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1. 发明申请

US20130116231A1 TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20130116231A1
公开(公告)日：2013-05-09
申请号：US13809436
申请日：2011-07-07
申请人： Kevin Wilson , Michael Altman , Kathryn Lipford , Catherine White , Matthew Daniels
发明人： Kevin Wilson , Michael Altman , Kathryn Lipford , Catherine White , Matthew Daniels
IPC分类号： C07D411/14 , C07D403/14 , C07D403/04 , C07D401/14 , C07D401/12
CPC分类号： C07D411/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention relates to 1,4-dihydropyridazinone derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及1,4-二氢哒嗪酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

2. 发明申请

US20130158041A1 Tyrosine Kinase Inhibitors 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20130158041A1
公开(公告)日：2013-06-20
申请号：US13818312
申请日：2011-08-26
申请人： Kevin Wilson , Matthew Daniels
发明人： Kevin Wilson , Matthew Daniels
IPC分类号： C07D403/14 , C07D403/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D237/04
CPC分类号： C07D403/14 , C07D237/04 , C07D237/18 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10
摘要： The present invention relates to pyridazinthione derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病和用于抑制受体酪氨酸激酶MET的哒嗪二酮衍生物。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

3. 发明申请

US20080061078A1 Devices Useful in System and Method for Dispensing Prescriptions 有权
公开(公告)号：US20080061078A1
公开(公告)日：2008-03-13
申请号：US11935441
申请日：2007-11-06
申请人： Matthew Daniels , Jeffrey Williams , Richard Michelli , Jasper Pollard , Demetris Young , Joseph Moran , George Abrams , David Calderwood , Pete Klein
发明人： Matthew Daniels , Jeffrey Williams , Richard Michelli , Jasper Pollard , Demetris Young , Joseph Moran , George Abrams , David Calderwood , Pete Klein
IPC分类号： A61J1/16
CPC分类号： G07F11/62 , G06F19/00 , G06F19/3462 , G07F11/44 , G07F11/70 , G07F13/10 , G07F17/0092
摘要： An automated method for dispensing pharmaceuticals, particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

4. 发明申请

US20110275719A1 NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR 有权
标题翻译：新型三氟甲磺酰胺游离氨基酸抑制剂
公开(公告)号：US20110275719A1
公开(公告)日：2011-11-10
申请号：US13145190
申请日：2010-01-29
申请人： Matthew Daniels , Jed Hubbs , Thomas Miller
发明人： Matthew Daniels , Jed Hubbs , Thomas Miller
IPC分类号： A61K31/18 , A61P25/28 , C07C305/18
CPC分类号： C07D233/42 , C07C317/30 , C07C2601/14 , C07D295/185
摘要： The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明涉及一种新的三氟甲基磺酰胺衍生物，其抑制通过推定的γ-分泌酶处理APP，因此可用于治疗或预防阿尔茨海默氏病。该化合物在较高种类（恒河猴）中具有有利的药代动力学性质，因此可以间歇给药剂量（例如每周一次）给药。当这样一个团体配合时，该化合物显示出显着和连续的A＆Bgr; 降低Notch相关胃肠道毒性长期持续的表现，例如7天。还包括药物组合物和使用方法。

5. 发明申请

US20060002734A1 Method and apparatus for converting process cartridges to fit various types of printing machines 有权
公开(公告)号：US20060002734A1
公开(公告)日：2006-01-05
申请号：US11213203
申请日：2005-08-26
申请人： Matthew Daniels
发明人： Matthew Daniels
IPC分类号： G03G15/00
CPC分类号： G03G21/181 , G03G15/0844 , G03G15/0894 , G03G21/12 , G03G21/1814 , G03G2215/0685 , G03G2221/1815 , G03G2221/1876
摘要： A method for modifying a process cartridge includes providing the process cartridge comprising a waste bin having physical characteristics. The method further includes altering the physical characteristics of the waste bin to form an altered process cartridge.

6. 发明申请

US20070237543A1 Methods for imaging process cartridge modification 有权
公开(公告)号：US20070237543A1
公开(公告)日：2007-10-11
申请号：US11400693
申请日：2006-04-07
申请人： Matthew Daniels
发明人： Matthew Daniels
IPC分类号： G03G15/00
CPC分类号： G03G15/00 , G03G15/0894 , G03G21/181 , G03G2215/0863 , G03G2221/1876
摘要： Techniques are provided for modifying a printer cartridge and an imaging drum unit intended for installation in one type of printer to be installed in another type of printer or a plurality of printers. In one aspect, a method of modifying a toner cartridge may include modifying one or more end plate of the toner cartridge. In another aspect, a method of modifying a toner cartridge may include replacing one or more end plates of the toner cartridge with replacement end plates. In yet another aspect of the present invention, an imaging drum unit may include modifying one or more end plates of the imaging drum unit. In another aspect, an imaging drum unit may include replacing one or more end plates with replacement end plates.

