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1. 发明申请

US20070021801A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070021801A1
公开(公告)日：2007-01-25
申请号：US11374852
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel , Gary King
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel , Gary King
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。

2. 发明申请

US20070039625A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070039625A1
公开(公告)日：2007-02-22
申请号：US11374793
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
IPC分类号： A61B19/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz) frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.
摘要翻译：描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输注泵的系统。

3. 发明申请

US20070021802A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070021802A1
公开(公告)日：2007-01-25
申请号：US11375492
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。描述了通过植入式输注系统递送疼痛治疗剂。还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。

4. 发明申请

US20060009806A1 Anti-infective medical device 有权
标题翻译：抗感染医疗器械
公开(公告)号：US20060009806A1
公开(公告)日：2006-01-12
申请号：US11008445
申请日：2004-12-09
申请人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , William Bertrand
发明人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , William Bertrand
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/0568 , A61N1/375
摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译：描述具有抗感染性的植入式医疗装置（IMDS）。抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性抗感染剂会发展。

5. 发明申请

US20050267543A1 Antimicrobial protection for implantable medical device 审中-公开
标题翻译：可植入医疗器械的抗菌保护
公开(公告)号：US20050267543A1
公开(公告)日：2005-12-01
申请号：US11008664
申请日：2004-12-09
申请人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , Richard Ries , Kenneth Cobian
发明人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , Richard Ries , Kenneth Cobian
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/375 , A61N1/05
摘要： An anti-infective covering for an implantable medical device is described. The covering may be a polymeric boot that comprises an anti-infective agent in an amount effective to prevent an infection when implanted in a pocket of a patient. The boot is configured to snuggly engage at least a portion of the implantable medical device. The boot may contain a side hole that allows a housing of the implantable medical device to serve as a return electrode. The boot may be placed about the implantable medical device to render the device anti-infective.
摘要翻译：描述了用于可植入医疗装置的抗感染覆盖物。覆盖物可以是聚合物护套，其包含有效防止植入患者口袋时感染的抗感染剂。靴子被配置成紧密接合可植入医疗装置的至少一部分。靴子可以包含允许可植入医疗装置的壳体用作返回电极的侧孔。引导可以围绕可植入医疗装置放置以使装置抗感染。

6. 发明授权

US07596408B2 Implantable medical device with anti-infection agent 失效
标题翻译：具有抗感染剂的植入式医疗器械
公开(公告)号：US07596408B2
公开(公告)日：2009-09-29
申请号：US10837319
申请日：2004-04-30
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device with anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：具有抗感染剂的可植入医疗器械。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

7. 发明授权

US07596399B2 Implantation of implantable medical device 有权
标题翻译：植入式植入式医疗器械
公开(公告)号：US07596399B2
公开(公告)日：2009-09-29
申请号：US10835527
申请日：2004-04-29
申请人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
发明人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
IPC分类号： A61B5/04 , A61B8/00
CPC分类号： A61B5/6864 , A61B5/107 , A61B5/686 , A61B5/6868
摘要： In general, the invention is directed to strategies pertaining to implantation of an implantable medical device between a scalp and a skull of the patient. The invention pertains to collection of data such as data pertaining to the skull of the patient, the scalp of the patient, the vascular structure or neurological structures in the head of the patient, and the like. The data may be in the form of images, such as images generated by X-ray, magnetic resonance imaging, CT-scan and fluoroscopy. A surgeon can use the collected data to determine, for example, whether the patient is a candidate for a cranial implantation, whether the patient's skull and scalp can support the implantation, what configuration of device should be implanted, where the device should be implanted, and how the surgical incisions should be made.
摘要翻译：通常，本发明涉及关于在头皮和患者头骨之间植入可植入医疗装置的策略。本发明涉及诸如患者头骨，患者头皮，患者头部的血管结构或神经结构等数据的收集等。数据可以是图像的形式，例如通过X射线产生的图像，磁共振成像，CT扫描和荧光透视。外科医生可以使用收集的数据来确定例如患者是颅骨植入的候选者，患者的颅骨和头皮是否能够支撑植入，应植入装置的哪些配置，植入装置的位置，以及如何做外科切口。

