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1. 发明申请

US20070088347A1 Magnetically augmented radio frequency ablation 有权
标题翻译：磁放大射频消融
公开(公告)号：US20070088347A1
公开(公告)日：2007-04-19
申请号：US11250063
申请日：2005-10-13
申请人： Kimbolt Young , Steven M. Anderson , John Spiridigliozzi , Paul DiCarlo
发明人： Kimbolt Young , Steven M. Anderson , John Spiridigliozzi , Paul DiCarlo
IPC分类号： A61B18/14
CPC分类号： A61B18/1477
摘要： A tissue ablation assembly comprises an elongate probe device, at least one ablation electrode element carried by the probe device for conveying ablation energy, and at least one magnetic element for substantially altering the path of the ablation energy conveyed by the electrode element(s). In one embodiment, the magnetic element substantially urges the ablation energy radially outward. In another embodiment, magnetic element takes the form of a ring magnet that exhibits at least four alternating magnetic poles circumferentially disposed around the probe device axis. A method of treating tissue (e.g., a tumor) is also provided. The method comprises introducing a probe device into the patient, conveying ablation energy from the probe device, and applying a magnetic field adjacent the probe device to substantially alter the path of the ablation energy, e.g., by urging the ablation energy conveyed from the probe device radially outward into the tissue to create a tissue lesion, or by urging the ablation energy longitudinally.
摘要翻译：组织消融组件包括细长的探针装置，由探针装置承载的用于传送消融能量的至少一个消融电极元件以及用于基本上改变由电极元件传送的消融能量的路径的至少一个磁性元件。在一个实施例中，磁性元件基本上推动消融能量径向向外。在另一个实施例中，磁性元件呈环形磁铁的形式，其呈现围绕探针器件轴线周向设置的至少四个交变磁极。还提供了治疗组织（例如肿瘤）的方法。该方法包括将探针装置引入患者体内，从探针装置输送消融能量，以及施加邻近探针装置的磁场，以基本上改变消融能量的路径，例如通过促使从探针装置传送的消融能量径向向外进入组织以产生组织损伤，或通过纵向推动消融能量。

2. 发明授权

US07744596B2 Magnetically augmented radio frequency ablation 有权
标题翻译：磁放大射频消融
公开(公告)号：US07744596B2
公开(公告)日：2010-06-29
申请号：US11250063
申请日：2005-10-13
申请人： Kimbolt Young , Steven M. Anderson , John Spiridigliozzi , Paul DiCarlo
发明人： Kimbolt Young , Steven M. Anderson , John Spiridigliozzi , Paul DiCarlo
IPC分类号： A61B18/18
CPC分类号： A61B18/1477
摘要： A tissue ablation assembly comprises an elongate probe device, at least one ablation electrode element carried by the probe device for conveying ablation energy, and at least one magnetic element for substantially altering the path of the ablation energy conveyed by the electrode element(s). In one embodiment, the magnetic element substantially urges the ablation energy radially outward. In another embodiment, magnetic element takes the form of a ring magnet that exhibits at least four alternating magnetic poles circumferentially disposed around the probe device axis. A method of treating tissue (e.g., a tumor) is also provided. The method comprises introducing a probe device into the patient, conveying ablation energy from the probe device, and applying a magnetic field adjacent the probe device to substantially alter the path of the ablation energy, e.g., by urging the ablation energy conveyed from the probe device radially outward into the tissue to create a tissue lesion, or by urging the ablation energy longitudinally.
摘要翻译：组织消融组件包括细长探针装置，由探针装置承载的至少一个消融电极元件，用于传送消融能量，以及至少一个磁性元件，用于基本上改变由电极元件传送的消融能量的路径。在一个实施例中，磁性元件基本上推动消融能量径向向外。在另一个实施例中，磁性元件呈环形磁铁的形式，其呈现围绕探针器件轴线周向设置的至少四个交变磁极。还提供了治疗组织（例如肿瘤）的方法。该方法包括将探针装置引入患者体内，从探针装置输送消融能量，以及施加邻近探针装置的磁场，以基本上改变消融能量的路径，例如通过促使从探针装置传送的消融能量径向向外进入组织以产生组织损伤，或通过纵向推动消融能量。

