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1. 发明授权

US07189828B2 Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof 失效
标题翻译：白细胞滚动的糖基多肽抑制剂及其使用方法
公开(公告)号：US07189828B2
公开(公告)日：2007-03-13
申请号：US11239576
申请日：2005-09-29
申请人： Richard D. Cummings , Rodger P. McEver
发明人： Richard D. Cummings , Rodger P. McEver
IPC分类号： C07H3/06 , A61K31/70 , A61K38/14
CPC分类号： C07H3/06 , A61K38/08 , A61K38/14 , C07K9/00 , C07K9/001 , C07K9/005 , C07K14/705 , C07K14/70596
摘要： Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.
摘要翻译：描述了用于治疗以白细胞转动为特征的病症的化合物，组合物和方法。所述化合物含有包含硫酸化酪氨酸和唾液酸化的岩藻糖化N-乙酰基乳糖氨基聚糖的糖链多肽结构。例如，糖磺肽可以与其它化合物缀合或络合以增强血清半衰期或控制释放。治疗条件的实例包括炎症，缺血再灌注损伤，类风湿性关节炎，动脉粥样硬化，白细胞介导的肺损伤，再狭窄和血栓形成。

2. 发明授权

US06667036B2 Methods of treatment using antibodies to P-selectin glycoprotein ligand 失效
标题翻译：使用P-选择蛋白糖蛋白配体的抗体治疗方法
公开(公告)号：US06667036B2
公开(公告)日：2003-12-23
申请号：US10299917
申请日：2002-11-18
申请人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
发明人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
IPC分类号： A61K39395
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K14/70564 , C07K14/70596 , C07K16/2854
摘要： P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [3H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells, and to treat various conditions involving leukocyte binding via P-selectin glycoprotein ligand.
摘要翻译：已经证明P-选择蛋白主要结合嗜中性粒细胞和HL-60细胞上的单个主要糖蛋白配体，当通过印迹测定和通过[3 H]葡糖胺标记的HL-60细胞提取物对固定化P的亲和层析 - 选择该分子的特征与其他具有相似表观分子量的其他具有良好表征的嗜中性粒细胞膜蛋白区别。纯化的配体或其片段（包括碳水化合物和蛋白质组分）或配体的抗体或其片段可用作P-选择素与细胞结合的抑制剂，并且用于治疗涉及白细胞结合的各种病症 P-选择素糖蛋白配体。

3. 发明授权

US06461835B1 Fucosyltransferases, polynucleotides encoding fucosyltransferases, and transgenic mammal incorporating same 有权
标题翻译：岩藻糖基转移酶，编码岩藻糖基转移酶的多核苷酸，以及掺入其的转基因哺乳动物
公开(公告)号：US06461835B1
公开(公告)日：2002-10-08
申请号：US09390131
申请日：1999-09-03
申请人： Richard D. Cummings , Russell A. DeBose-Boyd , A. Kwame Nyame
发明人： Richard D. Cummings , Russell A. DeBose-Boyd , A. Kwame Nyame
IPC分类号： C12P2106
CPC分类号： C12N9/1051 , A01K2217/05
摘要： This invention is biological in nature and relates to the synthesis, structure and biological activities of novel &agr;-1,2 and &agr;-1,3 fucosyltransferases from Caenorhabditis elegans (“C. elegans”). The present invention also contemplates a transgenic non-human eukaryotic mammal whose germ cells and somatic cells incorporate cDNA sequences encoding one or more of the novel &agr;-1,2 and &agr;-1,3 fucosyltransferases from C. elegans, introduced into the non-human eukaryotic mammal, or an ancestor of the non-human eukaryotic mammal, at an embyonic stage.
摘要翻译：本发明是生物学的，涉及从秀丽隐杆线虫（“秀丽隐杆线虫”）的新型α-1,2和α-1,3岩藻糖基转移酶的合成，结构和生物学活性。本发明还考虑了一种转基因非人类真核哺乳动物，其生殖细胞和体细胞引入编码来自秀丽隐杆线虫的新型α-1,2和α-1,3岩藻糖基转移酶中的一种或多种的cDNA序列，人类真核哺乳动物，或非人类真核哺乳动物的祖先。

