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1. 发明申请

US20060019945A1 Granzyme b inhibitors 审中-公开
标题翻译：颗粒酶b抑制剂
公开(公告)号：US20060019945A1
公开(公告)日：2006-01-26
申请号：US10503155
申请日：2003-01-31
申请人： Kevin Chapman , Christopher Willoughby , Yuang Cheng
发明人： Kevin Chapman , Christopher Willoughby , Yuang Cheng
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/06 , A61K38/00 , C07K5/0202 , C07K5/06078 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827 , C07K5/1008 , C07K5/1021
摘要： The present invention encompasses compounds of Formula (I) and pharmaceutically acceptable salts or hydrates thereof. The compounds are inhibitors of granzyme B and are useful for treating autoimmune and chronic inflammatory diseases. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明包括式（I）的化合物及其药学上可接受的盐或水合物。这些化合物是颗粒酶B的抑制剂，可用于治疗自身免疫性和慢性炎性疾病。还包括药物组合物和使用方法。

2. 发明授权

US06248755B1 Pyrrolidine modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的吡咯烷调节剂
公开(公告)号：US06248755B1
公开(公告)日：2001-06-19
申请号：US09542617
申请日：2000-04-04
申请人： Kevin Chapman , Jeffrey Hale , Dooseop Kim , Christopher Lynch , Shrenik Shah , Kothandaraman Shankaran , Dong-Ming Shen , Christopher Willoughby , Malcolm MacCoss , Sander G. Mills , Jennifer L. Loebach , Ravindra N. Guthikonda
发明人： Kevin Chapman , Jeffrey Hale , Dooseop Kim , Christopher Lynch , Shrenik Shah , Kothandaraman Shankaran , Dong-Ming Shen , Christopher Willoughby , Malcolm MacCoss , Sander G. Mills , Jennifer L. Loebach , Ravindra N. Guthikonda
IPC分类号： A61K3150
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R14 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译：本发明涉及可用作趋化因子受体活性调节剂的式I的吡咯烷化合物（其中R 1，R 2，R 3，R 4，R 5，R 6，R 14和n如本文所定义）。特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。

3. 发明授权

US06063796A Somatostatin agonists 失效
公开(公告)号：US06063796A
公开(公告)日：2000-05-16
申请号：US53299
申请日：1998-04-01
申请人： Lihu Yang , Arthur A. Patchett , Alexander Pasternak , Scott Berk , Meng Hsin Chen , David Johnston , Kevin Chapman , Ravi Nargund , James R. Tata , Liangqin Guo
发明人： Lihu Yang , Arthur A. Patchett , Alexander Pasternak , Scott Berk , Meng Hsin Chen , David Johnston , Kevin Chapman , Ravi Nargund , James R. Tata , Liangqin Guo
IPC分类号： A61P25/04 , A61K31/454 , A61P1/00 , A61P3/10 , A61P9/00 , A61P25/24 , A61P27/02 , A61P35/00 , A61P43/00 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/445 , C07D211/14 , C07D211/40
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of the formula: ##STR1## including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome, pain and diabetic retinopathy. Many of the compounds are also orally active.

4. 发明申请

US20050148629A1 Compounds useful in the treatment of anthrax and inhibiting lethal factor 失效
标题翻译：用于治疗炭疽和抑制致死因子的化合物
公开(公告)号：US20050148629A1
公开(公告)日：2005-07-07
申请号：US10509972
申请日：2003-05-23
申请人： Yusheng Xiong , Kevin Chapman , Suresh Singh , Jian Guo , Arthur Patchett
发明人： Yusheng Xiong , Kevin Chapman , Suresh Singh , Jian Guo , Arthur Patchett
IPC分类号： C07D309/04 , A61K31/00 , A61K31/18 , A61K31/19 , A61K31/351 , A61K31/381 , A61K31/405 , A61K31/4172 , A61K31/445 , A61K35/00 , A61P1/00 , A61P1/12 , A61P31/04 , A61P43/00 , C07C311/19 , C07C311/29 , C07C311/45 , C07C317/48 , C07C323/60 , C07D209/20 , C07D211/34 , C07D233/54 , C07D309/06 , C07D309/10 , C07D317/62 , C07D333/24 , C07D333/28 , C07D333/34 , C07D413/04
CPC分类号： C07C311/19 , C07B2200/11 , C07C311/29 , C07C317/48 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D209/20 , C07D211/34 , C07D233/64 , C07D309/04 , C07D309/06 , C07D309/10 , C07D317/62 , C07D333/24 , C07D333/28 , C07D333/34 , C07D413/04
摘要： This invention relates to compounds of formula (I), and a method for treating anthrax or inhibiting lethal factor by administrating a composition containing a compound of formula (I) and a pharmaceutically acceptable carrier. This invention further relates to the use of the compounds of formula (I) to treat other conditions related to an anthrax infection.
摘要翻译：本发明涉及式（I）化合物，以及通过施用含有式（I）化合物和药学上可接受的载体的组合物来治疗炭疽或抑制致死因子的方法。本发明还涉及式（I）化合物用于治疗与炭疽感染有关的其它病症的用途。

