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1. 发明申请

US20110212163A1 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：磁力加热用于药物输送和其他应用
公开(公告)号：US20110212163A1
公开(公告)日：2011-09-01
申请号：US13055195
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
发明人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
IPC分类号： A61K47/02 , A61K9/127
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/00
摘要： The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.
摘要翻译：本发明一般涉及使用外部触发器（例如磁场）从制品中释放化合物的系统和方法。本发明的一个方面通常涉及含有易磁化物质的制品。将易磁感应材料暴露于诸如振荡磁场的磁场可能导致敏感材料的温度升高。在一些实施方案中，可以使用这种温度升高来引起药物或其它可释放材料从制品中的释放。例如，药物可以包含在与易感材料热连通的热敏材料中，或者药物可以包含在外壳内，该外壳至少部分地由热敏材料隔热与易感材料的通讯。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过在受试者内植入制品，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

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