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1. 发明申请

US20060142252A1 Tubulin binding agents and corresponding prodrug constructs 审中-公开
公开(公告)号：US20060142252A1
公开(公告)日：2006-06-29
申请号：US11359095
申请日：2006-02-21
申请人： Kevin Pinney , Vani Mocharla , Zhi Chen , Charles Garner , Anjan Ghatak , Usha Ghatak , Mallinath Hadimani , Jimmy Kessler , James Dorsey , Klaus Edvardson , David Chaplin , Joseph Prezioso
发明人： Kevin Pinney , Vani Mocharla , Zhi Chen , Charles Garner , Anjan Ghatak , Usha Ghatak , Mallinath Hadimani , Jimmy Kessler , James Dorsey , Klaus Edvardson , David Chaplin , Joseph Prezioso
IPC分类号： A61K31/66 , A61K31/075
CPC分类号： C07C43/23 , A61K31/075 , A61K31/66 , C07C43/215 , C07C45/512 , C07C45/64 , C07C45/673 , C07C49/755 , C07C49/84 , C07C205/37 , C07C205/45 , C07C217/84 , C07C217/94 , C07C223/06 , C07C225/22 , C07C237/08 , C07C2602/08 , C07C2602/10 , C07D307/80 , C07D307/81 , C07D333/56 , C07D333/64 , C07F9/12 , C07F9/18 , C07F9/247 , C07F9/65517 , C07F9/655354
摘要： A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

2. 发明申请

US20060035868A1 Functionalized stilbene derivatives as improved vascular targeting agents 有权
公开(公告)号：US20060035868A1
公开(公告)日：2006-02-16
申请号：US11183556
申请日：2005-07-18
申请人： David Chaplin , Charles Garner , Robert Kane , Kevin Pinney , Joseph Prezioso , Klaus Edvardsen
发明人： David Chaplin , Charles Garner , Robert Kane , Kevin Pinney , Joseph Prezioso , Klaus Edvardsen
IPC分类号： A61K31/66 , C07F9/12
CPC分类号： C07C43/23 , C07C45/63 , C07C47/575 , C07C205/37 , C07C207/04 , C07C217/84 , C07C237/04 , C07F9/12
摘要： Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.

3. 发明申请

US20060194770A1 Methods for modulating tumor growth and metastasis 审中-公开
标题翻译：调节肿瘤生长和转移的方法
公开(公告)号：US20060194770A1
公开(公告)日：2006-08-31
申请号：US11415731
申请日：2006-05-01
申请人： Francis Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardson
发明人： Francis Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardson
IPC分类号： A61K31/66 , A61K31/28 , A01N31/14
CPC分类号： A61K31/337 , A61K31/05 , A61K31/66 , A61K2300/00
摘要： Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.
摘要翻译：提供了调节肿瘤生长或转移的方法和药物组合物。

4. 发明申请

US20050245489A1 Chromene-containing compounds with anti-tubulin and vascular targeting activity 审中-公开
标题翻译：含有色素的化合物具有抗微管蛋白和血管靶向活性
公开(公告)号：US20050245489A1
公开(公告)日：2005-11-03
申请号：US10837841
申请日：2004-05-03
申请人： Kevin Pinney , Phyllis Arthasary , Anupama Shirali , Klaus Edvardsen , David Chaplin
发明人： Kevin Pinney , Phyllis Arthasary , Anupama Shirali , Klaus Edvardsen , David Chaplin
IPC分类号： A61K31/353 , A61K31/665 , C07D311/04 , C07D311/12 , C07D311/16 , C07D311/18
CPC分类号： C07D311/18 , C07D311/12 , C07D311/16
摘要： Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
摘要翻译：已经发现了三甲氧基苯基取代的吲哚配体，其表现出令人印象深刻的细胞毒性以及抑制微管蛋白聚合的显着能力。这些化合物以及相关衍生物是用于治疗人类癌症的优异临床候选物。此外，作为前药的这些配体中的某些可以很好地证明是肿瘤选择性血管靶向化学治疗剂或具有导致选择性预防和/或破坏非恶性增殖血管的血管靶向活性。

