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1. 发明申请

US20110223247A1 PHARMACEUTICAL COMPOSITIONS FOR RELEASE CONTROL OF METHYLPHENIDATE 有权
标题翻译：药物组合物用于释放甲基苯甲酸酯的控制
公开(公告)号：US20110223247A1
公开(公告)日：2011-09-15
申请号：US13126855
申请日：2009-11-06
申请人： Sang Yeob Park , Hojin Chung , Chaul Min Pai
发明人： Sang Yeob Park , Hojin Chung , Chaul Min Pai
IPC分类号： A61K9/58 , A61K9/00 , A61K9/22 , A61K9/54 , A61K31/445 , A61P25/00 , A61K9/56
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/5073 , A61K31/445
摘要： Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.
摘要翻译：公开了一种用于释放控制的药物组合物，其包含多个用于释放控制的颗粒。用于释放控制的多个颗粒包括含有哌甲酯的核心材料和用于在芯材上形成的用于释放控制的聚合物涂层。用于释放控制的多个颗粒基于用于释放控制的聚合物涂层的平均厚度被分成两组或更多组。在聚合物涂层中聚合物的组成方面，颗粒组是相同的，但是在涂层的平均厚度方面是不同的。根据本发明的用于释放控制的药物组合物可以根据需要控制核心材料中所含的哌甲酯的释放模式，并且可以以各种形式如口腔崩解片等的口服制剂使用。

2. 发明申请

US20130052264A1 CONTROLLED-RELEASE PHARMACEUTICAL COMPOSITION INCLUDING TAMSULOSIN OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND ORAL FORMULATION INCLUDING THE SAME 审中-公开
公开(公告)号：US20130052264A1
公开(公告)日：2013-02-28
申请号：US13695814
申请日：2011-04-27
申请人： Ho-Jin Chung , Sang-Yeob Park , Chaul-Min Pai
发明人： Ho-Jin Chung , Sang-Yeob Park , Chaul-Min Pai
IPC分类号： A61K9/58 , A61K9/32 , A61P13/02 , A61K9/08 , A61K31/18 , A61K9/14 , A61K9/16
CPC分类号： A61K31/18 , A61K9/5073 , A61K9/5078 , A61K9/5084
摘要： A controlled-release pharmaceutical composition including first and second groups of microparticles, each of the microparticles including a core including tamsulosin or pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the average thickness of the controlled-release polymer coating layer is different in each of the first and second groups of microparticles, and an oral formulation including the same, are provided. This pharmaceutical composition can easily control the extent of release of an active ingredient depending on changes in pH in the intestinal tract and the release pattern of the active ingredient in the small intestine, thus preventing the active ingredient from being rapidly transferred into the blood to thereby minimize side-effects, and maintaining the effective blood concentration of the active ingredient for a predetermined period of time. Furthermore, this composition can shield the bitter taste of the active ingredient even when exposed to the inside of the mouth, thus increasing the therapeutic effects for patients upon oral administration.

3. 发明授权

US07070610B2 Monofilament suture and manufacturing method thereof 有权
公开(公告)号：US07070610B2
公开(公告)日：2006-07-04
申请号：US10218336
申请日：2002-08-13
申请人： Jung-nam Im , Jang-il Seo , Chong-taek Hong , Hye-sung Yoon , Chaul-min Pai
发明人： Jung-nam Im , Jang-il Seo , Chong-taek Hong , Hye-sung Yoon , Chaul-min Pai
IPC分类号： A61L17/00
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/0619 , A61L17/12 , D01D5/34 , D01D5/36 , D01F8/04 , D01F8/14
摘要： The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.

4. 发明授权

US06319518B1 Colon selective drug delivery composition 失效
标题翻译：结肠选择性药物输送组合物
公开(公告)号：US06319518B1
公开(公告)日：2001-11-20
申请号：US08919957
申请日：1997-08-29
申请人： Seung-Seo Lee , Sung-Bum La , Chang-Baeg Lim , Sujung Lee , Bo-Youn Seo , Chaul-Min Pai
发明人： Seung-Seo Lee , Sung-Bum La , Chang-Baeg Lim , Sujung Lee , Bo-Youn Seo , Chaul-Min Pai
IPC分类号： A61K922
CPC分类号： A61K9/4816 , A61K9/286 , A61K9/5036
摘要： A composition comprising gelatin and a polysaccharide which is degradable by a colonic enzyme and, optionally, with an aldehyde and/or a polyvalent metal ion and/or an additional polysaccharide, which is not degraded or disintegrated in the upper gastrointestinal tract, thereby rendering the active substance loaded therein to be selectively delivered to the colon and to be effectively released in the colon.
摘要翻译：一种包含明胶和多糖的组合物，其可以通过结肠酶和任选的醛和/或多价金属离子和/或另外的多糖降解，其在上胃肠道中不会降解或分解，从而使载入其中的活性物质被选择性地递送到结肠并且有效地释放在结肠中。

