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1. 发明授权

US06767637B2 Microencapsulation using ultrasonic atomizers 失效
标题翻译：使用超声波雾化器进行微胶囊化
公开(公告)号：US06767637B2
公开(公告)日：2004-07-27
申请号：US10392245
申请日：2003-03-19
申请人： Kinam Park , Yoon Yeo
发明人： Kinam Park , Yoon Yeo
IPC分类号： B32B1502
CPC分类号： A61K9/5031 , A61K9/19 , A61K9/5089 , A61L31/16 , A61L2300/606 , A61L2300/622 , B01J13/04 , B01J13/12 , B01J13/20 , Y10T428/2984 , Y10T428/2985 , Y10T428/2991
摘要： A method for generating a plurality of drug-containing microcapsules employs one or more atomizers to form the microcapsules by the phenomenon of solvent exchange. A plurality of microdroplets of an aqueous solution is contacted with a plurality of microdroplets containing a polymer dissolved in a hydrophilic solvent under conditions whereby the polymer solution envelops the aqueous microdroplet. Exchange of solvent molecules between the aqueous core and its polymer-containing shell deposits the polymer as a membrane around the aqueous core. A preferred atomizer is a coaxial ultrasonic atomizer. Microcapsules can be generated in air as well as when submersed in a collection bath. Desired properties of the microcapsules, e.g., controlled release, can be achieved by providing protective excipients within the aqueous core, providing a hydrophilic polymer capable of undergoing a sol-to-gel transition within the aqueous core, optimizing selection of the polymer solvent, adjusting relative flow rates, and the like.
摘要翻译：用于产生多种含药微胶囊的方法使用一种或多种雾化器通过溶剂交换的现象形成微胶囊。使多个微滴的水溶液与含有溶解在亲水溶剂中的聚合物的多个微滴接触，由此聚合物溶液包围水性微滴。水性芯和其含聚合物壳之间的溶剂分子的交换将聚合物作为围绕水性芯的膜沉积。优选的雾化器是同轴超声波雾化器。微胶囊可以在空气中以及浸入收集浴中时产生。可以通过在含水芯内提供保护性赋形剂来实现微胶囊的所需性质，例如控制释放，提供能够在水性芯内经历溶胶 - 凝胶转移的亲水聚合物，优化聚合物溶剂的选择，调节相对流速等。

2. 发明授权

US06599627B2 Microencapsulation of drugs by solvent exchange 失效
公开(公告)号：US06599627B2
公开(公告)日：2003-07-29
申请号：US10017338
申请日：2001-12-13
申请人： Yoon Yeo , Alvin Un-Teh Chen , Osman A. Basaran , Kinam Park
发明人： Yoon Yeo , Alvin Un-Teh Chen , Osman A. Basaran , Kinam Park
IPC分类号： B32B1502
CPC分类号： B01J13/046 , A61K9/5031 , Y10T428/2984 , Y10T428/2985 , Y10T428/2991
摘要： A solvent exchange method is employed to provide microencapsulated compositions, such as microcapsules of pharmaceutical preparations. The method is based on an exchange of water and a hydrophilic organic solvent, whereby a decline in solvent quality for the organic solvent causes a polymer dissolved therein to be deposited onto an aqueous core. Optimal results are rationalized in terms of a balance of water solubility and surface tension for the organic solvent. In a preferred embodiment, microcapsules of selected drugs are formed by contacting microdroplets of an aqueous solution containing the drug with the organic solvent containing a polymer dissolved therein. A preferred method employs biodegradable poly(lactic acid-co-glycolic acid) (PLGA) dissolved in acetic acid, ethyl acetate, methyl acetate, or ethyl formate, to form a PLGA membrane around an aqueous drug core. The method is particularly attractive for encapsulating protein-based drugs without substantial denaturation.

3. 发明申请

US20110212163A1 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：磁力加热用于药物输送和其他应用
公开(公告)号：US20110212163A1
公开(公告)日：2011-09-01
申请号：US13055195
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
发明人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
IPC分类号： A61K47/02 , A61K9/127
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/00
摘要： The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.
摘要翻译：本发明一般涉及使用外部触发器（例如磁场）从制品中释放化合物的系统和方法。本发明的一个方面通常涉及含有易磁化物质的制品。将易磁感应材料暴露于诸如振荡磁场的磁场可能导致敏感材料的温度升高。在一些实施方案中，可以使用这种温度升高来引起药物或其它可释放材料从制品中的释放。例如，药物可以包含在与易感材料热连通的热敏材料中，或者药物可以包含在外壳内，该外壳至少部分地由热敏材料隔热与易感材料的通讯。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过在受试者内植入制品，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

