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1. 发明申请

US20130224795A1 IMMOBILIZATION METHOD OF BIOACTIVE MOLECULES USING POLYPHENOL OXIDASE 审中-公开
标题翻译：使用聚苯乙烯氧化酶的生物活性分子的固定方法
公开(公告)号：US20130224795A1
公开(公告)日：2013-08-29
申请号：US13882539
申请日：2011-08-19
申请人： Ki-Dong Park , Kyung-Min Park , Yoon-Ki Joung , Yun-Ki Lee , Ji-Hye Oh , Seung-Mi Hyun
发明人： Ki-Dong Park , Kyung-Min Park , Yoon-Ki Joung , Yun-Ki Lee , Ji-Hye Oh , Seung-Mi Hyun
IPC分类号： C12P21/00 , C12P13/02
摘要： A method is provided for immobilizing a bioactive molecule onto a surface using polyphenol oxidase. In the presence of polyphenol oxidase, a bioactive molecule containing a phenol or catechol group can be simply in situ oxidized within a short time to dopa or dopaquinone which forms a coordinate bond with a metal or polymer substrate, thus immobilizing the bioactive molecule onto the surface with stability. Based on the surface immobilization of bioactive molecules using polyphenol oxidase, various bioactive molecules such as osteogenetic peptides and growth factors can be simply immobilized to medical metal or polymer substrate surfaces such as orthopedic or dental implants which can be then effectively used to induce rapid osteogenesis after being transplanted. Also, antithrombotic agents and/or entothelialization inducing agents may be immobilized to medical substrates for vascular systems, such as stents and artificial blood vessels, thus guaranteeing hemocompatibility to the medical substrates.
摘要翻译：提供了一种使用多酚氧化酶将生物活性分子固定在表面上的方法。在多酚氧化酶的存在下，含有苯酚或儿茶酚基团的生物活性分子可在短时间内简单地原位氧化成与金属或聚合物底物形成配位键的多巴或多巴醌，从而将生物活性分子固定在表面上稳定。基于使用多酚氧化酶的生物活性分子的表面固定化，各种生物活性分子如成骨肽和生长因子可以简单地固定在医疗金属或聚合物基底表面如矫形或牙科植入物上，然后可以有效地用于诱导快速成骨被移植。此外，抗血栓形成剂和/或内皮化诱导剂可以固定在用于血管系统如支架和人造血管的医疗基底上，从而保证对医用基底的血液相容性。

2. 发明授权

US08968716B2 In situ-forming hydrogel for tissue adhesives and biomedical use thereof 有权
标题翻译：用于组织粘合剂的原位成膜水凝胶及其生物医学用途
公开(公告)号：US08968716B2
公开(公告)日：2015-03-03
申请号：US13393094
申请日：2010-09-02
申请人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park , Eu-Gene Lih
发明人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park , Eu-Gene Lih
IPC分类号： A61L24/04 , A61L24/08 , A61K38/39 , A61K31/722 , A61K31/765 , A61K38/02 , A61K38/18 , A61K38/27 , A61K38/19 , A61K38/20 , A61K38/23 , A61K38/25 , A61K38/28 , A61K38/31 , A61K38/26 , A61K39/395 , A61K39/00 , A61K33/24 , A61L24/00 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58
CPC分类号： A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
摘要： Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.
摘要翻译：本文公开了原位形成的生物粘附性水凝胶及其医疗用途。通过酶反应原位交联形成的水凝胶在生物相容性方面具有优于常规生物粘附性水凝胶的优点。此外，原位成型生物粘附性水凝胶具有优异的生物相容性和机械强度，并且通过/不使用多巴衍生物进行改性而具有优异的组织粘合性。水凝胶在生物医学领域中发现各种应用，包括生物粘合剂或止血剂，用于组织再生和增殖的植入物质，用于递送生物活性物质或药物的载体等。