4. 发明授权

US06309639B1 Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand 失效
标题翻译：使用P-选择蛋白糖蛋白配体的抗体抑制炎症反应的方法
公开(公告)号：US06309639B1
公开(公告)日：2001-10-30
申请号：US09635297
申请日：2000-08-09
申请人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
发明人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
IPC分类号： A61K39395
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K14/70564 , C07K14/70596 , C07K16/2854
摘要： P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [3H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
摘要翻译：已经证明P-选择蛋白主要结合中性粒细胞和HL-60细胞上的单个主要糖蛋白配体，当通过印迹测定和通过[3 H]葡糖胺标记的HL-60细胞提取物对固定化P-选择素的亲和层析进行评估时。该分子的特征与其他具有相似表观分子量的其他具有良好表征的嗜中性粒细胞膜蛋白区别。纯化的配体或其片段（包括碳水化合物和蛋白质组分）或配体的抗体或其片段可用作P-选择素与细胞结合的抑制剂。

5. 发明授权

US06177547B1 Antibodies to P-selectin glycoprotein ligand 失效
标题翻译： P-选择素糖蛋白配体的抗体
公开(公告)号：US06177547B1
公开(公告)日：2001-01-23
申请号：US09207375
申请日：1998-12-08
申请人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
发明人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
IPC分类号： C07K1628
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K14/70564 , C07K14/70596 , C07K16/2854
摘要： P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [3H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
摘要翻译：已经证明P-选择蛋白主要结合中性粒细胞和HL-60细胞上的单个主要糖蛋白配体，当通过印迹测定和通过[3 H]葡糖胺标记的HL-60细胞提取物对固定化P-选择素的亲和层析进行评估时。该分子的特征与其他具有相似表观分子量的其他具有良好表征的嗜中性粒细胞膜蛋白区别。纯化的配体或其片段（包括碳水化合物和蛋白质组分）或配体的抗体或其片段可用作P-选择素与细胞结合的抑制剂。

6. 发明授权

US5948628A Methods of screening for compounds which mimic galectin-1 失效
标题翻译：筛选模拟半乳凝素-1的化合物的方法
公开(公告)号：US5948628A
公开(公告)日：1999-09-07
申请号：US929291
申请日：1997-09-05
申请人： Richard D. Cummings , Moon-Jae Cho
发明人： Richard D. Cummings , Moon-Jae Cho
IPC分类号： G01N33/569 , G01N33/68 , C12Q1/34 , G01N33/53
CPC分类号： G01N33/56972 , G01N33/6893 , G01N2333/4724 , G01N2500/10 , G01N2510/00
摘要： Methods for treating and modulating an inflammatory response using compositions containing a primarily monomeric or primarily dimeric form of galectin-1. The dimeric form stimulates apoptosis of activated neutrophils while the monomeric form inhibits apoptosis of activated neutrophils. Methods of screening for compounds which have galectin-1-like functions are also identified.
摘要翻译：使用含有主要单体或主要二聚体形式的半乳凝素-1的组合物治疗和调节炎症反应的方法。二聚形式刺激活化的嗜中性粒细胞的凋亡，而单体形式抑制活化的嗜中性粒细胞的凋亡。还鉴定了具有半乳凝素-1-样功能的化合物的筛选方法。

7. 发明授权

US5880091A Glycoprotein ligand for P-selectin and methods of use thereof 失效
公开(公告)号：US5880091A
公开(公告)日：1999-03-09
申请号：US473253
申请日：1995-06-07
申请人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
发明人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , A61K38/15 , C07H5/04
CPC分类号： C07K16/2896 , C07K14/705 , C07K14/70564 , C07K14/70596 , C07K16/2854 , A61K2039/505 , A61K38/00
摘要： P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of �.sup.3 H!glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.

