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1. 发明授权

US06188928B1 Apparatus for tissue stimulation 失效
标题翻译：组织刺激装置
公开(公告)号：US06188928B1
公开(公告)日：2001-02-13
申请号：US09308077
申请日：1999-07-22
申请人： Kjell Norén , Jakub Hirschberg , Hans Strandberg
发明人： Kjell Norén , Jakub Hirschberg , Hans Strandberg
IPC分类号： A61N137
CPC分类号： A61N1/3712 , A61N1/3716
摘要： Mathematical functions such as recursive autoregression models which include parameters are used for defining the heart signal and any signals disturbing the heart signal, such as polarization signals. By registering, during a predetermined time interval, the electrode signal for determining the parameters for one or more different mathematical functions, the parameters can be used on their own or in combination to determine the activity of the heart, i.e., whether the registered electrode signal corresponds to a stimulated, spontaneous or absence of heart activity.
摘要翻译：诸如包括参数的递归自回归模型的数学函数用于定义心脏信号和干扰心脏信号的任何信号，例如偏振信号。通过在预定时间间隔内登记用于确定一个或多个不同数学函数的参数的电极信号，可以单独或组合使用这些参数以确定心脏的活动，即，是否注册的电极信号对应于刺激，自发或不存在心脏活动。

2. 发明申请

US20130066222A1 SYSTEMS AND METHODS FOR DETECTING FAR-FIELD OVERSENSING BASED ON SIGNALS SENSED BY THE PROXIMAL ELECTRODE OF A MULTIPOLAR LV LEAD 有权
标题翻译：用于检测基于由多个LV引线的接近电极感测的信号的场地超声波的系统和方法
公开(公告)号：US20130066222A1
公开(公告)日：2013-03-14
申请号：US13230482
申请日：2011-09-12
申请人： Stuart Rosenberg , Tomas Svensson , Kjell Norén , Edward Karst , Kyungmoo Ryu
发明人： Stuart Rosenberg , Tomas Svensson , Kjell Norén , Edward Karst , Kyungmoo Ryu
IPC分类号： A61B5/0464 , A61N1/39 , A61B5/0452 , A61N1/365 , A61B5/0402 , A61B5/0456
CPC分类号： A61N1/3704 , A61B5/0464 , A61B5/0468 , A61B5/686 , A61N1/3627 , A61N1/3684
摘要： A device senses cardioelectrical signals using a right atrial (RA) lead, which might include far-field R-waves as well as near-field P-waves. The device concurrently senses events using a proximal electrode of an LV lead, which can sense both P-waves and R-waves as substantially near-field events. Suitable templates are then applied to the signals sensed via the proximal LV electrode to identify the origin of the signals (e.g. atrial vs. ventricular) so as to properly classify the corresponding events sensed in the RA as near-field or far-field events. In this manner, far-field oversensing is conveniently detected.
摘要翻译：一种装置使用右心房（RA）导联感测心电信号，其可能包括远场R波以及近场P波。该装置使用LV引线的近侧电极同时感测事件，其可以感测P波和R波作为基本近场事件。然后将合适的模板施加到经由近端LV电极感测的信号以识别信号的来源（例如心房与心室），以便将在RA中感测到的相应事件适当地分类为近场或远场事件。以这种方式，可以方便地检测远场超检测。

3. 发明申请

US20110295137A1 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING ELECTROMECHANICAL DELAY FROM REALTIME ELECTRODE MOTION TRACKING 有权
标题翻译：使用电动延迟从实际电极运动跟踪的心脏再生治疗优化
公开(公告)号：US20110295137A1
公开(公告)日：2011-12-01
申请号：US13206395
申请日：2011-08-09
申请人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Norén , Thao Thu Nguyen , Michael Yang
发明人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Norén , Thao Thu Nguyen , Michael Yang
IPC分类号： A61B5/0402
CPC分类号： A61N1/3627 , A61B5/0422 , A61B5/0452 , A61B5/1107 , A61B5/6876 , A61B2562/043 , A61N1/36514 , A61N1/36578 , A61N1/3684 , A61N1/37252
摘要： An exemplary method includes providing a mechanical activation time (MA time) for a myocardial location, the location defined at least in part by an electrode and the mechanical activation time determined at least in part by movement of the electrode; providing an electrical activation time (EA time) for the myocardial location; and determining an electromechanical delay (EMD) for the myocardial location based on the difference between the mechanical activation time (MA time) and the electrical activation time (EA time).
摘要翻译：示例性方法包括提供用于心肌位置的机械活化时间（MA时间），至少部分地由电极限定的位置和至少部分地通过电极的移动确定的机械激活时间; 为心肌位置提供电激活时间（EA时间）; 并且基于机械激活时间（MA时间）和电激活时间（EA时间）之间的差异来确定心肌位置的机电延迟（EMD）。