3. 发明申请

US20120100103A1 IN SITU FORMING HYDROGEL AND BIOMEDICAL USE THEREOF 有权
标题翻译：在现场形成水凝胶和生物医学用途
公开(公告)号：US20120100103A1
公开(公告)日：2012-04-26
申请号：US13381843
申请日：2010-07-01
申请人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
发明人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
IPC分类号： A61K38/39 , A61P19/08 , A61P1/02 , A61P17/02 , A61P9/00 , A61K33/24 , A61P13/00 , A61P35/00 , A61P29/00 , A61P31/04 , A61K39/395 , A61K39/00 , A61P19/04 , A61F2/16
CPC分类号： A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
摘要： Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.
摘要翻译：公开了原位成形可注射水凝胶及其医疗用途。在原位形成的可注射水凝胶中，两个或更多个均相或非均相聚合物通过相邻聚合物上的苯酚或苯胺部分之间的脱氢反应彼此键合，其中聚合物主链使用连接体用苯酚或苯胺部分接枝。与常规水凝胶相比，由于引入水溶性聚合物作为接头，原位成形可注射水凝胶在体内稳定性和机械强度方面是优异的，这导致酚或苯胺部分的反应性的改善。具有优异的生物稳定性和机械强度的优点，水凝胶在生物医学领域中发现了多种应用。

4. 发明授权

US08815277B2 In situ forming hydrogel and biomedical use thereof 有权
标题翻译：原位形成水凝胶及其生物医学用途
公开(公告)号：US08815277B2
公开(公告)日：2014-08-26
申请号：US13381843
申请日：2010-07-01
申请人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
发明人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
IPC分类号： A61F2/00 , A61K45/00 , A61K39/395 , A61K39/00 , C07K14/495 , C07K14/50 , C07K14/485 , A61L27/54 , A61K9/00 , A61L27/52 , A61K47/42
CPC分类号： A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
摘要： Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.
摘要翻译：公开了原位成形可注射水凝胶及其医疗用途。在原位形成的可注射水凝胶中，两个或更多个均相或非均相聚合物通过相邻聚合物上的苯酚或苯胺部分之间的脱氢反应彼此键合，其中聚合物主链使用连接体用苯酚或苯胺部分接枝。与常规水凝胶相比，由于引入水溶性聚合物作为接头，原位成形可注射水凝胶在体内稳定性和机械强度方面是优异的，这导致酚或苯胺部分的反应性的改善。具有优异的生物稳定性和机械强度的优点，水凝胶在生物医学领域中发现了多种应用。

5. 发明申请

US20120156164A1 IN SITU-FORMING HYDROGEL FOR TISSUE ADHESIVES AND BIOMEDICAL USE THEREOF 有权
标题翻译：用于组织粘合剂的生成水凝胶及其生物医学用途
公开(公告)号：US20120156164A1
公开(公告)日：2012-06-21
申请号：US13393094
申请日：2010-09-02
申请人： Ki-Dong Park , Yoon-ki Joung , Kyung-Min Park , Eu-Gene Lih
发明人： Ki-Dong Park , Yoon-ki Joung , Kyung-Min Park , Eu-Gene Lih
IPC分类号： A61L24/04 , A61L24/08 , A61K31/785 , A61K38/39 , A61K31/722 , A61K31/765 , A61K38/02 , A61K38/18 , A61K38/27 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/22 , A61K38/28 , A61K38/31 , A61K38/26 , A61K39/395 , A61K39/00 , A61K33/24 , A61P31/04 , A61P35/00 , A61P29/00 , A61P7/04 , A61P37/04 , A61P41/00 , A61P19/04 , A61P19/08 , A61P17/00 , A61P9/00 , A61P27/02 , A61P25/00 , A61P13/00 , A61Q19/00 , A61P43/00 , A61L24/10
CPC分类号： A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
摘要： Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.
摘要翻译：本文公开了原位形成的生物粘附性水凝胶及其医疗用途。通过酶反应原位交联形成的水凝胶在生物相容性方面具有优于常规生物粘附性水凝胶的优点。此外，原位成型生物粘附性水凝胶具有优异的生物相容性和机械强度，并且通过/不使用多巴衍生物进行改性而具有优异的组织粘合性。水凝胶在生物医学领域中发现各种应用，包括生物粘合剂或止血剂，用于组织再生和增殖的植入物质，用于递送生物活性物质或药物的载体等。