4. 发明授权

US5741511A Transdermal drug delivery device for treating erectile dysfunction 失效
标题翻译：用于治疗勃起功能障碍的透皮药物递送装置
公开(公告)号：US5741511A
公开(公告)日：1998-04-21
申请号：US627805
申请日：1996-04-10
申请人： Hun Han Lee , Joong Woong Cho , Choul Young Kim , Chaul Min Pai , Jin Deog Song , Chul Min Park , Hye Jeong Yoon , Yoon Yeo , Jae Seung Paick
发明人： Hun Han Lee , Joong Woong Cho , Choul Young Kim , Chaul Min Pai , Jin Deog Song , Chul Min Park , Hye Jeong Yoon , Yoon Yeo , Jae Seung Paick
IPC分类号： A61M37/00 , A61F5/41 , A61F6/04 , A61K9/00 , A61K9/70 , A61F13/00 , A61F6/02
CPC分类号： A61K9/703 , A61F5/41 , A61F6/04 , A61K9/0034 , A61K9/7092 , Y10S602/901
摘要： The present invention is to provide a method and a transdermal drug delivery device for treating erectile dysfunction which comprises a patch containing pharmaceutically active ingredient and being directly apply to the male glans penis and its support and the rings for constricting the base part of the penis to aid the erection. The patch according to the present invention may be divided into two types, i.e. a cylinder type patch and a multi-reservoir type patch. The transdermal drug delivery patch device of the present invention is painless and safely to use and may be effectively produced and maintained erection of the penis without the adverse side effects and with a high degree of patient acceptability in the case of male impotence.
摘要翻译：本发明提供一种用于治疗勃起功能障碍的方法和透皮药物递送装置，其包含含有药物活性成分的补片，并且直接应用于雄性龟头阴茎及其支撑体和用于收缩阴茎基部的环帮助勃起。根据本发明的贴片可以分为两种类型，即圆柱型贴片和多储器型贴片。本发明的透皮药物递送贴片装置是无痛且安全使用的，并且可以有效地产生和维持阴茎的勃起而没有不利的副作用，并且在男性阳the的情况下具有高度的患者可接受性。

5. 发明授权

US09186640B2 Delivery and controlled release of encapsulated lipophilic nutrients 有权
标题翻译：包装的亲脂性营养物的交付和控制释放
公开(公告)号：US09186640B2
公开(公告)日：2015-11-17
申请号：US11846212
申请日：2007-08-28
申请人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
发明人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
IPC分类号： A23P1/08 , A23L1/00 , B01J13/10 , A23L1/0522 , A23L1/053 , A23L1/0562 , A23L1/30 , A23L1/48
CPC分类号： A61K9/1075 , A23L2/52 , A23L29/219 , A23L29/25 , A23L29/281 , A23L33/12 , A23P10/30 , A23V2002/00 , A61K9/0053 , A61K9/0095 , A61K31/202 , A61K35/60 , B01J13/10 , A23V2250/187 , A23V2250/1868 , A23V2200/254 , A23V2250/5432 , A23V2250/51 , A23V2200/224 , A23V2250/511 , A23V2250/5022 , A23V2250/54252
摘要： A complex coacervate delivery system is provided which encapsulates lipophilic nutrients such as, for example, fish oils high in omega-3 fatty acids. The complex coacervate delivery system protects the lipophilic nutrient from degradation, e.g., oxidation and hydrolysis, and also reduces or eliminates the unpleasant taste and odor of the lipophilic nutrient. The complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner. The complex coacervate delivery system may be included in a food or beverage product having a pH value within the range of about 1.5 to about 5.0.
摘要翻译：提供了一种复合凝聚物递送系统，其包封亲脂性营养物质，例如ω-3脂肪酸高的鱼油。复合凝聚物递送系统保护亲脂性营养物免受降解，例如氧化和水解，并且还减少或消除亲脂性营养物质的令人不快的味道和气味。摄入后的复合凝聚物递送系统可操作以基于pH控制的方式基本上释放下胃肠道中的亲脂性营养物质。复合凝聚物递送系统可以包含在pH值在约1.5至约5.0范围内的食品或饮料产品中。