3. 发明申请

US20060089635A1 Methods and apparatus for focused bipolar tissue ablation using an insulated shaft 审中-公开
标题翻译：使用绝缘轴的聚焦双极组织消融的方法和装置
公开(公告)号：US20060089635A1
公开(公告)日：2006-04-27
申请号：US10971373
申请日：2004-10-22
申请人： Kimbolt Young , Steve Anderson , Paul DiCarlo , Jeffrey Zerfas
发明人： Kimbolt Young , Steve Anderson , Paul DiCarlo , Jeffrey Zerfas
IPC分类号： A61B18/14
CPC分类号： A61B18/082 , A61B18/1477 , A61B18/148 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1475
摘要： A tissue ablation probe is provided. The probe comprises a proximal electrode element, which includes a proximal electrode stem and a deployable proximal electrode array, and a distal electrode element, which includes a distal electrode stem and a deployable distal electrode array. The probe is configured, such that a majority of electrical energy conveyed between the proximal and distal electrode elements is conveyed between distal termini of the electrode arrays, whereas a relatively small amount of the electrical energy is conveyed between the electrode stems. One or more of the electrodes on the arrays may be optionally insulated to further enhance the electrical characteristics of the arrays.
摘要翻译：提供组织消融探针。探针包括近端电极元件，其包括近端电极杆和可展开的近端电极阵列，以及远端电极元件，其包括远端电极杆和可展开的远端电极阵列。探针被构造成使得在近端和远端电极元件之间传送的大部分电能在电极阵列的远端之间传送，而相对少量的电能在电极杆之间传送。阵列上的一个或多个电极可以可选地绝缘，以进一步增强阵列的电特性。

4. 发明申请

US20090131855A1 APPARATUS AND METHODS FOR DRUG RELEASE IN TISSUE ABLATION PROCEDURES 有权
标题翻译：组织吸收程序中药物释放的装置和方法
公开(公告)号：US20090131855A1
公开(公告)日：2009-05-21
申请号：US12271714
申请日：2008-11-14
申请人： Kimbolt Young , Steven Walak , Paul DiCarlo
发明人： Kimbolt Young , Steven Walak , Paul DiCarlo
IPC分类号： A61M37/00 , A61B18/18
CPC分类号： A61B18/1477 , A61B18/148 , A61B2018/00154 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61B2018/1495 , A61B2218/002
摘要： Tissue ablation probes and methods for treating tissue are provided. The tissue ablation probe comprises an elongated probe shaft, at least one electrode carried by the distal end of the probe shaft, and a pharmaceutical agent carried by the probe shaft. The pharmaceutical agent may be disposed on the electrode(s), the probe shaft, or a releasable portion associated with the electrode or the probe shaft. A method for treating tissue comprises introducing a tissue ablation probe to a tissue site, operating the tissue ablation probe to ablate tissue at the tissue site, and releasing a pharmaceutical agent from the tissue ablation probe at the tissue site.
摘要翻译：提供组织消融探针和治疗组织的方法。组织消融探针包括细长的探针轴，由探针轴的远端承载的至少一个电极和由探针轴承载的药剂。药剂可以设置在与电极或探针轴相关联的电极，探针轴或可释放部分上。一种用于治疗组织的方法包括将组织消融探针引入组织部位，操作组织消融探针以烧蚀组织部位处的组织，以及在组织部位从组织消融探针释放药剂。

