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    • 3. 发明申请
    • METHOD FOR PRODUCING OPTICALLY ACTIVE a-IONONE
    • 用于生产光学活性α-离子的方法
    • US20110118500A1
    • 2011-05-19
    • US13012199
    • 2011-01-24
    • Tetsuya YamamotoKenji YagiKenya Ishida
    • Tetsuya YamamotoKenji YagiKenya Ishida
    • C07C69/78C07C69/533C07C69/63C07C69/24C07C69/708
    • C12P7/26A23L2/56A23L27/204A61K8/37A61Q11/00A61Q13/00C07B53/00C07B2200/07C07C403/08C07C403/12C07C403/14C07C2601/16C12G3/06C12P41/004
    • Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.
    • 本发明提供了一种低成本地生产光学活性α-紫罗兰酮的方法,其具有高产率和高不对称产率,并且在短时间内具有良好的可加工性,以及包含通过上述方法获得的光学活性α-紫罗兰酮的香料组合物。 一种光学活性α-紫罗兰酮的制造方法,其特征在于,使作为旋光异构体的混合物的α-紫罗烯酮与酯化反应,水解得到的α-紫罗烯酮烯醇酯; 一种光学活性α-紫罗兰酮的制造方法,其特征在于,将α-紫罗烯酮作为光学异构体的混合物进行不对称还原,使得所得光学活性α-离子酚与酯化反应,得到光学活性α-离子醇酯,水解 根据需要纯化后得到的光学活性α-离子醇酯,然后氧化所得光学活性α-离子醇; 和包含这样得到的光学活性α-紫罗兰酮的香料组合物。
    • 6. 发明授权
    • Method for producing optically active α-ionone
    • 光学活性α-紫罗兰酮的制造方法
    • US08053592B2
    • 2011-11-08
    • US13012199
    • 2011-01-24
    • Tetsuya YamamotoKenji YagiKenya Ishida
    • Tetsuya YamamotoKenji YagiKenya Ishida
    • C07C69/78C07C69/533C07C69/63
    • C12P7/26A23L2/56A23L27/204A61K8/37A61Q11/00A61Q13/00C07B53/00C07B2200/07C07C403/08C07C403/12C07C403/14C07C2601/16C12G3/06C12P41/004
    • Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.
    • 本发明提供了一种低成本地生产光学活性α-紫罗兰酮的方法,其具有高产率和高不对称产率,并且在短时间内具有良好的可加工性,以及包含通过上述方法获得的光学活性α-紫罗兰酮的香料组合物。 一种光学活性α-紫罗兰酮的制造方法,其特征在于,使作为旋光异构体的混合物的α-紫罗烯酮与酯化反应,水解得到的α-紫罗烯酮烯醇酯; 一种光学活性α-紫罗兰酮的制造方法,其特征在于,将α-紫罗烯酮作为光学异构体的混合物进行不对称还原,使得所得光学活性α-离子酚与酯化反应,得到光学活性α-离子醇酯,水解 根据需要纯化后得到的光学活性α-离子醇酯,然后氧化所得光学活性α-离子醇; 和包含这样得到的光学活性α-紫罗兰酮的香料组合物。
    • 8. 发明申请
    • COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION
    • 冷却感觉剂组合物和感觉刺激剂组合物
    • US20110117147A1
    • 2011-05-19
    • US12936160
    • 2009-04-01
    • Kenya IshidaTakashi AidaTetsuya Yamamoto
    • Kenya IshidaTakashi AidaTetsuya Yamamoto
    • A61K8/49A61K8/55A61Q11/00C07C69/96C07D317/22A61Q17/00A61K31/357
    • C07D317/36A23L27/203A23L27/2052A61K8/0208A61K8/37A61K8/4973A61K2800/244A61Q5/02A61Q11/00A61Q13/00A61Q15/00A61Q19/00A61Q19/10C07C69/24C07C69/96C07C2601/14
    • The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from 1-menthol, 1-isopulegol, 3-(1-menthoxy)propan-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.
    • 本发明涉及具有延长的凉爽感觉效果的冷却感觉剂组合物,其包含至少一种选自式(1)的化合物,其中A和B各自为氢原子或可具有一个或多个取代基的烃基,其中 A和B不同时为氢原子,A和B中碳原子总数为6〜18; 和式(2)至(4)其中R 1,R 2和R 3各自表示选自1-薄荷醇,1-异胡耳醇,3-(1-薄荷氧基)丙-1,2-二醇,2- (1-薄荷氧基)乙-1-醇,3-(1-薄荷氧基)丙-1-醇,2-甲基-3-(1-薄荷氧基)丙-1,2-二醇和对 - 薄荷烷-3,8 - 二醇),R4代表具有6-18个碳原子的支链或直链,环状或直链或饱和或不饱和醇的残基,其可具有一个或多个可具有稠环的芳环和取代基如 作为羟基和醚基团; R6表示可以具有支链并含有一个以上的不饱和键的碳原子数为11〜19的烃基。 本发明还涉及包含冷却感觉剂组合物的感觉刺激剂组合物; 香料或香料组合物,饮料或食品,香水或化妆品,化妆品,日常用品或杂货,纤维,纤维制品,布或包含该冷却感觉组合物或感官的药物 刺激剂组成; 其制造方法; 纤维,纤维制品或布的冷却处理方法,其包括将冷却感觉剂组合物或感觉刺激剂组合物混合; 和新化合物。
    • 10. 发明申请
    • Method for Producing Optically Active Alpha-Ionone
    • 生产光学活性α-紫罗兰酮的方法
    • US20090216039A1
    • 2009-08-27
    • US11991966
    • 2006-09-13
    • Tetsuya YamamotoKenji YagiKenya Ishida
    • Tetsuya YamamotoKenji YagiKenya Ishida
    • C12P7/26C07C69/75C07C45/42
    • C12P7/26A23L2/56A23L27/204A61K8/37A61Q11/00A61Q13/00C07B53/00C07B2200/07C07C403/08C07C403/12C07C403/14C07C2601/16C12G3/06C12P41/004
    • Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.
    • 本发明提供了一种低成本地生产光学活性α-紫罗兰酮的方法,其具有高产率和高不对称产率,并且在短时间内具有良好的可加工性,以及包含通过上述方法获得的光学活性α-紫罗兰酮的香料组合物。 一种光学活性α-紫罗兰酮的制造方法,其特征在于,使作为光学异构体的混合物的α-紫罗兰酮与酯化剂反应,水解得到的α-紫罗兰酮烯醇酯; 制备光学活性α-紫罗兰酮的方法,包括将α-紫罗烯酮作为光学异构体的混合物进行不对称还原,使得到的光学活性α-离子酚与酯化反应得到光学活性α-离子醇酯,水解 根据需要纯化后得到的光学活性α-离子醇酯,然后氧化得到的光学活性α-离子醇; 和包含由此获得的光学活性α-紫罗兰酮的香料组合物。