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1. 发明申请

US20130116231A1 TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20130116231A1
公开(公告)日：2013-05-09
申请号：US13809436
申请日：2011-07-07
申请人： Kevin Wilson , Michael Altman , Kathryn Lipford , Catherine White , Matthew Daniels
发明人： Kevin Wilson , Michael Altman , Kathryn Lipford , Catherine White , Matthew Daniels
IPC分类号： C07D411/14 , C07D403/14 , C07D403/04 , C07D401/14 , C07D401/12
CPC分类号： C07D411/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention relates to 1,4-dihydropyridazinone derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及1,4-二氢哒嗪酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

2. 发明申请

US20130158041A1 Tyrosine Kinase Inhibitors 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20130158041A1
公开(公告)日：2013-06-20
申请号：US13818312
申请日：2011-08-26
申请人： Kevin Wilson , Matthew Daniels
发明人： Kevin Wilson , Matthew Daniels
IPC分类号： C07D403/14 , C07D403/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D237/04
CPC分类号： C07D403/14 , C07D237/04 , C07D237/18 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10
摘要： The present invention relates to pyridazinthione derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病和用于抑制受体酪氨酸激酶MET的哒嗪二酮衍生物。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

3. 发明授权

US09023865B2 Compounds that are ERK inhibitors 有权
标题翻译： ERK抑制剂的化合物
公开(公告)号：US09023865B2
公开(公告)日：2015-05-05
申请号：US14353381
申请日：2012-10-25
申请人： Jongwon Lim , Elizabeth Helen Kelley , Joey L. Methot , Hua Zhou , Alessia Petrocchi , Umar Faruk Mansoor , Christian Fischer , Brendan O'Boyle , David Joseph Guerin , Corey E. Bienstock , Christopher W. Boyce , Matthew H. Daniels , Danielle Falcone , Ronald D. Ferguson , Salem Fevrier , Xianhai Huang , Kathryn Ann Lipford , David L. Sloman , Kevin Wilson , Wei Zhou , David Witter , Milana M. Maletic , Phieng Siliphaivanh
发明人： Jongwon Lim , Elizabeth Helen Kelley , Joey L. Methot , Hua Zhou , Alessia Petrocchi , Umar Faruk Mansoor , Christian Fischer , Brendan O'Boyle , David Joseph Guerin , Corey E. Bienstock , Christopher W. Boyce , Matthew H. Daniels , Danielle Falcone , Ronald D. Ferguson , Salem Fevrier , Xianhai Huang , Kathryn Ann Lipford , David L. Sloman , Kevin Wilson , Wei Zhou , David Witter , Milana M. Maletic , Phieng Siliphaivanh
IPC分类号： C07D401/14 , A61K31/437 , C07D471/04 , C07D519/00 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要翻译：公开了式（1）的ERK抑制剂及其药学上可接受的盐。还公开了使用式（1）的化合物治疗癌症的方法。

4. 发明授权

US08847715B2 Multi integrated switching device structures 有权
标题翻译：多集成开关器件结构
公开(公告)号：US08847715B2
公开(公告)日：2014-09-30
申请号：US13627233
申请日：2012-09-26
申请人： Kevin Wilson , Robert Tarzwell , Patrick McGuire
发明人： Kevin Wilson , Robert Tarzwell , Patrick McGuire
IPC分类号： H01H9/00 , H01H53/00 , H01H51/22
CPC分类号： H01H51/2281 , H01F7/0221 , H01H50/043 , H01H51/229 , H01H2050/007
摘要： A permanent magnet is pivotally mounted in a top spacer layer of a switching device and rests on a flex arm created in an underlying flex circuit layer. The underside of the flex arm rests on a thin bar formed in a lower spacer layer beneath which lies a base layer including an electromagnet. Activation of the electromagnet causes rotation of the flex arm to thereby close and open electrical contacts formed respectively on the underside of the flex arm and on the top surface of the base layer.
摘要翻译：永磁体枢转地安装在开关装置的顶部间隔层中并且搁置在在下面的柔性电路层中产生的挠性臂上。柔性臂的下侧搁置在形成在下部间隔层中的细条上，下部隔离层位于包括电磁体的基底层。电磁体的激活导致柔性臂的旋转，从而闭合并打开分别形成在柔性臂的下侧和基底层的顶表面上的电触头。

5. 发明授权

US08420695B2 Inhibitors of janus kinases 有权
标题翻译：痛风激酶抑制剂
公开(公告)号：US08420695B2
公开(公告)日：2013-04-16
申请号：US13002776
申请日：2009-07-01
申请人： Kevin Wilson , Gabriela de Almeida , Andrew Haidle , Kaleen Konrad , Michelle Machacek , Ann Zabierek
发明人： Kevin Wilson , Gabriela de Almeida , Andrew Haidle , Kaleen Konrad , Michelle Machacek , Ann Zabierek
IPC分类号： A61K31/38 , C07D333/36 , C07D333/42
CPC分类号： C07D333/38 , C07D409/04 , C07D409/12 , C07D413/12
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制四种已知的哺乳动物JAK激酶（JAK1，JAK2，JAK3和TYK2）的化合物。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物施用于需要治疗骨髓增生性疾病或癌症的患者的JAK1，JAK2，JAK3和TYK2的活性的方法。