8. 发明申请

US20080081982A1 Method And Apparatus For Optimizing A Computer Assisted Surgical Procedure 有权
标题翻译：用于优化计算机辅助外科手术的方法和装置
公开(公告)号：US20080081982A1
公开(公告)日：2008-04-03
申请号：US11683796
申请日：2007-03-08
申请人： David Simon , Mark S. Lent , Ruchika Singhal , Andrew N. Csavoy
发明人： David Simon , Mark S. Lent , Ruchika Singhal , Andrew N. Csavoy
IPC分类号： A61B5/05
CPC分类号： A61B34/25 , A61B5/0066 , A61B5/0084 , A61B5/062 , A61B5/066 , A61B5/7435 , A61B34/10 , A61B34/20 , A61B90/06 , A61N1/0534 , A61N5/1048 , G06F19/00 , G06F19/3481 , G16H50/50
摘要： A method and apparatus for optimizing a computer assisted procedure is provided. A method and apparatus for performing a procedure is also provided. Data can be accessed and processed to optimize and perform a procedure. The data can be augmented or supplemented with patient specific data.
摘要翻译：提供了一种用于优化计算机辅助程序的方法和装置。还提供了一种用于执行过程的方法和装置。可以访问和处理数据以优化和执行一个过程。数据可以增加或补充患者特定数据。

9. 发明授权

US07242982B2 Overmold for a modular implantable medical device 有权
标题翻译：用于模块化可植入医疗设备的包覆模型
公开(公告)号：US07242982B2
公开(公告)日：2007-07-10
申请号：US10730873
申请日：2003-12-09
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： A modular implantable medical device permits implantable medical devices to have a smaller profile in order to better fit into locations within the human body. A modular implantable medical device separates various functional components of the implantable medical device into a set of interconnected modules. This distributed architecture of a modular implantable medical device may permit the device footprint to be distributed over a larger area while making the profile smaller, and may permit the overall shape of the implantable medical device to better match the body location into which it is to be implanted. An overmold integrates the modules of a modular implantable medical device into a single structure. In some embodiments the overmold is flexible and provides a biocompatible interface from the component modules and the patient, while restraining potentially harmful intermodule motion.
摘要翻译：模块化可植入医疗装置允许植入式医疗装置具有更小的外形，以便更好地适应人体内的位置。模块化可植入医疗装置将可植入医疗装置的各种功能部件分离成一组互连的模块。模块化可植入医疗设备的这种分布式架构可以允许设备占地面积分布在更大的区域上，同时使轮廓更小，并且可以允许可植入医疗设备的整体形状更好地匹配要被植入的医疗设备的身体位置植入。包覆模具将模块化可植入医疗设备的模块集成到单个结构中。在一些实施方案中，包覆成型是柔性的并且提供来自组件模块和患者的生物相容性界面，同时限制潜在有害的模块间运动。

10. 发明授权

US08396565B2 Automatic therapy adjustments 有权
标题翻译：自动治疗调整
公开(公告)号：US08396565B2
公开(公告)日：2013-03-12
申请号：US10691917
申请日：2003-10-23
申请人： Ruchika Singhal , Robert M. Skime , Steven L. Jensen
发明人： Ruchika Singhal , Robert M. Skime , Steven L. Jensen
IPC分类号： A61N1/18
CPC分类号： A61N1/36071 , A61B5/1116 , A61B5/1118 , A61N1/36132 , A61N1/36135 , A61N1/36139 , A61N1/36535 , A61N1/36542 , A61N1/37264 , G06F19/00
摘要： A medical device detects a previously defined event, and controls delivery of therapy to a patient according to therapy information associated with the previously defined event. In exemplary embodiments, the medical device enters a learning mode in response to a command received from a user, e.g., the patient or a clinician. In such embodiments, the medical device defines the event, collects the therapy information, and associates the therapy information with the defined event while operating in the learning mode. In some embodiments, the medical device defines the event based on the output of a sensor that indicates a physiological parameter of the patient during the learning mode. The sensor may be an accelerometer, which generates an output that reflects motion and/or posture of the patient. The medical device may collect therapy information by recording therapy changes made by the user during the learning mode.
摘要翻译：医疗设备检测先前定义的事件，并且根据与先前定义的事件相关联的治疗信息来控制对患者的治疗递送。在示例性实施例中，医疗设备响应于从用户（例如患者或临床医生）接收的命令进入学习模式。在这样的实施例中，医疗设备定义事件，收集治疗信息，并且在学习模式下操作时将治疗信息与定义的事件相关联。在一些实施例中，医疗设备基于在学习模式期间指示患者的生理参数的传感器的输出来定义事件。传感器可以是加速度计，其产生反映患者的运动和/或姿势的输出。医疗装置可以通过在学习模式下记录用户进行的治疗改变来收集治疗信息。

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