4. 发明申请

US20110054560A1 PACING, SENSING AND OTHER PARAMETER MAPS BASED ON LOCALIZATION SYSTEM DATA 审中-公开
公开(公告)号：US20110054560A1
公开(公告)日：2011-03-03
申请号：US12553473
申请日：2009-09-03
申请人： Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Wenbo Hou , Thao Thu Nguyen , Steve Koh , Kjell Norén , Michael Yang
发明人： Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Wenbo Hou , Thao Thu Nguyen , Steve Koh , Kjell Norén , Michael Yang
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36585 , A61N1/368 , A61N1/3684
摘要： An exemplary method generates a map of a pacing parameter, a sensing parameter or one or more other parameters based in part on location information acquired using a localization system configured to locate electrodes in vivo (i.e., within a patient's body). Various examples map capture thresholds, qualification criteria for algorithms, undesirable conditions and sensing capabilities. Various other methods, devices, systems, etc., are also disclosed.

5. 发明授权

US07215996B2 Bi-ventricular heart stimulating device, system and method 有权
标题翻译：双心室心脏刺激装置，系统及方法
公开(公告)号：US07215996B2
公开(公告)日：2007-05-08
申请号：US10499253
申请日：2002-10-04
申请人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
发明人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.
摘要翻译：在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值。在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。时间间隔变化，并且在许多心脏周期上监测关系。设定时间间隔使得该关系满足预定的要求。

6. 发明授权

US06264606B1 Ischemia detector 有权
标题翻译：缺血检测器
公开(公告)号：US06264606B1
公开(公告)日：2001-07-24
申请号：US09355683
申请日：1999-09-22
申请人： Christer Ekwall , Kjell Norén
发明人： Christer Ekwall , Kjell Norén
IPC分类号： A61B500
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1107 , A61N1/36521 , G06F19/00
摘要： An ischemia detector has a patient workload sensor and a patient breathing sensor which emits a signal representing sensed workload, and a patient breathing sensor which emits a signal representing sensed breathing activity of a patient. These signals are supplied to a detector unit which identifies a state of ischemia upon an occurrence of a predetermined relation between the sensed workload and the sensed breathing activity. This predetermined relation is a sensed low workload and a simultaneously sensed high breathing activity.
摘要翻译：缺血检测器具有患者工作量传感器和发出表示感测到的工作负荷的信号的患者呼吸传感器，以及发出表示感测到的患者呼吸活动的信号的患者呼吸传感器。这些信号被提供给检测器单元，该检测器单元在感测到的工作量和所感测到的呼吸活动之间发生预定关系时识别缺血状态。该预定关系是感测到的低工作负荷和同时感测到的高呼吸活动。

7. 发明授权

US08886310B2 System and method for controlling a heart stimulator 有权
标题翻译：用于控制心脏刺激器的系统和方法
公开(公告)号：US08886310B2
公开(公告)日：2014-11-11
申请号：US12303987
申请日：2006-06-09
申请人： Kjell Norén , Taraneh G. Farazi
发明人： Kjell Norén , Taraneh G. Farazi
IPC分类号： A61N1/00 , A61N1/365 , A61B5/024 , A61N1/36 , A61N1/362 , A61B5/00
CPC分类号： A61N1/365 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/3622
摘要： In a system and method for controlling an implantable stimulator capable of producing pacing pulses to be delivered to cardiac tissue, as well as vagal stimulation pulses to be delivered to vagus nerve sites, upon detection of a premature cardiac event, such as a premature ventricular or atrial contraction, a simulated heart rate turbulence (HRT) procedure is applied if the intrinsic heart rate turbulence is weakened or absent. The simulated HRT includes a first phase in which the heart rate is increased, from the existing level, for a number of heart beats, a second phase in which the heart rate is decreased for a number of heart beats, and an optional third phase in which the heart rate is returned to said existing level.
摘要翻译：在一种用于控制可植入式刺激器的系统和方法中，所述系统和方法能够产生起搏脉冲以被传送到心脏组织，以及迷走神经刺激脉冲，以便在检测到过早心脏事件（例如心室早搏如果内在心率湍流减弱或不存在，则应用心房收缩模拟心率湍流（HRT）程序。模拟HRT包括第一阶段，其中心率从现有水平增加，对于多个心跳，第二阶段，其中多个心脏搏动的心率降低;以及可选择的第三阶段心率恢复到现有水平。