7. 发明申请

US20050185982A1 Method and apparatus for converting process cartridges to fit various types of printing machines 有权
标题翻译：用于将处理盒转换成适合各种类型的印刷机的方法和装置
公开(公告)号：US20050185982A1
公开(公告)日：2005-08-25
申请号：US11095444
申请日：2005-03-31
申请人： Matthew Daniels
发明人： Matthew Daniels
IPC分类号： G03G15/08 , G03G21/12 , G03G15/00
CPC分类号： G03G21/181 , G03G15/0844 , G03G15/0894 , G03G21/12 , G03G21/1814 , G03G2215/0685 , G03G2221/1815 , G03G2221/1876
摘要： A method for converting a process cartridge includes providing the process cartridge comprising a waste bin having physical characteristics. The process cartridge is suitable for use in a first type of printing device and not suitable for use in a second type of printing device. The method further includes altering the physical characteristics of the waste bin to form an altered process cartridge suitable for use in the second type of printing device.
摘要翻译：一种用于转换处理盒的方法，包括提供包括具有物理特性的垃圾箱的处理盒。处理盒适用于第一类型的打印装置，不适用于第二类型的打印装置。该方法还包括改变垃圾箱的物理特征以形成适用于第二类型打印装置的改变的处理盒。

8. 发明授权

US06736487B2 Printer cartridge and method of making or refurbishing 有权
标题翻译：打印机墨盒和制造或翻新的方法
公开(公告)号：US06736487B2
公开(公告)日：2004-05-18
申请号：US10065227
申请日：2002-09-26
申请人： Matthew Daniels
发明人： Matthew Daniels
IPC分类号： B49J294
CPC分类号： B41J2/17559 , B41J2/17553
摘要： A printer cartridge and method of making or refurbishing a printer cartridge are disclosed. The printer cartridge may include a first cartridge subassembly attached to a second cartridge subassembly. The first cartridge subassembly may include a first conductive terminal and the second cartridge subassembly may include a second conductive terminal that is normally in electrical contact with the first conductive terminal when the first and second subassemblies are assembled. An external access may be provided to the first conductive terminal in the event the first conductive terminal is inaccessible after assembling the printer cartridge.
摘要翻译：公开了一种打印机墨盒和制造或翻新打印机墨盒的方法。打印机墨盒可以包括附接到第二墨盒子组件的第一墨盒子组件。第一盒子组件可以包括第一导电端子，并且第二盒子组件可以包括第二导电端子，当组装第一和第二子组件时，第二导电端子通常与第一导电端子电接触。在组装打印机墨盒之后第一导电端子不能接近的情况下，可以向第一导电端子提供外部访问。

9. 发明申请

US20130176893A1 Loop Containment Enhancement 审中-公开
标题翻译：循环遏制增强
公开(公告)号：US20130176893A1
公开(公告)日：2013-07-11
申请号：US13344284
申请日：2012-01-05
申请人： Paul O. Caffrey , Matthew Daniels , Mark Asfaw
发明人： Paul O. Caffrey , Matthew Daniels , Mark Asfaw
IPC分类号： H04L12/28
CPC分类号： H04L12/462 , H04L12/4625
摘要： Systems, methods, and apparatus for providing a communication network free of bridge loops by providing a first message from one of two bridges and a second message in response to the first message from the other of the two bridges and establishing a communicative path if both the first and second messages were received.
摘要翻译：用于通过从两个网桥之一提供第一消息和响应于来自两个网桥中的另一个的第一消息而提供第一消息来提供没有桥接环路的通信网络的系统，方法和装置，并且如果两者都收到第一和第二条消息。

10. 发明申请

US20080061075A1 Devices Useful in System and Method for Dispensing Prescriptions 有权
公开(公告)号：US20080061075A1
公开(公告)日：2008-03-13
申请号：US11935430
申请日：2007-11-06
申请人： Matthew Daniels , Jeffrey Williams , Richard Michelli , Jasper Pollard , Demetris Young , Joseph Moran , George Abrams , David Calderwood , Pete Klein
发明人： Matthew Daniels , Jeffrey Williams , Richard Michelli , Jasper Pollard , Demetris Young , Joseph Moran , George Abrams , David Calderwood , Pete Klein
IPC分类号： G07F11/00
CPC分类号： G07F11/62 , G06F19/00 , G06F19/3462 , G07F11/44 , G07F11/70 , G07F13/10 , G07F17/0092
摘要： An automated method for dispensing pharmaceuticals, particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

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