings forming a 6π-electron system, the three rings being identical, partially identical or totally different from each other, and each ring may have a substituent; B1 and B2 are functional groups, each having an atomic number of five or larger, including a ring compound, and bonded to the 2-carbon of each of A2 and A3, respectively; and R1, R2 and R3 are substituents identical to or different from each other. This compound is highly colorable and durable even when it is dispersed into plastic macromolecular materials. Therefore, it is suitable as a dye material for sunglasses or similar products.
    • 本发明提供一种当用可见光照射时着色的光致变色化合物,并且当设置在黑暗处时迅速褪色。 根据本发明的光致变色化合物由以下通式(I)表示:其中A1,A2和A3各自为形成6pi电子体系的五元环,三个环相同,部分相同或完全相同 彼此不同,每个环可具有取代基; B1和B2分别是原子数为5以上的官能团,包括环化合物,分别与A2和A3各自的2碳键合。 并且R 1,R 2和R 3是彼此相同或不同的取代基。 该化合物即使分散在塑料大分子材料中也具有高度着色和耐用性。 因此,它适用于太阳镜或类似产品的染料。