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1. 发明申请

US20060142252A1 Tubulin binding agents and corresponding prodrug constructs 审中-公开
公开(公告)号：US20060142252A1
公开(公告)日：2006-06-29
申请号：US11359095
申请日：2006-02-21
申请人： Kevin Pinney , Vani Mocharla , Zhi Chen , Charles Garner , Anjan Ghatak , Usha Ghatak , Mallinath Hadimani , Jimmy Kessler , James Dorsey , Klaus Edvardson , David Chaplin , Joseph Prezioso
发明人： Kevin Pinney , Vani Mocharla , Zhi Chen , Charles Garner , Anjan Ghatak , Usha Ghatak , Mallinath Hadimani , Jimmy Kessler , James Dorsey , Klaus Edvardson , David Chaplin , Joseph Prezioso
IPC分类号： A61K31/66 , A61K31/075
CPC分类号： C07C43/23 , A61K31/075 , A61K31/66 , C07C43/215 , C07C45/512 , C07C45/64 , C07C45/673 , C07C49/755 , C07C49/84 , C07C205/37 , C07C205/45 , C07C217/84 , C07C217/94 , C07C223/06 , C07C225/22 , C07C237/08 , C07C2602/08 , C07C2602/10 , C07D307/80 , C07D307/81 , C07D333/56 , C07D333/64 , C07F9/12 , C07F9/18 , C07F9/247 , C07F9/65517 , C07F9/655354
摘要： A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

2. 发明授权

US07419061B1 Integrated rack for distributed signal and distributed energy components attachable to a facility 失效
标题翻译：用于分布式信号的集成机架和可连接到设施的分布式能量组件
公开(公告)号：US07419061B1
公开(公告)日：2008-09-02
申请号：US11073515
申请日：2005-03-07
申请人： James Dorsey
发明人： James Dorsey
IPC分类号： A47F5/00
CPC分类号： H02B1/301 , H05K7/18
摘要： An integrated rack for distributed signal and distributed energy components attachable to a facility includes a first end plate with a first front and first back side, a second end plate with a second front and second back side, a back wall for engaging the back sides of the end plates. The top of the back wall engages a facility ceiling and the bottom of the back wall engages a facility floor. At least one wireway can be disposed in the back wall. A opening can be formed between a first mounting angle connected to the first front side and a second mounting angle connected to the second front side and wherein the mounting angles comprises at least one perforation per inch. At least one distributed signal or distributed energy equipment can be removably mounted to the perforations on the mounting angles.
摘要翻译：用于分布式信号的集成机架和可附接到设施的分布式能量部件包括具有第一前部和第一后侧的第一端板，具有第二前后侧的第二端板，用于接合端板。后壁的顶部与设施天花板接合，后壁的底部与设施楼层接合。至少一个线槽可以设置在后壁中。可以在连接到第一前侧的第一安装角度和连接到第二前侧的第二安装角度之间形成开口，并且其中安装角度包括每英寸至少一个穿孔。至少一个分布式信号或分布式能量设备可以可拆卸地安装在安装角度上的穿孔上。

3. 发明申请

US20080004328A1 FUSED HETEROCYCLES 失效
标题翻译：熔融杂环
公开(公告)号：US20080004328A1
公开(公告)日：2008-01-03
申请号：US11833903
申请日：2007-08-03
申请人： James Dorsey , Michele Heffernan , Qun Fang , Robert Foglesong , Seth Hopkins , Cyprian Ogbu , Mustapha Soukri , Kerry Spear
发明人： James Dorsey , Michele Heffernan , Qun Fang , Robert Foglesong , Seth Hopkins , Cyprian Ogbu , Mustapha Soukri , Kerry Spear
IPC分类号： A61K31/407
CPC分类号： A61K31/407 , C07D491/04 , C07D495/04
摘要： This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.
摘要翻译：本发明提供具有下式的稠合杂环：其中R 1是选自H，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R 2是选自H取代或未取代的烯基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R 3是选自H，C 1 -C 6取代或未取代的烷基，取代或未取代的芳基烷基和取代的或未取代的杂芳基烷基。 R 4是选自OH和O - O + X +的成员，其中X + +是正离子，其中是选自有机正离子和无机阳离子的成员。取代或未取代的芳基烷基和取代或未取代的杂芳基烷基部分具有下式：其中Ar是选自取代或未取代的芳基和取代或未取代的杂芳基的成员。索引n是从1到4的整数。

