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1. 发明授权

US5264372A Receptor-based screening methods for amylin agonists and antagonists 失效
标题翻译：胰岛淀粉样多肽激动剂和拮抗剂的基于受体的筛选方法
公开(公告)号：US5264372A
公开(公告)日：1993-11-23
申请号：US670231
申请日：1991-03-15
申请人： Kevin Beaumont , Timothy J. Rink
发明人： Kevin Beaumont , Timothy J. Rink
IPC分类号： C07K14/575 , A61K38/28 , C07K14/00 , C07K14/585 , C07K14/705 , C07K16/00 , C07K19/00 , C12P21/08 , G01N20060101 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： A61K38/28
摘要： Methods for identifying or screening or characterizing or assaying or isolating known or candidate agonists and antagonists of amylin, comprising binding assays utilizing preparations containing specific receptors for amylin. Membranes from the brain that contain high density receptors for amylin are particularly useful for the methods of this invention, and as a source of amylin receptors.
摘要翻译：用于鉴定或筛选或表征或鉴定或分离胰岛淀粉样多肽的已知或候选激动剂和拮抗剂的方法，其包括使用含有胰岛淀粉样多肽特异性受体的制剂的结合测定。包含胰岛淀粉样多肽的高密度受体的脑中的膜特别适用于本发明的方法和作为胰岛淀粉样多肽受体的来源。

2. 发明授权

US5580953A Amylin antagonist peptides and uses therefor 失效
标题翻译：胰岛淀粉样多肽拮抗肽及其用途
公开(公告)号：US5580953A
公开(公告)日：1996-12-03
申请号：US794288
申请日：1991-11-19
申请人： Elisabeth Albrecht , Howard Jones , Laura S. L. Gaeta , Kathryn S. Prickett , Kevin Beaumont
发明人： Elisabeth Albrecht , Howard Jones , Laura S. L. Gaeta , Kathryn S. Prickett , Kevin Beaumont
IPC分类号： A61K38/00 , A61P3/08 , A61P3/10 , C07K14/575 , A61K38/22
CPC分类号： C07K14/575 , A61K38/00
摘要： Compounds which inhibit amylin activity are provided. These compounds may be used in the treatment of conditions where it is of benefit to reduce amylin activity, including the treatment of Type 2 diabetes mellitus, impaired glucose tolerance, obesity and insulin resistance.
摘要翻译：提供抑制胰淀素活性的化合物。这些化合物可用于治疗有利于减少胰岛淀粉样多肽活性的病症，包括治疗2型糖尿病，葡萄糖耐量降低，肥胖和胰岛素抵抗。

3. 发明授权

US5321008A Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions 失效
标题翻译：用于治疗糖尿病，低血糖症和其他病症的方法和组合物
公开(公告)号：US5321008A
公开(公告)日：1994-06-14
申请号：US774411
申请日：1991-10-10
申请人： Kevin Beaumont , Andrew A. Young
发明人： Kevin Beaumont , Andrew A. Young
IPC分类号： A61K38/22 , A61K38/23 , A61K38/26 , A61K38/28 , A61K49/00 , A61P3/06 , A61K37/26 , A61K37/02
CPC分类号： A61K38/28 , A61K38/22 , A61K38/23 , A61K38/26 , A61K49/0008
摘要： Methods for treatment of diabetes and other insulin-requiring conditions by administering insulin and a calcitonin with or without amylin, and methods for treatment of hypoglycemic conditions by administering a calcitonin alone or in combination with glucagon and/or an amylin, and related compositions.
摘要翻译：通过施用胰岛素和降钙素来治疗糖尿病和其它需要胰岛素的病症的方法，以及通过单独或与胰高血糖素和/或胰岛淀粉样多肽组合施用降钙素和相关组合物来治疗降血糖病症的方法。

