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1. 发明申请

US20070039625A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070039625A1
公开(公告)日：2007-02-22
申请号：US11374793
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
IPC分类号： A61B19/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz) frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.
摘要翻译：描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输注泵的系统。

2. 发明申请

US20070021802A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070021802A1
公开(公告)日：2007-01-25
申请号：US11375492
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。描述了通过植入式输注系统递送疼痛治疗剂。还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。

3. 发明申请

US20070021801A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070021801A1
公开(公告)日：2007-01-25
申请号：US11374852
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel , Gary King
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel , Gary King
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。

4. 发明申请

US20050267543A1 Antimicrobial protection for implantable medical device 审中-公开
标题翻译：可植入医疗器械的抗菌保护
公开(公告)号：US20050267543A1
公开(公告)日：2005-12-01
申请号：US11008664
申请日：2004-12-09
申请人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , Richard Ries , Kenneth Cobian
发明人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , Richard Ries , Kenneth Cobian
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/375 , A61N1/05
摘要： An anti-infective covering for an implantable medical device is described. The covering may be a polymeric boot that comprises an anti-infective agent in an amount effective to prevent an infection when implanted in a pocket of a patient. The boot is configured to snuggly engage at least a portion of the implantable medical device. The boot may contain a side hole that allows a housing of the implantable medical device to serve as a return electrode. The boot may be placed about the implantable medical device to render the device anti-infective.
摘要翻译：描述了用于可植入医疗装置的抗感染覆盖物。覆盖物可以是聚合物护套，其包含有效防止植入患者口袋时感染的抗感染剂。靴子被配置成紧密接合可植入医疗装置的至少一部分。靴子可以包含允许可植入医疗装置的壳体用作返回电极的侧孔。引导可以围绕可植入医疗装置放置以使装置抗感染。

5. 发明申请

US20060009806A1 Anti-infective medical device 有权
标题翻译：抗感染医疗器械
公开(公告)号：US20060009806A1
公开(公告)日：2006-01-12
申请号：US11008445
申请日：2004-12-09
申请人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , William Bertrand
发明人： Kenneth Heruth , Christopher Hobot , William Hooper , Mark Lent , Ruchika Singhal , Robert Skime , Randall Sparer , Maura Donovan , William Bertrand
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/0568 , A61N1/375
摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译：描述具有抗感染性的植入式医疗装置（IMDS）。抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性抗感染剂会发展。

6. 发明申请

US20050182389A1 Implantable medical device and patch system and method of use 审中-公开
标题翻译：植入式医疗器械及贴片系统及使用方法
公开(公告)号：US20050182389A1
公开(公告)日：2005-08-18
申请号：US10137516
申请日：2002-04-30
申请人： Steve LaPorte , Markus Haller , William Hooper , Mark Lent , Kenneth Riff , Kenneth Heruth , James Olsen
发明人： Steve LaPorte , Markus Haller , William Hooper , Mark Lent , Kenneth Riff , Kenneth Heruth , James Olsen
IPC分类号： A61B5/00 , A61M5/142 , A61M5/172 , A61M37/00 , A61N1/08 , A61N1/30 , A61N1/37 , A61N1/372 , G06F19/00 , A61K9/22
CPC分类号： A61N1/37235 , A61B5/0031 , A61B2560/0271 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M37/0092 , A61M2005/14208 , A61M2005/14268 , A61M2205/3523 , A61N1/08 , A61N1/30 , A61N1/3702 , A61N1/37217 , A61N1/37258 , A61N1/37288 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： A system, method and apparatus relating to a therapeutic substance delivery patch for attachment to a patient such that the patch is in contact with the patient's skin, wherein the patch coordinates its delivery of the therapeutic substance to the patient based on information received relating to the operation of the implanted device. The information received by the patch may be received through telemetry from the implanted device, or alternatively from the patch sensing the action of the implanted device, or alternatively from the patch sensing the patient's physiologic reaction to the action taken by the implanted device.
摘要翻译：一种与用于附着于患者的治疗物质递送贴片相关的系统，方法和装置，使得贴片与患者的皮肤接触，其中贴片基于与植入装置的操作。补片接收的信息可以通过来自植入装置的遥测接收，或者替代地从感测植入装置的动作的贴片接收，或者可选地，从感测患者的生理反应的贴片到植入装置采取的动作。