4. 发明申请

US20110283457A1 Mattress Structures for Child Containment and Sleeping Devices 有权
标题翻译：用于儿童遏制和睡眠装置的床垫结构
公开(公告)号：US20110283457A1
公开(公告)日：2011-11-24
申请号：US13113836
申请日：2011-05-23
申请人： Ernest Son , Matthew Rivera , Melissa Wolf , Brandon Burkholder , James Dorsey
发明人： Ernest Son , Matthew Rivera , Melissa Wolf , Brandon Burkholder , James Dorsey
IPC分类号： A47D7/00
CPC分类号： A47D7/04 , A47D9/00
摘要： A mattress pad assembly for use with a child containment area is disclosed. The mattress pad assembly includes a mattress pad having a plurality of panels each of which is coupled to at least one other panel along a flexible seam, wherein the mattress pad is reconfigurable between a non-planar configuration and a planar configuration defined by the cooperation of the plurality of panels to form a flexible top surface and a substantially rigid bottom surface. The mattress pad assembly further includes a support assembly coupled to the bottom surface of the mattress pad when the mattress pad is in the planar configuration, the support assembly having one or more support connectors coupled to at least two of the plurality of panels, and a brace configured to removably cooperate with the one or more support connectors, wherein the brace is configured to engage each of the plurality of panels to prevent bending along the flexible seam.
摘要翻译：公开了一种与儿童收容区一起使用的床垫组件。床垫垫组件包括具有多个面板的床垫，每个面板沿着柔性接缝联接到至少一个其它面板，其中床垫可重新配置在非平面构型和由平面构型所述多个面板形成柔性顶表面和基本刚性的底表面。床垫垫组件还包括当床垫处于平面构型时联接到床垫的底表面的支撑组件，支撑组件具有联接到多个面板中的至少两个的一个或多个支撑连接器，以及一个支架构造成可移除地与所述一个或多个支撑连接器配合，其中，所述支架被构造成接合所述多个面板中的每一个以防止沿着所述柔性接缝弯曲。

5. 发明申请

US20080058395A1 Fused heterocyclic inhibitors of D-amino acid oxidase 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂
公开(公告)号：US20080058395A1
公开(公告)日：2008-03-06
申请号：US11825093
申请日：2007-07-02
申请人： Michele Heffernan , James Dorsey , Qun Fang , Robert Foglesong , Seth Hopkins , Michael Jones , Steven Jones , Cyprian Ogbu , Joe Perales , Mustapha Soukri , Kerry Spear , Mark Varney
发明人： Michele Heffernan , James Dorsey , Qun Fang , Robert Foglesong , Seth Hopkins , Michael Jones , Steven Jones , Cyprian Ogbu , Joe Perales , Mustapha Soukri , Kerry Spear , Mark Varney
IPC分类号： A61K31/40 , A61K31/415 , A61K31/425 , A61K31/48 , A61P43/00 , C07D231/02 , C07D303/02 , C07D487/02 , C07D513/00
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.
摘要翻译：本发明提供了D-氨基酸氧化酶酶的新型抑制剂以及包含本发明化合物的药物组合物。还提供了治疗和预防神经系统疾病如神经精神和神经退行性疾病以及疼痛，共济失调和惊厥的方法。本发明的化合物具有以下通式结构：其中Q是选自O，S，CR 1和N中的一个，X和Y是独立地选自CR 2，，O，S，N和NR 3。

6. 发明申请

US20050145594A1 Bullhorn cup 审中-公开
标题翻译：牛角杯
公开(公告)号：US20050145594A1
公开(公告)日：2005-07-07
申请号：US10888945
申请日：2004-07-08
申请人： Massai Dorsey , James Dorsey
发明人： Massai Dorsey , James Dorsey
IPC分类号： B65D1/26 , B65D3/06 , B65D81/36 , B65D19/00
CPC分类号： B65D1/265 , B65D3/06 , B65D81/36
摘要： A beverage cup or container that is usable as a bullhorn device is disclosed. The cup is preferably made of a disposable material, such as paper, molded plastic or foam. The cup has a hollow body portion, shaped to form a cylinder or cone, with an open first end, and a second end located distal from the first end. The second end has a removable, or selectively separable, portion formed by a perforation in a base portion. A pull tab or other device may be provided to aid in separation of the removable portion from the body portion.
摘要翻译：公开了一种可用作扩张器装置的饮料杯或容器。杯子优选地由一次性材料制成，例如纸，模制塑料或泡沫。杯具有中空的主体部分，其形状形成圆柱体或锥体，具有敞开的第一端，以及位于远离第一端的第二端。第二端具有由基部中的穿孔形成的可拆卸或可选择性分离的部分。可以提供拉片或其它装置以帮助可拆卸部分与主体部分分离。