5. 发明申请

US20050245490A1 Chromene-containing compounds with anti-tubulin and vascular targeting activity 有权
公开(公告)号：US20050245490A1
公开(公告)日：2005-11-03
申请号：US10851445
申请日：2004-05-21
申请人： Kevin Pinney , Phyllis Arthasary , Anupama Shirali , Klaus Edvardsen , David Chaplin
发明人： Kevin Pinney , Phyllis Arthasary , Anupama Shirali , Klaus Edvardsen , David Chaplin
IPC分类号： A61K31/35 , A61K31/353 , A61K31/665 , A61P35/00 , C07D311/58
CPC分类号： C07D311/58
摘要： Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

6. 发明申请

US20090192098A1 METHOD FOR TREATING HEMATOPOIETIC NEOPLASMS 审中-公开
标题翻译：治疗嗜酸性粒细胞的方法
公开(公告)号：US20090192098A1
公开(公告)日：2009-07-30
申请号：US12276197
申请日：2008-11-21
申请人： David Chaplin , Bronwyn G. Siim
发明人： David Chaplin , Bronwyn G. Siim
IPC分类号： A61K31/7048 , A61K31/6615 , A61K31/675 , A61P35/00
CPC分类号： A61K31/6615 , A61K31/52 , A61K31/661 , A61K31/675 , A61K31/7048 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： This invention relates to methods for treating a hematopoietic neoplasm comprising administering a therapeutically effective amount of a combretastatin compound, or a pharmaceutically acceptable salt thereof, to a subject having a hematological malignancy, wherein the combretastatin compound comprises a catechol or quinone moiety and is capable of forming a reactive oxygen species (ROS) in vivo. The method may further comprise co-administering a second chemotherapeutic agent.
摘要翻译：本发明涉及用于治疗造血肿瘤的方法，其包括向具有血液恶性肿瘤的受试者施用治疗有效量的考布他汀化合物或其药学上可接受的盐，其中所述考布他汀化合物包含儿茶酚或醌部分，并且能够在体内形成活性氧（ROS）。该方法还可以包括共同施用第二化学治疗剂。

7. 发明申请

US20050160958A1 Ballast system for tension leg platform 有权
标题翻译：压腿系统用于张力腿平台
公开(公告)号：US20050160958A1
公开(公告)日：2005-07-28
申请号：US11040406
申请日：2005-01-21
申请人： Terrence Kryska , David Chaplin
发明人： Terrence Kryska , David Chaplin
IPC分类号： B63B13/00 , B63B21/50 , B63G8/22 , B63B25/08
CPC分类号： B63B13/00 , B63B21/502 , B63B43/06 , B63B2021/505
摘要： An apparatus and method for ballasting and de-ballasting a vessel having a hull with several watertight ballast compartments. In a first embodiment, a pressure tank is isolatably and fluidly coupled to a common sea chest, to the atmosphere, to ballast compartments via a distribution manifold, and to a source of compressed gas. The pressure tank is first vented and filled with water from the sea chest, then isolated. The filled tank is then coupled to a ballast tank and the source of compressed gas, which displaces water from the tank to the ballast compartment. In other embodiments, ballasting is by venting and flooding compartments using individual sea chests located within the ballast compartments or a firewater system. For de-ballasting, compressed gas displaces ballast water through overboard discharges, through the common sea chest via the pressure tank, or through individual sea chests located within the ballast compartments.
摘要翻译：一种用具有几个水密压载舱的船体进行压载和卸载的船舶的装置和方法。在第一实施例中，压力罐可隔离并且流体地联接到共同的海底，大气，经由分配歧管和压缩气体源连接到压载舱。压力罐首先排放，并从海底充满水，然后隔离。填充的罐然后被连接到压载箱和压缩气体源，其将水从罐移动到镇流室。在其他实施例中，通过使用位于压载隔间内的个别海柜或消防水系统来排放和淹没隔室。对于卸载压缩气体，压缩气体通过舷外排放物，通过压力罐或通过位于压载舱内的各个海洋箱体的普通海底置换压载水。