6. 发明授权

US08415346B2 Inhibitors of Janus kinases 有权
标题翻译： Janus激酶抑制剂
公开(公告)号：US08415346B2
公开(公告)日：2013-04-09
申请号：US13056180
申请日：2009-07-21
申请人： Michael Altman , Kevin Wilson
发明人： Michael Altman , Kevin Wilson
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , C07D231/38 , C07D413/12 , C07D403/12 , C07D417/12
CPC分类号： C07D231/38 , C07D401/12
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制四种已知的哺乳动物JAK激酶（JAK1，JAK2，JAK3和TYK2）的化合物。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物施用于需要治疗骨髓增生性疾病或癌症的患者的JAK1，JAK2，JAK3和TYK2的活性的方法。

7. 发明授权

US08367706B2 Inhibitors of janus kinases 有权
公开(公告)号：US08367706B2
公开(公告)日：2013-02-05
申请号：US12665045
申请日：2008-06-16
申请人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
发明人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号： A61K31/4436 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

8. 发明申请

US20120161909A1 Multi Integrated Switching Device Structures 有权
标题翻译：多集成开关器件结构
公开(公告)号：US20120161909A1
公开(公告)日：2012-06-28
申请号：US13281310
申请日：2011-10-25
申请人： Kevin Wilson , Robert Tarzwell , Patrick McGuire
发明人： Kevin Wilson , Robert Tarzwell , Patrick McGuire
IPC分类号： H01H45/00
CPC分类号： H01H50/20 , H01H50/005 , H01H50/60 , H01H51/27 , H01H2050/007 , H01H2050/049
摘要： A switching device structure having a top layer and a bottom layer, each layer comprising a body of magnetizable material, such as permalloy, disposed within a coil wherein an armature is suspended in a cavity between the top and bottom layers, the armature having ferromagnetic material disposed on a top and bottom surface thereof. Each body of magnetizable material may be pulsed by its respective coil to switch it from a magnetic state to a non-magnetic state and then subsequently pulsed by the coil to switch it from the non-magnetic state to a magnetic state.
摘要翻译：一种具有顶层和底层的开关器件结构，每个层包括设置在线圈内的可磁化材料体例如坡莫合金，其中电枢悬挂在顶层和底层之间的空腔中，电枢具有铁磁材料设置在其顶表面和底表面上。可磁化材料的每个主体可以被其相应的线圈脉冲以将其从磁状态转换到非磁状态，然后由线圈脉冲以将其从非磁状态转换到磁状态。

9. 发明授权

US07804825B2 Matrix expansion lattice 有权
标题翻译：矩阵扩展格
公开(公告)号：US07804825B2
公开(公告)日：2010-09-28
申请号：US11950272
申请日：2007-12-04
申请人： Kevin Wilson , Ninh Nguyen
发明人： Kevin Wilson , Ninh Nguyen
IPC分类号： H04L12/50
CPC分类号： H04L49/45 , H04L49/1515
摘要： A cross-connect switching system includes a plurality of three stage switching arrays and an expansion switching array, wherein a second stage of each of the three stage switching arrays includes an expansion section comprising switches which facilitate interconnection of each three stage array to the expansion switching array. In one embodiment, the expansion switching array includes a plurality of square arrays, each having Q inputs and Q outputs and wherein the second stages of the three stage arrays each include 1 . . . M+1 . . . M+p vertical stages which connect to the square “D” arrays of the central expansion switching array.
摘要翻译：交叉连接交换系统包括多个三级开关阵列和扩展开关阵列，其中三级开关阵列中的每一级的第二级包括扩展部分，该扩展部分包括促进每个三级阵列与扩展开关的互连的开关数组。在一个实施例中，扩展开关阵列包括多个正方形阵列，每个阵列具有Q个输入和Q个输出，并且其中三个阶段阵列的第二阶段各自包括1个。。。 M + 1。。。 M + p垂直级连接到中心扩展开关阵列的“D”阵列。

10. 发明申请

US20090170824A1 Diarylsulfones as 5-HT2A Antagonists 审中-公开
标题翻译：二芳基砜为5-HT2A拮抗剂
公开(公告)号：US20090170824A1
公开(公告)日：2009-07-02
申请号：US12316388
申请日：2008-12-12
申请人： Jose Luis Castro Pineiro , Laura Catherine Cooper , Myra Gilligan , Alexander Charles Humphries , Peter Alen Hunt , Tamara Ladduwahetty , Angus Murray MacLeod , Kevin John Merchant , Monique Bodil Van Niel , Kevin Wilson
发明人： Jose Luis Castro Pineiro , Laura Catherine Cooper , Myra Gilligan , Alexander Charles Humphries , Peter Alen Hunt , Tamara Ladduwahetty , Angus Murray MacLeod , Kevin John Merchant , Monique Bodil Van Niel , Kevin Wilson
IPC分类号： A61K31/397 , A61K31/47 , A61K31/335 , A61K31/10 , A61K31/535 , A61K31/497
CPC分类号： C07C317/28 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/36 , C07C317/42 , C07C317/44 , C07D205/04 , C07D207/10 , C07D211/38 , C07D211/72 , C07D213/34 , C07D213/71 , C07D217/24 , C07D231/12 , C07D233/64 , C07D241/08 , C07D249/08 , C07D261/08 , C07D271/10 , C07D277/26 , C07D295/096 , C07D317/62 , C07D319/18
摘要： Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.
摘要翻译：式I化合物是人5-HT 2A受体的有效和选择性拮抗剂，因此可用于治疗CNS的多种不利条件。

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