5. 发明授权

US07962223B2 Ablation probe for drug release in tissue ablation procedures 有权
标题翻译：组织消融术中药物释放消融探针
公开(公告)号：US07962223B2
公开(公告)日：2011-06-14
申请号：US12271714
申请日：2008-11-14
申请人： Kimbolt Young , Steven Walak , Paul DiCarlo
发明人： Kimbolt Young , Steven Walak , Paul DiCarlo
IPC分类号： A61N1/06
CPC分类号： A61B18/1477 , A61B18/148 , A61B2018/00154 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61B2018/1495 , A61B2218/002
摘要： Tissue ablation probes and methods for treating tissue are provided. The tissue ablation probe comprises an elongated probe shaft, at least one electrode carried by the distal end of the probe shaft, and a pharmaceutical agent carried by the probe shaft. The pharmaceutical agent may be disposed on the electrode(s), the probe shaft, or a releasable portion associated with the electrode or the probe shaft. A method for treating tissue comprises introducing a tissue ablation probe to a tissue site, operating the tissue ablation probe to ablate tissue at the tissue site, and releasing a pharmaceutical agent from the tissue ablation probe at the tissue site.
摘要翻译：提供组织消融探针和治疗组织的方法。组织消融探针包括细长的探针轴，由探针轴的远端承载的至少一个电极和由探针轴承载的药剂。药剂可以设置在与电极或探针轴相关联的电极，探针轴或可释放部分上。一种用于治疗组织的方法包括将组织消融探针引入组织部位，操作组织消融探针以烧蚀组织部位处的组织，以及在组织部位从组织消融探针释放药剂。

6. 发明授权

US08430105B2 Tissue-treatment methods 有权
标题翻译：组织治疗方法
公开(公告)号：US08430105B2
公开(公告)日：2013-04-30
申请号：US13106563
申请日：2011-05-12
申请人： Janel L. Lanphere , Paul DiCarlo , Steven M. Anderson
发明人： Janel L. Lanphere , Paul DiCarlo , Steven M. Anderson
IPC分类号： A61B19/00
CPC分类号： A61B18/18 , A61B18/14 , A61B18/1815 , A61B90/04 , A61B2017/008 , A61B2090/0472 , A61B2090/0481 , A61B2090/049 , A61K9/0019 , A61K47/30 , A61L27/3683 , A61N7/02
摘要： Polymer insulators and methods of using polymer insulators are disclosed. In some embodiments, a method includes separating a first portion of a subject's tissue from a second portion of the subject's tissue so that there is a space between the first and second portions of tissue. Deionized water, a buffered saline solution, liquid polymers, gels, particles, foams, and/or gases are disposed between the first and second portions of tissue, and the first portion of tissue is exposed to energy to treat the first portion of tissue.
摘要翻译：公开了聚合物绝缘体和使用聚合物绝缘体的方法。在一些实施例中，一种方法包括将受试者组织的第一部分与受试者组织的第二部分分开，使得在组织的第一和第二部分之间存在空间。去离子水，缓冲盐溶液，液体聚合物，凝胶，颗粒，泡沫和/或气体设置在组织的第一和第二部分之间，并且组织的第一部分暴露于能量以处理组织的第一部分。

7. 发明授权

US08445022B2 Embolization 有权
标题翻译：栓塞
公开(公告)号：US08445022B2
公开(公告)日：2013-05-21
申请号：US13491915
申请日：2012-06-08
申请人： Paul DiCarlo , Thomas V. Casey, II , Stephan P. Mangin
发明人： Paul DiCarlo , Thomas V. Casey, II , Stephan P. Mangin
IPC分类号： A61K9/14
CPC分类号： A61L31/04 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/12186 , A61B17/42 , A61B2017/1205 , A61K9/0019 , A61K9/167 , A61L24/0015 , A61L24/0036 , A61L24/046 , A61L31/14 , A61L2300/62 , A61L2430/36 , Y10T428/2982 , Y10T428/2998
摘要： Embolization, as well as related particles, compositions, and methods, are disclosed.
摘要翻译：公开了栓塞，以及相关的颗粒，组合物和方法。

8. 发明授权

US08157850B2 Device and method for loading a luminal graft for endoluminal delivery 失效
标题翻译：用于装载腔内移植物用于腔内递送的装置和方法
公开(公告)号：US08157850B2
公开(公告)日：2012-04-17
申请号：US10629077
申请日：2003-07-29
申请人： Nancy Usiak , Paul DiCarlo , Robert F. Rioux , Kristian DiMatteo , James Weldon , Shubhang Mishra
发明人： Nancy Usiak , Paul DiCarlo , Robert F. Rioux , Kristian DiMatteo , James Weldon , Shubhang Mishra
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2002/9522
摘要： An endoluminal graft is wrapped axially upon itself to form a low profile, which facilitates endoluminal delivery. Apparatus and systems for making and using such grafts are also disclosed.
摘要翻译：腔内移植物在其自身上轴向包裹以形成低轮廓，其有助于腔内递送。还公开了用于制造和使用这种移植物的装置和系统。

