专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130224795A1 IMMOBILIZATION METHOD OF BIOACTIVE MOLECULES USING POLYPHENOL OXIDASE 审中-公开
标题翻译：使用聚苯乙烯氧化酶的生物活性分子的固定方法
公开(公告)号：US20130224795A1
公开(公告)日：2013-08-29
申请号：US13882539
申请日：2011-08-19
申请人： Ki-Dong Park , Kyung-Min Park , Yoon-Ki Joung , Yun-Ki Lee , Ji-Hye Oh , Seung-Mi Hyun
发明人： Ki-Dong Park , Kyung-Min Park , Yoon-Ki Joung , Yun-Ki Lee , Ji-Hye Oh , Seung-Mi Hyun
IPC分类号： C12P21/00 , C12P13/02
摘要： A method is provided for immobilizing a bioactive molecule onto a surface using polyphenol oxidase. In the presence of polyphenol oxidase, a bioactive molecule containing a phenol or catechol group can be simply in situ oxidized within a short time to dopa or dopaquinone which forms a coordinate bond with a metal or polymer substrate, thus immobilizing the bioactive molecule onto the surface with stability. Based on the surface immobilization of bioactive molecules using polyphenol oxidase, various bioactive molecules such as osteogenetic peptides and growth factors can be simply immobilized to medical metal or polymer substrate surfaces such as orthopedic or dental implants which can be then effectively used to induce rapid osteogenesis after being transplanted. Also, antithrombotic agents and/or entothelialization inducing agents may be immobilized to medical substrates for vascular systems, such as stents and artificial blood vessels, thus guaranteeing hemocompatibility to the medical substrates.
摘要翻译：提供了一种使用多酚氧化酶将生物活性分子固定在表面上的方法。在多酚氧化酶的存在下，含有苯酚或儿茶酚基团的生物活性分子可在短时间内简单地原位氧化成与金属或聚合物底物形成配位键的多巴或多巴醌，从而将生物活性分子固定在表面上稳定。基于使用多酚氧化酶的生物活性分子的表面固定化，各种生物活性分子如成骨肽和生长因子可以简单地固定在医疗金属或聚合物基底表面如矫形或牙科植入物上，然后可以有效地用于诱导快速成骨被移植。此外，抗血栓形成剂和/或内皮化诱导剂可以固定在用于血管系统如支架和人造血管的医疗基底上，从而保证对医用基底的血液相容性。

2. 发明申请

US20120100103A1 IN SITU FORMING HYDROGEL AND BIOMEDICAL USE THEREOF 有权
标题翻译：在现场形成水凝胶和生物医学用途
公开(公告)号：US20120100103A1
公开(公告)日：2012-04-26
申请号：US13381843
申请日：2010-07-01
申请人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
发明人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
IPC分类号： A61K38/39 , A61P19/08 , A61P1/02 , A61P17/02 , A61P9/00 , A61K33/24 , A61P13/00 , A61P35/00 , A61P29/00 , A61P31/04 , A61K39/395 , A61K39/00 , A61P19/04 , A61F2/16
CPC分类号： A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
摘要： Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.
摘要翻译：公开了原位成形可注射水凝胶及其医疗用途。在原位形成的可注射水凝胶中，两个或更多个均相或非均相聚合物通过相邻聚合物上的苯酚或苯胺部分之间的脱氢反应彼此键合，其中聚合物主链使用连接体用苯酚或苯胺部分接枝。与常规水凝胶相比，由于引入水溶性聚合物作为接头，原位成形可注射水凝胶在体内稳定性和机械强度方面是优异的，这导致酚或苯胺部分的反应性的改善。具有优异的生物稳定性和机械强度的优点，水凝胶在生物医学领域中发现了多种应用。

3. 发明授权

US08968716B2 In situ-forming hydrogel for tissue adhesives and biomedical use thereof 有权
标题翻译：用于组织粘合剂的原位成膜水凝胶及其生物医学用途
公开(公告)号：US08968716B2
公开(公告)日：2015-03-03
申请号：US13393094
申请日：2010-09-02
申请人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park , Eu-Gene Lih
发明人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park , Eu-Gene Lih
IPC分类号： A61L24/04 , A61L24/08 , A61K38/39 , A61K31/722 , A61K31/765 , A61K38/02 , A61K38/18 , A61K38/27 , A61K38/19 , A61K38/20 , A61K38/23 , A61K38/25 , A61K38/28 , A61K38/31 , A61K38/26 , A61K39/395 , A61K39/00 , A61K33/24 , A61L24/00 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58
CPC分类号： A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
摘要： Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.
摘要翻译：本文公开了原位形成的生物粘附性水凝胶及其医疗用途。通过酶反应原位交联形成的水凝胶在生物相容性方面具有优于常规生物粘附性水凝胶的优点。此外，原位成型生物粘附性水凝胶具有优异的生物相容性和机械强度，并且通过/不使用多巴衍生物进行改性而具有优异的组织粘合性。水凝胶在生物医学领域中发现各种应用，包括生物粘合剂或止血剂，用于组织再生和增殖的植入物质，用于递送生物活性物质或药物的载体等。

4. 发明授权

US08815277B2 In situ forming hydrogel and biomedical use thereof 有权
标题翻译：原位形成水凝胶及其生物医学用途
公开(公告)号：US08815277B2
公开(公告)日：2014-08-26
申请号：US13381843
申请日：2010-07-01
申请人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
发明人： Ki-Dong Park , Yoon-Ki Joung , Kyung-Min Park
IPC分类号： A61F2/00 , A61K45/00 , A61K39/395 , A61K39/00 , C07K14/495 , C07K14/50 , C07K14/485 , A61L27/54 , A61K9/00 , A61L27/52 , A61K47/42
CPC分类号： A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
摘要： Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.
摘要翻译：公开了原位成形可注射水凝胶及其医疗用途。在原位形成的可注射水凝胶中，两个或更多个均相或非均相聚合物通过相邻聚合物上的苯酚或苯胺部分之间的脱氢反应彼此键合，其中聚合物主链使用连接体用苯酚或苯胺部分接枝。与常规水凝胶相比，由于引入水溶性聚合物作为接头，原位成形可注射水凝胶在体内稳定性和机械强度方面是优异的，这导致酚或苯胺部分的反应性的改善。具有优异的生物稳定性和机械强度的优点，水凝胶在生物医学领域中发现了多种应用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式