6. 发明申请

US20120097965A1 THIN FILM TRANSISTOR AND DISPLAY DEVICE USING THE SAME 有权
标题翻译：薄膜晶体管和使用其的显示器件
公开(公告)号：US20120097965A1
公开(公告)日：2012-04-26
申请号：US13072625
申请日：2011-03-25
申请人： Jae-Min Shin , Ji-Yong Park , Kyung-Min Park
发明人： Jae-Min Shin , Ji-Yong Park , Kyung-Min Park
IPC分类号： H01L29/786
CPC分类号： H01L29/78621 , H01L27/1285 , H01L29/78696
摘要： In a thin film transistor and a display device provided with the same, a thin film transistor according to an exemplary embodiment includes: a semiconductor layer including a channel region, a source region, a drain region, a light-doped source region, and a light-doped drain region; a gate electrode overlapping the channel region; a source electrode contacting the source region; and a drain electrode contacting the drain region. The channel region includes a main channel portion, a source channel portion, and a drain channel portion, and the source channel portion and the drain channel portion are extended from the main channel portion and separated from each other. The light-doped source region is disposed between the source channel portion and the source region and the light-doped drain region is disposed between the drain channel portion and the drain region.
摘要翻译：在薄膜晶体管和具有该薄膜晶体管的显示装置中，根据示例性实施例的薄膜晶体管包括：半导体层，包括沟道区，源极区，漏极区，光掺杂源极区和光掺杂漏区; 栅电极与沟道区重叠; 源极接触源区; 漏极与漏区接触。沟道区域包括主沟道部分，源极沟道部分和漏极沟道部分，并且源极沟道部分和漏极沟道部分从主沟道部分延伸并彼此分离。光掺杂源极区域设置在源极沟道部分和源极区域之间，并且掺杂漏极区域设置在漏极沟道部分和漏极区域之间。

7. 发明申请

US20110134381A1 DISPLAY DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：显示装置及其制造方法
公开(公告)号：US20110134381A1
公开(公告)日：2011-06-09
申请号：US12957233
申请日：2010-11-30
申请人： Kyung-Min Park , Ji-Yong Park , Jin-Suk Park , Sung-In Ro
发明人： Kyung-Min Park , Ji-Yong Park , Jin-Suk Park , Sung-In Ro
IPC分类号： G02F1/1343 , H01L33/08
CPC分类号： H01L27/3265 , G02F1/136213 , G02F2201/40 , H01L27/1255 , H01L51/56
摘要： A display device and a method of manufacturing the same are disclosed. In one embodiment, the display device includes: i) a first insulating layer formed on a first substrate, ii) a lower electrode formed on the first insulating layer, iii) a dielectric layer formed to surround the top and side of the lower electrode, wherein the dielectric layer does not cover a pixel region of the display device and iv) an upper electrode formed on the dielectric layer.
摘要翻译：公开了一种显示装置及其制造方法。在一个实施例中，显示装置包括：i）形成在第一基板上的第一绝缘层，ii）形成在第一绝缘层上的下电极，iii）形成为围绕下电极的顶部和侧面的介电层，其中所述电介质层不覆盖所述显示装置的像素区域，以及iv）形成在所述电介质层上的上电极。

8. 发明申请

US20110014735A1 Dual Panel Type Organic Electroluminescent Display Device and Method of Fabricating the Same 有权
标题翻译：双面板型有机电致发光显示装置及其制造方法
公开(公告)号：US20110014735A1
公开(公告)日：2011-01-20
申请号：US12883772
申请日：2010-09-16
申请人： Jae-Hee Park , Kyung-Min Park , Seok-Jong Lee
发明人： Jae-Hee Park , Kyung-Min Park , Seok-Jong Lee
IPC分类号： H01L51/56
CPC分类号： H01L51/50 , H01L27/3244 , H01L27/3248 , H01L2251/5315
摘要： An organic electroluminescent device includes: a switching element and a driving element connected to each other on a substrate including a pixel region; a planarization layer on the switching element and the driving element, the planarization layer having a substantially flat top surface; a cathode on the planarization layer, the cathode connected to the driving element; an emitting layer on the cathode; and an anode on the emitting layer.
摘要翻译：有机电致发光器件包括：开关元件和在包括像素区域的衬底上彼此连接的驱动元件; 所述开关元件和所述驱动元件上的平坦化层，所述平坦化层具有基本平坦的顶表面; 平坦化层上的阴极，连接到驱动元件的阴极; 阴极上的发光层; 和发光层上的阳极。