4. 发明授权

US06602694B1 Uncoupling protein 4 (UCP-4) 失效
标题翻译：解偶联蛋白4（UCP-4）
公开(公告)号：US06602694B1
公开(公告)日：2003-08-05
申请号：US09743847
申请日：2001-06-27
申请人： Keith Albrandt , Kevin Beaumont , Andrew A. Young
发明人： Keith Albrandt , Kevin Beaumont , Andrew A. Young
IPC分类号： C12N900
CPC分类号： C07K14/47 , A61K48/00
摘要： A novel uncoupling protein, which we have designated UCP-4, that is expressed in various tissues, including brain, heart, pancreas, and muscle tissue, and nucleic acid molecules which encode for said novel protein, are described. Methods of screening for compounds that regulate the expression and the activity of UCP-4 are described, as well as methods of treating diseases or conditions in which the regulation of thermogenesis or respiratory ATP synthesis is desired. Such conditions include obesity, diabetes, malignant hyperthermia, and fever. The construction of cell lines that express UCP-4 is also described.
摘要翻译：描述了我们指定的UCP-4的新型解偶联蛋白，其在各种组织中表达，包括脑，心脏，胰腺和肌肉组织，以及编码所述新蛋白质的核酸分子。描述了筛选调节UCP-4的表达和活性的化合物的方法，以及治疗需要调节生热或呼吸ATP合成的疾病或病症的方法。这些病症包括肥胖，糖尿病，恶性高热和发烧。还描述了表达UCP-4的细胞系的构建。

5. 发明申请

US20070125800A1 Apparatus for dispensing measured batches of liquid 审中-公开
标题翻译：用于分配测量批次的液体的装置
公开(公告)号：US20070125800A1
公开(公告)日：2007-06-07
申请号：US10579516
申请日：2004-11-15
申请人： Kevin Beaumont
发明人： Kevin Beaumont
IPC分类号： B67D5/08
CPC分类号： G01F13/00 , B44D3/00 , G01F15/003 , G01F15/005
摘要： Apparatus for dispensing measured batches of liquid have hitherto employed metering pumps which can dispense accurately but are difficult to clean due to their complexity, or analogue meters which cannot dispense small quantities accurately due to their slow response. Apparatus which can dispense batches of any quantity with great precision and is easy to clean comprises a tank (30) containing liquid at a substantially constant pressure for supply to a batch dispensing on/off valve (44) by way of a digital mass flow meter (42), and a computer (48) for controlling the valve in accordance with a soft-ware programme and with information received from the meter. The tank is pressurised by the controlled supply or release of gas through a valve (36). The computer interacts with the valve (44) and the meter (42) by way of electro-pneumatic interfaces (50).
摘要翻译：用于分配测量批次的液体的装置迄今使用计量泵，其可以精确地分配，但是由于其复杂性而难以清洁，或者由于其响应缓慢而不能精确地分配少量的模拟计量。能够以高精度分配批次的易于清洁的装置包括容纳基本恒定压力的液体的罐（30），用于通过数字质量流量计供给批量分配开/关阀（44）（42），以及用于根据软件程序和从仪表接收的信息来控制阀的计算机（48）。通过阀（36）的控制供应或释放气体对罐进行加压。计算机通过电动气动接口（50）与阀（44）和仪表（42）相互作用。

6. 发明授权

US06936584B1 Mixed amylin activity compounds 失效
标题翻译：混合胰淀素活性化合物
公开(公告)号：US06936584B1
公开(公告)日：2005-08-30
申请号：US09622104
申请日：1999-02-05
申请人： Nigel R. A. Beeley , Kathryn Prickett , Kevin Beaumont
发明人： Nigel R. A. Beeley , Kathryn Prickett , Kevin Beaumont
IPC分类号： A61K38/00 , C07K14/575 , A61K37/02 , C07K7/10
CPC分类号： C07K14/575 , A61K38/00 , Y10S514/866
摘要： Compounds which inhibit certain activities of amylin but which also act as amylin agonists with respect to other amylin activities are disclosed. Such compounds are useful in treating disturbances in fuel metabolism in mammals, including but not limited to, diabetes, mellitus, including Type I diabetes and Type II diabetes, impaired glucose tolerance, insulin resistance and Syndrome X. The present invention also relates to methods of treating Type I diabetes, beneficially regulating gastrointestinal motility, treating impaired glucose tolerance, treating postprandial hyperglycemia, treating obesity and treating Syndromne X, comprising administration of a therapeutically effective amount of certain compounds, as described herein.
摘要翻译：公开了抑制胰岛淀粉多胺的某些活性但也用作其他胰淀素活性的胰岛淀粉样多肽激动剂的化合物。这些化合物可用于治疗哺乳动物的燃料代谢紊乱，包括但不限于糖尿病，包括I型糖尿病和II型糖尿病，葡萄糖耐量降低，胰岛素抵抗和X综合症。本发明还涉及治疗I型糖尿病，有利地调节胃肠蠕动，治疗葡萄糖耐量降低，治疗餐后高血糖症，治疗肥胖症和治疗Syndromne X，包括施用治疗有效量的某些化合物，如本文所述。

