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1. 发明授权

US09679110B2 Developing predictive dose-volume relationships for a radiotherapy treatment 有权
公开(公告)号：US09679110B2
公开(公告)日：2017-06-13
申请号：US13486809
申请日：2012-06-01
申请人： Kevin L. Moore , Sasa Mutic , Ryan Scott Brame , Lindsey Appenzoller
发明人： Kevin L. Moore , Sasa Mutic , Ryan Scott Brame , Lindsey Appenzoller
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00 , A61N5/10 , G06F19/24
CPC分类号： G16H50/50 , A61N5/1031 , G06F19/00 , G06F19/24 , G06F19/3481 , G06N5/04 , G06N99/005
摘要： Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients, wherein the data comprises a three-dimensional representation of the planning target volume and one or more organs-at-risk. The data further comprises an amount of radiation delivered to the planning target volume and the one or more organs-at-risk. The system further includes one or more processors programmed to access, from the memory area, the data and to develop a model that predicts dose-volume relationships using the three-dimensional representations of the planning target volume and the one or more organs-at-risk. The model is being derived from correlations between dose-volume relationships and calculated minimum distance vectors between discrete volume elements of the one or more organs-at-risk and a boundary surface of the planning target volume.

2. 发明申请

US20120310615A1 DEVELOPING PREDICTIVE DOSE-VOLUME RELATIONSHIPS FOR A RADIOTHERAPY TREATMENT 有权
标题翻译：发展放射治疗的预测剂量 - 体积关系
公开(公告)号：US20120310615A1
公开(公告)日：2012-12-06
申请号：US13486809
申请日：2012-06-01
申请人： Kevin L. Moore , Sasa Mutic , Ryan Scott Brame , Lindsey Appenzoller
发明人： Kevin L. Moore , Sasa Mutic , Ryan Scott Brame , Lindsey Appenzoller
IPC分类号： G06G7/60
CPC分类号： G16H50/50 , A61N5/1031 , G06F19/00 , G06F19/24 , G06F19/3481 , G06N5/04 , G06N99/005
摘要： Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients, wherein the data comprises a three-dimensional representation of the planning target volume and one or more organs-at-risk. The data further comprises an amount of radiation delivered to the planning target volume and the one or more organs-at-risk. The system further includes one or more processors programmed to access, from the memory area, the data and to develop a model that predicts dose-volume relationships using the three-dimensional representations of the planning target volume and the one or more organs-at-risk. The model is being derived from correlations between dose-volume relationships and calculated minimum distance vectors between discrete volume elements of the one or more organs-at-risk and a boundary surface of the planning target volume.
摘要翻译：实施例开发了放射治疗治疗的预测剂量 - 体积关系。系统包括用于存储对应于多个患者的数据的存储区域，其中数据包括规划目标体积的三维表示和一个或多个风险的器官。数据还包括传递到规划目标体积的辐射量和一个或多个处于风险中的器官。该系统还包括一个或多个处理器，其被编程为从存储器区域访问数据，并开发使用规划目标体积和一个或多个器官的体积关系的三维表示来预测剂量 - 体积关系的模型。风险。该模型是从一个或多个风险器官的离散体积元素与规划目标体积的边界表面之间的剂量 - 体积关系和计算的最小距离向量之间的相关性得出的。

3. 发明授权

US06605455B1 Tyrosylprotein sulfotransferases and methods of use thereof 失效
标题翻译：酪氨酸蛋白磺酸转移酶及其使用方法
公开(公告)号：US06605455B1
公开(公告)日：2003-08-12
申请号：US09785343
申请日：2001-02-16
申请人： Kevin L. Moore
发明人： Kevin L. Moore
IPC分类号： C12N910
CPC分类号： C12N9/13 , C07K14/70596 , C07K16/40 , C12Q1/48 , G01N33/573
摘要： Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosyiprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.
摘要翻译：描述了酪氨酰蛋白质磺酰转移酶和编码酪氨酸蛋白磺酸转移酶的核酸。已经在人，小鼠和秀丽隐杆线虫中鉴定了酶和编码所述酶的核酸的双重同位素。多肽和多核苷酸表现出广泛的同源性。多核苷酸可用于转化或转染宿主细胞以产生基本上纯的形式的酶，或用于在表达系统内产生的蛋白质或肽的翻译后酪氨酸硫酸化的表达系统中。酶可用于需要硫酸化的硫酸肽或蛋白质。

4. 发明授权

US06207414B1 Tyrosylprotein sulfotransferases and methods of use thereof 失效
公开(公告)号：US06207414B1
公开(公告)日：2001-03-27
申请号：US09374824
申请日：1999-08-13
申请人： Kevin L. Moore
发明人： Kevin L. Moore
IPC分类号： C12P2106
CPC分类号： C07K14/70596 , C07K16/40 , C12N9/13 , C12Q1/48 , G01N33/573
摘要： Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.