9. 发明申请

US20100253610A1 DISPLAY APPARATUS 有权
标题翻译：显示设备
公开(公告)号：US20100253610A1
公开(公告)日：2010-10-07
申请号：US12703730
申请日：2010-02-10
申请人： Seung-Kyu LEE , Chul-Ho Kim , Kyung-Min Park , Kyung-Hoon Kim , Jin-Suk Park
发明人： Seung-Kyu LEE , Chul-Ho Kim , Kyung-Min Park , Kyung-Hoon Kim , Jin-Suk Park
IPC分类号： G09G3/36 , H01L33/00
CPC分类号： G09G3/3611 , G09G3/3648 , G09G2300/0426 , G09G2320/0223
摘要： A display apparatus comprises a first thin film transistor (TFT) and a second TFT which are disposed in a display area. A first signal transmission line is disposed in a peripheral area surrounding the display area and is electrically connected to the first TFT. A second signal transmission line adjacent to the first signal transmission line is electrically connected to the second TFT. In a first portion of the peripheral area, the first signal transmission line is parallel to the second signal transmission line and is spaced by a first gap from the second signal transmission line. In a second portion of the peripheral area, the first signal transmission line is parallel to the second signal transmission line and is spaced by a second gap from and the second signal transmission line. The second gap is greater than the first gap. Other features are also provided.
摘要翻译：显示装置包括设置在显示区域中的第一薄膜晶体管（TFT）和第二TFT。第一信号传输线设置在围绕显示区域的周边区域中，并且电连接到第一TFT。与第一信号传输线相邻的第二信号传输线电连接到第二TFT。在外围区域的第一部分中，第一信号传输线路与第二信号传输线路平行，并与第二信号传输线路隔开第一间隙。在外围区域的第二部分中，第一信号传输线平行于第二信号传输线，并与第二信号传输线隔开第二间隙。第二个差距大于第一个差距。还提供其他功能。

10. 发明申请

US20100068841A1 Thin Film Transistor Array Panel and Method of Manufacturing the Same 有权
标题翻译：薄膜晶体管阵列面板及其制造方法
公开(公告)号：US20100068841A1
公开(公告)日：2010-03-18
申请号：US12433743
申请日：2009-04-30
申请人： Kyung-Min Park , Jin-Goo Jung , Chun-Gi You , Jae-Byoung Chae , Tae-Ill Kim
发明人： Kyung-Min Park , Jin-Goo Jung , Chun-Gi You , Jae-Byoung Chae , Tae-Ill Kim
IPC分类号： H01L21/336 , H01L21/28
CPC分类号： H01L27/1288 , H01L27/1214 , H01L29/4908 , H01L29/66757
摘要： A method of manufacturing a thin film transistor array panel is provided, which includes: forming a semiconductor layer of polysilicon on an insulating substrate; forming a gate insulating layer on the semiconductor layer; forming a gate electrode on the gate insulating layer; forming a source region and a drain region by doping conductive impurities in the semiconductor layer; forming an interlayer insulating layer covering the gate electrode; forming a source electrode and a drain electrode respectively connected to the source and the drain regions; forming a passivation layer covering the source and the drain electrodes; forming a pixel electrode connected to the drain electrode; and forming a first alignment key when forming one selected from the semiconductor layer, the gate electrode, the source and the drain electrodes, and the pixel electrode, wherein one selected from the semiconductor layer, the gate electrode, the source and the drain electrodes, and the pixel electrode is at least formed by photolithography process using a photoresist pattern as an etch mask, and a second alignment key completely covering the first alignment key is formed at the same layer as the photoresist pattern.
摘要翻译：提供一种制造薄膜晶体管阵列面板的方法，其包括：在绝缘衬底上形成多晶硅半导体层; 在所述半导体层上形成栅极绝缘层; 在栅极绝缘层上形成栅电极; 通过掺杂半导体层中的导电杂质形成源区和漏区; 形成覆盖所述栅电极的层间绝缘层; 形成分别连接到源区和漏区的源电极和漏电极; 形成覆盖源极和漏极的钝化层; 形成连接到所述漏电极的像素电极; 以及在形成从半导体层，栅电极，源极和漏极以及像素电极中选择的一个时形成第一对准键，其中从半导体层，栅电极，源电极和漏电极中选择一个，并且至少通过使用光致抗蚀剂图案作为蚀刻掩模的光刻工艺形成像素电极，并且在与光致抗蚀剂图案相同的层处形成完全覆盖第一对准键的第二对准键。

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