9. 发明申请

US20110313368A1 Pressure Activated Valve with High Flow Slit 有权
标题翻译：高流量狭缝压力活化阀
公开(公告)号：US20110313368A1
公开(公告)日：2011-12-22
申请号：US13222277
申请日：2011-08-31
申请人： Karla Weaver , Paul DiCarlo
发明人： Karla Weaver , Paul DiCarlo
IPC分类号： A61M25/14
CPC分类号： A61M39/24 , A61M25/0097 , A61M25/0606 , A61M25/0637 , A61M39/22 , A61M2039/242 , A61M2039/2426
摘要： A pressure actuated valve for controlling the flow of fluid through a medical device, the valve comprises a housing including a lumen extending therethrough and a flow control membrane extending across the lumen to control the flow of fluid through the lumen. The membrane includes a plurality of slits extending therethrough so that, when the membrane is acted upon by a pressure of at least a threshold magnitude, the slits open to permit flow through the lumen and, when not acted upon by a pressure of at least the predetermined magnitude, the slits are maintained closed by a biasing force applied thereto by the membrane to prevent flow through the lumen. Each of the slits extends between end portions thereof along a curve wherein a distance between a first end portion of a first one of the slits and a first end portion of a second one of the slits is a minimum distance between the first and second slits.
摘要翻译：一种用于控制通过医疗装置的流体流动的压力致动阀，所述阀包括壳体，所述壳体包括延伸穿过其中的内腔和延伸穿过所述内腔的流动控制膜，以控制通过所述内腔的流体流动。膜包括延伸穿过其中的多个狭缝，使得当膜以至少阈值大小的压力作用时，狭缝开放以允许流过内腔，并且当不受至少通过由膜施加到其上的偏压力来保持狭缝保持关闭，以防止流过管腔。每个狭缝沿其曲线在其端部之间延伸，其中第一个狭缝中的第一个端部与第二个狭缝的第一端部之间的距离是第一和第二狭缝之间的最小距离。

10. 发明申请

US20110276038A1 METHOD AND SYSTEM FOR INTRACAVITARY AND EXTRACAVITARY PROCEDURES 有权
标题翻译：方法和系统的入侵和额外程序
公开(公告)号：US20110276038A1
公开(公告)日：2011-11-10
申请号：US13094736
申请日：2011-04-26
申请人： Jon T. McIntyre , Barry Weitzner , Paul DiCarlo , Paul Smith
发明人： Jon T. McIntyre , Barry Weitzner , Paul DiCarlo , Paul Smith
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B17/29 , A61B17/320016 , A61B17/42 , A61B18/1492 , A61B2017/00278 , A61B2017/003 , A61B2017/00477 , A61B2017/00876 , A61B2018/143 , A61B2018/1432
摘要： Embodiments include a method of performing a medical procedure in a patient. The method includes inserting a first working instrument and a second working instrument through an opening in the patient, creating an incision in body tissue inside the patient using at least one of the first and second working instruments, and advancing the second working instrument through the incision to position the second working instrument at a work site inside the patient. The method also includes positioning the first working instrument at the work site without advancing the first working instrument through the incision and performing a procedure at the work site inside the patient using the first and second working instruments.
摘要翻译：实施例包括在患者体内执行医疗程序的方法。该方法包括通过患者的开口插入第一工作器械和第二工作器械，使用第一和第二工作器械中的至少一个在身体组织内产生切口，并通过切口推进第二工作器械将第二工作仪器定位在患者体内的工作现场。该方法还包括将第一工作仪器定位在工作现场，而不通过切口推进第一工作仪器，并使用第一和第二工作仪器在病人内的工作现场执行过程。

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