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1. 发明授权

US4843072A Antihypertensive pyridazinone aminoisopropanol derivatives 失效
标题翻译：抗高血压哒嗪酮氨基异丙醇衍生物
公开(公告)号：US4843072A
公开(公告)日：1989-06-27
申请号：US93033
申请日：1987-09-04
申请人： Kikuo Yasuda , Kenyu Shibata , Seijiro Honma , Toshimi Seki , Kohichi Hasumi , Takeshi Masuda , Akihiro Izumi , Tsutomu Ishimori , Kotaro Gotanda , Masako Uno
发明人： Kikuo Yasuda , Kenyu Shibata , Seijiro Honma , Toshimi Seki , Kohichi Hasumi , Takeshi Masuda , Akihiro Izumi , Tsutomu Ishimori , Kotaro Gotanda , Masako Uno
IPC分类号： A61K31/50 , A61P9/12 , C07D237/04 , C07D237/14
CPC分类号： C07D237/04
摘要： A pyridazinone derivative represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either one of R.sub.2, R.sub.3 and R.sub.4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.
摘要翻译：由下列通式（I）表示的哒嗪酮衍生物，其中R1表示氢原子或甲基，R2，R3和R4中的任一个表示氢原子，其余两个表示低级烷基，三氟甲基，卤素原子，氰基或硝基，及其盐。该化合物可用作抗高血压药。

2. 发明授权

US4599333A Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament 失效
标题翻译：肼基哒嗪化合物，其制备方法及其作为药物的用途
公开(公告)号：US4599333A
公开(公告)日：1986-07-08
申请号：US591904
申请日：1984-03-22
申请人： Kikuo Yasuda , Takayuki Takezaki , Rikio Ohuchi , Hiroshi Ohuyabu , Yoshitaka Tanimoto , Toshimi Seki , Takashi Yamaguchi , Akihiro Izumi , Norio Himori , Tsutomu Ishimori
发明人： Kikuo Yasuda , Takayuki Takezaki , Rikio Ohuchi , Hiroshi Ohuyabu , Yoshitaka Tanimoto , Toshimi Seki , Takashi Yamaguchi , Akihiro Izumi , Norio Himori , Tsutomu Ishimori
IPC分类号： C07D237/20 , C07D237/22 , A61K31/50
CPC分类号： C07D237/20 , C07D237/22
摘要： A hydrazinopyridazine compound represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lower alkoxy, lower alkylthio, lower alkanoylamino, allyloxy or tetrahydrofurfuryloxy group, a lower alkoxy group which may optionally be substituted by a 2-furyl, phenyl or lower alkoxy group, a lower alkenyl group, a lower alkenyloxy group, or a lower alkynyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, a lower alkenyl group, or a lower alkenyloxy group; R.sup.3, R.sup.4 and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, a lower alkyl group which may optionally be substituted by a lower alkoxy group, or a lower alkoxy group; R.sup.6 and R.sup.7, independently from each other, represent a hydrogen atom or a methyl group; Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR2## Z represents --O--, --S--, or ##STR3## in which R.sup.8 represents a hydrogen atom or a lower alkyl group; and n is 1 or 2, or its salt; a process for the production the aforesaid compounds; and use of such compounds as antihypertensive agents.
摘要翻译：由式（I）表示的肼基哒嗪化合物，其中R 1表示氢原子，卤素原子，羟基，氰基，可任选被卤素原子或羟基取代的低级烷基，低级烷氧基，低级烷硫基，低级烷酰基氨基，烯丙氧基或四氢呋喃氧基，可任选被2-呋喃基，苯基或低级烷氧基，低级烯基，低级烯氧基或低级炔基取代的低级烷氧基; R 2表示氢原子，卤素原子，氰基，可以被卤素原子或低级烷氧基取代的低级烷基，低级烷氧基，低级链烯基或低级链烯氧基。 R 3，R 4和R 5彼此独立地表示氢原子，卤素原子，可以被低级烷氧基取代的低级烷基或低级烷氧基; R6和R7彼此独立地表示氢原子或甲基; Y表示-NH 2，-NH-COOC 2 H 5或Z表示-O - ， - S-或其中R 8表示氢原子或低级烷基的和n为1或2，或其盐; 一种生产上述化合物的方法; 并使用这些化合物作为抗高血压药。

3. 发明授权

US4018824A 1-Aryloxy-3-aminopropane derivatives 失效
标题翻译： 1-芳氧基-3-氨基丙烷衍生物
公开(公告)号：US4018824A
公开(公告)日：1977-04-19
申请号：US507793
申请日：1974-09-20
申请人： Kunio Tsukamoto , Yasushi Suzuki , Akihiro Izumi , Yoshio Hiramatsu
发明人： Kunio Tsukamoto , Yasushi Suzuki , Akihiro Izumi , Yoshio Hiramatsu
IPC分类号： C07D209/08 , C07C93/06
CPC分类号： C07D209/08
摘要： A process for the preparation of 1-aryloxy-3-aminopropane derivatives and acid addition salts thereof and such products per se, the process comprising ring opening of tertiary azetidinol derivatives. They possess .beta.-adrenegic block activity and an activity of controlling secretion of gastric juice and are therefore useful antiulcerative medicines for peptic ulcer and duodenal ulcer.
摘要翻译：一种制备1-芳氧基-3-氨基丙烷衍生物及其酸加成盐的方法及其制备方法，该方法包括开环三氮杂环丁醇衍生物。它们具有β-adrengic阻滞活性和控制胃液分泌的活性，因此是消化性溃疡和十二指肠溃疡的有用的抗溃疡药物。