5. 发明授权

US6124267A O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1 失效
标题翻译：来自PSGL-1的选择素介导的炎症的O-聚糖抑制剂
公开(公告)号：US6124267A
公开(公告)日：2000-09-26
申请号：US63237
申请日：1998-04-20
申请人： Rodger P. McEver , Richard D. Cummings , Kevin L. Moore
发明人： Rodger P. McEver , Richard D. Cummings , Kevin L. Moore
IPC分类号： C07K14/705 , C07K16/28 , A61K31/70
CPC分类号： C07K16/2896 , C07K14/705 , C07K2317/34
摘要： Tyrosine sulfate on PSGL-1, particularly at least one of residues 46, 48 and 51, functions in conjunction with sialylated and fucosylated glycans, most preferably Thr-57, to mediate high affinity binding to P-selectin. PSGL-1 O-glycans have been determined to consist of disialylated or neutral forms of the core-2 tetrasaccharide Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.6(Gal.beta.1.fwdarw.3)GalNAcOH. A minority of the O-glycans are .alpha.1,3 fucosylated that occur as two major species containing the sialyl Lewis x antigen--one species is a disialylated monofucosylated glycan: Fuc.alpha.1 .dwnarw. 3 NeuAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1 .dwnarw. 6 NeuAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.3GalNAc-R, and the other is a monosialylated, trifucosylated glycan having a polylactosamine backbone: Fuc.alpha.l .dwnarw. 3 NeuAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.3Gal.beta.1.fwdarw. Fuc.alpha.l Fuc.alpha.l .dwnarw. .dwnarw. 3 3 4GlcNAc.beta.1.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1 .dwnarw. 6 Gal.beta.1.fwdarw.3GalNAc-R wherein R=H, OH, another sugar or an aglycone such as an amino acid, peptide, or polypeptide. The O-glycans defined herewith can be used to inhibit inflammation mediated by P-selectin.
摘要翻译： PSGL-1上的酪氨酸硫酸盐，特别是残基46,48和51中的至少一个，与唾液酸化和岩藻糖基化聚糖结合起来，最优选Thr-57，以介导与P-选择素的高亲和力结合。已经确定PSGL-1 O-聚糖由二核苷酸或中性形式的核心二糖Galβ1-> 4GlcNAcβ1-> 6（Galβ1-> 3）GalNAcOH组成。少数O聚糖是α1,3-岩藻糖基化的，它们作为含有唾液酸基路易斯x抗原的两种主要物质发生，一种是二唾液酸化单糖基化聚糖： - Fucα1 - ＆darr＆ - 3 - NeuAc alpha 2-> 3Gal beta 1-> 4GlcNAc beta 1 - ＆darr＆ - 6 - NeuAc alpha 2-> 3Gal beta 1-> 3GalNAc-R， - 另一种是具有多聚乳糖胺骨架的单唾液酸化的三糖基聚糖： - Fucα1 - ＆amp; alpha 2-> 3Gal beta 1-> 4GlcNAc beta 1-> 3Gal beta 1-> - - Fuc alpha l Fuc alpha l - ＆darr＆＆darr＆ - 3 3 - 4GlcNAc beta 1-> 3Gal beta 1-> 4GlcNAc beta 1 - ＆darr＆ 6-Galβ1-> 3GalNAc-R - 其中R = H，OH，另一种糖或糖苷配基如氨基酸，肽或多肽。本文定义的O-聚糖可用于抑制P-选择素介导的炎症。

6. 发明授权

US07029890B2 Tyrosylprotein sulfotransferases and methods of use thereof 失效
公开(公告)号：US07029890B2
公开(公告)日：2006-04-18
申请号：US10201525
申请日：2002-07-22
申请人： Kevin L. Moore
发明人： Kevin L. Moore
IPC分类号： C12N9/10 , C12N1/20 , C12N15/00 , C12Q1/48 , C07H21/04
CPC分类号： C07K14/70596 , C07K16/40 , C12N9/13 , C12Q1/48 , G01N33/573 , G01N2333/70564 , G01N2333/91194 , G01N2500/02
摘要： Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.