6. 发明申请

US20090061048A1 DELIVERY AND CONTROLLED RELEASE OF ENCAPSULATED LIPOPHILIC NUTRIENTS 有权
标题翻译：输送和控制释放的包封的脂肪营养素
公开(公告)号：US20090061048A1
公开(公告)日：2009-03-05
申请号：US11846212
申请日：2007-08-28
申请人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
发明人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
IPC分类号： A23C9/13 , A23C13/16 , A23C9/152 , A23F5/00 , A23L1/105 , A23L1/30 , A61K31/045 , A61K31/12 , A61K31/20 , A61P43/00 , A61K9/52 , A61K38/00 , A61K31/59 , A61K31/355 , A61K31/195 , A61K31/07 , A23L2/52 , A23L1/185 , A23L1/06 , A23F3/00 , A23C19/00
CPC分类号： A61K9/1075 , A23L2/52 , A23L29/219 , A23L29/25 , A23L29/281 , A23L33/12 , A23P10/30 , A23V2002/00 , A61K9/0053 , A61K9/0095 , A61K31/202 , A61K35/60 , B01J13/10 , A23V2250/187 , A23V2250/1868 , A23V2200/254 , A23V2250/5432 , A23V2250/51 , A23V2200/224 , A23V2250/511 , A23V2250/5022 , A23V2250/54252
摘要： A complex coacervate delivery system is provided which encapsulates lipophilic nutrients such as, for example, fish oils high in omega-3 fatty acids. The complex coacervate delivery system protects the lipophilic nutrient from degradation, e.g., oxidation and hydrolysis, and also reduces or eliminates the unpleasant taste and odor of the lipophilic nutrient. The complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner. The complex coacervate delivery system may be included in a food or beverage product having a pH value within the range of about 1.5 to about 5.0.
摘要翻译：提供了一种复合凝聚物递送系统，其包封亲脂性营养物质，例如ω-3脂肪酸高的鱼油。复合凝聚物递送系统保护亲脂性营养物免受降解，例如氧化和水解，并且还减少或消除亲脂性营养物质的令人不快的味道和气味。摄入后的复合凝聚物递送系统可操作以基于pH控制的方式基本上释放下胃肠道中的亲脂性营养物质。复合凝聚物递送系统可以包含在pH值在约1.5至约5.0范围内的食品或饮料产品中。

7. 发明申请

US20080069857A1 Compositions And Methods For Inhibiting Adhesions 审中-公开
标题翻译：用于抑制粘合剂的组合物和方法
公开(公告)号：US20080069857A1
公开(公告)日：2008-03-20
申请号：US11734537
申请日：2007-04-12
申请人： Yoon Yeo , Taichi Ito , Robert Langer , Daniel Kohane , George Kodokian
发明人： Yoon Yeo , Taichi Ito , Robert Langer , Daniel Kohane , George Kodokian
IPC分类号： A61K9/14 , A61K31/717 , A61P43/00 , A61K31/721
CPC分类号： A61L31/145 , A61L31/041 , A61L31/129 , C08J3/075 , C08J3/246 , C08J2301/28 , C08J2305/02 , C08J2305/08 , C08L1/28 , C08L5/08 , C08L5/02
摘要： The present invention provides compositions and methods for inhibiting adhesions. The methods involve administering solutions containing hydrogel precursors such as polysaccharide derivatives, e.g., derivatives of hyaluronic acid, cellulose, or dextran, to a subject at a site where adhesions may form, e.g., as a consequence of surgery, injury, or infection. The hydrogel precursors, e.g., polysaccharide derivatives, become crosslinked following their administration to form a hydrogel that maintains tissue separation. In certain embodiments of the invention one or both solutions contains particles, e.g., polymeric nanoparticles or microparticles, so that a composite hydrogel containing the particles is formed. The solution(s), particle(s), or both, may contain a biologically active agent such as an agent that contributes to inhibiting adhesions. The biologically active agent may be covalently attached to a hydrogel precursor.
摘要翻译：本发明提供抑制粘连的组合物和方法。所述方法包括将诸如多糖衍生物例如透明质酸衍生物，纤维素或葡聚糖的水凝胶前体施用于在可能形成粘连的部位（例如作为手术，损伤或感染的结果）的受试者的溶液。水凝胶前体，例如多糖衍生物在其施用后变得交联以形成维持组织分离的水凝胶。在本发明的某些实施方案中，一种或两种溶液含有颗粒，例如聚合物纳米颗粒或微粒，使得形成含有颗粒的复合水凝胶。溶液，颗粒或两者都可以含有生物活性剂，例如有助于抑制粘连的试剂。生物活性剂可以共价连接到水凝胶前体。

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