4. 发明授权

US5449737A Urethane modified epoxy resin compositions 失效
标题翻译：聚氨酯改性环氧树脂组合物
公开(公告)号：US5449737A
公开(公告)日：1995-09-12
申请号：US196348
申请日：1994-02-14
申请人： Hiroshi Uchida , Akihiro Izumi
发明人： Hiroshi Uchida , Akihiro Izumi
IPC分类号： C08G18/00 , C08G59/02 , C08G59/28 , C08G18/28 , C08G59/00 , C08G59/68
CPC分类号： C08G59/02 , C08G18/003 , C08G59/28
摘要： A reaction product formed between an epoxy resin, a phenol compound such as bisphenol or the like and an isocyanate compound contains oxazolidone rings and it is a polymeric epoxy resin. Herein is provided an epoxy resin composition comprising said reaction product and a curing agent.The said reaction product contains oxazolidone rings and epoxy groups, and is excellent in heat resistance and adhesive property. Further said reaction product is made into a polymer by the use of the bisphenol compound and at the same time it contains oxazolidone rings; it is excellent in toughness and water resistance. When a tetrabromobisphenol is used as the bisphenol compound, flame retardance is also good.Accordingly, the epoxy resin composition of the present invention is excellent in heat resistance, toughness, adhesive property and water resistance. When a brominated compound is used as the phenol compound, the epoxy resin composition of the invention exhibits an excellent flame retardance.
摘要翻译：在环氧树脂，双酚等酚化合物和异氰酸酯化合物之间形成的反应产物含有恶唑烷酮环，是聚合环氧树脂。本发明提供了包含所述反应产物和固化剂的环氧树脂组合物。所述反应产物含有恶唑烷酮环和环氧基，耐热性和粘合性优异。此外，通过使用双酚化合物将反应产物制成聚合物，同时含有恶唑烷酮环; 韧性和耐水性优异。当使用四溴双酚作为双酚化合物时，阻燃性也良好。因此，本发明的环氧树脂组合物的耐热性，韧性，粘合性和耐水性优异。当使用溴化合物作为酚化合物时，本发明的环氧树脂组合物显示出优异的阻燃性。

5. 发明授权

US4360464A Process for production of 1-aryloxy-aminopropane derivatives 失效
标题翻译： 1-芳氧基 - 氨基丙烷衍生物的制备方法
公开(公告)号：US4360464A
公开(公告)日：1982-11-23
申请号：US913238
申请日：1978-06-06
申请人： Kunio Tsukamoto , Yasushi Suzuki , Akihiro Izumi , Yoshio Hiramatsu
发明人： Kunio Tsukamoto , Yasushi Suzuki , Akihiro Izumi , Yoshio Hiramatsu
IPC分类号： C07D205/04 , C07D209/08 , C07D319/18 , C07D207/24 , C07D317/06
CPC分类号： C07D209/08 , C07D205/04 , C07D319/18
摘要： A process for the preparation of 1-aryloxy-3-aminopropane derivatives and acid addition salts thereof and such products per se the process comprising ring opening of tertiary azetidinol derivatives. They possess .beta.-adrenergic blocking activity and an activity of controlling secretion of gastric juice and are therefore useful antiulcerative medicines for peptic ulcer and duodenal ulcer.
摘要翻译：一种制备1-芳氧基-3-氨基丙烷衍生物及其酸加成盐的方法，本发明涉及三氮杂环丁醇衍生物的开环方法。它们具有β-肾上腺素能阻滞活性和控制胃液分泌的活性，因此是消化性溃疡和十二指肠溃疡的有用的抗溃疡药物。

6. 发明授权

US3954227A Pharmaceutical compositions containing 1-(2',3'-dimethylphenoxy)-3-tert. butylamino-2-propanol or pharmaceutically acceptable salt thereof for treating or preventing coronary disorders 失效
标题翻译：含有1-（2 {40,3 {40-二甲基苯氧基）-3-叔 - 丁基氨基-2-丙醇或其药学上可接受的盐，用于治疗或预防冠状动脉疾病
公开(公告)号：US3954227A
公开(公告)日：1976-05-04
申请号：US324100
申请日：1973-01-16
申请人： Kunio Tsukamoto , Yasushi Suzuki , Akihiro Izumi , Yoshio Hiramatsu
发明人： Kunio Tsukamoto , Yasushi Suzuki , Akihiro Izumi , Yoshio Hiramatsu
IPC分类号： C07D209/08 , A61K31/125
CPC分类号： C07D209/08
摘要： A method of treating or preventing coronary disorders by the administration orally or rectally of a pharmaceutical preparation containing 1-(2',3'-dimethylphenoxy)-3-tert. butylamino-2-propanol or a salt thereof.
摘要翻译：一种通过口服或直肠给药含有1-（2'，3'-二甲基苯氧基）-3-叔 - 丁基氨基-2-丙醇或其盐。

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