7. 发明申请

US20050079199A1 Porous coatings for drug release from medical devices 审中-公开
标题翻译：从医疗器械释放药物的多孔涂层
公开(公告)号：US20050079199A1
公开(公告)日：2005-04-14
申请号：US10933734
申请日：2004-09-03
申请人： Kenneth Heruth , Edouard Koullick , Mark Lent
发明人： Kenneth Heruth , Edouard Koullick , Mark Lent
IPC分类号： A61K9/50 , A61M5/00 , A61M27/00 , A61M29/00
CPC分类号： A61M27/006
摘要： Extravascular implantable medical devices are described. The devices include a polymeric layer comprising a polymeric matrix and pores. Therapeutic agent is loaded in the matrix, in the pores, or in the matrix and the pores. The devices include a structural surface layer. Additional therapeutic agent may be loaded in or on the surface layer. The devices may also include one or more intermediate layer, into or onto which additional therapeutic agent may be loaded.
摘要翻译：描述了血管内可植入医疗装置。所述装置包括聚合物层，其包含聚合物基质和孔。治疗剂加载到基质，孔中或基质和孔中。这些装置包括结构表面层。另外的治疗剂可以装载在表面层中或表面层上。装置还可以包括一个或多个中间层，可以加载另外的治疗剂。

8. 发明申请

US20060039946A1 Drug eluting medical device 审中-公开
标题翻译：药物洗脱医疗器械
公开(公告)号：US20060039946A1
公开(公告)日：2006-02-23
申请号：US10975253
申请日：2004-10-28
申请人： Kenneth Heruth , Mark Lent
发明人： Kenneth Heruth , Mark Lent
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61K9/0024 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61L2300/61 , A61M37/00 , A61M2025/0057 , A61N1/0534 , A61N1/0536 , A61N1/0551 , A61N1/36071
摘要： Medical devices configured to be implanted in two or more tissues simultaneously are discussed. A therapeutic agent is disposed on, in, or about at least a portion of an external surface of a medical device configured to be placed in one tissue, but not on, in or about a surface configured to be placed in another tissue. The therapeutic agent may be disposed on or in a polymeric material, which is disposed on or about at least a portion of an external surface of first portion the medical device. Such targeted placement of polymeric material may allow for the therapeutic agent to be eluted in an appropriate tissue and may allow for decreased undesired effects.
摘要翻译：讨论了被配置为同时植入在两个或更多个组织中的医疗装置。治疗剂设置在医疗装置的外表面的至少一部分上，或者围绕被配置成放置在一个组织中但不在其上或周围的配置为放置在另一组织中的表面上。治疗剂可以设置在聚合物材料上或聚合物材料中，聚合物材料设置在医疗装置的第一部分的外表面的至少一部分上或周围。聚合材料的这种靶向放置可以使治疗剂在适当的组织中洗脱并且可以减少不期望的效果。

9. 发明申请

US20050137579A1 Permeable membrane catheters, systems, and methods 审中-公开
标题翻译：可渗透膜导管，系统和方法
公开(公告)号：US20050137579A1
公开(公告)日：2005-06-23
申请号：US10874158
申请日：2004-06-22
申请人： Kenneth Heruth , Mark Lent , Justin Blanco
发明人： Kenneth Heruth , Mark Lent , Justin Blanco
IPC分类号： A61M25/00 , A61M25/16
CPC分类号： A61M25/0043 , A61M5/14276 , A61M5/16827 , A61M25/003 , A61M25/007 , A61M25/0105 , A61M2025/0007 , A61M2025/0057 , A61M2025/0073 , A61M2025/0166 , A61M2202/0464 , A61M2205/0244 , A61M2205/123 , A61M2205/128 , A61M2205/3331 , A61M2205/3523 , A61M2205/50 , A61M2210/0693 , A61M2210/1003
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more valves that control flow to the infusion sections.
摘要翻译：公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。在各个方面，系统和方法可以包括具有可渗透膜的输注部分的导管和控制向输注部分流动的一个或多个阀。

10. 发明申请

US20050106545A1 Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein 有权
标题翻译：三维体外脊髓模型及其分析物质分布的方法
公开(公告)号：US20050106545A1
公开(公告)日：2005-05-19
申请号：US10957359
申请日：2004-10-01
申请人： Kenneth Heruth , Mark Lent , Michael Hegland
发明人： Kenneth Heruth , Mark Lent , Michael Hegland
IPC分类号： G09B23/28 , G09B23/30 , G09B23/34
CPC分类号： G09B23/34 , B33Y50/00 , B33Y80/00 , G09B23/30
摘要： An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticum of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
摘要翻译：人体脊柱体外模型装置及其中物质分布模式的检测和分析方法。在一个实施例中，模型设备包括定义通道的柱体，该通道基本上模拟成年人脊柱的尺寸，形状和结构。还包括可以位于和锚定在通道内的绳索结构。帘线结构基本上模仿成年人脊髓的尺寸，形状和结构。例如，绳索结构可以包括类似神经根，齿状韧带和人脊柱的隔膜的连接元件。模型装置的通道可以填充有模拟脑脊液（CSF）的第一流体，并且可以将含有药物（或模拟药物）的第二流体引入通道中，之后药物在通道内的分布可以分析。

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