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1. 发明申请

US20090258937A1 Methods for Modulating Tumor Growth and Metastasis 审中-公开
标题翻译：调节肿瘤生长和转移的方法
公开(公告)号：US20090258937A1
公开(公告)日：2009-10-15
申请号：US12266727
申请日：2008-11-07
申请人： Francis Y. Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardsen
发明人： Francis Y. Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardsen
IPC分类号： A61K31/337 , A61K31/09 , A61P35/00
CPC分类号： A61K31/337 , A61K31/05 , A61K31/66 , A61K2300/00
摘要： Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.
摘要翻译：提供了调节肿瘤生长或转移的方法和药物组合物。

2. 发明申请

US20060194770A1 Methods for modulating tumor growth and metastasis 审中-公开
标题翻译：调节肿瘤生长和转移的方法
公开(公告)号：US20060194770A1
公开(公告)日：2006-08-31
申请号：US11415731
申请日：2006-05-01
申请人： Francis Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardson
发明人： Francis Lee , Ronald Peck , David Chaplin , Ronald Pero , Klaus Edvardson
IPC分类号： A61K31/66 , A61K31/28 , A01N31/14
CPC分类号： A61K31/337 , A61K31/05 , A61K31/66 , A61K2300/00
摘要： Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.
摘要翻译：提供了调节肿瘤生长或转移的方法和药物组合物。

3. 发明申请

US20060100179A1 Compositions and methods for use in targeting vascular destruction 审中-公开
公开(公告)号：US20060100179A1
公开(公告)日：2006-05-11
申请号：US11112055
申请日：2005-04-22
申请人： Ronald Pero , David Sherris , David Chaplin , George Pettit , John Lippert
发明人： Ronald Pero , David Sherris , David Chaplin , George Pettit , John Lippert
IPC分类号： A61K31/66 , A01N31/14
CPC分类号： A61K31/66
摘要： Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.

4. 发明申请

US20050287227A1 Supplement containing carotenoid, nicotinamide, zinc, water soluble extract of uncaria species and method of the same 审中-公开
标题翻译：含有类胡萝卜素，烟酰胺，锌，脱落物种的水溶性提取物的补充物及其方法
公开(公告)号：US20050287227A1
公开(公告)日：2005-12-29
申请号：US11106200
申请日：2005-04-14
申请人： Ronald Pero , Vincent Giampapa
发明人： Ronald Pero , Vincent Giampapa
IPC分类号： A61K31/015 , A61K31/445 , A61K33/30 , A61K33/32 , A61K36/74 , A61K35/78
CPC分类号： A61K31/445 , A61K31/015 , A61K33/30 , A61K36/74 , A61K2300/00
摘要： A supplement for administering to a human, or other mammals, includes a carotenoid material, a nicotinamide material, a zinc source material, and a water soluble extract material of an Uncaria species. The supplement can be in a form for oral administration, particularly in a form of nutritional drink, or in a formulation for parenteral administration. Also disclosed is a method of treating a human including administering to an individual the supplement daily in amounts effective, in combination, to improve the individual's resistance to DNA damage, enhance DNA repair capacity, stimulate immune cell function, and inhibit tumor cell growth.
摘要翻译：用于对人或其他哺乳动物施用的补充剂包括类胡萝卜素物质，烟酰胺物质，锌源物质和Uncaria物种的水溶性提取物质。补充剂可以是用于口服给药的形式，特别是营养饮料的形式，或用于肠胃外给药的制剂。还公开了一种治疗人的方法，包括以有效组合的方式向个体施用补充剂以改善个体对DNA损伤的抗性，增强DNA修复能力，刺激免疫细胞功能和抑制肿瘤细胞生长。

5. 发明申请

US20060068035A1 Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals 有权
标题翻译：用于增强温血动物的免疫，抗炎，抗肿瘤和DNA修复过程的植物物种Uncaria的生物活性成分的水溶性提取物的制备方法和组合物
公开(公告)号：US20060068035A1
公开(公告)日：2006-03-30
申请号：US11270235
申请日：2005-11-09
申请人： Ronald Pero
发明人： Ronald Pero
IPC分类号： A61K36/185
CPC分类号： A61K36/74
摘要： A method for isolating the bioactive component of the water-soluble extract of Uncaria tomentosa known as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii) using the resulting C-MED-100® to obtain a spotting mixture for thin layer chromatography (TLC); (iii) spotting the C-MED-100® spotting mixture on pre-run TLC plates and eluting the plates to obtain the fluorescing band with Rf=0.2-0.3; (iv) scraping off the Rf=0.2-0.3 band, eluting it in ammonia and freeze drying the eluted band to form a powder; and (v) extracting the powder with methanol to remove solubilized silica gel, concentrating the methanol solution and crystalizing the concentrated solution to obtain the bioactive component. The isolated bioactive component is a quinic acid analog, preferably quinic acid lactone. A pharmaceutical composition comprising a pharmaceutically effective amount of the bioactive component and a nontoxic inert carrier or diluent. The bioactive component may be used to enhance immune competency, treat disorders associated with the immune system, inhibit the inflammatory response, treat disorders associated with the inflammatory response, enhance the anti-tumor response, and treat disorders associated with the response to tumor formation and growth, all in mammals.
摘要翻译：用于分离被称为C-MED-100（R）的Uncaria tomentosa的水溶性提取物的生物活性成分的方法，包括（i）从C-MED-100沉淀喷雾干燥载体; （ii）使用所得的C-MED-100（R）获得薄层色谱（TLC）的点样混合物; （iii）在预先运行的TLC板上点样C-MED-100（R）点样混合物，并洗脱板以获得具有R 0 = 0.2-0.3的荧光带; （iv）刮去R 2 = 0.2-0.3波段，在氨中洗脱并冷冻干燥洗脱的带以形成粉末; 和（v）用甲醇萃取粉末以除去溶解的硅胶，浓缩甲醇溶液并使浓缩溶液结晶得到生物活性成分。分离的生物活性成分是奎宁酸类似物，优选奎尼酸内酯。一种药物组合物，其包含药学上有效量的生物活性成分和无毒的惰性载体或稀释剂。生物活性成分可用于增强免疫能力，治疗与免疫系统相关的病症，抑制炎症反应，治疗与炎性反应相关的病症，增强抗肿瘤反应，以及治疗与肿瘤形成的反应有关的疾病;以及增长，都在哺乳动物。