7. 发明授权

US08566988B2 Mattress structures for child containment and sleeping devices 有权
标题翻译：用于儿童遏制和睡眠设备的床垫结构
公开(公告)号：US08566988B2
公开(公告)日：2013-10-29
申请号：US13113836
申请日：2011-05-23
申请人： Ernest Son , Matthew Rivera , Melissa Wolf , Brandon Burkholder , James Dorsey
发明人： Ernest Son , Matthew Rivera , Melissa Wolf , Brandon Burkholder , James Dorsey
IPC分类号： A47C17/00
CPC分类号： A47D7/04 , A47D9/00
摘要： A mattress pad assembly for use with a child containment area is disclosed. The mattress pad assembly includes a mattress pad having a plurality of panels each of which is coupled to at least one other panel along a flexible seam, wherein the mattress pad is reconfigurable between a non-planar configuration and a planar configuration defined by the cooperation of the plurality of panels to form a flexible top surface and a substantially rigid bottom surface. The mattress pad assembly further includes a support assembly coupled to the bottom surface of the mattress pad when the mattress pad is in the planar configuration, the support assembly having one or more support connectors coupled to at least two of the plurality of panels, and a brace configured to removably cooperate with the one or more support connectors, wherein the brace is configured to engage each of the plurality of panels to prevent bending along the flexible seam.
摘要翻译：公开了一种与儿童收容区一起使用的床垫组件。床垫垫组件包括具有多个面板的床垫，每个面板沿着柔性接缝联接到至少一个其它面板，其中床垫可重新配置在非平面构型和由平面构型所述多个面板形成柔性顶表面和基本刚性的底表面。床垫垫组件还包括当床垫处于平面构型时联接到床垫的底表面的支撑组件，支撑组件具有联接到多个面板中的至少两个的一个或多个支撑连接器，以及一个支架构造成可移除地与所述一个或多个支撑连接器配合，其中，所述支架被构造成接合所述多个面板中的每一个以防止沿着所述柔性接缝的弯曲。

8. 发明申请

US20070183859A1 Method for machining a molded part and machine tool therefor 失效
标题翻译：用于加工模制零件和机床的方法
公开(公告)号：US20070183859A1
公开(公告)日：2007-08-09
申请号：US11348573
申请日：2006-02-07
申请人： Edward Hulse , Kevin Pennewell , James Dorsey , Gregg Teel
发明人： Edward Hulse , Kevin Pennewell , James Dorsey , Gregg Teel
IPC分类号： B23C3/00 , B23Q11/08
CPC分类号： B24B15/04 , B24B19/22 , Y10T29/49407 , Y10T29/49995 , Y10T409/303808 , Y10T409/30392 , Y10T409/304256 , Y10T409/304424 , Y10T409/304536 , Y10T409/304648 , Y10T409/305376 , Y10T409/305544
摘要： A machine tool for machining a molded part, such as an elastomeric coated valve component includes a rotatable cutting tool having a shape corresponding to the shape of a cavity of the valve component. A method of machining the molded part is also disclosed.
摘要翻译：用于加工模制部件的机床，例如弹性体涂覆的阀部件包括具有对应于阀部件的腔的形状的形状的可旋转切削工具。还公开了加工模制部件的方法。

9. 发明申请

US20050184137A1 Bullhorn cup 审中-公开
公开(公告)号：US20050184137A1
公开(公告)日：2005-08-25
申请号：US11016692
申请日：2004-12-17
申请人： Massai Dorsey , James Dorsey
发明人： Massai Dorsey , James Dorsey
IPC分类号： B65D3/00 , B65D3/28 , G10K11/00 , H04R27/04
CPC分类号： G10K11/08 , B65D1/265 , B65D3/06 , B65D81/36
摘要： A beverage cup or container that is usable as a bullhorn device is disclosed. The cup is preferably made of a disposable material, such as paper, molded plastic or foam. The cup has a hollow body portion, shaped to form a cylinder or cone, with an open first end, and a second end located distal from the first end. The second end has a removable, or selectively separable, portion formed by a perforation in a base portion. A pull tab or other device may be provided to aid in separation of the removable portion from the body portion.

10. 发明申请

US20050147259A1 Bull cup 审中-公开
标题翻译：公牛杯
公开(公告)号：US20050147259A1
公开(公告)日：2005-07-07
申请号：US10749393
申请日：2004-01-02
申请人： Massai Dorsey , James Dorsey
发明人： Massai Dorsey , James Dorsey
IPC分类号： B65D1/26 , B65D3/06 , B65D81/36 , H04R27/04 , B65D3/00 , G10K11/00
CPC分类号： B65D3/06 , B65D1/265 , B65D81/36
摘要： The present invention pertains to a drinking cup assembly, which may be converted into a bullhorn for amplifying the human speaking voice.
摘要翻译：本发明涉及一种饮用杯组件，其可以被转换成用于放大说话的声音的布喇叭。

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