5. 发明授权

US5672583A Carboxy-peptidyl derivatives as antidegenerative active agents 失效
标题翻译：羧基肽基衍生物作为抗再生活性剂
公开(公告)号：US5672583A
公开(公告)日：1997-09-30
申请号：US436347
申请日：1995-05-17
申请人： Kevin Chapman , William Hagmann , Philippe Durette , Craig Esser , Ihor Kopka , Charles Caldwell
发明人： Kevin Chapman , William Hagmann , Philippe Durette , Craig Esser , Ihor Kopka , Charles Caldwell
IPC分类号： C07D275/02 , A61K31/195 , A61K31/275 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5377 , A61K41/00 , A61P1/02 , A61P9/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C237/22 , C07C255/23 , C07C271/22 , C07C275/28 , C07C279/14 , C07D207/16 , C07D209/34 , C07D209/46 , C07D209/48 , C07D211/76 , C07D213/55 , C07D213/75 , C07D213/81 , C07D235/16 , C07D261/08 , C07D263/32 , C07D263/56 , C07D277/64 , C07D295/185 , A61K37/02 , C07C237/52 , C07C259/06 , C07D277/62
CPC分类号： C07D209/48 , A61K41/00 , C07C237/22 , C07C255/23 , C07C271/22 , C07C275/28 , C07C279/14 , C07D209/34 , C07D213/75 , C07D235/16 , C07D263/56 , C07D277/64 , C07D295/185 , C07C2101/08
摘要： Novel Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also have utility as a means for birth control by preventing ovulation or implantation. ##STR1##
摘要翻译： PCT No.PCT / US93 / 11207 Sec。 371日期1995年5月17日 102（e）日期1995年5月17日PCT 1993年11月18日PCT公布。 WO94 / 12169 PCT出版物 1994年6月9日发现式I的新型羧基肽基化合物是有用的基质金属蛋白酶介导的疾病的抑制剂，包括骨关节炎，类风湿性关节炎，脓毒性关节炎，某些癌症中的肿瘤侵袭，牙周病，角膜溃疡，蛋白尿，疏水性表皮松解与大动脉粥样硬化斑块破裂相关的冠状动脉血栓形成和动脉瘤性主动脉疾病。基质金属蛋白酶是含有蛋白酶的家族，包括但不限于基质溶素，胶原酶和明胶酶，其能够降解关节软骨和基底膜的主要成分。本文所要求的抑制剂也可用于预防可能导致永久性残疾的外伤性损伤后的病理后遗症。这些化合物也可以通过预防排卵或植入作为避孕的手段。

6. 发明申请

US20070093544A1 Benzamidazoles, compositions containing such compounds and methods of use 有权
标题翻译：苯甲胺，含有这些化合物的组合物和使用方法
公开(公告)号：US20070093544A1
公开(公告)日：2007-04-26
申请号：US10556230
申请日：2004-05-05
申请人： Emma Parmee , Ronald Kim , Rui Liang , Jiang Chang , Elizabeth Rouse , Kevin Chapman
发明人： Emma Parmee , Ronald Kim , Rui Liang , Jiang Chang , Elizabeth Rouse , Kevin Chapman
IPC分类号： A61K31/4184 , C07D403/02 , C07D235/28
CPC分类号： C07D235/30 , C07D403/12 , H04N5/4401 , H04N7/0887 , H04N7/163 , H04N21/4532 , H04N21/4542 , H04N21/84
摘要： The present invention relates to substituted benzimidazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译：本发明涉及取代的苯并咪唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。

7. 发明授权

US06025372A Somatostatin agonists 失效
标题翻译：生长抑素激动剂
公开(公告)号：US06025372A
公开(公告)日：2000-02-15
申请号：US53373
申请日：1998-04-01
申请人： Lihu Yang , Arthur A. Patchett , Alexander Pasternak , Kevin Chapman , James R. Tata , Liangqin Guo
发明人： Lihu Yang , Arthur A. Patchett , Alexander Pasternak , Kevin Chapman , James R. Tata , Liangqin Guo
IPC分类号： A61P25/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61P1/00 , A61P3/10 , A61P9/00 , A61P25/24 , A61P27/02 , A61P35/00 , A61P43/00 , C07D401/14 , C07D405/14 , A61K31/445 , C07D401/12 , C07D40/10
CPC分类号： C07D401/14 , C07D405/14
摘要： Somatostatin agonist compounds of formula I are disclosed: ##STR1## including pharmaceutically acceptable salts and hydrates thereof These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome and pain. The compounds are potent with high selectivity toward the receptor subtype 2.Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了式I的生长抑素激动剂化合物：包括其药学上可接受的盐和水合物。这些化合物可用于治疗糖尿病，癌症，肢端肥大症，再狭窄，抑郁症，肠易激综合征和疼痛。该化合物对于受体亚型2具有高选择性。药物组合物和治疗方法也包括在内。