5. 发明授权

US5948020A Implantable bioresorbable membrane and method for the preparation thereof 失效
标题翻译：植入式生物可吸收膜及其制备方法
公开(公告)号：US5948020A
公开(公告)日：1999-09-07
申请号：US765021
申请日：1997-12-26
申请人： Seok-Joon Yoon , Guw-Dong Yeo , You-Chan Kim , Min-Hyo Seo , Chaul-Min Pai , Jong-Pyoung Jung , Seung-Jin Lee
发明人： Seok-Joon Yoon , Guw-Dong Yeo , You-Chan Kim , Min-Hyo Seo , Chaul-Min Pai , Jong-Pyoung Jung , Seung-Jin Lee
IPC分类号： A61K9/00 , A61L15/64 , A61L27/00 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/02
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/606
摘要： An implantable bioresorbable membrane for the separation and regeneration of tissue in a defect site and augmentation of tissues surrounding other implants comprises: (a) porous bioresorbable polymer matrix made of a bioresorbable polymer selected from the group consisting of polylactic acid, poly(lactic-co-glycolic acid), polycarprolactone, polyparadioxanone, polytrimethylene carbonate and a mixture thereof; and (b) a reinforcing fabric made of bioresorbable fibers embedded in said matrix, and is produced by preparing a fabric as a support from bioresorbable fibrous materials, coating the fabric with a solution containing a bioresorbable polymer and a pore forming agent, and treating the coated fabric to generate pores.
摘要翻译：用于分离和再生缺损部位中的组织并增加包围其他植入物的组织的可植入生物再吸收膜包括：（a）由生物可再吸收聚合物制成的多孔生物可再吸收聚合物基质，所述生物可再吸收聚合物选自聚乳酸，聚乳酸乙醇酸），聚己内酯，聚对二恶烷酮，聚三亚甲基碳酸酯及其混合物; 和（b）由嵌入所述基质中的可生物再吸收的纤维制成的增强织物，并且通过由生物可再吸收的纤维材料制备作为支持物的织物制备，用含有生物可再吸收聚合物和成孔剂的溶液涂布织物，涂层织物产生毛孔。

6. 发明申请

US20120076838A1 POORLY SOLUBLE DRUG CONTAINING MICROSPHERE WITH IMPROVED BIOAVAILABILTY AND METHOD OF PREPARING THE SAME 审中-公开
标题翻译：具有改善生物利用度的含有微生物的不溶性溶剂及其制备方法
公开(公告)号：US20120076838A1
公开(公告)日：2012-03-29
申请号：US13322549
申请日：2010-05-27
申请人： Kyung-Hee Kim , Hyun-Ki Lee , Jun- Seok Hwang , Su-long Hwang , Chaul-Min Pai
发明人： Kyung-Hee Kim , Hyun-Ki Lee , Jun- Seok Hwang , Su-long Hwang , Chaul-Min Pai
IPC分类号： A61K9/14 , A61K31/519 , A61K31/343 , A61K31/216 , A61K31/55 , A61K31/593 , A61K31/4184 , A61K31/7048 , A61K31/522 , A61K31/52
CPC分类号： A61K9/1694 , A61K9/1635 , A61K9/1652 , A61K31/522
摘要： A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.
摘要翻译：提供了具有改善的生物利用度的含有微溶性微球的药物，包含其的口服制剂及其制备方法，其中所述难溶性药物微球体是固体分散体，其中难溶性药物分散在水溶性聚合物载体以非结晶形式通过喷雾干燥，从而提高难溶性药物的生物利用度。

7. 发明授权

US07273619B2 Transdermal composition of an antivomiting agent 有权
标题翻译：抗病毒剂的透皮组合物
公开(公告)号：US07273619B2
公开(公告)日：2007-09-25
申请号：US10414827
申请日：2003-04-15
申请人： Chaul Min Pai , Jin Deog Song , Joong Woong Cho
发明人： Chaul Min Pai , Jin Deog Song , Joong Woong Cho
IPC分类号： A61F13/00 , A61F15/16
CPC分类号： A61K9/0014 , A61K9/7023 , A61K31/00 , A61K31/46 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/38
摘要： The present invention relates to a transdermal composition of an antivomiting agent, and more particularly to a transdermal composition of an antivomiting agent which can minimize skin irritation by employing tropisetron as the antivomiting agent as well as by adjusting its pH to be in the range of 8 to 9 thus enhancing its rate of skin penetration thereby reducing the amount of a skin penetration enhancer used.
摘要翻译：本发明涉及抗病毒剂的透皮组合物，更具体地说，涉及一种抗病毒剂的透皮组合物，其可以通过使用托烷司琼作为抗病毒剂，并通过将其pH调节至8范围内来最小化皮肤刺激从而提高其皮肤渗透速率，从而减少使用的皮肤渗透增强剂的量。