6. 发明申请

US20050202105A1 Water soluble compositions derived from plant material and preparation thereof 审中-公开
标题翻译：衍生自植物材料的水溶性组合物及其制备方法
公开(公告)号：US20050202105A1
公开(公告)日：2005-09-15
申请号：US11081296
申请日：2005-03-16
申请人： Ronald Pero
发明人： Ronald Pero
IPC分类号： A61K20060101 , A61K36/13 , A61K36/15 , A61K36/38 , A61K36/82 , A61K36/87 , A61K35/78
CPC分类号： A61K36/82 , A61K36/13 , A61K36/15 , A61K36/38 , A61K36/87
摘要： A process for producing a composition of water-soluble phytomedicinal compounds is provided comprising combining plant material with water, in a ratio of plant material to water within a range of about 1:5 to about 1:50, at a temperature between about 75° C. and about 100° C. for a period of time to solubilize a substantial portion of thermal aqueous extractable phytocompounds present in the plant material, to produce a first extract; and removing substantially all entities having a molecular weight greater than about 10 kd from the extract to produce a composition of water-soluble phytomedicinal compounds. Compositions of water-soluble phytomedicinal compounds are provided that exhibit improved efficacy and reduced toxicity.
摘要翻译：提供了一种用于生产水溶性植物药物组合物的方法，包括将植物材料与水的比例以约1:5至约1:50的范围内的植物材料与水的比例在约75° C.和约100℃下一段时间以溶解存在于植物材料中的大部分热可水解植物化合物，以产生第一提取物; 并从提取物中基本上除去分子量大于约10kd的所有实体，以产生水溶性植物药用化合物的组合物。提供了水溶性植物性化合物的组合物，其表现出改进的功效和降低的毒性。

7. 发明申请

US20050176825A1 Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals 有权
标题翻译：用于增强温血动物的免疫，抗炎，抗肿瘤和DNA修复过程的植物物种的生物活性成分的水溶性提取物的制备方法和组合物
公开(公告)号：US20050176825A1
公开(公告)日：2005-08-11
申请号：US10970144
申请日：2004-10-21
申请人： Ronald Pero
发明人： Ronald Pero
IPC分类号： A61K36/18 , A61K20060101 , A61K31/05 , A61K31/225 , A61K31/34 , A61K36/74 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P43/00
CPC分类号： A61K36/74
摘要： A method for isolating the bioactive component of the water-soluble extract of Uncaria tomentosa known as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii) using the resulting C-MED-100® to obtain a spotting mixture for thin layer chromatography (TLC); (iii) spotting the C-MED-100® spotting mixture on pre-run TLC plates and eluting the plates to obtain the fluorescing band with Rf=0.2-0.3; (iv) scraping off the Rf=0.2-0.3 band, eluting it in ammonia and freeze drying the eluted band to form a powder; and (v) extracting the powder with methanol to remove solubilized silica gel, concentrating the methanol solution and crystalizing the concentrated solution to obtain the bioactive component. The isolated bioactive component in vitro is a quinic acid analog, preferably quinic acid lactone. By contrast, the isolated bioactive component in vivo is quinic acid, whether as free acid or as a quinic acid salt, including quinic acid ammonium salt. A pharmaceutical composition comprising a pharmaceutically effective amount of the bioactive component and a nontoxic inert carrier or diluent. The bioactive component may be used to enhance immune competency, treat disorders associated with the immune system, inhibit the inflammatory response, treat disorders associated with the inflammatory response, enhance the anti-tumor response, and treat disorders associated with the response to tumor formation and growth, all in mammals.
摘要翻译：用于分离被称为C-MED-100（R）的Uncaria tomentosa的水溶性提取物的生物活性成分的方法，包括（i）从C-MED-100沉淀喷雾干燥载体; （ii）使用所得的C-MED-100（R）获得薄层色谱（TLC）的点样混合物; （iii）在预先运行的TLC板上点样C-MED-100（R）点样混合物，并洗脱板以获得具有R 0 = 0.2-0.3的荧光带; （iv）刮去R 2 = 0.2-0.3波段，在氨中洗脱并冷冻干燥洗脱的带以形成粉末; 和（v）用甲醇萃取粉末以除去溶解的硅胶，浓缩甲醇溶液并使浓缩溶液结晶得到生物活性成分。体外分离的生物活性成分是奎尼酸类似物，优选奎尼酸内酯。相比之下，体内分离的生物活性成分是奎尼酸，无论是游离酸还是作为奎尼酸盐，包括奎尼酸铵盐。一种药物组合物，其包含药学上有效量的生物活性成分和无毒的惰性载体或稀释剂。生物活性成分可用于增强免疫能力，治疗与免疫系统相关的病症，抑制炎症反应，治疗与炎性反应相关的病症，增强抗肿瘤反应，以及治疗与肿瘤形成的反应有关的疾病;以及增长，都在哺乳动物。

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