8. 发明授权

US08073540B2 Implantable heart stimulating device with stimulation rate optimization 有权
标题翻译：具有刺激速率优化的植入式心脏刺激装置
公开(公告)号：US08073540B2
公开(公告)日：2011-12-06
申请号：US12305552
申请日：2006-06-21
申请人： Kjell Norén , Kenth Nilsson
发明人： Kjell Norén , Kenth Nilsson
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： An implantable heart stimulating device has a stimulation pulse generator that emits stimulation pulses at an adjustable stimulation rate, an activity sensor that emits an activity signal in response to detected activity of the patient, and a physiological parameter sensor that generates a physiological sensor signal in response to a detected physiological parameter. The activity and physiological sensor signals are supplied to a control arrangement that sets the stimulation rate for the stimulation pulse generator by executing a stimulation rate algorithm dependent on those signals. In the stimulation rate algorithm, if the physiological signal indicates an emotional stress on the part of the patient, the stimulation rate is increased to an adjustable emotional stress rate level, and if no increase in the activity signal occurs during a predetermined time period following the stimulation rate increase, the stimulation rate is decreased.
摘要翻译：可植入心脏刺激装置具有以可调节刺激速率发出刺激脉冲的刺激脉冲发生器，响应于患者的检测到的活动而发出活动信号的活动传感器，以及响应于生成生理传感器信号的生理参数传感器到检测到的生理参数。活动和生理传感器信号被提供给控制装置，其通过执行依赖于那些信号的刺激速率算法来设定刺激脉冲发生器的刺激速率。在刺激速率算法中，如果生理信号表示患者的情绪应激，则刺激率增加到可调节的情绪应激率水平，并且如果活动信号的增加在后面的预定时间段内不发生刺激率增加，刺激率降低。

9. 发明申请

US20100121400A1 IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE 有权
标题翻译：可注射的心脏装置和监测心血管疾病状态的方法
公开(公告)号：US20100121400A1
公开(公告)日：2010-05-13
申请号：US12528653
申请日：2007-03-23
申请人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
发明人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device has a heart stimulator for electrically stimulating the heart of a patient, detector that measures a physiologic parameter that is affected by the status of a cardiovascular disease associated with sympathetic activation, a signal processor that determines at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and analyzer that automatically analyzes the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detector is a cardio-mechanical parameter detector that measures, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analyzed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置具有用于电刺激患者心脏的心脏刺激器，所述心脏刺激器测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测器，信号处理器确定低频 LF，以及在测量参数中的非常低频VLF，Mayer波分量，以及分析仪，其自动分析与预定参考值相关的确定的Mayer波分量，以确定心血管疾病的状态。检测器是心机械参数检测器，其作为所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，迈耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。心脏的四个腔室中的至少一个的机械变化被测量为生理参数。

10. 发明授权

US07569020B2 Method for extracting timing parameters using a cardio-mechanical sensor 有权
标题翻译：使用心机械传感器提取定时参数的方法
公开(公告)号：US07569020B2
公开(公告)日：2009-08-04
申请号：US11455518
申请日：2006-06-19
申请人： Kjell Norén , Nils Holmström
发明人： Kjell Norén , Nils Holmström
IPC分类号： A61B5/026
CPC分类号： A61B5/02416 , A61B5/0031 , A61B5/0452 , A61B5/083 , A61B5/1116 , A61B5/686 , A61B5/7239 , A61N1/36514 , A61N1/36578
摘要： In a method and apparatus for measuring the ejection fraction in a mammalian heart, the opening and closing of a heart valve is sensed with an implanted sensor, and a pre-ejection period is measured as a function of the sensed opening and closing of the heart valve. The ventricular ejection time also is measured, and the ejection fraction is determined as a function of the measured pre-ejection period and the ejection time.
摘要翻译：在用于测量哺乳动物心脏中的射血分数的方法和装置中，用植入的传感器感测心脏瓣膜的打开和关闭，并且根据检测到的心脏的开启和关闭来测量预喷射周期阀。也测量心室射血时间，并且将射血分数确定为所测量的预喷射时间和喷射时间的函数。

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