7. 发明授权

US5625032A Selective amylin antagonist peptides and uses therefor 失效
标题翻译：选择性胰岛淀粉样多肽拮抗肽及其用途
公开(公告)号：US5625032A
公开(公告)日：1997-04-29
申请号：US96172
申请日：1993-07-21
申请人： Lori Gaeta , Kevin Beaumont , Kathryn Prickett
发明人： Lori Gaeta , Kevin Beaumont , Kathryn Prickett
IPC分类号： A61K38/00 , C07K14/575 , A61K38/16 , C07K14/00
CPC分类号： C07K14/575 , A61K38/00
摘要： Peptides that inhibit amylin activity and that exhibit selectivity for amylin receptors relative to calcitonin and CGRP receptors are provided. These peptides may be used in the treatment of conditions where it is of benefit to reduce amylin activity, including the treatment of Type 2 diabetes mellitus, impaired glucose tolerance, obesity, insulin resistance and hypertension.
摘要翻译：提供了抑制胰岛淀粉样多肽活性并相对于降钙素和CGRP受体显示对胰岛淀粉样多肽受体的选择性的肽。这些肽可用于治疗有利于减少胰岛淀粉样多肽活性的病症，包括治疗2型糖尿病，葡萄糖耐量降低，肥胖，胰岛素抵抗和高血压。

8. 发明授权

US5527771A Methods and Compositions for treatment of diabetes mellitus, hypoglycemia & other conditions 失效
标题翻译：治疗糖尿病，低血糖等症状的方法和组成
公开(公告)号：US5527771A
公开(公告)日：1996-06-18
申请号：US260493
申请日：1994-06-14
申请人： Kevin Beaumont , Andrew A. Young
发明人： Kevin Beaumont , Andrew A. Young
IPC分类号： A61K38/22 , A61K38/26 , A61K38/28 , A61K49/00 , A61K38/00 , A61K38/23 , C07K14/585 , C07K14/605
CPC分类号： A61K49/0008 , A61K38/22 , A61K38/23 , A61K38/26
摘要： Methods for treatment of diabetes and other insulin-requiring conditions by administering insulin and a calcitonin with or without amylin, and methods for treatment of hypoglycemic conditions by administering a calcitonin alone or in combination with glucagon and/or an amylin, and related compositions.
摘要翻译：通过施用胰岛素和降钙素来治疗糖尿病和其它需要胰岛素的病症的方法，以及通过单独或与胰高血糖素和/或胰岛淀粉样多肽组合施用降钙素和相关组合物来治疗降血糖病症的方法。

9. 发明授权

US5508260A Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions 失效
标题翻译：用于治疗糖尿病，低血糖症和其他病症的方法和组合物
公开(公告)号：US5508260A
公开(公告)日：1996-04-16
申请号：US259755
申请日：1994-06-10
申请人： Kevin Beaumont , Andrew A. Young
发明人： Kevin Beaumont , Andrew A. Young
IPC分类号： A61K38/22 , A61K38/23 , A61K38/26 , A61K38/28 , A61K49/00 , A61P3/06 , C07K14/585 , C07K14/62
CPC分类号： A61K38/28 , A61K38/22 , A61K38/23 , A61K38/26 , A61K49/0008
摘要： Methods for treatment of diabetes and other insulin-requiring conditions by administering insulin and a calcitonin with or without amylin, and methods for treatment of hypoglycemic conditions by administering a calcitonin alone or in combination with glucagon and/or an amylin, and related compositions.
摘要翻译：通过施用胰岛素和降钙素来治疗糖尿病和其它需要胰岛素的病症的方法，以及通过单独或与胰高血糖素和/或胰岛淀粉样多肽组合施用降钙素和相关组合物来治疗降血糖病症的方法。

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