8. 发明授权

US5516491A Disposable reactor vessel 失效
标题翻译：一次性反应堆容器
公开(公告)号：US5516491A
公开(公告)日：1996-05-14
申请号：US281813
申请日：1994-07-28
申请人： Gary S. Kath , Gregory W. King , Kevin Chapman
发明人： Gary S. Kath , Gregory W. King , Kevin Chapman
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , C40B60/14 , C40B70/00 , G01N35/10
CPC分类号： B01L3/50255 , B01J19/0046 , B01L3/021 , B01J2219/00283 , B01J2219/00308 , B01J2219/00335 , B01J2219/00373 , B01J2219/00418 , B01J2219/00484 , B01J2219/005 , B01J2219/00547 , C40B60/14 , C40B70/00 , G01N2035/1062
摘要： A disposable transportable reactor vessel can be prepared by modifying an eye-dropper pipette. A HDPE plug is inserted in one end of the pipette to permit selective passage of fluid while preventing resin flow. The pipette is looped into the shape of a u-tube and inserted into a holder such that the pipette is axially aligned with the holder to facilitate use in a robotic system.
摘要翻译：一次性可运输的反应器容器可以通过改变滴眼吸移管来制备。 HDPE塞子插入移液管的一端，以允许选择性地通过流体同时防止树脂流动。移液管被环绕成U形管的形状并插入到保持器中，使得移液管与保持器轴向对准以便于在机器人系统中使用。

9. 发明申请

US20150105129A1 Video Game Body Suit 审中-公开
标题翻译：视频游戏身体套装
公开(公告)号：US20150105129A1
公开(公告)日：2015-04-16
申请号：US14514478
申请日：2014-10-15
申请人： Kevin Chapman
发明人： Kevin Chapman
IPC分类号： A63F13/285 , A63F13/212
CPC分类号： A63F13/285 , A63F13/212 , A63F13/215 , A63F13/28
摘要： A video game body suit for use when playing a video game. The video game body suit includes a torso covering, leg coverings, arm coverings, and a headset. Each of the components includes one or more feedback devices thereon, wherein the feedback device may include one or more of a vibration motor, a speaker, a temperature controlling device, and a scent-emitting device. The headset comprises a headband, an earpiece, and a microphone thereon for allowing the user to remotely communicate with other players. The body suit further includes a control circuit that includes a microprocessor and a transceiver capable of wirelessly communicating with a video game console and the various feedback devices. In this way, the video game body suit can provide feedback to the user corresponding to the events that occur within the game.
摘要翻译：一款视频游戏机身套装，用于播放视频游戏。视频游戏机身套装包括躯干覆盖物，腿部覆盖物，手臂覆盖物和耳机。每个部件包括一个或多个反馈装置，其中反馈装置可以包括振动马达，扬声器，温度控制装置和香味发射装置中的一个或多个。头戴式耳机包括头带，耳机和麦克风，用于允许用户与其他玩家远程通信。身体套装还包括控制电路，其包括微处理器和能够与视频游戏控制台和各种反馈装置无线通信的收发器。以这种方式，视频游戏机身套装可以根据游戏中发生的事件向用户提供反馈。

10. 发明授权

US07504425B2 Compounds useful in the treatment of anthrax and inhibiting lethal factor 失效
标题翻译：用于治疗炭疽和抑制致死因子的化合物
公开(公告)号：US07504425B2
公开(公告)日：2009-03-17
申请号：US10509972
申请日：2003-05-23
申请人： Yusheng Xiong , Kevin Chapman , Suresh Singh , Jian Guo , Arthur A. Patchett
发明人： Yusheng Xiong , Kevin Chapman , Suresh Singh , Jian Guo , Arthur A. Patchett
IPC分类号： A61K31/415 , A61K31/335 , C07D233/00 , C07D321/00
CPC分类号： C07C311/19 , C07B2200/11 , C07C311/29 , C07C317/48 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D209/20 , C07D211/34 , C07D233/64 , C07D309/04 , C07D309/06 , C07D309/10 , C07D317/62 , C07D333/24 , C07D333/28 , C07D333/34 , C07D413/04
摘要： This invention relates to compounds of formula (I), and a method for treating anthrax or inhibiting lethal factor by administrating a composition containing a compound of formula (I) and a pharmaceutically acceptable carrier. This invention further relates to the use of the compounds of formula (I) to treat other conditions related to an anthrax infection.
摘要翻译：本发明涉及式（I）化合物，以及通过施用含有式（I）化合物和药学上可接受的载体的组合物来治疗炭疽或抑制致死因子的方法。本发明还涉及式（I）化合物用于治疗与炭疽感染有关的其它病症的用途。

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