7. 发明授权

US5852175A P-selectin glycoprotein ligand blocking antibodies 失效
标题翻译： P-选择素糖蛋白配体阻断抗体
公开(公告)号：US5852175A
公开(公告)日：1998-12-22
申请号：US438280
申请日：1995-05-10
申请人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
发明人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , C07K16/18
CPC分类号： C07K16/2896 , C07K14/705 , C07K14/70564 , C07K14/70596 , C07K16/2854 , A61K2039/505 , A61K38/00
摘要： P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of �.sup.3 H!glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
摘要翻译：已经证明P-选择蛋白主要结合中性粒细胞和HL-60细胞上的单个主要糖蛋白配体，当通过印迹测定和通过[3 H]葡糖胺标记的HL-60细胞提取物对固定化P-选择素的亲和层析进行评估时。该分子的特征与其他具有相似表观分子量的其他具有良好表征的嗜中性粒细胞膜蛋白区别。纯化的配体或其片段（包括碳水化合物和蛋白质组分）或配体的抗体或其片段可用作P-选择素与细胞结合的抑制剂。

8. 发明申请

US20090042738A1 TYROSYLPROTEIN SULFOTRANSFERASES AND METHODS OF USE THEREOF 失效
标题翻译：酪氨酸蛋白酶SULFOTRANSFERASES及其使用方法
公开(公告)号：US20090042738A1
公开(公告)日：2009-02-12
申请号：US11969167
申请日：2008-01-03
申请人： Kevin L. Moore
发明人： Kevin L. Moore
IPC分类号： C40B30/08 , C12Q1/48
CPC分类号： C07K14/70596 , C07K16/40 , C12N9/13 , C12Q1/48 , G01N33/573 , G01N2333/70564 , G01N2333/91194 , G01N2500/02
摘要： Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.
摘要翻译：描述了酪氨酰蛋白质磺基转移酶和编码酪氨酰蛋白质磺酸转移酶的核酸。已经在人，小鼠和秀丽隐杆线虫中鉴定了酶和编码所述酶的核酸的双重同位素。多肽和多核苷酸表现出广泛的同源性。多核苷酸可用于转化或转染宿主细胞以产生基本上纯的形式的酶，或用于在表达系统内产生的蛋白质或肽的翻译后酪氨酸硫酸化的表达系统中。酶可用于需要硫酸化的硫酸肽或蛋白质。

9. 发明授权

US07316912B2 Tyrosylprotein sulfotransferases and methods of use thereof 失效
标题翻译：酪氨酸蛋白磺酸转移酶及其使用方法
公开(公告)号：US07316912B2
公开(公告)日：2008-01-08
申请号：US11336497
申请日：2006-01-20
申请人： Kevin L. Moore
发明人： Kevin L. Moore
IPC分类号： C12Q1/48 , C12P21/06
CPC分类号： C07K14/70596 , C07K16/40 , C12N9/13 , C12Q1/48 , G01N33/573 , G01N2333/70564 , G01N2333/91194 , G01N2500/02
摘要： Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.
摘要翻译：描述了酪氨酰蛋白质磺基转移酶和编码酪氨酰蛋白质磺酸转移酶的核酸。已经在人，小鼠和秀丽隐杆线虫中鉴定了酶和编码所述酶的核酸的双重同位素。多肽和多核苷酸表现出广泛的同源性。多核苷酸可用于转化或转染宿主细胞以产生基本上纯的形式的酶，或用于在表达系统内产生的蛋白质或肽的翻译后酪氨酸硫酸化的表达系统中。酶可用于需要硫酸化的硫酸肽或蛋白质。

10. 发明授权

US06713283B2 Tyrosylprotein sulfotransferases 失效
标题翻译：酪氨酸蛋白磺酸转移酶
公开(公告)号：US06713283B2
公开(公告)日：2004-03-30
申请号：US10411976
申请日：2003-04-11
申请人： Kevin L. Moore
发明人： Kevin L. Moore
IPC分类号： C12P2106
CPC分类号： C07K14/70596 , C07K16/40 , C12N9/13 , C12Q1/48 , G01N33/573
摘要： Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding the enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.
摘要翻译：描述了酪氨酰蛋白质磺基转移酶和编码酪氨酰蛋白质磺酸转移酶的核酸。已经在人，小鼠和秀丽隐杆线虫中鉴定了酶和编码酶的核酸的双重同位素。多肽和多核苷酸表现出广泛的同源性。多核苷酸可用于转化或转染宿主细胞以产生基本上纯的形式的酶，或用于在表达系统内产生的蛋白质或肽的翻译后酪氨酸硫酸化的表达系统中。酶可用于需要硫酸化的硫酸肽或蛋白质。

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