8. 发明申请

US20090137687A1 Compositions and Methods With Enhanced Therapeutic Activity 审中-公开
标题翻译：具有增强治疗活性的组合物和方法
公开(公告)号：US20090137687A1
公开(公告)日：2009-05-28
申请号：US12142495
申请日：2008-06-19
申请人： David Chaplin , Kevin G. Pinney , Peter Wardman , Vani P. Mocharla , Lisa K. Folkes
发明人： David Chaplin , Kevin G. Pinney , Peter Wardman , Vani P. Mocharla , Lisa K. Folkes
IPC分类号： A61K31/122 , C07C49/84 , A61K31/09 , C07C43/23
CPC分类号： A61K31/122 , A61K31/09 , C07C43/23 , C07C50/34 , C07C2603/26
摘要： This invention relates to novel tricyclic quinone and catechol compositions, compositions containing prodrugs of tricyclic quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. In certain aspects, the compositions of the invention are capable of generating both a vascular targeting effect and tumor cell cytotoxicity (e.g., by oxidative stress) in order to achieve an enhanced anti-tumor response in a patient.
摘要翻译：本发明涉及新型三环醌和儿茶酚组合物，含有三环醌和儿茶酚组合物前药的组合物，以及用于治疗实体瘤癌症和其它血管增生性疾病的方法。在某些方面，本发明的组合物能够产生血管靶向效应和肿瘤细胞毒性（例如通过氧化应激），以便在患者体内实现增强的抗肿瘤反应。

9. 发明申请

US20060018642A1 Mobile laser designated infrared multimedia mapping system 审中-公开
标题翻译：移动激光指定红外多媒体制图系统
公开(公告)号：US20060018642A1
公开(公告)日：2006-01-26
申请号：US10894022
申请日：2004-07-20
申请人： David Chaplin
发明人： David Chaplin
IPC分类号： G03B39/00
CPC分类号： G08B17/005 , G01V8/10 , G03B29/00 , G03B37/00
摘要： A system for collecting GPS positioning data in correlation with infrared imagery and digital imagery from an aerial based platform. The system can complete the said data collection assignments without requiring physically connecting any hardware or sensors to the exterior of the aircraft. Our inventions exclusive niche in the aerial remote sensing industry consists of a mobile hardware platform, which facilitates mounting an array of cameras, sensors, and recording equipment inside the aircraft without any hardware mounted to the exterior of the aircraft. The mobile hardware platform supports multiple types and configurations of cameras and a diverse sensor array. The preferred embodiment of the sensory and camera configuration operates concurrently in real-time to facilitate the data collection process. The said preferred embodiment allows an operator to collect infrared imagery, digital imagery, and geopspatial position coordinates for a single target or multiple targets simultaneously. The system was also designed to enable the data collection process during normal flight without requiring the aircraft to hover or reverse direction. Due to the field of view and mobility the tree-way tripod head provides, targets can be acquired and recorded while the aircraft is in motion. The MOBILE LASER DESIGNATED INFRARED MULTIMEDIA MAPPING SYSTEM was designed for, but not limited to, use on forest fire monitoring, utilities inspections, and riparian wildlife and habitat mapping homeland security, agricultural inspection, forest management, burn area rehabilitation assessment, HAZMAT assessment, surveillance, aerial perimeter mapping and calculations, and many other remote sensing applications.
摘要翻译：一种用于从基于天线的平台与红外成像和数字图像相关的GPS定位数据的收集系统。该系统可以完成所述数据采集分配，而不需要将任何硬件或传感器物理连接到飞行器的外部。我们的发明在空中遥感行业的专有利基包括一个移动硬件平台，有助于在飞机内部安装一系列相机，传感器和记录设备，而无需安装在飞机外部的任何硬件。移动硬件平台支持多种类型和配置的摄像机和不同的传感器阵列。感觉和相机配置的优选实施例同时实时地进行以促进数据收集过程。所述优选实施例允许操作员同时收集单个目标或多个目标的红外图像，数字图像和地理空间位置坐标。该系统还被设计为使得在正常飞行期间的数据收集过程不需要飞机悬停或反向。由于树形三脚架头部提供的视野和移动性，在飞机运动时可以获取和记录目标。手机激光指定红外多媒体映射系统是为森林火灾监测，公用事业检查和河岸野生动物和栖息地绘制国土安全，农业检查，森林管理，烧伤区域恢复评估，HAZMAT评估，监测而设计的，但不限于此，空中周边测绘和计算，以及许多其他遥感应用。

10. 发明申请

US20090258937A1 Methods for Modulating Tumor Growth and Metastasis 审中-公开
标题翻译：调节肿瘤生长和转移的方法
公开(公告)号：US20090258937A1
公开(公告)日：2009-10-15
申请号：US12266727
申请日：2008-11-07
申请人： Francis Y. Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardsen
发明人： Francis Y. Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardsen
IPC分类号： A61K31/337 , A61K31/09 , A61P35/00
CPC分类号： A61K31/337 , A61K31/05 , A61K31/66 , A61K2300/00
摘要： Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.
摘要翻译：提供了调节肿瘤生长或转移的方法和药物组合物。

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