8. 发明授权

US4102325A Temperature control in solar-to-thermal energy converters 失效
标题翻译：太阳能到热能转换器的温度控制
公开(公告)号：US4102325A
公开(公告)日：1978-07-25
申请号：US793495
申请日：1977-05-04
申请人： Richard D. Cummings
发明人： Richard D. Cummings
IPC分类号： F24J2/24 , F24J2/04 , F24J2/26 , F24J2/40 , F24J2/46 , F24J3/02
CPC分类号： F24J2/4625 , F24J2/265 , F24J2/402 , Y02E10/44
摘要： Solar-to-thermal energy converter comprising an insulated frame, a solar energy absorber mounted in the frame, a fluid flow heat exchange means thermally coupled to the absorber to carry away as thermal energy the absorbed solar energy, and a window transmissive to solar energy mounted in the frame above the absorber, featuring a temperature actuated heat loss enhancer comprising a fluid flow heat pickup means thermally coupled to the absorber, an exterior heat rejector element, a fluid flow heat rejector means thermally coupled to the heat rejector element, and a thermally actuated valve connected between said fluid flow pickup and rejector means to form a fluid flow circuit separate from the fluid flow heat exchange means and powered by the heat-produced differential buoyancy forces of the fluid therein when the valve is open.
摘要翻译：太阳能 - 热能转换器，包括绝缘框架，安装在框架中的太阳能吸收器，热耦合到吸收器的流体热交换装置，作为热能携带吸收的太阳能，以及透过太阳能的窗户安装在吸收器上方的框架中，具有温度启动的热损失增强器，其包括热耦合到吸收器的流体流热采集装置，外部加热排出器元件，热耦合到散热器元件的流体流热释放器装置，以及连接在所述流体流动拾取器和排出装置之间的热致动阀，以形成与流体流动热交换装置分离的流体流动回路，并且当阀门打开时由热量产生的流体在其中的不均匀的浮力作用。

9. 发明申请

US20120328568A1 COMPOSITIONS AND USES OF LECTINS 审中-公开
标题翻译：组合物和用途
公开(公告)号：US20120328568A1
公开(公告)日：2012-12-27
申请号：US13577446
申请日：2011-02-11
申请人： Richard D Cummings , Sean R. Stowell , Connie Arthur
发明人： Richard D Cummings , Sean R. Stowell , Connie Arthur
IPC分类号： A61K38/16 , A61P31/04 , A61P31/12 , A61K38/21 , A61P31/16 , A61P31/22 , A61P31/14 , A61P31/18 , C07K14/42 , A61P31/10
CPC分类号： A61K38/1732 , A61K38/178 , A61K45/06 , Y02A50/387 , Y02A50/463 , Y02A50/467 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , A61K2300/00
摘要： The disclosure relates to uses of a purified or isolated lectin to kill bacteria, viruses, and other pathogens. In certain embodiments, the disclosure relates to method of treating or preventing an infection comprising administering a purified or isolated galectin to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, or diagnosed with a pathogenic infection.
摘要翻译：本公开涉及纯化或分离的凝集素杀死细菌，病毒和其它病原体的用途。在某些实施方案中，本公开涉及治疗或预防感染的方法，包括向有需要的受试者施用纯化或分离的半乳凝素。在某些实施方案中，受试者处于患有病原体感染的症状或诊断患有风险。

10. 发明授权

US06545123B2 Synthetic glycosulfopeptides and methods of synthesis thereof 失效
标题翻译：合成糖磺肽及其合成方法
公开(公告)号：US06545123B2
公开(公告)日：2003-04-08
申请号：US09849562
申请日：2001-05-04
申请人： Richard D. Cummings , Rodger P. McEver
发明人： Richard D. Cummings , Rodger P. McEver
IPC分类号： A61K3814
CPC分类号： C07H3/06 , A61K38/00 , C07K14/705 , C07K14/70596
摘要： A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a sialyl Lewisa group. In a preferred version the GSPs have an O-glycan comprising a &bgr;1, 6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
摘要翻译：一类具有一个或多个硫酸化酪氨酸残基的合成糖磺肽（GSP）和与该肽连接的聚糖，该聚糖优选包括唾液酸路易斯基组或唾液酸Lewisa组。在优选的版本中，GSP具有包含与GalNAc的β1,6键的O-聚糖。本发明还考虑了不使用细胞的这些GSP的合成的体外方法及其在体内用于强力抗炎抗凝血或抗转移化合物的方法。本发明还考虑了通过从GSP切割聚糖来合成寡糖的方法。

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