8. 发明授权

US06413494B1 Composition and pharmaceutical dosage form for colonic drug delivery using polysaccharides 有权
标题翻译：使用多糖的结肠药物递送的组合物和药物剂型
公开(公告)号：US06413494B1
公开(公告)日：2002-07-02
申请号：US09318579
申请日：1999-05-25
申请人： Seung Seo Lee , Chang Baeg Lim , Chaul Min Pai , Sujung Lee , In Park , Moon Gun Seo , Heenam Park
发明人： Seung Seo Lee , Chang Baeg Lim , Chaul Min Pai , Sujung Lee , In Park , Moon Gun Seo , Heenam Park
IPC分类号： A61K4900
CPC分类号： A61K9/5078 , A61K9/286 , A61K9/4816 , A61K9/4891 , A61K9/5036 , C08L5/06 , Y10S514/96 , Y10S514/962 , C08L2666/02
摘要： A colonic drug delivery composition contains a first polysaccharide and a second polysaccharide wherein both polysaccharide are degradable by colonic enzymes and are mixed at a environmental pH of about 7 or above, without use of a cross-linking agent. A colon selective pharmaceutical composition and dosage form for oral delivery of a drug, diagnostic reagent, or mixture thereof includes the drug, diagnostic reagent, or mixture thereof in contact with the polysaccharide composition. A method of preparing such a colonic drug delivery composition and the colon selective pharmaceutical composition and dosage from are also disclosed.
摘要翻译：结肠药物递送组合物包含第一多糖和第二多糖，其中两种多糖可通过结肠酶降解，并且在环境pH约为7或更高的条件下混合，而不使用交联剂。用于口服递送药物，诊断试剂或其混合物的结肠选择性药物组合物和剂型包括与多糖组合物接触的药物，诊断试剂或其混合物。还公开了制备这种结肠药物递送组合物和结肠选择性药物组合物和剂量的方法。

9. 发明授权

US07749533B2 Highly plastic granules for making fast melting tablets 失效
标题翻译：用于制作快速熔融片的高度塑料颗粒
公开(公告)号：US07749533B2
公开(公告)日：2010-07-06
申请号：US10841979
申请日：2004-05-07
申请人： Yourong Fu , Chaul Min Pai , Sang Yeob Park , Gun Seomoon , Kinam Park
发明人： Yourong Fu , Chaul Min Pai , Sang Yeob Park , Gun Seomoon , Kinam Park
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/0056
摘要： A fast-melting pharmaceutical tablet comprises a porous, plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the porous, plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.
摘要翻译：快速熔化的药物片剂包括多孔塑料物质，水渗透增强剂和粘合剂。可以在该方法的不同阶段将一种或多种药物并入制剂中，从而得到药用活性片剂。制备药片的方法需要结合多孔，塑料，水渗透增强剂和粘合剂，以形成高度塑性的颗粒，将其压制成片剂。所得片剂迅速溶于口中，硬度好，脆性低。这些片剂对吞咽常规药丸有困难的人特别有价值。

10. 发明授权

US07674767B2 Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof 有权
标题翻译：用于口服给药的水溶性药物的纳米颗粒组合物及其制备方法
公开(公告)号：US07674767B2
公开(公告)日：2010-03-09
申请号：US10584449
申请日：2004-12-24
申请人： Chaul Min Pai , Mi Hong Min , Jun Seok Hwang , Kyung Mi Cho
发明人： Chaul Min Pai , Mi Hong Min , Jun Seok Hwang , Kyung Mi Cho
IPC分类号： A61K38/28 , A61K47/06 , C09D105/04
CPC分类号： A61K9/5123 , A61K9/08 , A61K9/146 , A61K9/5146 , A61K9/5192 , A61K31/545 , A61K31/66 , A61K31/727 , A61K38/1816 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/31 , A61K47/32 , A61K47/34 , A61K47/44
摘要： The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1-30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble drug is bonded with the counter-ion substance, 0.5-80 weight % of a lipid, 0.5-80 weight % of a polymer, and 1-80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05-3, and a preparation method thereof. The composition of the present invention has high gastrointestinal absorption rate upon oral administration, and has high drug entrapping rate in the nanoparticle, and is also stable against lipases.
摘要翻译：本发明涉及含有粒径为500nm以下的纳米粒子的可口服给药的组合物，其含有0.1-30重量％的水溶性药物和抗衡离子物质的复合物，其中带电的水溶性药物与抗衡离子物质，0.5-80重量％的脂质，0.5-80重量％的聚合物和1-80重量％的乳化剂结合，其中所述脂质和所述聚合物的重量比在范围为1：0.05-3，及其制备方法。本发明的组合物在口服给药时具有高的胃肠吸收速率，并且在纳米颗粒中具有高的药物截留速率，并且对脂肪酶也是稳定的。

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